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Results for “Endodermal Sinus Tumor”

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At least 145 records · Page 8Linked to original sources
PubMed1977

Ovarian extraembryonal teratoma. II. Endodermal sinus tumor mixed with other germ cell tumors.

From the files of the Emil Novak Ovarian Tumor Registry, 18 cases of mixed ovarian germ-cell neoplasms containing endodermal sinus tumor as one element have been reviewed. The data regarding the patient age, presenting symptoms, gross appearance of the tumors, and response to therapy are similar to those reported in a previous series of pure endodermal sinus tumors. Response to all modes of therapy is disappointing but there is growing evidence that combination chemotherapy should be added to surgical excision as a routine part of therapy in such patients. The rarity of this lesion is such that meaningful data are likely to be available only if individual and institutional experiences are combined in central tumor registries.

Adolescent↗
PubMed2003

Primary prostatic endodermal sinus tumor (yolk sac tumor) combined with a small focal seminoma.

We report on a primary endodermal sinus tumor (EST) (yolk sac tumor) combined with a focal seminoma of the prostate occurring in a 24-year-old man. The prostate was widely infiltrated with neoplasms that penetrated the capsule and invaded into the bladder wall and urethra. Most areas of the tumor were composed of papillary and glandular epithelium in the fibrous or myxoid stroma. Schiller-Duval bodies and periodic acid-Schiff-positive hyaline bodies were focally present. In addition to yolk sac tumor, solid nests of seminoma were found in some areas. Immunohistochemistry using specific antibodies for alpha-fetoprotein and cytokeratin showed positive reaction on the EST portion, and placental alkaline phosphatase revealed positive staining in the seminoma portion and a part of EST. Tumor cells exhibited negative staining for prostate-specific antigen, prostatic acid phosphatase, carcinoembryonic antigen, vimentin, chromogranin A, and human chorionic gonadotropin. Despite radical surgery and ordinary cisplatin-based chemotherapy, the patient died 8 months after operation. At autopsy, only EST elements had metastasized to the lungs, liver, and brain, and no tumors were found in either testis. To our knowledge, this is the first reported case of a primary EST combined with a focal seminoma in the prostate.

Adult↗
PubMed1977

[Terminology and chemotherapy of the so-called endodermal sinus tumor].

In addition to a discussion on the histogenetic, terminological and clinical problems concerning the so called endodermal sinus tumor a typical case in a far advanced stage is reported. Chemotherapy with vincristine and adriblastine was not able to influence the deleterious course of desease. Anyhow, since little is known about the effect of chemotherapy on the so called endodermal sinus tumor, this report might be of advantage.

Adult↗
PubMed1977

Ovarian extraembryonal teratoma. I. Endodermal sinus tumor.

Forty-one cases of pure endodermal sinus ovarian tumors are reported. The extraembryonal nature of this tumor is supported with comparative studies utilizing early human implantations. The clinical picture is one of a virulent malignancy occurring in young women, and although the tumor is commonly unilateral and encapsulated at the time of initial diagnosis, the outcome is almost always fatal. Experience with different therapeutic modalities is limited, but there is significant evidence that vigorous combination chemotherapy will improve the therapeutic outcome.

Adolescent↗
PubMed1985

Modified VAB-3 combination chemotherapy of advanced and recurrent endodermal sinus tumors of the ovary.

Three patients with advanced and recurrent endodermal sinus tumor (EST) of the ovary were treated with modified vinblastine, actinomycin-D, and bleomycin (VAB-3) regimen. Serum alpha-fetoprotein (AFP) levels were monitored for all patients during and after therapy. In all patients a clinical response was achieved. In one stage IV patient with huge multiple liver metastases complete response was attained and she is free of disease following secondlook larparotomy. In other two patients, one stage IV and another recurrent, with large liver metastases, partial responses were achieved with normalization of serum AFP. Serum AFP monitoring is valuable for the management of EST, but a negative AFP titer does not eliminate the possibility of persistent or recurrent disease. The VAB-3 combination, previously found effective in metastatic nonseminomatous testicular cancer, is also effective in advanced and recurrent EST of the ovary.

Adolescent↗
PubMed1989

Endodermal sinus tumor treated with high dose cisplatin.

A woman with an endodermal sinus tumor of the ovary stage IV obtained a short but complete remission after treatment with vinblastine, bleomycin and standard dose cisplatin. A second complete remission for 42+ months was obtained with a regimen of vinblastine, bleomycin, etoposide, and high dose cisplatin. This result suggests a dose-response relationship for cisplatin in ovarian germ cell tumors.

Adult↗
PubMedDate not supplied

Endodermal sinus tumor of vulva (a case report).

An unusual case of endodermal sinus tumor (EST) of the ovary at an extragonadal site-vulva, in an unmarried female of 25 yr is reported. The patient presented only with a vulval swelling on the right side without any other signs or symptoms. The internal genital organs mainly the ovaries were normal.

Adult↗
PubMed1995

[Endodermal sinus tumor of the testis in children: report of 9 cases].

Nine children with endodermal sinus tumor of testis have been treated since 1982. Their age ranged from 7 months to 5 years. Radical inguinal orchiectomy was carried out in all the patients. Four patients have received irregular chemotherapy. The follow-up showed that 4 died of the metastasis within 5 years and 5 (stage I clinically) survived without evidence of the recurrence for 1.5-7 years after operation. Serum AFP determination may give important information for the classification of the tumor and the evaluation of the follow-up results. For the cases of clinical stage I, radical orchiectomy, short course of chemotherapy, and frequent observations of AFP level are advocated.

Child, Preschool↗
PubMed1986

Pregnancy following treatment of endodermal sinus tumor of the ovary with combination chemotherapy, including cis-platinum.

A 16-year-old woman with endodermal sinus tumor of the ovary underwent conservative surgical debulking and combination chemotherapy and had a recurrence documented by a rise in alpha-fetoprotein. She had a complete response to a second chemotherapy regimen, including cis-platinum. Subsequently, she became pregnant. The case emphasizes the management of endodermal sinus tumor, including conservative surgery, combination chemotherapy, and monitoring serum alpha-fetoprotein levels. This is the second report of pregnancy following cis-platinum administration.

Adolescent↗
PubMed1984

The prognostic significance of endodermal sinus tumor histology among patients treated for stage III nonseminomatous germ cell tumors of the testes.

A retrospective study was undertaken to determine the prognostic significance of endodermal sinus tumor (EST) elements in 56 patients with Stage III nonseminatous germ cell tumors of the testes (NSGCTT). The study patients were treated with conventional vinblastine, bleomycin and cisplatinum chemotherapy prior to our recognition of EST as a distinct entity. Twenty-one (37.5%) of the patients had EST elements in their tumors. Nineteen patients had EST in their primary testis tumor, whereas two had EST in metastatic sites only. Prognostic criteria (tumor volume, Dixon-Moore classification and chemotherapy vinblastin and bleomycin [VB] and VB plus cisplatin [VB + P] ) were similar in EST and non-EST patients. Long-term disease-free survival was significantly poorer for patients with Stage III NSGCTT containing EST (38%) compared with those not containing EST (71%) (P = 0.04). All 12 patients with small volume disease (III-B1-III-B2), independent of the presence of EST, are alive and free of disease for more than 2 years. Only 6 of 18 patients (33%) with advanced disease and EST are alive and free of disease, whereas 17 of 26 (65%) of patients with advanced disease not containing EST are alive and free of disease (P = 0.074). The addition of single agent bolus cisplatin to the treatment of patients with advanced disease achieved no improvement in survival. Endodermal sinus tumor must be included in future studies of advanced Stage III NSGCTT as an important prognostic variable.

Abdominal Neoplasms↗
PubMed1989

Endodermal sinus tumor of the infant vagina treated exclusively by chemotherapy.

A 5-month-old Hispanic female, diagnosed as having endodermal sinus tumor of the vagina, was treated with combination chemotherapy in an attempt to preserve pelvic function. An incisional biopsy was performed before starting chemotherapy. After completion of chemotherapy, no residual disease was found at exploratory laparotomy. The patient received no further therapy and is disease-free 45 months later. This case represents successful treatment of a vaginal endodermal sinus tumor without any operative excision.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Retroperitoneal endodermal sinus tumor. Report of a case with an abnormal cervicovaginal smear.

An unusual case of an endodermal sinus tumor arising in the retroperitoneum and invading the fallopian tube is reported. The patient presented with malignant cells mimicking adenocarcinoma in the cervicovaginal smear. The differential diagnoses of such cells in cervicovaginal cytology are discussed. The cytohistologic, immunohistochemical and ultrastructural findings of the tumor are correlated.

Adult↗
PubMed1995

[Response of ovarian endodermal sinus tumor to combination chemotherapy with cis-platinum, vincristine and bleomycin or vincristine, actinomycin and cyclophosphamide].

The treatment results of 63 cases of ovarian endodermal sinus tumor admitted to Peking Union Medical College Hospital from August 1977 through April 1992 by combination chemotherapy were reported. Patients were divided into three groups. The first group received full courses of vincristine, actinomycin and cyclophosphamide (VAC) or cis-platinum, vincristine and bleomycin (PVB) chemotherapy in adequate dosages (37 cases). The second group also received VAC or PVB chemotherapy but in inadequate dosages (17 cases). The third group took no VAC or PVB chemotherapy but some other chemotherapeutic drugs (9 cases). 28 of the 63 patients died. The 35 surviving patients have been followed for 1 to 15 years. The sustained remission rates were 81.1%, 23.5% and 11.1% for the first, second and third group respectively. As the ovarian endodermal sinus tumor is very sensitive to VAC or PVB chemotherapy an extensive or aggressive cytoreductive surgery and retroperitoneal lymphadenectomy seemed to be not necessary. Such a point of view is demonstrated by our preliminary study. The treatment results for the primary cases are significantly better than that of the recurrent cases. The sustained remission rate is 94.7% for the former while that for the latter is 66.7%.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

Maternal and fetal survival following surgery and chemotherapy of endodermal sinus tumor of the ovary during pregnancy: a case report.

An ovarian endodermal sinus tumor was found in a patient with a 15-week intrauterine gestation. She received conservative surgery and six courses of combination chemotherapy from 16 weeks' gestation, and delivered a normal term infant at 37 weeks' gestation. Two other courses of combination chemotherapy including cisplatin were added. No residual tumor was found at subsequent exploration, and she is alive 33 months after the original diagnosis without any evidence of recurrence. We believe this is the first reported case of maternal survival past 2 years and the earliest chemotherapy done in the early second trimester of pregnancy without resulting in fetal abnormalities.

Adult↗
PubMedDate not supplied

Successful treatment of an endodermal sinus tumor of the vagina by chemotherapy alone: a rare case of an infant diagnosed by pathological examination of discharged tumor fragment.

A 7-month-old infant was noted to have vaginal bleeding that was accompanied by a discharged tumor fragment. The histological diagnosis was endodermal sinus tumor. Her serum alpha-fetoprotein (AFP) was increased to 358.7 ng/mL, and magnetic resonance imaging showed a 1.8 x 1.0 cm tumor in the vagina. She received combination chemotherapy with cyclophosphamide, pirarubicin, carboplatin, and etoposide. The tumor in the images disappeared and the serum level of AFP returned to the normal range after 2 cycles. Treatment was complete without surgical or radiological therapy. More than 45 months after the completion of chemotherapy, she is alive without signs of recurrence.

Antineoplastic Combined Chemotherapy Protocols↗