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Treatment of pyogenic granuloma by shave excision and laser photocoagulation.

We present herein our technique for the management of pyogenic granulomas. Twenty such lesions were treated in 13 patients by shave excision followed by laser photocoagulation of the base. Recurrence was noted in just one case and was successfully treated by repeated laser treatment. The cosmetic results have been uniformly excellent. Shave excision followed by laser photocoagulation is an effective therapeutic alternative to excision and linear closure for the treatment of pyogenic granuloma, one that minimizes scar formation while preserving the ability to confirm the diagnosis.

Adolescent↗

The development during pregnancy of pyogenic granulomas superimposed upon a congenital hemangioma: a case report.

A case of a 25-year old female school teacher with pyogenic granulomas of the gingiva developing during her first pregnancy in the area of a congenital hemangioma is described. The recurrence of the pyogenic granulomas of the gingiva during the second pregnancy could be successfully prevented by scaling and root planing prior to and bi-weekly professional tooth cleaning during pregnancy period. Hormonal changes during pregnancy were in this case found not to influence the development of gingival pyogenic granulomas during maintenance of optimal dental hygiene.

Adult↗

Rare case of pyogenic granuloma of the tongue in an 8-week-old infant.

We present a case of a large pyogenic granuloma of the tongue causing swallowing difficulties in an 8-week-old infant. In the literature, we found no case reports of pyogenic granuloma in such a young infant. It is a quickly growing, hypertrophic inflammatory change consisting of exceptionally richly vascularized granular tissue. The granuloma was located in the central part of the tongue and appeared dark pink in color. It was an easily bleeding pedunculated tumor measuring 3 x 2.5 cm. The etiology of the tumor is unknown; it can arise in sites of previous injury, chronic irritation and infection. The course of the disease is benign and painless, though it can be recurrent. No recurrence was found in the control examination after 3 years.

Deglutition Disorders↗

Pyogenic granuloma subsequent to injury of a primary tooth. A case report.

This paper shows a case of pyogenic granuloma occurring as a post-traumatic oral lesion, in a 19-month-old patient. The palatally chamfered fracture of a maxillary primary incisor together with the continuous sucking of a dummy could have caused the special shape of the pyogenic granuloma over the remaining coronal fragment.

Accidental Falls↗

Beau's lines and pyogenic granulomas following hand trauma.

We report two cases of trauma-induced Beau's lines accompanied by pyogenic granulomas of the proximal nail folds of the affected fingers. The preceding trauma was not directly to the nail matrix but was more proximal, on the palm in one case and the arm in the other. The simultaneous occurrence of Beau's lines and pyogenic granulomas following trauma has not been reported previously in the literature.

Adolescent↗

Metaplastic ossification in a cutaneous pyogenic granuloma: a case report.

Cutaneous ossification may occur in association with a variety of cutaneous neoplasms and inflammatory conditions, such as pilomatricomas, basal cell carcinomas, nevi, chondroid syringomas, venous stasis, and scars. However, it has rarely been reported in pyogenic granuloma, a relatively common benign vascular tumor of the skin and mucous membranes. We herein presented a rare case of cutaneous pyogenic granuloma with ectopic ossification on the big toe of a 37-year-old man, with high recurrence despite repeated CO2 laser ablations. We propose the hypothesis that vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs) play pathologic roles in the development of ectopic bone formation in pyogenic granuloma.

Adult↗

Apoptosis and expression of Bax/Bcl-2 proteins in pyogenic granuloma: a comparative study with granulation tissue and capillary hemangioma.

BACKGROUND: Pyogenic granuloma (PG) has been regarded as a florid expression of granulation tissue (GT) proliferation and shows distinct biological behavior compared to conventional GT. PG has not been examined from a standpoint of apoptosis. METHODS: PG (15 cases), GT (14 cases) and capillary hemangioma (CH, 8 cases) were compared using in situ 3'-tailing reaction (ISTR), a histochemical method for identifying apoptotic cells, and immunohistochemistry for Ki-67, Bcl-2 and Bax proteins, in order to clarify and involvement of apoptosis in the difference of biological characteristics between PG and GT. RESULTS: PG showed significantly lower ISTR-labeling indices than GT and CH and more frequent Bcl-2/Bax expression than GT, whereas Ki-67-labeling indices were variable from case to case and did not show any significant differences among any groups. CONCLUSIONS: It is consequently suggested that the low apoptotic rate in PG is closely related to its characteristic rapid growth and is regulated by Bcl-2 family proteins.

Apoptosis↗