PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Integrative interaction”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 145 records · Page 8Linked to original sources
PubMed2002

Intentionality: applications within selected theories of nursing.

Intentionality is an important concept for nurses to study for professional and theoretical reasons. Lewis states that intentionality is best studied within an active, rather than reactive, worldview. This article is a level-by-level outline of Lewis' five-level model for the study of intentionality. These levels are: necessity, interactive necessity, action intent, divergent intent, and conscious intent. Newman's tri-part categorization of nursing theory paradigms (particularate-deterministic, interactive-integrative, and unitary-transformative) proves to be a useful framework to compare the Lewis model of intentionality with nursing theory. Examples from nursing theory development, such as the Roy adaptation model, chronotherapeutics, Rogers' theory of unitary human being, health as expanding consciousness, and therapeutic touch, are used to support all five levels of intentionality in providing guidance for practice and research by nurse theorists.

Consciousness↗
PubMed2004

Spreading dynamics of 2D dipolar Langmuir monolayer phases.

We study the spreading of a liquid 2D dipolar droplet in a Langmuir monolayer. Interfacial tensions (line tensions) and microscopic contact angles depend on the scale on which they are probed and obey a scaling law. Assuming rapid equilibration of the microscopic contact angle and ideal slippage of the 2D solid/liquid and solid/gas boundary, the driving force of spreading is merely expressed by the shape-dependent long-range interaction integrals. We obtain good agreement between experiment and numerical simulations using this theory.

Computer Simulation↗
PubMedDate not supplied

Modulation of presbycusis: current status and future directions.

Literature and ideas are reviewed concerning the modulation of presbycusis - the influence of variables that can alter the severity and/or time course of presbycusis or counteract its negative aspects. Eleven topics are identified: variables related to biological aging; genetics; noise-induced hearing loss; moderately augmented acoustic environment; neural plasticity and the central auditory system; neural plasticity and hearing aids; socioeconomic and cultural barriers to hearing aid use; lifestyle (diet, exercise, etc.); medical variables; pharmaceutical interventions for presbycusis, and cognitive variables. It is concluded that the field of otogerontology will best be served by a comprehensive, integrative interaction among basic researchers and clinical scientists who will continue to learn how the auditory problems associated with presbycusis can be intentionally modulated in beneficial ways.

Age Factors↗
PubMed1997

Parental experience and meaning construction during a pediatric health crisis.

This study explores parental lived experience following admission of their child to a pediatric intensive care unit. The interview data used were collected from 10 randomly chosen families from the Family Impact of Catastrophic Childhood Illness Project recruited during the early phase of critical care hospitalization of their child. A 3-stage contextual analysis procedure integrating interactional and contextual perspectives into Colaizz's phenomenological approach was used to reduce text data to thematic content. The analysis uncovered a multidimensional and holistic phenomenon consisting of four organizing concepts: initial boundary ambiguity, parents' coping patterns, family resources, and functioning of the family boundary. These results provide evidence of a collective family level perception of stress when experiencing the health crisis of a child and support further use of family stress perception as a family level phenomenon that represents family meaning construction during critical illness of a child.

Adaptation, Psychological↗
PubMed1998

Antibody-mediated thrombosis: relation to the antiphospholipid syndrome.

Various forms of antibody-mediated thrombosis are presented and the mechanisms involved in their pathogenesis are discussed. Antibody-mediated thrombosis includes heparin-induced thrombocytopenia and thrombosis, autoantibodies to von Willebrand factor mimicking an antiphospholipid syndrome, thrombosis following injection of the murine monoclonal antibody OKT3, hyperacute and acute xenograft rejection, and varicella-associated antibody against protein S. In several of these entities the pathogenesis of thrombosis is closely related to development of cellular procoagulant activity through tight occupancy of Fc receptors, or through complement activation, or through cell-cell interactions. Integrating the antiphospholipid syndrome into the more general category of antibody-mediated thrombosis may provide some hints as to how we could approach the study of those intriguing patients who have the clinical features of the antiphospholipid syndrome but lack those antibodies that currently characterize it.

Adult↗
PubMed1985

Effect of human menopausal gonadotropin and follicle regulatory protein(s) on 3 beta-hydroxysteroid dehydrogenase in human granulosa cells.

Recently, a protein fraction [follicle regulatory protein (FRP)] which inhibits FSH-induced granulosa cell aromatase activity was isolated from both human and porcine follicular fluid. In this study, the actions of FRP on 3 beta-hydroxysteroid dehydrogenase (3 beta-HSDH) activity were examined using granulosa cells obtained from hyperstimulated patients undergoing oocyte aspiration for in vitro fertilization. Granulosa cells were cultured with 0, 167, or 500 micrograms/ml FRP with or without human menopausal gonadotropin (hMG; 10 mIU/ml). After 48 h, the medium (S) was removed and stored. Cells then were mechanically lysed and centrifuged at 10,000 X g. The supernatant was further centrifuged (100,000 X g) to obtain a microsomal fraction (M) and cytosol (C). The M fraction was resuspended in medium 199 with 10(-6) M pregnenolone plus 5 microM NAD+ and incubated for 2 h to determine 3 beta-o1 dehydrogenase activity. The S, C, and M fractions were all assayed for progesterone (P) by RIA. hMG markedly increased P concentrations in the S and C fractions. The M fraction demonstrated a hMG-dependent enhancement in 3 beta-HSDH activity. However, the hMG-associated S, C, and M P levels were decreased in granulosa cells coincubated with FRP. In conclusion, ovarian steroidogenesis may be dependent on the integrated interactions of both gonadotropins and local nonsteroidal paracrine/autocrine modulators of granulosa cell function.

3-Hydroxysteroid Dehydrogenases↗
PubMed2005

Regulation of gene expression by light.

Light signals perceived mainly by phytochromes and cryptochromes regulate plant growth and development by driving dramatic shifts of the transcriptome. Early light-responsive genes include a large proportion of transcripton factors of different DNA binding motifs. Mutations at loci encoding several transcriptional regulators, including some of those showing rapid changes in transcript levels, impair responses to light in Arabidopsis thaliana. Proteasome-mediated degradation involving the E3 ligase COP1 provides an additional layer of control of the levels of transcription factors. Some transcriptional regulators are shared by light, circadian and/or hormonal signalling circuits creating complex networks that interactively integrate environmental and endogenous cues.

Arabidopsis↗
PubMed2004

Concurrent group and individual psychotherapy in a psychiatric day hospital for depressed elderly.

Concurrent psychotherapy is used in various settings for patients of different diagnoses and ages. The concurrent group and individual psychotherapy of older adults with depressive disorders in a psychiatric day hospital is described, emphasizing phases of treatment and transference and countertransference themes uniquely relevant to working with depressed elderly patients in a day hospital. Case examples are offered to illustrate these issues. The special technical considerations that need to be utilized when multiple therapists and settings are present are described. The model employs the use of an integrative, interactive group therapy, along with various other group treatments and antidepressant medication, with individual therapy serving a subordinate but organizing role.

Adaptation, Psychological↗
PubMed2006

[Protection factors against alcohol consumption promoted by pre-school teachers].

This study aimed to describe what protection factors against alcohol consumption are promoted by pre-school teachers at the department of San Alberto, Córdoba, Argentina. This is a quantitative and descriptive study. An auto-administrated instrumented was applied to 43 teachers. The study variables were submitted to descriptive statistical analysis. It was observed that, in a general and indirect way, the teachers' actions focused on the institutional and sociocultural protection factors, since a large part of the developed activities mainly refer to: Stimulating healthy habits, school climate, recreation, group strengthening and integration, interaction and participation in institutions and society. There is a need for the teachers to implement reformulated direct and concrete actions to solve the alcohol problem among pre-school students, with a view to a greater social impact.

Alcohol Drinking↗
PubMed2006

Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes.

The Genetics of Kidneys in Diabetes (GoKinD) study is an initiative that aims to identify genes that are involved in diabetic nephropathy. A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria and consented to participate were enrolled. When possible, both parents also were enrolled to form family trios. As of November 2005, GoKinD included 3075 participants who comprise 671 case singletons, 623 control singletons, 272 case trios, and 323 control trios. Interested investigators may request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form that are available at http://www.gokind.org/access. Participating scientists will have access to three data sets, each with distinct advantages. The set of 1294 singletons has adequate power to detect a wide range of genetic effects, even those of modest size. The set of case trios, which has adequate power to detect effects of moderate size, is not susceptible to false-positive results because of population substructure. The set of control trios is critical for excluding certain false-positive results that can occur in case trios and may be particularly useful for testing gene-environment interactions. Integration of the evidence from these three components into a single, unified analysis presents a challenge. This overview of the GoKinD study examines in detail the power of each study component and discusses analytic challenges that investigators will face in using this resource.

Adult↗
PubMed1987

Ontogenesis of transcallosal responses in cats: I. Formation of interhemispheric connections in kittens in the first month of life.

In acute experiments on kittens at the age of 1 to 30 days, anaesthesized with nembutal and immobilized with diplacine, multiple transcallosal response (TCR) recording from different cortical areas was performed. In 2-15-day kittens homotopical TCRs appeared earlier, were wider represented, and revealed a greater configuration maturity and amplitude-time parameters in associative (parietal and sensorimotor) areas as compared to projection (somatosensory, visual and auditory) zones. It has been established that interhemispheric relations in the kitten associative cortex are mediated, not only by the callosal, but also by the extracallosal system, which was evidenced by the presence of late negative components preserved after callosotomy. The results of per-layer analysis of interhemispheric responses in 1 month kittens have shown that in the parietal cortex, in the course of development, the drains of surface-positive oscillation shifted from the V to the III layer, whereas the drain of surface-negative deviation remained at the level of II-III layers. The late component was registered at the depth of layers III-IV, having a drain in the I-II layers. In the sensorimotor cortex, the surface-negative oscillation had a drain in the I-II layers, whereas the surface-positive oscillation had a drain in the II and V-VI layers. The data obtained reflect the dynamics of the formation of interhemispheric relations in the first-month-of-life kittens and testify to an increased level of their integrative interaction.

Animals↗
PubMed2001

3-D simulation of craniofacial surgical procedures.

An integrated system for simulating craniofacial surgical procedures is presented. The system computes nonlinear soft-tissue deformation due to bone realignment. It is capable of simulating bone cutting and bone realignment with integrated interactive collision detection. Furthermore, soft-tissue deformation and cutting due to surgical instruments can be visualized. The system has been tested with several individual patient data sets. Simulation processes are based on a 3-D model of a patient's preoperative bone structure of the skull derived from a computer tomography scan and on a 3-D, photorealistic model of the patient's preoperative appearance obtained by a laser range scanner. The multi-layer soft-tissue model is represented by nonlinear springs. Very fast and robust prediction of nonlinear soft-tissue deformation is computed by optimizing a nonlinear cost function.

Cephalometry↗
PubMed2001

A virtual reality simulator for bone marrow harvest for pediatric transplant.

Bone marrow transplant is a relatively new procedure to treat recently considered incurable diseases. One important part of the procedure is the process of harvesting the donor bone marrow. We are developing a virtual reality simulator for bone marrow harvest that integrates interactive stereo visualization and force feedback techniques. The main objective is to offer a low cost virtual reality system to boost current adopted training methodologies for bone marrow harvesting.

Bone Marrow Transplantation↗
PubMed2001

Keratin-mediated resistance to stress and apoptosis in simple epithelial cells in relation to health and disease.

Epithelial cells such as hepatocytes exhibit highly polarized properties as a result of the asymmetric distribution of subsets of receptors at unique portions of the surface membrane. While the proper targeting of these surface receptors and maintenance of the resulting polarity depend on microtubules (MTs), the Golgi sorting compartment, and different actin-filament networks, the contribution of keratin intermediate filaments (IFs) has been unclear. Recent data show that the latter cytoskeletal network plays a predominant role in providing resistance to various forms of stress and to apoptosis targeted to the surface membrane. In this context, we first summarize our knowledge of the domain- or assembly-related features of IF proteins and the dynamic properties of IF networks that may explain how the same keratin pair K8/K18 can exert multiple resistance-related functions in simple epithelial cells. We then examine the contribution of linker protein(s) that integrate interactions of keratin IFs with MTs and the actin-cytoskeleton network, polarity-dependent surface receptors and cytoplasmic organelles. We next address likely molecular mechanisms by which K8/K18 can selectively provide resistance to a mechanical or toxic stress, or to Fas-mediated apoptosis. Finally, these issues on keratin structure-function are examined within a context of pathological anomalies emerging in tissue architecture as a result of natural or targeted mutations, or posttranslational modifications at specific amino acid residues. Clearly. the data accumulated in recent years provide new and significant insights on the role of K8/K18, particularly under conditions where polarized cells resist to stressful or apoptotic insults.

Animals↗
PubMed2003

Professional competence and palliative care: an ethical perspective.

The aim of this article is to explore an ethical view of professional competence by examining the professional competence of physicians in the context of palliative care. A discussion of the four dimensions of professional competence--knowledge, technical skills, relationships, and affective and moral attitude--leads us to the conclusion that "habits of mind" are important in every aspect of professional competence. This observation is then considered in the context of virtue ethics and ethics of care. Virtue ethics focuses on personal qualities and moral attitudes, while the ethics of care concentrates on the way these qualities are lived out in specific care relationships. Our conclusion points up the importance of education in ethics in the development of professional competence, and argues that because palliative care involves intense human interactions, integrating palliative care into the medical curriculum may improve the ethical culture of health care as a whole.

Health Knowledge, Attitudes, Practice↗
PubMed1991

Reimbursement of ICFs/MR program costs based on client resource use.

In this article we have described the impetus, research, and recommendations for a new reimbursement system based on client resource use for ICFs/MR in Minnesota. Research to develop a targeted reimbursement strategy has been completed and a proposal for basing program rates on client resource use developed. Residents (N = 913) in a stratified sample of 65 facilities were assessed and staff resource use determined. Results showed that although predictors in the area of personal interaction, integration, and independence, activities of daily living, special treatment/medical complexity, and behavior accounted for a significant amount of variation in resource use, the unaccounted for variation was sufficiently large to support recommending a system that will base program rates on individual client resource use and the historical costs of individual facilities. Key design issues were also discussed.

Child↗
PubMed1982

[Effect of high ambient temperature on regional redistribution of blood flow in the cat].

Supersound flowmetry revealed that the effect of heat (50 degrees C) involved an increase of the blood flow in skin vessels and its decrease in the vessels of small intestine and skeletal muscles. The blood flow resistance was diminished in skin vessels and increased in the vessels of small intestine and skeletal muscles. These shifts of the regional blood flow are due to the integral interaction of active and passive vascular responses. Specifics of the small intestine and skeletal muscle vessels' constrictory responses to hyperthermia suggest a difference in the mechanisms of their occurrence.

Animals↗