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At least 145 records · Page 8Linked to original sources
PubMed2000

[Epidemiology of human Listeria infections in France].

Human listeriosis is a relatively rare but serious disease with case fatality rates between 20 and 30%. The majority of patients who have listeriosis present with meningitis or septicaemia. Listeriosis during pregnancy can lead to a congenital infection, neonatal sepsis and meningitis or foetal death. The main mode of transmission is through contaminated foods. The infection usually occurs sporadically but small outbreaks and even large epidemics have occurred in a large number of industrialised countries. During the last 10 years several Listeria monocytogenes control measures have been introduced and implemented at the retail level and in production for plants or foods potentially contaminated with Listeria monocytogenes. During this period the incidence of listeriosis decreased substantially and is at present estimated at 300-400 cases annually.

Food Contamination↗
PubMed1993

Therapeutic effect of granulocyte colony-stimulating factor (G-CSF) on the protection against Listeria infection in SCID mice.

Anti-listerial activity in SCID mice as well as in control C.B-17 mice was augmented by granulocyte colony-stimulating factor (G-CSF). After 1 x 10(3) colony-forming units of Listeria monocytogenes (strain EGD) were intravenously inoculated, mice were intraperitoneally injected with G-CSF at a daily dose of 500 micrograms/kg for 5 days. The numbers of viable bacteria in the liver were significantly lower in G-CSF-treated SCID and C.B-17 mice than in non-treated mice. The surface marker analyses on gamma delta T-cell receptor (TcR), Mac-1 and F4/80, and dichlorofluorescein oxidative activity, showed a possible contribution of activated neutrophils, but not gamma/delta T cells nor activated macrophages, to the augmentation of anti-listerial activity in SCID mice. This study is one of the first reports on the anti-microbial effect of G-CSF in therapeutic use.

Animals↗
PubMed1989

[Risk of Listeria infections in humans].

Serological and clinical examinations were made among persons contacting animals infected by listeriosis. It was found that the risk of the infection among humans is small.

Animals↗
PubMed1996

Copper and zinc exposure of zebrafish, Brachydanio rerio (Hamilton-Buchaman): effects in experimental Listeria infection.

To investigate the effects of heavy metals on susceptibility of fish to Listeriosis, normal zebrafish, Brachydanio rerio (Hamilton-Buchanan), were exposed to varying concentrations of zinc (0.05, 0.15, and 0.25 mg/liter) and copper (0.05, 0.10, and 0.15 mg/liter). During copper exposure, this heavy metal did not accumulate in zebrafish kidney. Unlike copper, a small amount of zinc accumulated in kidneys of fish exposed at 0.25 mg/liter. To estimate the effects of this heavy metal on listerial infection, the mortality of fish and the number of viable bacteria in fish kidney were determined at various times (1, 4, 7, and 10 days) after ip challenge with Listeria monocytogenes (strain 31386, serotype 4b). The results indicate that the number of colony-forming units in zinc-exposed fish decreased at 4, 7, and 10 days after challenge with 0.2 x LD50 of viable bacteria. In contrast, copper-exposed fish indicated both decreases and increases in the number of colony-forming units depending on the concentration of L. monocytogenes used.

Adjuvants, Immunologic↗
PubMed1996

Live tularemia vaccine confers protection against lethal Legionella and Listeria infections in experimental animals.

The efficacy of a live Francisella tularensis vaccine strain to cause nonspecific immunity toward experimental legionellosis and listeriosis was studied. Immunisation with tularemia vaccine protected over 80% and 17% of experimental animals against subsequent lethal challenge with Legionella pneumophila and Listeria monocytogenes, respectively. The protection was maximal during the first month following immunisation and declined thereafter. In order to delineate the immunostimulatory moieties of the Francisella microbe, several cell wall proteins have been purified and characterized. However, isolated cell wall components failed to induce protection.

Animals↗