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At least 145 records · Page 8Linked to original sources
PubMed1984

Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.

The effect on the liver carcinogenicity in rats of sequential administration of either phenobarbital (PB) or diethylnitrosamine (DEN) given either before or after N-2-fluorenylacetamide (FAA) was studied. DEN given in the drinking water either before or after dietary FAA enhanced liver carcinogenicity over that produced by FAA alone. In contrast, dietary PB produced enhancement only when given after FAA. Thus, the effects of DEN summate with those of FAA, whereas PB produces a promoting, but not syncarcinogenic, effect. The usefulness of reverse sequence protocols for distinguishing between initiation-promotion and syncarcinogenesis by sequentially administered chemicals is demonstrated.

2-Acetylaminofluorene↗
PubMed1999

Effect of a microwave coagulator on implanted liver neoplasms in rats.

An experimental study was conducted to determine the applicability of a microwave (MW) source for coagulation and dissection of metastatic tumour and liver parenchyma. Twenty PVG rats were studied after implantation of MC28 tumour cells into the liver. Eleven days later they underwent sham laparotomy (control) MW coagulation of the tumour deposit, local resection of the tumour deposit with 2 mm clearance or resection of the tumour with MW coagulation of the resection zone. The control animals all died with blood-stained ascites and heavy tumour burden in the liver. After MW coagulation, tumours disappeared in all but one rat. Local resection also led to tumour clearance in 4 of 5 rats. MW coagulation of the resection zone allowed rapid bloodless resection, and no tumour recurrence was observed after 40-89 days. We conclude that MW coagulation is a potentially useful tool for ablation of hepatic metastasis and as an adjunct to hepatic resection.

Animals↗