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Nonalcoholic steatohepatitis (NASH) syndrome.

Many asymptomatic patients who present for routine examinations are found to have elevation of liver functions. There are many etiologies for elevations of liver functions; however, a growing number of individuals are found to have nonalcoholic steatohepatitis. With this condition, fat builds up in the liver and eventually scar tissue does as well. This article will explore this etiology, work up, and thoughts regarding prognosis.

Fatty Liver↗

Treating NASH.

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Clinical Trials as Topic↗

Orlistat in the treatment of NASH: a case series.

Nonalcoholic steatohepatitis is now recognized as a common chronic liver disorder. Up to 16% of affected patients may progress to cirrhosis. The incidence and prevalence of this disease are noted to be increasing, in parallel with the nationwide increase in obesity and diabetes. Treatment options for these patients remain quite limited, however. Weight reduction has been advocated, but there are little data to support this practice, as most patients are unable to comply with the proper dietary modifications. We report three obese patients with biopsy-proven nonalcoholic steatohepatitis treated for 6-12 months with a weight reduction medication, orlistat, who lost between 22-42 lb, and had significant clinical and histopathological improvement on follow-up.

Adult↗