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PubMedDate not supplied

Multiple primary malignant neoplasms in England and Wales, 1971-1981.

In the period 1971-81, more than 1.9 million persons were registered with a malignant neoplasm among the 49.2 million population of England and Wales. For 63,536 people, two or more tumor registrations (multiple tumor records) have arisen in that period. Because of the structure of the National Cancer Registration scheme, some errors in registration are inevitable, particularly duplicate registration of a single tumor by adjacent regional cancer registries. A pilot study showed that 61 percent of multiple records would represent true multiple primary malignancy, and that these records could be readily separated from registration errors. After abstraction of identifying codes from each tumor, 129,047 tumors involved in 63,536 multiple records were matched to the national cancer file, and the full data set extracted for successfully matched tumors. Person-years data were extracted for the 1.8 million tumors not involved in a multiple record. Eleven percent of multiple records were not completely matched, and a further 16 percent were excluded on SEER criteria, or as probable registration errors, leaving 46,155 multiple primary tumors for further analysis. Over 3 million person-years at risk of a second tumor were accrued. The overall risk of a second tumor at any site before age 85 was 0.77 for males and 0.80 for females, after exclusion of second tumors observed within 12 months of the first. The risk of a new primary apparently decreased with increasing duration of survival, a trend which may be due in part to under-registration of second tumors in the early 1970s and an improvement in linkage since 1971.

England↗
PubMed1992

[Multiple primary malignant neoplasms: a case report].

One individual with two or three malignant neoplasms is not uncommon. However, a patient with more than 5 primary malignancies is unusual. We present a 51-year-old female who developed 6 metachronous primary malignant neoplasms in a period of 10 years. The anatomic sites of neoplasms in this patient included the cervix, larynx, skin, left breast, bladder and right lung (middle lobe). All of the tumors were proven by pathologic examination, and each of these tumors was recognized as a distinct primary tumor. Aggressive surgical resection, post-operative irradiation and chemotherapy showed good response in this patient. This patient had no familial or hereditary tendencies but, definite impairment of the cellular immunity had been identified.

Breast Neoplasms↗
PubMed1984

[Multiple primary malignant neoplasms in the national cancer center during 1962-1981].

Four hundred and eight cases with multiple primary malignant neoplasms from 5,456 autopsy cases were reviewed, and their age, sex, sites and relationship between the two cancers were analysed. Expected number of the second cancer was calculated based upon the person-years of 8,444 cases with primary gastro-intestinal cancers. Significant higher incidence was observed in the oropharyngeal cancer, esophageal cancer in male, and colon cancer in female. Organ relationship was present along the gastrointestinal tract, as observed in autopsy cases. Biological meaning of multiple primary malignant neoplasms was discussed.

Breast Neoplasms↗
PubMed1977

Statistical methods for studying multiple primary malignant neoplasms.

Case reports and case series dealing with multiple primary malignant neoplasms provided useful criteria for defining and documenting this phenomenon. The formation of tumor registries greatly aided in identifying a sufficient number of multiple primary cancer patients and facilitated case-control comparisons. Reports of two or more neoplasms occurring together in the same individual do not constitute proof of a significant association; the tumors must be shown to occur together more frequently than expected by chance. The person-years approach applied to data derived from a well-defined population makes it possible to compare the observed and expected number of subsequent primary cancers. The results of the most sophisticated procedures are no better than the quality of the data, however, and one must critically examine possible sources of bias before accepting statistical significance as representing biologic significance.

Adult↗
PubMed2005

[Clinical analysis of multiple primary carcinomas in colorectal cancer patients].

OBJECTIVE: To explore the prevalence, clinical features and prognosis of multiple primary neoplasms in patients with colorectal carcinoma (CRC). METHODS: Data of colorectal cancer patients admitted to our hospital from June 1994 to June 2002 were analyzed retrospectively. Patients were divided into multiple-cancer group (MCG) and single- cancer group (SCG). Clinical features and prognosis were compared between two groups. RESULTS: The incidence of multiple cancers was 7.4 % (83/ 1125). Forty- seven patients had multiple colorectal cancers metachronous CRC(S) in 12 and synchronous CRC(S) in 35. Thirty- six patients 5 patients with synchronous cancers had malignant tumors outside colorectal tract,12 of whom were gastric carcinomas. No significant differences were found between MCG and SCG regarding gender, onset age, Dukes stage and differentiation of index CRC. Cancer family history (P=0.002) and colorectal adenoma (P=0.036) were significantly more common in MCG than those in SCG. The local recurrence or distant metastasis in MCG was significantly higher than that in SCG (P=0.047), though there was no significant difference in survival between the two groups. Forty- one percent of index tumors were located in right colon in MCG, significantly higher than that in SCG (P=0.048). The secondary tumors were mainly adenoma cancerization in MCG. CONCLUSION: Cancer family history and colorectal adenoma seems to be at high risk for developing multiple cancers in CRC patients. Gastric cancer and colorectal adenoma cancerization were common secondary tumors of multiple primary neoplasms in patients with colorectal carcinoma.

Adenomatous Polyps↗
PubMed1991

Thyroid cancer and multiple primary malignancies in Israel.

The exact risk of multiple primary neoplasms in patients with thyroid cancer is difficult to ascertain from the data available in the literature. Three thousand seventy-two patients with thyroid cancer, listed in the Israel Cancer Registry during a 16-year time span, were studied to determine the true incidence of another primary cancer. Ninety-two cases were reported as having an additional primary cancer. The prevalence of multiple primary malignancies was 3%. The frequency was higher among patients of European rather than of Asian or African origin. The second primary cancers in order of decreasing frequency were of the breast, lung, colorectum, head and neck, and lymphoma/myeloma. Most of the deaths were due to the additional cancer. The 5-year survival rate was highest for head and neck and lowest for lung cancer patients. These results emphasize the need for greater awareness of the possibility of developing additional cancers, and indicate the need to incorporate strategies for the prevention, early detection, and treatment of multiple primary neoplasms.

Breast Neoplasms↗