PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Neoplastic Processes”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 145 records · Page 8Linked to original sources
PubMed1993

[Angiogenesis in the neoplastic process].

Solid tumor growth is accompanied by neovascularisation. In the absence of neovascularisation most tumors might become dormant at a tiny diameter 2-3 mm. New capillary growth is elicited by a diffusible factors generated by malignant tumor cells and by host cells. The inhibition of angiogenesis may provide a form of cancer treatment, either substitutional or additional to the conventional form of therapy. The present review summarized the state of our knowledge on this topic, angiogenesis and tumor growth.

Animals↗
PubMedDate not supplied

[Quantitative and functional characteristics of T-lymphocytes and monocytes in lymphosarcoma patients at various stages of the neoplastic process].

IKO monoclonal antibodies were used to study peripheral blood mononuclear types in 92 patients with various histomorphological types of diffuse lymphosarcoma at various stages of tumorous process. Absolute counts of CD7 and CD5 cells (T cells) were found reducing as was CD4 cell (T helpers) level as the disease progressed. CD8 cell (T suppressors) count reliably increased only in the phase of lymphoblastic lymphosarcoma leukemic degeneration. A group of patients with stage IV lymphoblastic lymphosarcoma was detected with drastically increased counts of mononuclears carrying mature T cell markers. Clinical course of the disease in these patients was characterized by the highest malignancy degree and metastatic involvement of the central nervous system. Examination of peripheral blood monocyte/macrophage ratio in the same patient population (n = 26) revealed reduced Fc receptor expression, EA phagocytosis, and increased levels of circulating immune complexes, these shifts augmenting with the tumor progress. The results may be valuable for prediction of lymphosarcoma course and for immunocorrection.

Adult↗
PubMed1977

[Is an early diagnosis of neoplastic processes of the rectum possible?].

The better operative results and lasting cure of malignant tumors can be ascribed to early detection rather than to the improvement of surgical techniques. In the cancer of the breast and gynecological carcinoma the importance of early detection has been more emphasized than in cancers of other location. On a total of 5210 rectoscopies performed the authors detected 285 malignant tumors of the rectum. On the average the diagnosis was made 9 months after the appearance of the first symptoms. In 74% of cases the tumors were detected already by the digital examination, while in 46.9% of the rest of the patients inoperable carcinoma was involved. By obligatory digital examination in all cases of "hemorrhoidal" complaints and additional rectoscopy neoplasms of the rectum can be detected at an early time and more patients can be afforded lasting cure.

Adolescent↗
PubMed1976

[Mutational-metabolic model of carcinogenesis and the progression of the neoplastic process].

The given data indicate the presence of a negative correlation between metabolic indices (a decrease of the tolerance to glucose, increase of the blood level of free fatty acids, insulin, cholesterol triglycerides, cortisol, stc) and the indices of cellular immunity, which is determined by the number of rosette-forming cells and blasttransformation reaction to PHA and skin tests. Accordingly, the administration of an antidiabetic drug-phenformin (phenetylbiguanide)--apart from the improvement of metabolic pattern, results in the restoration of the cell-mediated immunity indices. These findings provide a basis for stating the phenomenon of metabolic immunodepression. The metabolic immunodepression may be supposed to prevent immunological surveillance activation, which normally is realized through the signals, provided by cells subjected to somatic mutation. It is noteworthy that the given metabolic conditions (hypercholesterinemia, hyperinsulinemia, the enhanced utilization of free fatty acids) promote the division of somatic cells. Thus, the same metabolic shifts which increase the pull of proliferating cells and, accordingly, increase the possibility of mutation development, also cause the metabolic immunodepression at the same time. These opposite metabolic influences on somatic cells and T-dependent lymphocytes cause the development of the syndrome of cancrophilia. The syndrome of cancrophilia normally arises at pregnancy, in intensive growth of the organism in childhood, accelerated development, stress and during normal ageing. Many carcinogens cause the decrease of tolerance to glucose, the increase in blood-insulin level and elevation of the threshold of sensitivity of the hypothalamus to feedback suppression. This phenomenon is based on the decrease of catecholamine level in thehypothalamus in ageing, stress and the action of some carcinogens. Thus, the syndrome of cacrophilia provides the conditions for cancer development and tumor progression, besides, the tumor itself produces the metabolic shifts typical of cancrophilia. In the light of mutation-metabolic model of cancer development, it is possible to consider the fundamental factors which increase of hinder carcinogenesis.

Aging↗
PubMed1976

An approach to the characterization of mononuclear phagocytes involved in pathological processes.

Cells participating in an inflammatory response are derived from the bone marrow (i.e. granulocytes and monocytes) or lymphoid organes (i.e. T and B lymphocytes), or of mesenchymal origin (i.e. fibroblast, reticulum cells). The identification of these different kinds of cell in the inflammatory exudate is often difficult, because the morphological characteristics are not specific enough. For example, in the morphological description of pathological processes often terms such as round-cell infiltration and mononuclear cells are used, which is confusing. For the clear understanding of the course of an inflammatory reaction and the effect of anti-inflammatory drugs it is necessary, however, to define exactly the participating cells. Such an identification can be performed on the basis of morphological, cytochemical and immunological characteristics of the cells, together with their kinetic parameters. These characteristics have been established for murine mononuclear phagocytes. Recently these characteristics have also been studied in human promonocytes, monocytes and skin macrophages. The results show that human mononuclear phagocytes are in many respects similar to those of mice. On this basis an outline for the participation of mononuclear phagocytes in pathological processes (i.e. inflammatory processes, neoplastic processes, and storage disorders) has been made.

Animals↗