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At least 145 records · Page 8Linked to original sources
PubMed1993

[Angiogenesis in the neoplastic process].

Solid tumor growth is accompanied by neovascularisation. In the absence of neovascularisation most tumors might become dormant at a tiny diameter 2-3 mm. New capillary growth is elicited by a diffusible factors generated by malignant tumor cells and by host cells. The inhibition of angiogenesis may provide a form of cancer treatment, either substitutional or additional to the conventional form of therapy. The present review summarized the state of our knowledge on this topic, angiogenesis and tumor growth.

Animals↗
PubMedDate not supplied

[Quantitative and functional characteristics of T-lymphocytes and monocytes in lymphosarcoma patients at various stages of the neoplastic process].

IKO monoclonal antibodies were used to study peripheral blood mononuclear types in 92 patients with various histomorphological types of diffuse lymphosarcoma at various stages of tumorous process. Absolute counts of CD7 and CD5 cells (T cells) were found reducing as was CD4 cell (T helpers) level as the disease progressed. CD8 cell (T suppressors) count reliably increased only in the phase of lymphoblastic lymphosarcoma leukemic degeneration. A group of patients with stage IV lymphoblastic lymphosarcoma was detected with drastically increased counts of mononuclears carrying mature T cell markers. Clinical course of the disease in these patients was characterized by the highest malignancy degree and metastatic involvement of the central nervous system. Examination of peripheral blood monocyte/macrophage ratio in the same patient population (n = 26) revealed reduced Fc receptor expression, EA phagocytosis, and increased levels of circulating immune complexes, these shifts augmenting with the tumor progress. The results may be valuable for prediction of lymphosarcoma course and for immunocorrection.

Adult↗
PubMed1977

[Is an early diagnosis of neoplastic processes of the rectum possible?].

The better operative results and lasting cure of malignant tumors can be ascribed to early detection rather than to the improvement of surgical techniques. In the cancer of the breast and gynecological carcinoma the importance of early detection has been more emphasized than in cancers of other location. On a total of 5210 rectoscopies performed the authors detected 285 malignant tumors of the rectum. On the average the diagnosis was made 9 months after the appearance of the first symptoms. In 74% of cases the tumors were detected already by the digital examination, while in 46.9% of the rest of the patients inoperable carcinoma was involved. By obligatory digital examination in all cases of "hemorrhoidal" complaints and additional rectoscopy neoplasms of the rectum can be detected at an early time and more patients can be afforded lasting cure.

Adolescent↗
PubMed1997

[The role of the modal class of cells in the neoplastic process].

Cytophotometric findings point to a feedback link between tumor influence and remote organs and tissues in a tumor-bearing body, an important factor being whether tumor cells are located to the right or left of the modal class of normal cells of an organ. It is also important that the functional activity pattern of tumor cells genome match that of normal organ cells (Kfagen's ratio) and the number of tumor cells does not exceed that of normal cells by more than 33%.

Animals↗