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PubMedDate not supplied

Medico-historical study of "Kilasa" (vitiligo/leucoderma) a common skin disorder.

The earliest known reference to Kilăsa was in 2200 B.C. in the period of Aushooryan. In 1550 B.C. information regarding Vitiligo was noted in the Ebers Papyrus. Atharvavĕda also carries the description of the disease Kilăsa along with several herbal prescriptions. Buddhist literature (Pĭtikăs) especially Vinaya Pĭtika carries the description of Kilăsa. Old Testament also carries the description of white spots i.e. in the Leviticus chapter 13. In ayurvĕda the word Kuşţa was used for all types of skin diseases. Both Kilăsa and Switra are mentioned together in ayurvĕda because of similarity in their aetiology. Kilăsa is also called as Băhya (external) Kuşţa. It is classified into three types based on three Dŏşăs. Prognosis of the disease was also described in ayurvĕda. This disease can be compared with Vitiligo/leucoderma in modern medicine. The Roman Physician Celsus first coined the term Vitiligo in the 2nd Century A.D. This article carries medico-historical references of Kilăsa from ancient to modern literature.

History, Ancient↗
PubMedDate not supplied

[Surgical findings in an Egyptian mummy's skull].

Reports of hard and soft tissue injuries of the head in ancient Egypt were first published in the surgical "Book of Wounds" of E. Smith's Papyrus, which dates back to the 16th century B.C., and is assumed (Pahl, 1986) to be a collection of experiences gained over a thousand years. Diagnostic clues and guidelines for the treatment of fractures of the maxilla and the zygomatic bone are described in several cases.

Cephalometry↗
PubMed1988

Identification and characterization of human hemopoietic mast cell colonies.

Persisting mast cell colonies from human bone marrow and cord blood cells grown in semisolid agar cultures for over 56 days have been positively identified and characterized using morphology and cytochemistry. Mast cells demonstrated the following features: Cytoplasmic granules frequently contained the specific and characteristic papyrus rolls (transmission electron microscopy); mature cells were positive to the mouse monoclonal antibody YB5.B8 specific for human mast cells (raised against acute myeloid leukemia cells) and RPA-M1 specific for human monocytes but negative to the human basophil monoclonal antibody Bsp-1; morphologically the cells were large (diameter 20-25 micron), deeply basophilic, and contained granules that measured up to 2 micron in diameter (May-Grünwald-Giemsa stain); the presence of heparin by the thrombin clotting time and positive staining with toluidine blue and alcian blue; the presence of histamine by a positive fluorescent o-phthalaldehyde stain; the presence of IgE receptor sites with human IgE and a rabbit anti-human IgE second antibody; and a unique zone of lysis around mast cell colonies occurred when cultured on peripheral blood feeder layers in agar plates that was not present around monocytic, neutrophilic, or eosinophilic colonies under the same culture conditions. Our results identify the cells in persisting colonies as mast cells and describe some specific characteristics that distinguish these cells from basophils.

Bone Marrow Cells↗
PubMed1985

[The nasal speculum. Its historical development and remarks on the history of rhinoscopy].

The examination of the nose has been known to the ancient Egyptian medical doctors (Papyrus Ebers), and is exactly described by Hippocrates (460-377 B. C.). It has been performed in direct sunlight until the 13th century when candle light was recommended by Arnold de Villanova. However, G. C. Arranzi, in the 15th century, used a glass flask, filled with water, directing candle light through it into the patient's nose. The first endoscopic lamps appeared during the 18th century. The nasal speculum was first mentioned by Guy de Chauliac (13th century) and was illustrated for the first time by Arcolano (14th century). Fabricius Hildanus (1560-1634) constructed an aural speculum which was nearly identical to the nasal specula of today. It was developed further by Peret (18th century) and Wilhelm Kramer (1801-1875) to the type of nasal speculum which is still. Predecessors of the nasal speculum are specula which were in use for the examination of the vagina and the anus. The eldest specimens were found in Pompeji, the city that was destroyed in 76 A. D. These specula consisted of two or three blades which opened by pressure or by means of a crank. The prototype of these specula is a tubular speculum as described by the so-called Ayurvedic doctors of ancient Indian medicine (Ayurveda of Suşruta ca. 500 B. C.).

Endoscopes↗
PubMed1984

[Historical milestones in the treatment of night blindness].

Most cases of night-blindness (nyctalopia or hemeralopia) do occur without an apparent organic eye-disease. In the past one spoke of essential or epidemic night-blindness. It is caused by a vitamin deficiency, and is a result of failing dark adaptation; it may lead to xerophthalmia, and finally to a complete permanent blindness, if not treated in time with vitamin A or vitamin A containing food (butter, egg-yolk, fish-liver oil). From time immemorial the healing effects of the intake of liver from fish and various animals for night-blindness has been reported from countries all over the world. In medical literature it has been recommended in the Papyrus Ebers (ca. 1500 B.C.), by the old Greek writers, from Hippocrates to Galen, and later to Oribasius and others. In the early sixteenth century Jac. Bontius (1592-1631) learned this therapy from empiric folk-medicine and advocated shark-liver as a specific medicine. Notwithstanding scattered reports of the dramatic favourable result of liver-treatment in patients with night-blindness, it would last until experimental research with a fat-poor diet led to the discovery (1913) and identification of vitamin A in our century, and the high vitamin A content of liver was established. Thus recognizing the value of the old liver-treatment, finally vitamin A was introduced in official ophthalmology. So an age-old, nearly universal favourable experience of empiric medicine had been neglected to the detriment of countless sufferers of night-blindness. Today systematic administration in cases of impending blindness, especially in some Asiatic areas, has already prevented the development of lasting blindness on a large scale.

Europe↗
PubMed1995

From information statics to information dynamics. The developing world has no alternative.

Libraries as presently constituted are essentially static paper-containing information systems often enclosed in massive specific spaces. The new electronic systems are by their very nature dynamic global systems that take up almost no space. Static information systems evolved from clay tablets to papyrus scrolls to parchment and finally to paper produced in vast quantities by the printing press. Medical and scientific journals have been growing exponentially since the seventeeth century as have the static paper-based libraries. This growth has been non-Darwinian, being outside of the laws of natural selection and survival of the fittest. Thus, the great majority of medical information is uncited and unread. Moreover, the vast investment in static libraries in the developed world has inhibited the development of modern electronic systems. In contrast, the developing world is largely bereft of such institutions, and has the unique opportunity to leap unencumbered by the static past into the far more efficient and dynamic electronic future.

Developing Countries↗
PubMed1994

[History of the treatment of varices].

Diseases of the vein and particularly varicose veins have been recognized since antiquity. The Ebers papyrus, dated 1550 b.c., mentions serpent-shaped dilatation of the lower limbs. The Acropolis tablet of the IVth century b.c. concerning Dr Amynos allows us to visualize an enlarged lower limb clearly showing a varicosity. From 460-377 b.c., Hippocrates noted that a loose tourniquet leads to haemorrhages but that when the tourniquet is tight gangrene ensues and finally that standing up can exaggerate leg ulcerations. Of course much progress has been made since Hippocrates. The school at Alexandria, with Herophilus and Erasistrates speak of vascular ligatures. Their work was unfortunately lost in the fire of the Alexandria library in 391 a.d. Galien himself described varicose vein ligatures in 200 a.d. Leonardo de Vinci's magnificent anatomic studies of veins are widely known. In 1525, Ambroise Paré described leg bandaging for ulcers beginning from the foot up to the knee. In 1585, Fabrice d'Acquapendente described venous valves. In 1676, Wiseman invented the first supportive stockings made of leather and in 1854, Unna described in Vienna the supportive boot which now carries his name. Shortly thereafter new medical and surgical techniques were developed for the treatment of varicose veins. Pravaz, in 1860, invented a syringe which now carries his name and initiated sclerotherapy. At the end of the XIXth century, Trendelenburg performed the first ligatures of the greater saphenous veins. In 1905, and 1906, Keller and Mayo performed the first ablation of the greater saphenous vein and in 1906, Carrel reported the first venous transplantation.(ABSTRACT TRUNCATED AT 250 WORDS)

Europe↗
PubMed1995

[Garlic--a "secret miracle of God"?].

Garlic belongs to the oldest traditional medicinal plants. It has already been mentioned 1500 A. D. in an ancient egyptian medical script, the Papyrus Ebers. In modern times antitumoral and antiarteriosclerotic effects are attributed to garlic-derived drugs. These effects could be demonstrated in vitro and appear to be supported by epidemiologic studies. Production of commercial products and pharmacologic studies, however, are rendered more difficult by chemical instability and low bioavailability of the active drugs. Clinical studies on effects and case reports about side effects of garlic consumption are summarized in this paper.

Antineoplastic Agents↗
PubMed1993

Skull trauma in Egyptian and Hippocratic medicine.

To compare the treatment of skull trauma in Egyptian and Hippocratic medicine, the author reviews the pertinent passages of the Smith Papyrus and of the Hippocratic Corpus. By examining the treatment of similar cases reported in the two documents, it is concluded that the Egyptian physician, with his more conservative approach, pursued a more effective and less dangerous course of action than the Hippocratic physician, who would aggressively intervene with trephination and scraping of the bone.

Egypt, Ancient↗
PubMedDate not supplied

Bibliography database managers. A comparative review.

Bibliography database managers (BDMs) are used to manage information resources: specifically, to maintain a database of references and create bibliographies and reference lists for written works. This comparative review provides an overview of BDMs and capsule reviews of five programs: EndNote Plus 2.0; Library Master 3.0; Papyrus 7.0.11; Pro-Cite 2.2.1; and Reference Manager 6.02.

Bibliographies as Topic↗
PubMedDate not supplied

[History of enuresis].

Revision on enuresis, its etiopathogenic theories, repercussion on society and the family as well as of the various therapeutical methods used throughout history since the first description in the Ebers Papyrus in 15500 B.C. until the present times.

Enuresis↗
PubMedDate not supplied

[Atherosclerosis and ischemic heart disease. Short historical notes].

A review of some historical accounts in Medicine reveals concepts, clinical descriptions and prognosis of coronary atherosclerosis and ischemic heart disease in the recent past and in remote antiquity. Herein, the historical accounts disclosed include some concepts and terms utilized in reference to atherosclerosis: the oldest documentation of coronary atherosclerosis and myocardial infarction in Egyptian mummies; the clinical syndrome of angor pectoris in the Ebers' papyrus, as well as clinical and prognostic data in the Corpus Hippocraticum regarding possible cases of angina, infarction and sudden death. These reports give a better insight into primitive medicine in the Ancient Western World, revealing the evolving concept of atherosclerosis and the existence of this disease in humanity's remote past.

Angina Pectoris↗
PubMed1996

[African neurosurgery. 1: Historical outline].

This outline of the history of African Neurosurgery explains the role that North Africa has played in the Middle Ages in the development of Neurosurgery, the origins of the development of the latter in twentieth century, and the delay that African Neurosurgery still shows at the present time in the majority of African countries. On the papyrus of the pharaonic era, we have found the description of some neurosurgical procedures such as trephination and brain aspiration by a transphenoidal approach used before mummification. It is particularly trephination which summarizes the ancient history of African neurosurgery, as it was widely used throughout the continent, practised and taught by healers in African tribes. The technical concepts of trephination are based, to a great extent, on the descriptions of Arab physicians of the Middle Ages. It was at that time (Middle Ages) that several Arab physicians such as Avicenne, Rhazes, and Avenzhoer described many types of nervous system diseases and the techniques to treat them. But it was mainly Abulkassim Al Zahraoui (Abulkassis) who was the pioneer of neurosurgery as he devoted one volume of his treatise (made up of 30 volumes) to neurosurgery, a precise description of many aspects of neurosurgical pathology, its treatment, instruments and neurosurgical techniques. We have reported in this article five original extracts in Arabic which deal with skull fractures and their treatment, vertebro-medullary traumas and their treatment, hydrocephalus and its treatment, tumors of the skull vault and their treatment, and finally the basic knowledge of anatomy which is of great interest for a surgeon. The medical knowledge of that time which gave birth to medical schools and hospitals was transmitted progressively to Europe and played an important role in the development of medicine during the European Renaissance in the fifteenth and sixteenth centuries. During colonization, neurosurgical practice started and developed in many African countries, together with the development of the health system that the colonial forces initiated in general as soon as they had come to these countries. This neurosurgery practised in the departments of general surgery either by neurosurgeons or general surgeons took part in the birth and development of neurosurgery as an independent specialty, thanks to the combined efforts of some European and African pioneers. Modern neurosurgery was introduced and started to develop in African countries from 1960, and the teaching of this specialty in many African universities began between 1960 and 1970.

Africa↗
PubMedDate not supplied

[Impact of changes in the environment on vector-transmitted diseases].

We have defined the relationship between infectious diseases and environmental conditions and considered the development of this relationship to its current situation, where human intervention is occurring more often and is becoming more aggressive. The increase in the transport of freight and passengers by air has allowed parasite vectors to spread quickly and easily over large distances. Every country can now be reached from any other country within a couple of days. Usually, foreign species are unable to establish themselves and to persist in the new environment; but the recent arrival of Aedes albopictus in Albania, Italy and the Americas is a cause for concern. Demographic pressure has increased the need for land and the exploitation of new areas leads to large changes in the vegetation. The classic example of this man-made damage is the destruction of tropical forest in Western Africa, but the destruction of herbaceous vegetation, such as papyrus, in East Africa, could also have serious epidemiological consequences. Streams and rivers have been managed for power production and irrigation. The use of dams, both large and small, and the culture of rice in paddy-fields produces large expanses of water which are suitable breeding grounds for mosquitoes and snails, the vectors of human diseases such as malaria and schistosomiasis in sub-Saharan Africa. They are, however, of lesser importance in Asia and the Americas. Urbanization imposes a set of very similar structures on a specific rural environment. The effect of these two factors on each other determines the pathologies associated with each town. The suburban area is a specific environment where both urban and rural diseases occur and are made worse by poor hygiene conditions (waste, sewage, etc.). However, not all man-made changes to the environment cause a deterioration in public health. Urban and agricultural development projects must consider these issues and should use medical and environmental studies to avoid causing epidemic-prone conditions or spreading endemic diseases. Currently, most studies are limited to listing the specific diseases in the target area and very few attempt to assess the possible consequences of changing the environment. Forecasting the consequences of changes in environmental management is of great importance, but it requires the development of multi-disciplinary teams in the field who must be involved in the planning and implementation of the projects.

Aedes↗
PubMed1998

[Origin of malaria epidemics on the plateaus of Madagascar and the mountains of east and south Africa].

The Highlands of Madagascar were malaria free until 1878, when a severe epidemic occurred, following the development of irrigated rice farming. Then, the disease became endemic. Between 1949 and 1962, malaria was "eradicated" on the Highlands by joint house spraying and chemoprophylaxis measures. The main vector An. funestus disappeared. In 1986-1988, a very severe epidemic with high lethality rate devastated the Highlands. It is now under control. Thanks to the data of a religious dispensary, we could follow the evolution of malaria on the Highlands from 1971 to 1995. The number of cases begin to grow in 1975 when the surveillance was neglected. A second step was observed in 1979, when chemoprophylaxis/chemotherapy centres were closed. Then, the increase of malaria became exponential up to 1988. At the time, the prevalence had became similar to that of 1948, before the eradication. The epidemic is not due to global warming because the temperature has been stable for the last 30 years. The malaria rise was due the cancellation of control measures. When control was reactivated, the epidemic ceased. In Swaziland, Zimbabwe and South Africa, malaria epidemics were also due to control failure. In Uganda Highlands, above 1500 m, malaria rise seems linked to the environmental changes, e.g. the cultures which replace papyrus swamp in the valley. But malaria did not overcame the altitude of 1900 which it had already reached in 1960. Rainfall should also be considered as a key factor in the epidemics. In the Sahel West Africa, temperature increased from 0.5 degree C to 01 degree C degree in the last 25 years, but rainfall decreased from 30%. As a result, one of the vector, Anopheles funestus disappeared and malaria prevalence dropped by 60 to 80%. It is not acceptable to predict the future evolution of malaria in taking in account only one parameter: the temperature. The whole factors involved in the epidemiology should be taken into account. The predictions based only on the temperature increase (global warming) can be totally wrong if the rainfall, for example, decreases.

Africa↗
PubMed1998

The lethal effects of Cyperus iria on Aedes aegypti.

The sedge Cyperus iria, a common weed in rice, contains large amounts of the insect hormone (10R) juvenile hormone III (JH III). Given its widespread distribution in Asia and Africa, we examined the possibility that C. iria could be used as a safe, inexpensive, and readily available mosquito larvicide. Plants of varying ages were harvested and leaves tested for lethal effects on larvae of the yellow fever mosquito, Aedes aegypti. The median lethal doses (LD50s) for frozen leaves from 1- and 2-month-old plants were 267 and 427 mg/100 ml of water, respectively. Leaves from 1-month-old C. iria contained 193 micrograms JH III/g fresh weight, whereas leaves from 2-month-old plants contained 143 micrograms JH III/g fresh weight. Larval sensitivity to the plant differed with age; 4-day-old larvae displayed the greatest mortality followed in decreasing sensitivity by larvae 5, 6, 3, and 2 days old. Six Cyperus species (C. albostriatus, C. alternifolius, C. esculentus, C. iria, C. miliifolius, and C. papyrus) of similar developmental stage were assayed for JH III content. Only C. iria was found to contain significant levels of JH III.

Aedes↗
PubMed1998

[Laënnec, re-inventor of the stethoscope?].

According to our common medical culture, some facts are simply unquestionable, for instance Laënnec invented the stethoscope. But was he the first one? On a recent trip to Egypt we visited the temple of Kom Ombo, built prior to the roman period and renowned as a medical care center. Today, the tourist is fascinated by the magnificent hieroglyphics on the well-preserved walls testifying to significant advances in various fields of medicine including ophthalmology and gynecology. We were particularly interested by the basreliefs presenting vivid drawings of some of the first medical instruments. We easily identified curettes, scissors, a balance, forceps for dental extraction, and a surgical saw, but were captivated by two other instruments. The first one looked a lot like what Laënnec invented around 1820. The second one was amazingly similar to the instrument we use everyday, with a distal opening and flexible tubes (woven papyrus?) leading to proximal ear pieces. Our Egyptian guide was formal: the stethoscope was invented in Egypt. The scientific impact of our observations leaves something to be desired, but did make us think about the huge gap between the advancement of medical knowledge in ancient Egypt and Laënnec's (re)-invention. Exposed to a similar gap in history, what would our documents stored on CD and video tapes have to say to future touring doctors?

Egypt↗