PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “PASTEURELLA PESTIS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 145 records · Page 8Linked to original sources
PubMed1966

Pasteurella pestis: growth temperature, virulence, and the graded response.

Rosenwald, Albert J. (Fort Detrick, Frederick, Md.), and Ralph E. Lincoln. Pasteurella pestis: growth temperature, virulence, and the graded response. J. Bacteriol. 91:1693-1695. 1966.-A comparison of the virulence of Pasteurella pestis was made by the graded and quantal response methods. Both tests reflected the difference in virulence of cultures grown at three temperatures. Cultures grown at lower temperatures gave the most variable response in virulence tests, and cultures grown at higher temperatures were more virulent. Results from the graded response test were obtained more quickly and more economically than those from the quantal response test.

Animals↗
PubMed1965

Isolation of Antigens of Pasteurella pestis I. Lipopolysaccharide-Protein Complex and R and S Antigens.

Larrabee, Allan R. (Fort Detrick, Frederick, Md.), John D. Marshall, and Dan Crozier. Isolation of antigens of Pasteurella pestis. I. Lipopolysaccharide-protein complex and R and S antigens. J. Bacteriol. 90:116-119. 1965.-Pasteurella pestis contains at least 18 different antigens, 2 of which will protect experimental animals from challenge infection. A specific polysaccharide isolated and described as a hapten was isolated as a complete antigen. Two additional antigens were isolated from P. pestis. The preparation of antisera directed against these three antigens and the content of protein, lipid, and carbohydrate of each preparation were studied. None of the preparations will protect mice from challenge infection with virulent P. pestis. A basis for naming the new antigens which does not conflict with previously published designations is presented.

Journal Article↗
PubMed1970

Interconversion of Purine Mononucleotides in Pasteurella pestis.

Included among the five established determinants of virulence in Pasteurella pestis are the abilities of cells to accomplish the de novo biosynthesis of purines and to grow as dark pigmented (P(+)) colonies on a solid synthetic medium containing hemin. P(+) isolates of P. pestis strain KIM-10 (mouse intraperitoneal ld(50) < 10 cells) failed to convert exogenous guanine-8-(14)C to adenine residues of ribonucleic acid (RNA) when cultivated in a minimal medium which favored the pigmentation reaction. This conversion occurred in P(+) cells grown in an enriched medium which did not support the pigmentation reaction and was observed in P(-) mutants cultivated in both types of media. Both P(+) and P(-) isolates converted exogenous adenine-8-(14)C but not adenine-2-(14)C at a significant rate to guanosine residues of RNA when grown under a variety of conditions. This difference appeared to reflect a deficiency of adenine deaminase. The mouse intraperitoneal ld(50) of purine-auxotrophs was about 10(2) cells when the metabolic block occurred prior to the de novo formation of inosine monophosphate (IMP). In contrast, the corresponding value for a mutant blocked between IMP and guanine monophosphate was > 10(7) cells in mice and > 10(8) cells in guinea pigs.

Journal Article↗
PubMed1972

Gene transfer in Pasteurella pestis harboring the F'Cm plasmid of Escherichia coli.

A strain of Pasteurella pestis, harboring the F'Cm plasmid from Escherichia coli, was able to donate its chromosome to auxotrophic recipient strains of P. pestis. The frequency of gene transfer in P. pestis was approximately 10(-6) per donor cell, 100 times less efficient than gene transfer in Pasteurella pseudotuberculosis, but efficient enough to determine entry times for the markers histidine, threonine, and tryptophan and to show linkage to the markers arginine and pigmentation. An attempt to extend the conjugation system to different serotypes of P. pseudotuberculosis and to Yersinia enterocolitica did not succeed.

Arginine↗
PubMed1956

Studies on Pasteurella pestis in fleas, comparative plague-vector efficiency of Xenopsylla vexabilis hawaiiensis and Xenopsylla cheopis.

The authors report on a study carried out to determine the experimental plague-vector efficiency of X. v. hawaiiensis compared with X. cheopis after both species had been infected with a virulent Hawaiian plague strain (S113). In deriving the numerical values for vector efficiency the concepts of Wheeler and Douglas were followed with some modifications. An additional component, the blocking-survival potential, was used to obtain a vector index.The experiments showed that the mean extrinsic incubation period was shorter in X. v. hawaiiensis than in X. cheopis but that the latter species produced more blocked fleas. The observed values for vector efficiency indicate that X. cheopis was about twice as efficient in plague transmission as the Hawaiian flea. The time and percentage mortality curves of mice dying of plague after blocked fleas had fed upon them were observed to be similar to the curves of mice succumbing to the intracutaneous inoculation of known dosages of P. pestis.In general, it was found that bacteriological culture of the faecal droppings of fleas was unreliable as a check on plague infection in fleas.

Animals↗