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At least 145 records · Page 8Linked to original sources
PubMed1977

Analytical problems with putrefaction in a fatal case involving ergotamine and pentazocine.

A 29-year-old male drug addict was found dead at the bottom of a staircase. Analysis of the acid-hydrolized blood showed the presence of pentazocine and two characteristic compounds that contained L-phenylalanine and D-proline, linked together by peptide bounds. It was shown that the latter two components could emanate from the peptide part of ergotamine under the conditions used. It seemed likely that, at the time of analysis, pentazocine and ergotamine were present at concentrations far above therapeutic values. A third component in the blood could not be identified.

Adult↗
PubMed1982

Studies on putrefactive ethanol production. I: Lack of spontaneous ethanol production in intact human bodies.

The possibility of the production of ethanol by bacterial metabolism of blood glucose was investigated by studying a series of 26 hospital autopsies. The patients died from a wide variety of nontraumatic causes and the bodies were transported within 4 h of death to the morgue, where they were refrigerated for 0 to 28 h before samples of vitreous humor were collected for ethanol analysis. In addition, right heart blood was obtained using sterile technique for cultures as well as ethanol and glucose determinations. Ethanol was measured using gas-liquid chromatography, and glucose values were determined with a glucose oxidase method. In 13 cases, one to three species of microorganisms were isolated, but in no case was a blood or vitreous ethanol value greater than 10 mg/dL recorded. Ethanol values were also less than 10 mg/dL in the 13 cases with negative culture results. These data strongly suggest that de-novo production of ethanol by microbial metabolism does not occur in intact bodies which are refrigerated within 4 h of death. The detection of ethanol under such conditions is therefore probably indicative of antemortem consumption.

Adolescent↗