SEARCH · PubMed Health
Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
A neutered male cat with a history of intermittent antibiotic-responsive fever and strangury had pyometra involving uterus masculinus. The infected structure was removed, and episodes of infection and strangury ceased.
Renal function and pathologic changes in 27 dogs with pyometra were studied. Evaluation included CBC; serum biochemical evaluation; urinalysis; urine and uterine bacteriologic culture; uterine morphologic features; and light, electron, and immunofluorescent microscopic evaluation of renal tissues. Measurements of 24-hour creatinine clearance, protein excretion, Na excretion, and urine volume were made in 12 dogs without azotemia. Of 27 dogs, 26% were azotemic and 89% had a urine sp gr less than 1.035. Glomerular filtration rate was reduced in 75% of 12 dogs without azotemia. None of these 12 dogs was proteinuric. Examination of renal biopsy specimens revealed a high prevalence of mild tubulointerstitial nephritis, but few specific glomerular lesions. Minimal immunofluorescence was detected within the mesangium in 18% of the dogs. Immunofluorescence was not associated with the interstitium or tubules. Urinary tract infection was detected in 22% of the dogs. Escherichia coli and Klebsiella were recovered from the uterus in 59 and 15% of the dogs, respectively. Low urine specific gravity values were obtained from dogs without azotemia and from dogs with uterine cultures considered negative for E coli and other gram-negative bacteria. The reduction in glomerular filtration rate was a functional abnormality not correlated with structural damage in the glomerulus.
In a group of 58 dogs with proven pyometra, 10 bitches developed renal failure, combined with increased (p less than 0.01) urinary excretion of protein, glucose, gamma-glutamyltransferase (GGT), alkaline phosphatase (AP), amylase, lipase and casts. Thirty-two bitches without renal failure showed nevertheless signs of renal dysfunction as indicated by increased (p less than 0.01) urinary levels of protein, glucose, GGT, AP and amylase. Six bitches without significant proteinuria showed increased (p less than 0.02) urinary levels of GGT, AP as well as amylase. Thus renal injury was detected in 72 per cent of the bitches. Sixteen bitches showed normal urinary levels of protein, glucose, GGT, AP, amylase and lipase, indicating absence of renal disease.
Uterine fluid was obtained from eight clinical cases of pyometra with retained corpus luteum and nine additional samples of fluid were collected from animals slaughtered at an abattoir. These samples, along with uterine flushes from normal cows in their luteal phase were analyzed for prostaglandin of the F (PGF) and E (PGE) groups. Blood samples were also obtained from the clinical cases for analysis of 13,14-dihydro-15-keto PGF (PGFM) the major metabolite of PGF. Pyometrial exudate from clinical cases of abattoir samples had high concentrations of PGF (17.9 ng/mL) and PGE (33.2 ng/mL) and the total amount of PGF and PGE in the uterus was calculated to be several hundred times as great as in normal cows. Furthermore, clinical cases had elevated PGFM in their blood compared to that of controls, which suggests that at least some of the PGF was being absorbed from the uterus. These results are discussed in light of our current understanding of the maternal recognition of pregnancy in cattle.
Spontaneously perforated pyometra is rare, but the condition must be born in mind in women with acute abdomen. Two cases are reported, one resembling perforated peptic ulcer, the other was mistaken for acute appendicitis.
A severe pyometra was found in a typical case of anorexia nervosa, with the latter illness apparently precipitated by the former. Compulsory alimentation before and after operation brought some weight gain as well as reversal of dilated cerebral sulci and hypothyroidism, though hypothalamo-pituitary dysfunction persisted.
Arterial pH, oxygen and carbon dioxide tensions, and standard bicarbonate, as well as serum electrolytes (Na, Cl, K, inorganic P, Ca and anion gap) have been investigated in bitches with pyometra. A respiratory alkalosis was a common finding in the patients, and a smaller group showed a metabolic acidosis of mixed origin superimposed on the respiratory alkalosis. In this group 4 out of 9 patients died. In addition, the patients showed moderate electrolyte disturbances indicating a "sick cell syndrome" and a mild to severe renal dysfunction.
An investigation on the pathophysiological mechanisms underlying the hypoalbuminaemia and the hypercholesterolaemia of the pyometra syndrome in dogs was performed on 15 patients. The control material consisted of blood from 15 and urine from 6 healthy dogs. The presence of intrahepatic cholestasis in most of the dogs was indicated by an increase of serum alkaline phosphatases and phosphodiesterase I, and by the morphological demonstration of bile pigment retention in liver biopsy material. Serum cholesterol (total- and free-) was positively correlated with serum phospholipids, alkaline phosphatases and phosphodiesterase I, as regularly seen in cholestatic syndromes. Fibrinogen and alpha 2-globulins were increased in most patients. Albumin was inversely related to these parameters, and the main cause of the hypoalbuminaemia was probably the presence of an "acute phase reaction". The levels of coagulation factors in plasma were not lowered. Enzyme markers of hepatocellular injury (ALAT, OCT) were not increased, but on the contrary significantly lowered. The possible presence of enzyme inhibitors as the cause of the decrease of ALAT and OCT is discussed.
The blood gas status of 52 bitches presented with pyometra-endometritis complex was examined. Nine healthy bitches with a normal sexual cycle served as control group. Depending on the clinical symptoms, the sick bitches were divided into two groups (A and B). Compared to the control group, both test groups showed significant differences in pH, HCO3 and base excess levels. A correlation between the severity of disease and the decreasing pH level was noted. The disturbance of acid-base balance also resulted in respiratory and metabolic acidosis. A high proportion of these acidotic states was not compensated (group A: 71.4%; group B: 50.0%).
Eight bitches presenting with vaginal discharges were diagnosed as having open pyometra, as assessed by ultrasonographic, radiographic, haematological and clinical investigation. Plasma progesterone was assessed before treatment with prostaglandin F2 alpha (Dinoprost) and three of the bitches had low concentrations. Each bitch was given multiple injections of PGF2 alpha and monitored during and after treatment. All bitches had basal progesterone concentrations after treatment and the uterine diameters were markedly reduced by that time. One bitch has subsequently produced a litter of seven pups. Five of six bitches that were subjected to ovariohysterectomy 1-2 months later had normal uteri, although one had caseated areas in the uterine wall.
652 bitches suffering from the pyometra-endometritis complex were divided into three groups. General condition and the haemogramm were examined. The bitches of group III (n = 220) had greatest disturbances, and the mortality rate was high, especially in bitches with uterine rupture (50%). The healing rate of 63.7% in this group is the result of a special treatment schedule that is also possible under practical conditions.
We describe a clinical case of a postmenopausal woman with a perforated pyometra with clinical manifestations of generalized peritonitis. In the English literature there are 15 reported cases and only 2 secondary to cancer of cervix, our case in the 3rd. case reported in detail. We make pertinent considerations regarding the management of this extremely rare complication.
Thirty-eight complete genital tracts were obtained fresh from local veterinary practices after bitches had been ovariohysterectomised for the treatment of cystic endometrial hyperplasia (pyometra). The aerobic and anaerobic culture of swabs obtained aseptically from the uterine lumen demonstrated the presence of Escherichia coli in 28 of the 29 cases from which bacteria were isolated and, from 25, a pure culture was obtained. Sixteen different serotypes were identified from 24 genital tracts; 032K+ CNF+ was isolated from four of 16 cases and 04K-; from three of 16 cases. Cytotoxin necrotising factors (CNFs) were identified in seven of the 16 serotypes; they included 02, 04, 06, 022, 025, 045 and 075, which except for 06 and 045 were haemolytic. Strains 04K- and 07K+ completely destroyed the integrity of the endometrial epithelium whereas 088K+ and 088K- had the least effect. The scores for the reduction in the integrity of the endometrial epithelium and the degree of infiltration of inflammatory cells were greater in the presence of CNF 1.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.