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At least 145 records · Page 8Linked to original sources
PubMed1996

Salivary duct carcinoma secreting prostate-specific antigen.

Prostate-specific antigen (PSA) is a 30 kDa glycoprotein serine protease that shows high tissue specificity for prostatic tissue, both benign and malignant. However, recent reports have shown that a variety of normal and neoplastic tissue types express PSA immunohistochemically. In addition, rare instances of the secretion of PSA by nonprostatic cancers have been reported in the literature. The authors present a case of salivary duct carcinoma associated with elevated serum levels of PSA. Both the primary tumor and metastases stained positively with anti-PSA monoclonal antibodies, but were negative with antibodies directed against prostate-specific acid phosphatase. Elevated serum PSA levels were confirmed with three different immunoassay methods. A peak serum level of 140 micrograms/L was measured and this correlates with levels of PSA associated with metastatic prostatic carcinoma. High performance liquid chromatography with a molecular sieve column characterized the serum PSA into both free protein (approximately 20%) and protein bound to alpha-1-antichymotrypsin (PSA-ACT)(approximately 80%). Molecular weights of the free PSA and PSA-ACT subfractions were 27-31 kDa and 100-110 kDa, respectively.

Adenocarcinoma↗
PubMed1984

Salivary duct carcinoma: an analysis of four cases with review of literature.

Salivary duct carcinoma (SDC) is a histologically distinctive neoplasm of the parotid gland. The criteria for the diagnosis of SDC are circumscribed epithelial nests having a papillary, cribriform, and/or solid architecture coupled with central necrosis. The infiltrating cancer can be papillary, resembling the intraductal component or have a nonspecific, undifferentiated pattern. The authors are presenting four cases and compare them with 11 other acceptable cases from the literature. The neoplasm occurs beyond the age of 50 (median 63 years) and has a dismal prognosis with nearly two-thirds of the patients developing distant metastases. All surviving patients have been treated with combined parotidectomy and radiotherapy.

Adenocarcinoma↗
PubMed1995

Control of the amiloride-sensitive Na+ current in mouse salivary ducts by intracellular anions is mediated by a G protein.

1. We have previously reported that the Na+ conductance in mouse intralobular salivary duct cells is controlled by cytosolic anions, being inhibited by high cytosolic concentrations of Cl- and NO3- but not of glutamate. In the present paper, we use whole-cell patch-clamp methods to investigate whether this anion effect is mediated by a G protein. 2. Inclusion of 100 mumol l-1 GTP-gamma-S, a non-hydrolysable GTP analogue, in the glutamate-containing pipette solution, i.e. when the Na+ conductance is active, reduced the size of the Na+ conductance whereas inclusion of 100 mumol l-1 GDP-beta-S, a non-hydrolysable GDP analogue, had no effect. 3. Inclusion of 100 mumol l-1 GDP-beta-S in the NO3(-)-containing pipette solution, i.e. when the Na+ conductance is inhibited, reactivated the conductance. Inclusion of 500 ng ml-1 activated pertussis toxin in the NO3(-)-containing pipette solution had a similar effect on the Na+ conductance. 4. We conclude that the inhibitory effect of intracellular anions such as NO3- and Cl- on the amiloride-sensitive Na+ conductance in mouse mandibular intralobular duct cells is mediated by a G protein sensitive to pertussis toxin.

Amiloride↗
PubMed1987

Submandibular duct salivary bladder of the rat.

This investigation is a light and electron microscopic description of the submandibular duct salivary bladder of the rat, a dilation of the distal end of the main excretory duct. The wall of the bladder consists of a mucosa with pseudostratified epithelium, a submucosal layer of connective tissue, and an underlying layer of striated muscle. The pseudostratified columnar epithelium lining the bladder is composed of three cell types: light cells, dark cells, and basal cells. The lamina propria contains bundles of collagen, attenuated fibrocytes, capillaries with fenestrated endothelia, and nerve fibers which enter the epithelial layer. The capillaries of the submucosa are not fenestrated. The morphology of the wall of this structure provides evidence that the primary fluid of the submandibular gland is modified in the bladder by transepithelial fluid and ion transport.

Animals↗
PubMed1981

Infiltrating salivary duct carcinoma. A clinicopathologic study of five cases.

The clinicopathologic features of five cases of salivary gland carcinoma characterized by the presence of intraductal components of the carcinomatous process were studied and compared with those of other types of salivary gland carcinoma. The term "infiltrating salivary duct carcinoma" seems to be appropriate for this type of tumor because of its morphologic resemblance to the infiltrating ductal carcinomas of the breast. Its biologic behavior is highly aggressive; the metastatic and tumor-related death rates were 75% and 73%, respectively.

Aged↗
PubMed1981

Laryngeal salivary duct carcinoma: a light and electron microscopic study.

The light microscopic and ultrastructural features of a laryngeal salivary duct carcinoma are presented. By light microscopy, the neoplasm bore a marked resemblance to the infiltrating duct carcinoma of the breast. Ultrastructurally, the tumour was characterized by the presence of two principal types of cells, i.e. epithelial and myoepithelial cells, arranged in duct-formation.

Carcinoma↗
PubMed1989

Different contents of glycosaminoglycans in a human neoplastic salivary duct cell line and its subclone with a myoepithelial phenotype.

The glycosaminoglycans (GAG) biosynthesized by a neoplastic human salivary duct cell line, HSGc, and by its nontumorigenic subclone, HSGc-E1, having a myoepithelial-like phenotype, were examined by incorporation of [3H]-acetate into GAG. The rate of GAG radiolabeling in HSGc-E1 was significantly greater than that in HSGc. The radiolabeled GAG recovered from HSGc-E1 showed a distribution of 22-32% in the cells and 68-78% secreted into the medium, while the amounts of GAG in the cells and medium of HSGc were equal. Two-dimensional electrophoresis of GAG extracted from the cells demonstrated that HSGc-E1 contained a much greater amount of heparan sulfate (HS, 53.5% of total), while HSGc synthesized hyaluronic acid (HA, 17.5%), HS 38.8%, chondroitin sulfate (Ch-S, 27.6%) and dermatan sulfate (DS, 16.1%). Moreover, treatment of HSGc with sodium butyrate or dibutyryl cyclic AMP (each is a potent inducer of differentiation to myoepithelial-like cells) strongly enhanced GAG synthesis, while dexamethasone (an inducer of differentiation to a more functional duct epithelium) did not stimulate GAG synthesis. These findings suggest that biosynthetic changes in the GAG content of neoplastic salivary cells are associated with their myoepithelial differentiation.

Clone Cells↗
PubMed1999

Salivary duct carcinoma of the parotid gland: a case report.

The authors report a case of a salivary duct carcinoma (SDC) of the parotid gland revealed by a facial palsy. The clinical and pathological features of this highly malignant neoplasm are described. The aggressive nature of this form demands a combined chemo-radio-surgical treatment; only early recognition and treatment are likely to result in a favourable outcome.

Adenocarcinoma↗
PubMed2004

Salivary duct carcinoma with neuroendocrine features: report of a case with cytological and immunohistochemical study.

We report a salivary duct carcinoma (SDC) of parotid gland in a 75-year-old male. Initially, it was studied by fine-needle aspiration, which disclosed features of malignancy consistent with a high-grade carcinoma. Histologically, the tumor showed typical features of SDC, predominantly with a solid and apocrine pattern. The aggressive behavior of this tumor was documented by facial palsy and the presence of 12 regional lymph node metastases. Immunohistochemical study showed positivity for cytokeratins (AE1/AE3), cytokeratin 7, GCDFP-15, C-erbB-2, Mib-1, topoisomerase II alpha, p53, and androgen receptors. Diffuse positivity with chromogranin-A, synaptophysin, and Grimelius stains was also observed, suggesting endocrine features. Phosphotungstic acid hematoxylin, antimitochondrial antigen, progesterone and estrogen receptors, cytokeratin 20, and S-100 stains were negative. To our knowledge, this is the first case reported of SDC exhibiting neuroendocrine differentiation.

Aged↗
PubMed1998

[Magnetic resonance sialography. A new diagnostic method for imaging salivary duct patency].

The new technique of non-invasive magnetic resonance (MR) sialography was evaluated for normal and various pathologic conditions of the parotid gland. Ten volunteers and 15 patients with various symptomatic diseases of the parotid gland were tested in the present study. Diseases included pleomorphic adenoma, cystadenolymphoma, carcinoma ex pleomorphic adenoma, ductal carcinoma, adenoid cystic carcinoma, lymphoepithelial carcinoma, non-Hodgkin's lymphoma, sialolithiasis, sialadenitis, Heerfordt's syndrome and congenital duct ectasies. In addition to the usually performed T1 and T2 cross-sectional sequences a heavily weighted T2 sequence (TR 3600, TE 800) was performed and allowed depiction of a fluid-filled parotid duct. Results showed that the main parotid and primary branching ducts were depicted reliably in all normal cases and all patients, except one with sicca syndrome. Pathological conditions such as duct dilatations, duct strictures, obstructing duct calculus and irregular shapes and courses of the ductal system were demonstrable. While X-ray sialography obtained a higher resolution, only MR sialography was able to depict dilated ducts proximal from a complete obstruction, as well as all ductal cysts. Our findings show that MR sialography can be applied successfully to investigations of the parotid gland system. There have been no contraindications or complications to date because MR sialography is non-invasive. The technique will also allow the salivary ducts and lesions to be differentiated from the course of the facial nerve.

Constriction, Pathologic↗
PubMed1990

[Detection of serum anti-salivary duct antibody and its clinical significance].

The authors developed an indirect immunofluorescence technique for the detection of Anti-salivary duct antibody (ASDA) and screened 34 patients with rheumatoid arthritis, 15 patients with Sjögren's syndrome-rheumatoid arthritis and 15 patients with primary Sjögren's syndrome, 63 cases with other connective tissue diseases, 9 cases with other diseases and 40 normal controls. The incidence of ASDA in patients with Sjögren's syndrome rheumatoid arthritis (66.67%) or rheumatoid arthritis (32.35%) was significantly higher than that in normal controls (P less than 0.001). In patients with primary Sjögren's syndrome and other CTDs, non-CTDs, no ASDA was found. However, in patients with Sjögren's syndrome-rheumatoid arthritis or rheumatoid arthritis alone, ASDA was not correlated with age, sex, disease duration or serological findings. The result suggests that the detection of serum ASDA might be useful in the differentiation of Sjögren's syndrome with rheumatoid arthritis from primary Sjögren's syndrome with arthralgia and/or arthritis.

Arthritis, Rheumatoid↗
PubMed1983

Crystalloids in salivary duct cysts of the human parotid gland. Scanning electron microscopical study with electron probe X-ray microanalysis.

Crystalloids found in salivary duct cysts of the human parotid gland were examined by scanning electron microscopical observations with electron probe X-ray microanalysis. The cystic spaces were filled with numerous crystalloids which had a variety of forms with slight eosinophilic and glassy appearance. Scanning electron microscopically, crystalloids were hexagonal and rhombohedral in shape, and cutting the surface showed a polycyclic structure or regular parallel lamination. By electron probe X-ray microanalysis, sulphur was the only detected element. The present study suggests that crystalloids resulted from deposition from supersaturated saliva containing sulphur containing compounds into the cystic lumen or into epithelial cytoplasm.

Crystalloid Solutions↗
PubMed1990

[Lithiasis in small salivary ducts. Report of 3 cases].

Three cases with sialolithiasis of minor salivary gland are presented. The sialoliths were found on the left side of the upper lip (two patients) with local infection and on the right side of buccal mucosa (one patient) without any symptom. The histologic findings resulted from our own cases and the etiology are discussed extensively and a literature review is made as well.

Aged↗
PubMed2000

Evidence that dilation of isolated salivary ducts from the tick Dermacentor variabilis (Say) is mediated by nitric oxide.

We used pharmacological methods to test the hypothesis that female Dermacentor variabilis salivary ducts dilated when dopamine-stimulated and that dilation was nitric oxide-mediated. Stimulation with dopamine resulted in an increased diameter (19.7%) compared to unstimulated ducts (P<0.005). Pretreatment with L-NAME, an inhibitor of nitric oxide synthase, or cytochalasin D abolished the dilation. Addition of L-arginine to L-NAME-treated ducts partially restored the ability to dilate. A cuticular coil composed of a series of concentric rings ran the length of the duct adjacent to the epithelial cell layer. In stimulated ducts, the center-to-center periodicity of these rings increased from 0.59 µm in unfed ducts to 1.0 µm from partially fed ducts (P<0.05). When the ducts from partially fed females were stimulated with dopamine, the periodicity increased further to 1.75 µm (P<0.05), suggesting the coils moved further apart in response to stimulation. Prominent folds lining the lumen of unstimulated ducts were less pronounced in stimulated preparations, suggesting that the cuticle stretches, thereby increasing lumen size. Actin was localized in epithelial cells as a honeycomb pattern that we suggest links the epithelial cells to the rings. Together, these data support the following hypothesis: stimulated ducts dilated during fluid production; dilation involved an actin-based system, and was mediated by nitric oxide. Dilation of the duct may enhance its role as a reservoir for saliva produced by the acini during the period between imbibition and salivation.

Journal Article↗