[Value of the streptokinase-streptodornase reaction in the diagnosis of rheumatic fever in children].
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During of potency for SK/SD solutions used as recall antigens in delayed hypersensitivity skin testing had not been determine. In a study of 50 normal subjects over a one-year period it was found that antigenicity diminished with time. At four months, however, there was no evidence of impaired potency at any of the dilutions tested. Authors suggest that reconstitution of SK/SD be made every three months when kept at room temperature and that increasing strengths be applied beginning at 4/1 units.
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A series of patients who received intracavitary streptokinase/streptodornase after thoracotomy or laparotomy were compared with a control group. They showed a highly significant increase in plasma streptokinase tolerance, indicating absorption of the streptokinase from the cavity. Changes in blood coagulation, plasma cell count and immunoglobulins were not observed. In a series of patients with leg ulcers treated with streptokinase/streptodornase by mouth, no increase in plasma streptokinase tolerance was observed, indicating that orally administered streptokinase is not absorbed from the gastro-intestinal tract.
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