Splanchnic circulation during halothane anesthesia and hypercapnia in normal man.
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Superior mesenteric angiograms were obtained in a series of dogs before and again after the injection of a 1-ml bolus of prostaglandin E1 (0.1-1.0 mug/kg) through the angiographic catheter. The prostaglandin E1 produced, on the average, a 100% increase in the superior mesenteric arterial blood flow with only minimal changes in the heart rate, systemic arterial pressure, and portal venous pressure. Opacification of the portal venous system was consistently enhanced after the prostaglandin E1. The arterial phase was preserved by increasing the rate of contrast administration.
A single bolus injection of prostaglandin E1 (5-7.5 microgram) into the superior mesenteric, hepatic or pancreatico-duodenal arteries was employed as a pharmacoangiographic aid in 22 patients. Good quality arterial phase and greatly enhanced portal venograms were obtained. No significant complications were observed. The authors found the technique useful in diagnosis of primary and metastatic lesions in the liver and pancreas.
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