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Results for “Stereotyped Behavior”

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At least 145 records · Page 8Linked to original sources

PubMed1977

Effects of withdrawal from chronic amphetamine intoxication on exploratory and stereotyped behaviors in the rat.

Rats were administered 3, 6, and 12 mg/kg of d-amphetamine s.c. twice daily on a weekly increasing staircase schedule. On days 1, 7, 14, and 28 after the last injection of amphetamine the animals were challenged with 1 and 3 mg/kg of d-amphetamine and their behavior was observed. The 7-, 14-, and 28-day withdrawn animals required less amphetamine than controls to induce stereotyped behaviors. However, it was found that withdrawn animals and control animals were equally sensitive to the effects of apomorphine. Reserpine pretreatment eliminated the differences between control and withdrawn animals. alpha-Methyl tyrosine pretreatment blocked the effects of 1 but not 3 mg/kg of d-amphetamine in the withdrawn animals. Possible chemical mechanisms underlying the change in amphetamine sensitivity in the withdrawn animals are discussed.

Animals↗

PubMed1978

Phencyclidine-induced stereotyped behavior in monkeys: antagonism by pimozide.

The psychotomimetic substance, phencyclidine (PCP), was administered chronically to selected members of a primate social colony. PCP induced stereotyped behavior in all treated monkeys at each of three test doses. Furthermore, there was a significant increase in the amount of stereotypy seen during the second and third weeks of treatment compared to the first week. The dopamine receptor blocking agent pimozide antagonized PCP stereotypy. The results are discussed in terms of dopamine mediation of these responses.

Animals↗

PubMed1979

Differential effects of methylphenidate and d-amphetamine on stereotyped behavior in the rat.

Different equimolar doses of d-amphetamine and methylphenidate were compared for their potency in eliciting stereotyped behavior in rats. Although at lower doses d-amphetamine appeared more effective in causing stereotyped gnawing, repetitive body movements, and sniffing, at higher doses methylphenidate at certain times caused a greater incidence of gnawing than did d-amphetamine. Understanding these differences and comparing related biochemical correlates may lead to a better definition of mechanisms underlying psychostimulant effects.

Animals↗

PubMed1985

Stereotyped behavior and diabetes mellitus in rats: reduced behavioral effects of amphetamine and apomorphine and reduced in vivo brain binding of [3H]spiroperidol.

Rats made diabetic with streptozotocin showed decreased stereotyped behaviors following administration of amphetamine or apomorphine. Spontaneous activity in an open field was lower in diabetics than in controls, but a low dose of apomorphine produced equivalent fractional decreases in activity in both groups. In vivo accumulation of amphetamine and apomorphine was generally similar in both groups: Reduced tissue access did not appear to be responsible for the decreased behavioral effects of these agents. The in vivo accumulation of spiroperidol in several brain regions was generally less in diabetics than in controls. These data are discussed in terms of altered catecholamine biochemistry and behavior in diabetics.

Animals↗

PubMed1981

The effects of scopolamine pretreatment on stereotyped behavior induced by apomorphine in rats withdrawn from long-term haloperidol administration.

1. The effects of scopolamine on intensity of stereotyped behavior induced by the ED50 dose of apomorphine in controls and in animals withdrawn from long-term haloperidol treatment were studied. 2. Doses of 1.0 and 3.0 microgram/kg of scopolamine increased apomorphine-induced stereotypy in both groups. However, this increase was smaller in the haloperidol-treated than in the control animals. 3. These data support the hypothesis that long-term administration of haloperidol may produce a change not only in dopaminergic but also in central cholinergic receptor sensitivity.

Animals↗

PubMed1975

Supersensitivity to d-amphetamine- and apomorphine-induced stereotyped behavior induced by chronic d-amphetamine administration.

Guinea pigs exhibit an increased sensitivity to both d-amphetamine- and apomorphine-induced stereotyped behavior following chronic pretreatment with d-amphetamine. This chronic agonist or "innervation" supersensitivity is believed to be a reflection of an increased sensitivity of dopamine receptor sites within the corpus striatum to dopaminergic agonists. The appearance of dyskinetic movement disorders in humans following the chronic use of levodopa or amphetamine may be a manifestation of similarly increased dopamine receptor site sensitivity within the striatum. It is suggested that the animal model of "innervation" supersensitivity may be useful in the investigation of these human movement disorders.

Animals↗

PubMed1981

[Effect of phenamine and haloperidol on stereotyped behavior in response to electric stimulation of the substantia nigra in cats].

On being given in low doses (0.25 mg/kg) amphetamine potentiates stereotyped behavior induced in cats by stimulation of substantia nigra. As the dose is raised the effect increases eventuating in the formation of the typical amphetamine-induced stereotypy. Little doses of haloperidol (0.03-0.06 mg/kg) reduce the behavioral and electroencephalographic signs of nigral stereotypy. Amphetamine potentiates, while haloperidol reduces the impairment of the restrained function of the caudate nucleus which occurs in the presence of nigral stereotypy.

Amphetamine↗

PubMed1988

Effects of single and long-term metoclopramide administration on open field and stereotyped behavior of rats.

The effects of single and long-term metoclopramide administration on rat open-field and apomorphine-induced stereotyped behavior were studied. A single dose of metoclopramide decreased dose dependently not only locomotion and rearing frequencies in the open field but also the apomorphine effects. Withdrawal from long-term metoclopramide administration induced a significant increase in all parameters of activity recorded in the open field. The responsiveness to apomorphine was also augmented in metoclopramide-withdrawn rats. These results were considered to be a consequence of the supersensitivity of central dopaminergic receptors.

Animals↗

PubMed1986

[Effect of cortisol on a model of stereotypical behavior in the rabbit in the form of hindlimb thumping].

A 5-sec electrical shock applied to the rabbit medial hypothalamus induced series of stereotype behavioral responses in the form of synergic blows with hindlimbs. Adaptation to the stimulation occurred in repetition of the stimuli every 1.5-2.0 min. Pharmacological experiments revealed that intraperitoneal administration of cortisol (10 and 20 mg/kg) enhanced the stimulation-induced behavioral response and shortened its latency.

Animals↗

PubMedDate not supplied

Reduction of motor behavioral deficits in senescent animals via chronic prolactin administration. II. Non-stereotypic behaviors.

The effects of chronic prolactin administration on three non-stereotypic psychomotor behaviors (inclined screen performance, rod walking and wire hanging) were examined in senescent (24 month) Fisher 344 rats. Prolactin (150 ng/hr) was administered for 7 days via Alzet minipumps to rats which had been pretested on the three tasks. The animals were tested on days 4 and 7 following the implants and the pumps were removed after testing on day 7. In order to assess the persistence of any prolactin effects on psychomotor performance the animals were tested again on days 7 and 14 after pump removal. Control animals were implanted with Alzet pumps containing only saline and tested in a similar manner. Results demonstrated that the prolactin treated animals showed improvements on both the inclined screen and rod walking tasks but not the wire hanging test. Moreover, the improved performance seen on the inclined screen test persisted for as long as 7 days after pump removal. Results are discussed in terms of the importance of techniques which increase striatal dopaminergic responsivity on enhancing psychomotor performance in senescence.

Aging↗

PubMed1984

Vasopressin injected into the hypothalamus triggers a stereotypic behavior in golden hamsters.

Microinjection of arginine vasopressin into the medial preoptic area of the hypothalamus of male and female golden hamsters triggered a complex, stereotypic behavior--flank marking--a type of scent marking used in olfactory communication. The flank marking was not elicited by saline, oxytocin, neurotensin, or angiotensin II. Vasopressin was ineffective when injected into other areas of the hypothalamus or into the lateral cerebroventricle.

Angiotensin II↗

PubMed1983

Automated analysis of stereotypic behavior induced by psychomotor stimulants.

A newly developed rotation sensing device has been applied to the continuous monitoring of animal movement. Animals treated with morphine, amphetamine or apomorphine display different stereotypic movements which can be distinguished by the apparatus. Initial studies have indicated that the apparatus is able not only to identify but also to quantitate some measures of stereotypic behavior. For example, the number and direction of rotations (a measure of motor asymmetry), frequency of changes in movement direction (a measure of stereotypic movement) and periods of cessation of movement are affected differentially with acute morphine, apomorphine or amphetamine treatment. Moreover, using this apparatus, morphine was shown to increase the degree of rotational asymmetry of normal animals and of animals with unilateral lesions of the nigrostriatal pathway.

Amphetamine↗

PubMed1994

Effects of noncontingent sensory reinforcement on stereotypic behaviors in a child with posttraumatic neurological impairment.

A multiple baseline design across instructional sessions was used to evaluate the therapeutic effects of noncontingent sensory reinforcement on stereotypic behaviors (grabbing and mouthing objects) displayed by an 8-year-old child with posttraumatic neurological impairment. The programmed sensory reinforcement was oral stimulation made accessible to the child by allowing her to chew on a designated and acceptable stimulus. Treatment was associated with a decrease in both object-grabbing and object-mouthing behaviors to near-zero levels. At a 6-month follow-up, the behaviors were absent without the use of sensory reinforcement. Issues of treatment formulation and implementation are discussed.

Behavior Therapy↗

PubMed1998

Nervous habits and stereotyped behaviors in preschool children.

OBJECTIVE: To examine the frequency, age trends, and situational correlates of nervous habits (e.g., nail-biting, thumb-sucking) and motor stereotyped behaviors (e.g., body-rocking) in typically developing preschool children. METHOD: Data were compiled from 100 teacher interviews and 32 parent interviews on children aged 3 to 6 years. A semistructured, individually administered interview was used. RESULTS: Parents reported the most behaviors, with the most common behaviors being thumb-sucking (25%) and nail-biting (23%). Motor stereotypies demonstrated a frequency of 4% as reported by the teachers and a frequency of 3% as reported by the parents. Teachers reported a decrease in children having the nervous habit of picking at sores, lips, etc., with age. Parents reported a significant decrease in all nervous habits with age. Nervous habits were associated with structured times during the day and negative mood states, and teachers reported that girls were more likely than boys to display nervous habits. CONCLUSION: Nervous habits and stereotypies are prevalent in typically developing preschool children, and their presence appears to be a reflection of mood state.

Affect↗

PubMed1986

Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin.

We investigated the effects of thiorphan, a specific inhibitor of enkephalinase A and bestatin, a specific inhibitor of aminopeptidase, on the stereotyped behaviors induced by phencyclidine (PCP) in cannulated rats. The PCP-induced turning was significantly potentiated when thiorphan (50 micrograms) and bestatin (50 micrograms) were injected simultaneously into the rat lateral ventricle. The increase of PCP-induced turning was completely antagonized by the pretreatment with naloxone. Thiorphan (50 micrograms) or bestatin (50 micrograms) alone failed to potentiate PCP-induced turning. Thiorphan and/or bestatin did not affect significantly the PCP-induced head weaving and back-pedalling except that thiorphan (50 micrograms) potentiated the PCP-induced head weaving 15-18 min after the PCP injection. The combination of thiorphan and bestatin alone did not induce any behavioral change. These results suggest that thiorphan and bestatin produce an increase of endogenous enkephalins and that as a result, PCP-induced turning may be enhanced.

Amino Acids, Sulfur↗

PubMed1998

Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila.

Cocaine abuse is a large social and economic problem that has received much public and scientific attention in recent years. Rodent and primate models have been used to study the behavioral and neurological effects of cocaine. Repeated intermittent doses of cocaine lead to progressive increases in both locomotor activity and stereotyped behaviors known as 'reverse tolerance' or behavioral sensitization, which may model the behavioral and neurochemical processes occurring in cocaine-addicted humans [1]. The biological basis of sensitization is poorly understood. We report that free-base cocaine administered in volatile form to the fruit fly Drosophila melanogaster induces multiple reflexive motor responses that resemble cocaine-induced behaviors in rodents. These behaviors are both dose dependent and sexually dimorphic. Furthermore, Drosophila develops a behavioral sensitization to intermittent doses of cocaine. These results suggest that the pathways leading to cocaine-induced responses and sensitization are evolutionarily conserved between Drosophila and higher vertebrates, and that this genetically tractable animal can be used as a new model system to help determine the biological mechanisms underlying these processes.

Animals↗

PubMed1990

The use of tactile and vestibular stimulation to reduce stereotypic behaviors in two adults with mental retardation.

In this study, two institutionalized adults with mental retardation were treated twice weekly over a 7-month period with activities that provided tactile and vestibular stimulation for the purpose of reducing stereotypic behaviors. Statistically significant treatment effects were demonstrated, but the target behaviors continued at a high and variable rate. Greater treatment frequency may be necessary for therapeutic benefit to occur in adults. Future single case studies need to be completed, with each variable manipulated systematically and with closer adherence to previous studies.

Adult↗

PubMed1986

Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats.

We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitoneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.

Animals↗