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At least 145 records · Page 8Linked to original sources

Bayesian model averaging of Bayesian network classifiers over multiple node-orders: application to sparse datasets.

Bayesian model averaging (BMA) can resolve the overfitting problem by explicitly incorporating the model uncertainty into the analysis procedure. Hence, it can be used to improve the generalization performance of Bayesian network classifiers. Until now, BMA of Bayesian network classifiers has only been performed in some restricted forms, e.g., the model is averaged given a single node-order, because of its heavy computational burden. However, it can be hard to obtain a good node-order when the available training dataset is sparse. To alleviate this problem, we propose BMA of Bayesian network classifiers over several distinct node-orders obtained using the Markov chain Monte Carlo sampling technique. The proposed method was examined using two synthetic problems and four real-life datasets. First, we show that the proposed method is especially effective when the given dataset is very sparse. The classification accuracy of averaging over multiple node-orders was higher in most cases than that achieved using a single node-order in our experiments. We also present experimental results for test datasets with unobserved variables, where the quality of the averaged node-order is more important. Through these experiments, we show that the difference in classification performance between the cases of multiple node-orders and single node-order is related to the level of noise, confirming the relative benefit of averaging over multiple node-orders for incomplete data. We conclude that BMA of Bayesian network classifiers over multiple node-orders has an apparent advantage when the given dataset is sparse and noisy, despite the method's heavy computational cost.

Algorithms↗

Scale reliant mixed effects models enhance microbiome data analysis.

Linear models, including those used for differential abundance analyses, are frequently used in microbiome research to assess how experimental conditions (e.g., disease state or age) affect microbial abundance. Linear mixed-effects models (MEMs) extend linear models to accommodate complex designs, such as longitudinal sampling or hierarchical study structures. However, when applied to microbiome data, existing MEM approaches suffer from high false positive and false negative rates because sequence counts are compositional - they reflect relative rather than absolute abundances. Current methods attempt to overcome this limitation through normalization, but these approaches rely on strong, often unrealistic assumptions about the unmeasured biological scale (e.g., total microbial load). Here we introduce scale-reliant mixed-effects models (SR-MEM), which extend our earlier scale-reliant inference framework by explicitly modeling uncertainty in the unmeasured scale via user-defined probability distributions. By treating scale as a latent variable rather than fixing it through normalization, SR-MEM enables robust inference for complex experimental designs. SR-MEM can incorporate external scale measurements (e.g., flow cytometry, qPCR) or leverage scale information from independent studies to further improve inference. Across simulations and multiple real-world case studies, SR-MEM consistently controls the false discovery rate while maintaining comparable or higher power than standard approaches relying on normalization or bias correction. In reanalyses of published datasets, SR-MEM yields results that are more reproducible across studies and more consistent with known biological and pharmacological effects. SR-MEM provides a principled and practical framework for mixed-effects modeling of microbiome sequence count data in the presence of unmeasured biological scale. By avoiding normalization-based assumptions and instead propagating scale uncertainty through inference, SR-MEM improves error control and reproducibility in longitudinal and hierarchical studies. An accessible implementation is provided in the ALDEx3 R package.

Microbiota↗

Risk management for plausibly hormetic environmental carcinogens: the case of radon.

Risk management typically involves efforts to reduce human exposures by establishing regulations that limit the concentration of the substance in environmental media. In cases where a substance is widely used in commerce or is naturally occurring in the environment, compliance costs can be substantial because of nationwide requirements to add expensive control technologies. Uncertainties in a dose-response function further impact risk management decisions because they may correspond to large differences in health benefit per unit exposure reduction. These problems are highlighted in the case of plausibly hormetic environmental carcinogens, for which a linear-no-threshold (LNT) dose-response model has been the traditional regulatory default assumption. In this case, model uncertainty is pivotal, and risk management is consequently inherently controversial. However, marginal cost functions that arise for plausibly hormetic carcinogens are expected to possess a common analytic feature that may be particularly useful for this type of risk management problem. Specifically, marginal cost functions in this context are expected to have roots reflecting contaminant concentration values above which regulatory goals may be optimally placed subject to cost constraints. Here we illustrate this heuristic feature in the case of residential radon, using both a LNT model and a biologically plausible hormetic model to predict associated risks of lung cancer mortality.

Air Pollution, Indoor↗

Oligogenic model selection using the Bayesian Information Criterion: linkage analysis of the P300 Cz event-related brain potential.

The traditional likelihood-based approach to hypothesis testing may not be an optimal strategy for evaluating oligogenic models of inheritance. Under oligogenic inheritance the number of possible multilocus models can become very large; there may be several competing linkage models having similar likelihoods; and comparisons among non-nested models can be required to determine if a given multilocus model provides a significantly better fit to observed phenotypic variation than an alternative model. We propose an efficient Bayesian approach to oligogenic model selection that makes use of existing model likelihoods, and show how model uncertainty can be incorporated into parameter estimation.

Alcoholism↗

Fluid flow and reactive transport around potential nuclear waste emplacement tunnels at Yucca Mountain, Nevada.

The evolution of fluid chemistry and mineral alteration around a potential waste emplacement tunnel (drift) is evaluated using numerical modeling. The model considers the flow of water, gas, and heat, plus reactions between minerals, CO(2) gas, and aqueous species, and porosity-permeability-capillary pressure coupling for a dual permeability (fractures and matrix) medium. Two possible operating temperature modes are investigated: a "high-temperature" case with temperatures exceeding the boiling point of water for several hundred years, and a "low-temperature" case with temperatures remaining below boiling for the entire life of the repository. In both cases, possible seepage waters are characterized by dilute to moderate salinities and mildly alkaline pH values. These trends in fluid composition and mineral alteration are controlled by various coupled mechanisms. For example, upon heating and boiling, CO(2) exsolution from pore waters raises pH and causes calcite precipitation. In condensation zones, this CO(2) redissolves, resulting in a decrease in pH that causes calcite dissolution and enhances feldspar alteration to clays. Heat also enhances dissolution of wall rock minerals leading to elevated silica concentrations. Amorphous silica precipitates through evaporative concentration caused by boiling in the high-temperature case, but does not precipitate in the low-temperature case. Some alteration of feldspars to clays and zeolites is predicted in the high-temperature case. In both cases, calcite precipitates when percolating waters are heated near the drift. The predicted porosity decrease around drifts in the high-temperature case (several percent of the fracture volume) is larger by at least one order of magnitude than in the low temperature case. Although there are important differences between the two investigated temperature modes in the predicted evolution of fluid compositions and mineral alteration around drifts, these differences are largely within to the model uncertainty and the variability of water compositions at Yucca Mountain.

Carbon Dioxide↗

Optimal nonlocal boundary control of the wide-angle parabolic equation for inversion of a waveguide acoustic field.

This paper applies the concept of optimal boundary control for solving inverse problems in shallow water acoustics. To treat the controllability problem, a continuous analytic adjoint model is derived for the Claerbout wide-angle parabolic equation (PE) using a generalized nonlocal impedance boundary condition at the water-bottom interface. While the potential of adjoint methodology has been recently demonstrated for ocean acoustic tomography, this approach combines the advantages of exact transparent boundary conditions for the wide-angle PE with the concept of adjoint-based optimal control. In contrast to meta-heuristic approaches the inversion procedure itself is directly controlled by the waveguide physics and, in a numerical implementation based on conjugate gradient optimization, many fewer iterations are required for assessment of an environment that is supported by the underlying subbottom model. Furthermore, since regularization schemes are particularly important to enhance the performance of full-field acoustic inversion, special attention is devoted to the application of penalization methods to the adjoint optimization formalism. Regularization incorporates additional information about the desired solution in order to stabilize ill-posed inverse problems and identify useful solutions, a feature that is of particular importance for inversion of field data sampled on a vertical receiver array in the presence of measurement noise and modeling uncertainty. Results with test data show that the acoustic field and the bottom properties embedded in the control parameters can be efficiently retrieved.

Acoustics↗

Issues of scale and uncertainty in the global remote sensing of disease.

Scale and uncertainty are important issues for the global prediction of disease. Disease mapping over the entire surface of the Earth usually involves the use of remotely sensed imagery to provide environmental covariates of disease risk or disease vector density. It further implies that the spatial resolution of such imagery is relatively coarse (e.g., 8 or 1km). Use of a coarse spatial resolution limits the information that can be extracted from imagery and has important effects on the results of epidemiological analyses. This paper discusses geostatistical models for (i) characterizing the scale(s) of spatial variation in data and (ii) changing the scale of measurement of both the data and the geostatistical model. Uncertainty is introduced, highlighting the fact that most epidemiologists are interested in accuracy, aspects of which can be estimated with measurable quantities. This paper emphasizes the distinction between data- and model-based methods of accuracy assessment and gives examples of both. The key problem of validating global maps is considered.

Animals↗

Parallelisation and application of a multi-layer atmospheric transport model to quantify dispersion and deposition of ammonia over the British Isles.

An atmospheric transport model, FRAME (Fine Resolution AMmonia Exchange), has been used to model the spatial pattern of ammonia concentrations and deposition over the British Isles for the first time. The model uses a multi-layer approach with diffusion through 33 layers to describe vertical concentration profiles in the atmosphere explicitly. Together with the necessary description of atmospheric reactions with sulphur and oxidised nitrogen, this imposes a major computational requirement, with the model having a run-time of 8.5 days on a mid-range workstation. Improvement in the model run-time was sought by developing a parallel implementation coded in a data-parallel approach using High Performance Fortran. Running the code on a Cray T3E with 128 processors provided a speedup by a factor of 69. The code's portability, its validation with measurements and new maps of its application to the British Isles, are presented. Good agreement is found with measured NH3 concentrations, while wet de-position is underestimated. In addition to model uncertainties, this may be due to an underestimation of the NH3 emissions input data.

Air Movements↗

Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.

Bayesian population analysis of a harmonized physiologically based pharmacokinetic (PBPK) model for trichloroethylene (TCE) and its metabolites was performed. In the Bayesian framework, prior information about the PBPK model parameters is updated using experimental kinetic data to obtain posterior parameter estimates. Experimental kinetic data measured in mice, rats, and humans were available for this analysis, and the resulting posterior model predictions were in better agreement with the kinetic data than prior model predictions. Uncertainty in the prediction of the kinetics of TCE, trichloroacetic acid (TCA), and trichloroethanol (TCOH) was reduced, while the kinetics of other key metabolites dichloroacetic acid (DCA), chloral hydrate (CHL), and dichlorovinyl mercaptan (DCVSH) remain relatively uncertain due to sparse kinetic data for use in this analysis. To help focus future research to further reduce uncertainty in model predictions, a sensitivity analysis was conducted to help identify the parameters that have the greatest impact on various internal dose metric predictions. For application to a risk assessment for TCE, the model provides accurate estimates of TCE, TCA, and TCOH kinetics. This analysis provides an important step toward estimating uncertainty of dose-response relationships in noncancer and cancer risk assessment, improving the extrapolation of toxic TCE doses from experimental animals to humans.

Animals↗

Assessment of ozone effects on nitrate export from Hubbard Brook Watershed 6.

The impact of the air pollution ozone on soil N dynamics and temporal and spatial patterns of streamflow nitrate flux at the Hubbard Brook Experimental Forest Watershed 6 during the 1964-1994 period was assessed using aggregated (one-cell) and spatially explicit (208-cell) versions of the SImple NItrogen Cycle (SINIC) model. Simulated ozone effects included reductions in stomatal conductance and plant N demand. Model uncertainty was evaluated using Monte Carlo simulations. Ambient ozone was estimated to cause an additional 0.042 gN/m2 per year of nitrate export, 12% of the mean annual streamflow nitrate flux. The 95% credible interval of this estimate was 0.002-0.083 gN/m2 per year, or 0.72-27.3% of the annual flux. The large uncertainty in this estimate suggests that it may be difficult to identify ozone effects on nitrate export utilizing long term data from a single site.

Air Pollutants↗

Site of the accelerating nonlinearity underlying luminance-change detection.

The visual psychometric function for luminance-increment detectability (d') is known to be an accelerating function of stimulus energy. Two different models have been suggested to explain this fact and also why a luminance-increment pedestal linearizes the psychometric function. In the present experiment it is shown that a dichoptically presented increment linearizes the psychometric function and facilitates detection of weak signals. Since the dichoptic pedestal combines with the signal centrally, the nonlinearity must then originate more centrally. This result is compatible with the uncertainty model of the nonlinear psychometric function but not with a model that requires a nonlinear transducer.

Humans↗

Monte Carlo calibration of avalanches described as Coulomb fluid flows.

The idea that snow avalanches might behave as granular flows, and thus be described as Coulomb fluid flows, came up very early in the scientific study of avalanches, but it is not until recently that field evidence has been provided that demonstrates the reliability of this idea. This paper aims to specify the bulk frictional behaviour of snow avalanches by seeking a universal friction law. Since the bulk friction coefficient cannot be measured directly in the field, the friction coefficient must be calibrated by adjusting the model outputs to closely match the recorded data. Field data are readily available but are of poor quality and accuracy. We used Bayesian inference techniques to specify the model uncertainty relative to data uncertainty and to robustly and efficiently solve the inverse problem. A sample of 173 events taken from seven paths in the French Alps was used. The first analysis showed that the friction coefficient behaved as a random variable with a smooth and bell-shaped empirical distribution function. Evidence was provided that the friction coefficient varied with the avalanche volume, but any attempt to adjust a one-to-one relationship relating friction to volume produced residual errors that could be as large as three times the maximum uncertainty of field data. A tentative universal friction law is proposed: the friction coefficient is a random variable, the distribution of which can be approximated by a normal distribution with a volume-dependent mean.

Complex Mixtures↗

Assessing occupational and environmental exposure.

Exposure assessment is a poorly understood component of the science of epidemiology. The relationship between exposure to chemicals and ill-health outcomes is often calculated using crude exposure measures such as ever/never exposed or duration. When investigating subtle effects, exposures need to be characterized much more fully in terms of intensity, frequency, duration and route. While occupational exposures tend to be much greater than those experienced from the wider environment there is a need to remember that, for many chemicals, exposure can occur occupationally, environmentally and through consumer use of products containing the material of interest. Inhalation exposure has generally been the traditional focus for most epidemiological investigations but there is now growing awareness of the importance of the dermal and ingested routes of contact and internalization. Quantification of the exposure also needs to be related to a biological mechanism of action and exposure metrics need to be selected accordingly. Occupational exposures can generally be measured using simple well-validated techniques. Environmental exposures require much more sensitive instruments and are more difficult to assess. Exposure modelling, particularly for the environmental fate of chemicals has undergone many recent developments and Monte Carlo techniques can be used to characterize model uncertainty and variability. This approach to exposure assessment can now be used in the setting of the wider environment and will enable a far better understanding of the relationship between exposure and disease.

Environmental Exposure↗

Dynamic electrical impedance imaging with the interacting multiple model scheme.

In this paper, an effective dynamical EIT imaging scheme is presented for on-line monitoring of the abruptly changing resistivity distribution inside the object, based on the interacting multiple model (IMM) algorithm. The inverse problem is treated as a stochastic nonlinear state estimation problem with the time-varying resistivity (state) being estimated on-line with the aid of the IMM algorithm. In the design of the IMM algorithm multiple models with different process noise covariance are incorporated to reduce the modeling uncertainty. Simulations and phantom experiments are provided to illustrate the proposed algorithm.

Algorithms↗

Identification and robust control of an experimental servo motor.

In this work, the design of a robust controller for an experimental laboratory-scale position control system based on a dc motor drive as well as the corresponding identification and robust stability analysis are presented. In order to carry out the robust design procedure, first, a classic closed-loop identification technique is applied and then, the parametrization by internal model control is used. The model uncertainty is evaluated under both parametric and global representation. For the latter case, an interesting discussion about the conservativeness of this description is presented by means of a comparison between the uncertainty disk and the critical perturbation radius approaches. Finally, conclusions about the performance of the experimental system with the robust controller are discussed using comparative graphics of the controlled variable and the Nyquist stability margin as a robustness measurement.

Computer Simulation↗

Solar modulation and nuclear fragmentation effects in galactic cosmic ray transport through shielding.

Crews of manned interplanetary missions may accumulate significant radiation exposures from the galactic cosmic ray (GCR) environment in space. Estimates of how these dose levels are affected by the assumed temporal and spatial variations in the composition of the GCR environment, and by the effects of the spacecraft and body self-shielding on the transported radiation fields are presented. In this work, the physical processes through which shielding alters the transported radiation fields are described. We then present estimates of the effects on model calculations of (1) nuclear fragmentation model uncertainties, (2) solar modulation, (3) variations between solar cycles, and (4) proposed changes to the quality factors which relate dose equivalent to absorbed dose.

Aluminum↗

A study of C3HD in cold interstellar clouds.

We have detected the 1(10)-1(01) transition of C3HD at 19.418 GHz at twelve positions in cold, dark clouds and resolved the D hyperfine components in two sources (L1498 and TMC-1C) well enough to derive values for the D quadrupole coupling constants. Simultaneous observations of C3H2 in each source yield relative integrated line intensities in the range 0.10-0.18, from which we derive relative [C3HD]/[C3H2] abundances in the range 0.05-0.15. These are among the highest deuteration ratios yet observed. Within the limits of the observational and modeling uncertainties it is possible to explain the derived [C3HD]/[C3H2] ratios by ion-molecule chemistry if [e-] approximately 3 x 10(-7).

Astronomical Phenomena↗

Computational intelligence in earth sciences and environmental applications: issues and challenges.

This paper introduces a generic theoretical framework for predictive learning, and relates it to data-driven and learning applications in earth and environmental sciences. The issues of data quality, selection of the error function, incorporation of the predictive learning methods into the existing modeling frameworks, expert knowledge, model uncertainty, and other application-domain specific problems are discussed. A brief overview of the papers in the Special Issue is provided, followed by discussion of open issues and directions for future research.

Artificial Intelligence↗