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PubMed1989

[The importance of magnesium in orthopedics. VI. The importance of magnesium in the treatment of ectopic calcification and ossification].

In a five-year investigation the authors demonstrate their results with Mg treatment in 54 patients with ectopic calcifications and ossifications. Based on the results of experimental work, where the inhibiting action of Mg ions on calcium phosphate precipitation was proved in vitro as well as in vivo, the authors treated by means of local MgSO4 injections and oral administration of Mg lactate 17 patients with ossifying myositis, 16 with calcareal bursitis, 4 patients with paraosteoarthropathy of the elbow after craniocerebral injuries, 6 calcifications of the hip joint after operations and 5 calcifications in the insertions of tendons and ligaments. In all instances diminution to complete disappearance of the calcificates and ossificates was observed. The authors achieved also very favourable functional results. In the majority of patients the mobility in adjacent joints was restored. Clinical experience indicates that Mg prevents the development or suppresses further growth of ectopic calcifications and ossifications. During the formation of the ossificate, which is still immature, Mg causes diminution and sometimes complete absorption of the immature bone.

Adolescent↗
PubMed1967

A review of some important problems concerning lung cancer. The importance of complete preoperative assessment in bronchogenic carcinoma.

Part I of this review described the pathogenesis of lung cancer and emphasized that it was largely a preventable disease. In the present paper, attention is drawn to the prevalent but false impression that treatment of established disease is quite in-effective. In eight consecutive series of cases (over 2300 patients) the authors have seen a change in the clinical environment in which lung cancer is treated-from one of discouragement and apathy to one of outspoken encouragement and enthusiasm.Complete preoperative assessment-an evaluation of the biology of the tumour-host relationship as well as technical resectability-avoids unnecessary surgical intervention and stimulates a trend to earlier referral. This has permitted increasing use of resection with a declining mortality and a continuing improvement in overall survival. On the basis of present resectability rates (37.5%) and a 39% five-year survival rate in those who have had curative resection, it is estimated that current over-all five-year salvage should exceed 13%. This is more than a five-fold increase in survival for all patients compared to that achieved by treatment before 1952.

Angiography↗