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PubMed2006

Collection, validation and generation of bitumen fumes for inhalation studies in rats Part 1: Workplace samples and validation criteria.

OBJECTIVES: Undertaking a chronic inhalation study on bitumen fume presents a challenge in terms of generating large amounts of representative fume. The objective of the study described in this and the following contributions was to collect sufficient fume and develop a laboratory-generated exposure atmosphere that resembles, as closely as possible, personal exposures seen in workers during road paving operations, for use in chronic inhalation toxicity studies in rats. METHODS: To achieve this goal, atmospheric workplace samples were collected at road paving work sites both by Shell Global Solutions, Int. (Shell) and by the 'Berufsgenossenschaftliches Institut für Arbeitssicherheit' (BIA, Germany) and compared with bitumen fume condensate samples collected from the head space of hot bitumen storage tanks. Part 1 describes the collection and analysis of personal and static workplace samples. Different sampling methods were also used to allow a comparison of the standard German sampling method with the most common industry method used. Samples were analyzed by Shell, BIA and by the Fraunhofer Institute of Toxicology and Experimental Medicine (Fh-ITEM, Germany) using different methods. Parameters determined were: total particulate matter (TPM), benzene soluble matter (BSM), semi-volatiles (SV), total organic matter (TOM), boiling point distribution (BPD), polycyclic aromatic hydrocarbons (PAHs) and UV fluorescence (UVF). RESULTS: The BPD of personal and static samples had almost identical start and end points, but static samples show a tendency towards an increase in amounts of higher boiling point compounds. Personal samples generally show higher PAH concentrations than comparable static samples. The results of the analysis of personal workplace samples were used to establish validation/acceptance criteria for the bitumen fume condensate sampled from storage tanks for the inhalation study, which is described in a further publication. CONCLUSIONS: The criteria involve a range of parameters that can be analyzed in both workplace samples and samples of tank fume condensate: BPD, UVF and content of individual PAHs were selected as parameters.

Air Pollutants, Occupational↗
PubMed2006

Collection, validation and generation of bitumen fumes for inhalation studies in rats Part 3: Regeneration of bitumen fumes, inhalation setup, validation.

Undertaking a chronic inhalation study on bitumen fume presents a challenge in terms of generating sufficient amounts of representative fume. The objective of the study described in this and in previous publications was to collect sufficient fume and use this to develop a laboratory-generated exposure atmosphere, for use in chronic inhalation toxicity studies in rats that resembles, as closely as possible, personal exposures seen in workers during road paving operation. To achieve this goal, atmospheric workplace samples were collected at road paving work sites and compared with bitumen fume condensate samples collected from the headspace of hot bitumen storage tanks. In Parts 1 and 2, we described the collection and analysis of workplace samples, the strategy for in-line extraction of a suitable fraction of bitumen fume collected from the headspace of a bitumen storage tank and the comparison of the collected condensate to the workplace samples. This paper (Part 3) describes the regeneration of bitumen fume for inhalation and the exposure setup used for inhalation studies.

Aerosols↗
PubMed1998

Preliminary validation of the MMPI-A for a male delinquent sample: an investigation of clinical correlates and discriminant validity.

Adolescent psychopathology, until recently, has been a largely neglected area of research and poses unique challenges for psychological assessments. In response to the specific need for adolescent-focused measures, the MMPI-A (Butcher et al., 1992) was among several measures to be developed. Although a sizeable literature exists on the original MMPI (Hathaway & McKinley, 1943) and adolescent populations, relatively few empirical studies have been published on the MMPI-A. The primary purpose of this study was the examination of clinical correlates for the MMPI-A for a male delinquent sample. MMPI-A protocols were collected from 99 adolescents at a North Texas juvenile correctional facility, and systematic comparisons were conducted between the Basic Scales and symptoms/diagnoses derived from the Schedule of Affective Disorders and Schizophrenia for School-Age Children (K-SADS-III-R; Ambrosini, Metz, Prabucki, & Lee, 1989). Using only K-SADS-III-R symptoms with high reliabilities (rs > .80), a comprehensive list of correlates was generated for the Clinical, Supplementary, and Content Scales. Additionally, stepwise discriminant functions successfully classified MMPI-A protocols according to K-SADS-III-R diagnoses. As an exploratory analysis, ethnic differences on MMPI-A profiles were also investigated, revealing significant differences among groups.

Adolescent↗