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PubMed1998

Uncoupling cognitive workload and prefrontal cortical physiology: a PET rCBF study.

Working memory is a fundamental cognitive building block involved in the short-term maintenance and transformation of information. In neuropsychological studies, working memory has been shown to be of limited capacity; however, the neurophysiological concomitants of this capacity limitation have not been explored. In this study we used the [15O] water PET rCBF technique and statistical parametric mapping to examine normal subjects while they performed two cognitive tasks, both individually and simultaneously. One task was the Wisconsin Card Sorting Test, a complex reasoning task involving working memory, and the other was a rapidly paced auditory verbal shadowing task. When both tasks were performed simultaneously, there were significant decrements in performance compared with the individual task performance scores, indicating that cognitive workload had been increased. Analysis of the rCBF maps showed that when the two tasks were performed together, in contrast to when they were performed separately, there was less prefrontal activation. These results suggest that increases in cognitive workload do not necessarily recruit and then sustain cortical neurophysiological resources to a maximum, but rather may actually be accompanied by a diminution in cortical activity.

Adult↗
PubMed1993

Temperature regulation in subtropical tree bats.

1. Rate of metabolism and temperature regulation were studied in five species of subtropical tree bats (Lasiurus seminolus, L. borealis, L. intermedius, L. cinereus and Nycticeius humeralis). 2. All species showed two states while resting below thermal neutrality: normothermia and torpor. Below 0-5 degrees C, bats in torpor maintained an intermediate body temperature. 3. Basal rate of metabolism was lower than expected on the basis of body mass (44-78%) and average body temperature in the normothermic state ranged between 32.5 and 35.7 degrees C. 4. Lasiurines have a high thermogenic capacity. 5. The metabolic and thermoregulatory traits studied in tree bats are generally similar to those of non-tropical bats roosting in caves and buildings.

Animals↗
PubMed2006

Biochemical hepatic alterations and body lipid composition in the herbivorous grass carp (Ctenopharyngodon idella) fed high-fat diets.

High-fat diets may have favourable effects on growth of some carnivorous fish because of the protein-sparing effect of lipids, but high-fat diets also exert some negative impacts on flesh quality. The goal of the study was therefore to determine the effects of fat-enriched diets in juvenile grass carp (Ctenopharyngodon idella) as a typical herbivorous fish on growth and possible lipid metabolism alterations. Three isonitrogenous diets containing 2, 6 or 10 % of a mixture of lard, maize oil and fish oil (1:1:1, by weight) were applied to fish for 8 weeks in a recirculation system. Data show that feeding diets with increasing lipid levels resulted in lowered feed intake, decreased growth and feed efficiency, and increased mesenteric fat tissue weight. Concomitantly, alteration of lipoprotein synthesis and greater level of lipid peroxidation were apparent in blood. In liver, muscle and mesenteric fat tissue, the percentages of alpha-linolenic acid and DHA were significantly increased or tended to increase with higher dietary lipid levels. Biochemical activity measurements performed on liver showed that, with the increase in dietary lipid level, there was a decrease in both mitochondrial and peroxisomal fatty acid oxidation capacities, which might contribute, at least in part, to the specific accumulation of alpha-linolenic acid and DHA into cells more active in membrane building. On the whole, grass carp have difficulty in energetically utilising excess dietary fat, especially when enriched in n-3 PUFA that are susceptible to peroxidation.

Animal Nutritional Physiological Phenomena↗
PubMed1997

Perceptions of children and community members concerning the circumstances of orphans in rural Zimbabwe.

Focus group discussions and interviews were held with 40 orphans, 25 caretakers and 33 other community workers from a rural area near Mutare, Zimbabwe. Orphan concerns included feeling different from other children, stress, stigmatization, exploitation, schooling, lack of visits and neglect of support responsibilities by relatives. Many community members, while recognizing their limitations due to poverty, were already actively helping orphans and caretakers. Extended family networks are the primary resource for orphans, though some relatives exploit orphans or fail to fulfil their responsibilities. Interventions are suggested which support community coping mechanisms by strengthening the capacities of families to care for orphans. Outside organizations can develop partnerships with community groups, helping them to respond to the impact of AIDS, by building upon existing concern for orphan families. They can help affected communities to develop orphan support activities which encourage caring responses by community leaders and relatives and which discourage property-grabbing and orphan neglect. Material support channelled through community groups to destitute families at critical times can strengthen family coping mechanisms. Income-generating activities should build upon communities' existing capabilities and benefit the most vulnerable orphan households. Some communities are responding to the AIDS disaster by adaptations to cope with devastating changes taking place in their communities.

Acquired Immunodeficiency Syndrome↗
PubMed1975

Medical school libraries in the United States and Canada built between 1961 and 1971.

Twenty-four medical school libraries in the United States and Canada build between 1961 and 1971 were surveyed by means of questionnaires and visits. Results indicated that half of these libraries will have reached maximum functional capacity approximately six years after they were moved into their new quarters. Space for technical processing is generally much less than is required. Special features and examples of effective planning are described, and problems in arrangement, traffic patterns for people and materials, and the lack of logical expansion space are discussed. Comparisons are made with a similar survey of twenty medical school libraries made in 1961.

Canada↗
PubMed1994

Population change, health planning and human resource development in the health sector.

As a result of the demographic and epidemiological transitions now occurring rapidly in many developed countries, a dramatic shift in the age structures of populations and the burden of disease towards the middle-aged and elderly is expected to take place over the next several decades. In the 1990s, however, there remains great diversity across countries in fertility levels and mortality patterns. The World Bank's 1993 World Development Report assessed the global burden of disease in order to define the minimum packages of public health measures and clinical interventions that would improve health conditions in low-income countries in a cost-effective and affordable way. Strategically implementing these programmes will require that government investments be directed toward a limited number of cost-effective health interventions, delivered equitably to the entire population. At the same time, steps must be taken to improve the efficiency and contain the costs of health care delivery in the public and private sectors. Such a population-based health strategy will require the development of a wide range of scientific, analytical and technical capacities, currently rare in most ministries of health. This will require the involvement of epidemiologists, demographers, sociologists, analysts, operations research specialists and environmental health scientists. Building up these capabilities in health ministries, universities or the private sector will be an essential ingredient of health system reform.

Adolescent↗
PubMedDate not supplied

A trust relationship. A medical advisory board builds physician commitment to a healthcare facility.

Today physicians and hospitals are in competition. To ensure consistent physician input and a forum for two-way communication, St. Edward Mercy Medical Center, Fort Smith, AR, has established a medical staff board. The medical staff board was organized so physicians could formally address managers' concerns without duplicating work done by other medical staff committees (e.g., executive committee, medical staff sections, hospital committees). Membership on the 24-member board was limited to the active staff. A two-year term was established, allowing for two consecutive terms to ensure continuity. The chief of staff and chief executive officer (CEO) are ex-officio members. Some of the issues of interest to physicians include how well informed operating room personnel were on current technology and procedures, how effective the emergency department could be, having been designed almost 20 years ago, and how volume purchasing affects physician familiarity with certain products. St. Edward's medical staff board has the potential to enhance the physician-hospital relationship and to serve as an effective tool in building commitment to the medical center.

Arkansas↗
PubMedDate not supplied

Development of a hospital information system for cytopathology.

The development of a system of ordering cytology tests and reporting cytodiagnoses as part of a hospital information system (HIS) is reported. Cytology tests are ordered by lightpen selections that carry the user along an ordering pathway that includes selection of specimen type, collection procedure information and a patient history matrix. On the patient history matrix the user is asked pertinent questions to which he or she may respond by making appropriate lightpen selections or type-ins. Test results ar communicated to HIS by the cytotechnologist through the accumulation of a series of lightpen selections with some type-in modifiers; this builds into a message containing a complete cytologic diagnosis.

Computers↗
PubMed2006

Neural processing of fearful faces: effects of anxiety are gated by perceptual capacity limitations.

Debate continues as to the automaticity of the amygdala's response to threat. Accounts taking a strong automaticity line suggest that the amygdala's response to threat is both involuntary and independent of attentional resources. Building on these accounts, prominent models have suggested that anxiety modulates the output of an amygdala-based preattentive threat evaluation system. Here, we argue for a modification of these models. Functional magnetic resonance imaging data were collected while volunteers performed a letter search task of high or low perceptual load superimposed on fearful or neutral face distractors. Neither high- nor low-anxious volunteers showed an increased amygdala response to threat distractors under high perceptual load, contrary to a strong automaticity account of amygdala function. Under low perceptual load, elevated state anxiety was associated with a heightened response to threat distractors in the amygdala and superior temporal sulcus, whereas individuals high in trait anxiety showed a reduced prefrontal response to these stimuli, consistent with weakened recruitment of control mechanisms used to prevent the further processing of salient distractors. These findings suggest that anxiety modulates processing subsequent to competition for perceptual processing resources, with state and trait anxiety having distinguishable influences upon the neural mechanisms underlying threat evaluation and "top-down" control.

Adolescent↗
PubMed2004

Strategies for stroke rehabilitation.

Rehabilitation after hemiplegic stroke has typically relied on the training of patients in compensatory strategies. The translation of neuroscientific research into care has led to new approaches and renewed promise for better outcomes. Improved motor control can progress with task-specific training incorporating increased use of proximal and distal movements during intensive practice of real-world activities. Functional gains are incorrectly said to plateau by 3-6 months. Many patients retain latent sensorimotor function that can be realised any time after stroke with a pulse of goal-directed therapy. The amount of practice probably best determines gains for a given level of residual movement ability. Clinicians should encourage patients to build greater strength, speed, endurance, and precision of multijoint movements on tasks that increase independence and enrich daily activity. Imaging tools may help clinicians determine the capacity of residual networks to respond to a therapeutic approach and help establish optimal dose-response curves for training. Promising adjunct approaches include practice with robotic devices or in a virtual environment, electrical stimulation to increase cortical excitability during training, and drugs to optimise molecular mechanisms for learning. Biological strategies for neural repair may augment rehabilitation in the next decade.

Arm↗
PubMed2005

Cultural diversity in the integration of disaster mental health and public health: a case study in response to bioterrorism.

Disaster leads to severe disruptions of the coping capacities of the community. Terrorism, and in particular bioterrorism, has tremendous impact on the community that is affected Cultural groups present unique issues that need to be appreciated for the effective integration of disaster mental health services with public health. The following paper identifies unique issues and challenges of cultural groups in disaster. It highlights issues such as language, cultural interpretation and expression of grief, and help-seeking behavior, as well as inherent cultural resources that can promote resilience. The implications of these cultural issues are illustrated in a potential bioterrorist event, addressing the areas of surge capacity, mass quarantine, and risk communication. Next steps are identified in promoting greater cultural competency in the integration of disaster mental health and public health, thus building greater community resilience.

Bioterrorism↗
PubMed1978

[Connective tissue diseases with cutaneous manifestation (author's transl)].

Connective tissue disorders affecting skin can be inherited or acquired and might result from an alteration of structure, function or metabolism of the constitutive elements of the supporting matrix. Collagen, the protein building the fibrous framework of the dermis, is considered as an example in understanding such a pathology at the molecular level. The molecular structure, the polymerizing capacity and the degradation of this large protein depends upon the activity of several specific post-transcriptional enzymes operating inside or outside of the cells. Pathology is known to be associated with an altered activity of most of these enzymes. Several pathological skin conditions are defined at the level of their molecular defect as in several types of the Ehlers-Danlos syndrome, osteogenesis imperfecta. Menkes' kinky hair disease, epidermolysis bullosa and scurvy. A similar molecular pathogenesis can be logically hypothesized for various other processes involving connective tissue as in scleroderma, pretibial myxoedema, cheloids, Werner syndrome, aging and corticosteroid induced atrophy.

Chemical Phenomena↗