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At least 1,441 records · Page 80Linked to original sources
PubMed1975

[Immunohistological findings in diffuse mesangial sclerosis associated with the nephrotic syndrome of infancy (author's transl)].

A 10-month-old infant developed a steroid resistant nephrotic syndrome. The renal biopsy revealed diffuse mesangial sclerosis of the glomerula. The child died from interstitial pneumonia 3 months after onset of the renal symptoms. Post mortem, the glomerular changes were diffuse but prominent in certain segments of the glomeruli. The immunohistological examination showed granular deposits of IgM and C3 in the mesangium and in the subendothelial region of the basement membrane. These findings are compatible with the hypothesis that diffuseal sclerosis is caused by glomerular deposition of immune complexes.

Autopsy↗
PubMed1999

The pathophysiology and management of renal bone disease in dialysis patients.

As renal function declines, changes in mineral metabolism occur including phosphate retention, calcitriol deficiency, and the development of secondary hyperparathyroidism. Renal bone disease related to disordered mineral metabolism may result in increased patient morbidity and mortality. Uncontrolled parathyroid hormone (PTH) secretion will result in osteitis fibrosa, a high turnover bone disease. The use of calcium and aluminum-based phosphate binders and vitamin D sterols may contribute to the development of low turnover bone diseases such as osteomalacia and aplastic bone disease. Prevention and control of renal bone disease is an important goal for the interdisciplinary health care team. This paper discusses disordered mineral metabolism and its relationship to renal bone disease. Case studies illustrate the development and treatment of renal bone disease related to secondary hyperparathyroidism and aluminum intoxication.

Aged↗
PubMed1975

[The value of roentgen examination in reno-vascular hypertension (author's transl)].

Renal arteriography plays a definitive role in diagnosis and evaluation of renal artery stenosis. Because of its high reliability and low risk, arteriography is more frequently being performed on the basis of clinical indications without reliance on screening tests. Arteriography will indicate the presence of stenosis, its cause, and the presence or absence of hemodynamic significance, and it is useful in evaluating the post-operative patient. Renal vein renin determinations are sometimes needed in evaluating the hemodynamic significance of the lesion. Arteriography may also reveal juxtaglomerular cell tumors, chronic renal inflammatory disease, or other diseases of renal parenchyma which could cause hypertension.

Adolescent↗
PubMedDate not supplied

[Hemolytic anemia caused by graft-versus-host reaction in ABO-nonidentical renal transplants from blood group O donors].

Acute hemolytic anemia is one of the side effects associated with cyclosporin and tacrolimus therapy, and three mechanisms have been described to account for hemolytic anemia in patients receiving these drugs: drug induced hemolysis, autoimmune hemolysis and alloimmune hemolysis resulting from donor lymphocytes derived from the allograft (passenger lymphocyte syndrome). We report four cases of renal transplant recipients who developed alloimmune hemolytic anemia due to minor ABO incompatibility while under treatment with cyclosporin (two) and tacrolimus (two). The anti-erythrocyte antibodies responsible for hemolysis were of the IgG isotype and showed anti-A or anti-B specificity. These findings suggest that the hemolysis could be related to alloantibodies derived from the clonal development of donor B lymphocytes in the recipients (microchimerism). In summary, hemolytic anemia due to ABO-minor incompatibility occurs infrequently after renal transplantation. Risks are higher for patients A, B or AB blood group receiving an O blood group graft under treatment with cyclosporin or tacrolimus. Follow-up of these patients is warranted for the early detection and optimal management may be achieved by reduction of immunosuppression and change to mycophenolate mofetil.

ABO Blood-Group System↗
PubMed2000

[Experimental study on effect of bushen qingli huoxue treatment on glomerular extracellular matrix of remnant kidney in rats].

OBJECTIVE: To study the effect of Bushen Qingli Huoxue (BQH) treatment on glomerular extracellular matrix (ECM) and in retarding glomerular sclerosis in rats and to explore the mechanism and key of regulation. METHODS: Animal model was established by 5/6 nephrectomy and the study was carried out by using immune histochemical and pathological methods. Treatment of BQH started 1 week after operation. RESULTS: After being treated with BQH, the serum creatinine (SCr), blood urea nitrogen (BUN) and urinary protein excretion reduced markedly. Pathological examination showed accumulation of ingredients of glomerular ECM such as type I, IV collagen and laminin decreased significantly, the number of glomerular cells and proliferation cell nuclear antigen positive cells also decreased obviously, and showed that the glomerular sclerosis was retarded. The effect of BQH was similar to that of Enapril, but superior to that of Enapril in reducing BUN and SCr. CONCLUSION: BQH has the effects of reducing ECM accumulation, improving renal function and retarding glomerular sclerosis.

Animals↗
PubMed1975

Characteristics of the tumours of the urinary tract in patients with endemic nephropathy.

The authors have studies in detail the development of tumours in the urinary tract of patients with endemic nephropathy (EN). They have found tumours in about 40% of these patients. They have performed operations for tumours of the urinary tract in 88 patients with EN, with a different localization in the upper part of the urinary tract. In 10% of the cases they have found bilateral tumours. The histological examination has revealed papillary tumours of a malignant character. They have shown specific symptoms of these tumours, not found with other tumours of the urinary tract. The main symptom is renal insufficiency which causes the death of the patients. The evolution of these tumours is comparatively slow and the nature of EN has determined the operative approach of the authors, a radical operation with haemodialysis when indicated. The paper is illustrated with four typical cases.

Acute Kidney Injury↗
PubMed2002

Does magnesium dysbalance participate in the development of insulin resistance in early stages of renal disease?

We investigated the potential role of magnesium (Mg) dysbalance in the pathogenesis of insulin resistance (IR) in patients with mildly-to-moderately decreased renal function (creatinine: 142.8+/-11.0 mmol/l). The data were compared to those of 8 age- and sex-matched healthy controls (CTRL). The standard oral glucose tolerance test (oGTT) was performed in 61 patients. Twenty-two patients were classified as IR according to their values on fasting and after-load immunoreactive insulin concentrations. Serum and total erythrocyte Mg (tErMg) (atomic absorption spectro-photometry) and free erythrocyte Mg (fErMg) concentrations ((31) P NMR spectroscopy) were determined prior to and two hours after the glucose load. Ten out of 39 insulin-sensitive (IS) patients, but only one out of 22 insulin-resistant (IR) patients, had a low basal fErMg concentration (<162.2 micromol/l, chi2, p<0.01). IR patients had higher serum Mg, total erythrocyte Mg and bound erythrocyte Mg (bErMg) concentrations (both before and after glucose load) when compared with the IS group. Both groups responded to the glucose load with a significant decrease in serum Mg concentration (within the normal range), while the IR group also exhibited a decline in tErMg and bErMg. The mean sum of insulin needed to metabolize the same glucose load correlated positively with tErMg (r=0.545, p<0.01) and bErMg (r=0.560, p<0.01) in the IR patients. It is concluded that, at an early stage of renal dysfunction, IR is not associated with the decline in free erythrocyte Mg concentration, but the magnesium handling in red blood cells is altered.

Adult↗