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[Prognosis in the treatment outcome of patients with occlusive atherosclerosis of the arteries of lower extremity arteries by evaluation of lipid metabolism].

The authors discuss the results of correlative analysis of the relative content of the main lipid classes in blood of central and regional venous blood flow with the results of treatment of 75 patients with atherosclerosis obliterans of the lower limb vessels in the stage of collateral circulation decompensation. In patients without anatomo-functional reserves of collateral circulation the amount of phospholipids in the venous blood of the affected limb was found to be significantly lower (by more than 22%) than that in blood collected from the vein in the cubital fossa. This regularity may serve as a criterion for prognosticating the results of treatment of patients in the stage of severe decompensation.

Adult↗

[Trial assessment of pain threshold].

To elucidate the pathological aspects of silent myocardial ischemia, we studied 24 patients with ischemic heart disease who had culprit lesions in the left anterior descending artery (LAD). We determined the presence of myocardial ischemia and measured coronary wedge pressures (CWP; mmHg) and collateral circulation and ST deviation on the ECG (intracoronary ECG: ic-ECG, and surface ECG; mm) after balloon inflation during PTCA intervention. The study subjects included 9 with exertional angina, 10 with post-infarction angina, and 5 with Cohn type II angina. During 78 balloon inflations, the group of ischemic symptoms (Group S) occurred in 40% of all cases, the group without ischemic symptoms (Group A) constituted 45%, and the Cohn type II specific for ischemic symptoms accounted for 15%. The relationship between CWP (X-axis) and ST deviation (Y-axis) of ic-ECG was: Y = -0.46X + 20.19 (r = -0.59; p < 0.01), and the relationship between CWP and ST deviation of the surface ECG was: Y = -0.12X + 6.58 (r = -0.42; p < 0.01). Thus, a negative correlation was confirmed between them. Furthermore, similar results were obtained for Groups S and A. Based on this relationship, the pain threshold was estimated. In Group S, CWP exceeded 34 mmHg, i.e., ischemia was expected to be mild because of good collateral circulation, but an average ST deviation accompanying ischemic symptoms was observed. However, in Group A, CWP was less than 24 mmHg, i.e., ischemia was expected to be severe due to poor collateral circulation, but an average ST deviation lacking ischemic symptoms was observed. Comparison of these results showed that the pain threshold observed from the ST deviation of ic-ECG was 6.0-6.5 mm and that of the surface ECG was 2.6-2.8 mm. From these threshold values, the ST deviations during 12 balloon inflations in the Cohn type II were evaluated. Because 100% of ic-ECG and 75% of surface ECG exhibited values exceeding the threshold values, it was concluded that the cause of the Cohn type II was an increase of the pain threshold. ST deviations of the ic-ECG for Group S and the Cohn type II were 12.0 +/- 6.7 and 9.8 +/- 2.7 mm, respectively, and ST deviations of the surface ECG were 4.7 +/- 2.4 and 3.5 +/- 1.7 mm, respectively. Since there were no significant differences between Group S and the Cohn type II, it was concluded that the ischemic degree of the Cohn type II was approximately the same as that of Group S.

Adult↗

[Collateral blood circulation in the occlusion of femoro-popliteal segment of the lower extremity arteries].

Method of ultrasonic duplex scanning was applied for studying of hemodynamics of lower extremities in the norm and while the femoropopliteal segment occlusion. Three most hemodynamically significant ways of the blood flow collateral compensation in a. femoralis superficialis and a. poplitea occlusion: in upper third of femur--a. femoralis profunda, in canalis adductorius region--a. genus descendens; on the crus--a. suralis. Spectral characteristics of the main and collateral blood flow were studied, the criterions of the lower extremities hemodynamics compensation were established.

Arterial Occlusive Diseases↗

Grading the angiographic extent of collateral filling. Comparison with coronary flow, collateral flow, and regional coronary flow distribution measurements.

Angiography frequently demonstrates a collateral circulation in severe coronary artery disease. An easily applicable method to quantify collateral flow might be a useful adjunct for the assessment of the hemodynamic effects of coronary artery disease. The purpose of this study was to validate a visual scaling of the extent of angiographic collateral filling by comparison with flowmeter- and microsphere-derived measurements of collateral flow. In 12 open-chest dogs, collaterals from the circumflex artery were angiographically visualized (n = 80) by creating acute critical left anterior descending artery occlusion. The extent of collateral filling was graded in four levels from 0 = no visible filling to 3 = complete epicardial filling. Collateral filling correlated with the change in flow of the collateral supplying circumflex artery (delta Q; r = 0.84) which was + 5.3 +/- 4.6% with grade 1, + 9.1 +/- 3.5% with grade 2 and + 14.6 +/- 4.7% with grade 3 (p < 0.01). In parallel, coronary flow reserve decreased from 4.1 +/- 0.8 with grade 0 to 2.9 +/- 0.2 with grade 3 (p < 0.01). Colored microspheres were injected subselectively into the circumflex artery of 9 dogs (45 injections). The ratio of microspheres counted in the collateralized myocardium of the left anterior descending artery to the total number injected increased from 0.6 +/- 0.9% for grade 0 to 17.1 +/- 2.8% with grade 3 (p < 0.01). Absolute collateral flow derived from the microsphere counts averaged 5.5 +/- 0.9 ml/min with grade 3 and closely correlated with collateral filling grade (r = 0.88). Semiquantitative grading of angiographic collateral filling in response to acute coronary occlusion in a canine model correlates with an increase in collateral source artery flow, absolute collateral flow and a decrease in source artery flow reserve. These data suggest that this scale might be a simple but useful adjunct tool to assess the hemodynamic significance of a collateral circulation.

Animals↗

Should the inferior vena cava be reconstructed after resection for malignant tumors?

BACKGROUND: Caval replacement after circumferential resection of the inferior vena cava remains controversial. The aim of the current study is to determine whether or not inferior vena cava replacement should be performed. METHODS: We reviewed 36 cases undergoing resection of the inferior vena cava concomitant with resection of malignant neoplasms. Our criteria for circumferential resection of the inferior vena cava were half or more of the circumference of the vessel wall invaded by tumor, a primary tumor of the caval wall, or massive intraluminal tumor thrombus suspected of adhering to the caval wall. We detailed 10 patients undergoing circumferential resection of the inferior vena cava. RESULTS: Most of patients who did not undergo replacement of the inferior vena cava showed no sign of swelling of the lower limbs, but one showed persistent leg edema with oliguria. This patient had poor development of collateral circulation and mild obstruction of the inferior vena cava before surgery. Two patients who underwent replacement of inferior vena cava had no venous sequelae, although they had poor development of collateral circulation before surgery. CONCLUSION: Caval replacement after circumferential resection of the inferior vena cava may be necessary in patients who have preoperative poor development of collateral circulation or who have oliguria or unstable hemodynamics intraoperatively.

Adult↗

Significance of pre-infarction angina for occurrence of post-infarction angina.

We evaluated the factors determining the occurrence of post-infarction angina in 41 patients who had intra-coronary thrombolysis within 6 h of the onset of acute myocardial infarction. Pre-infarction angina was considered to be present if it occurred more than one week before acute myocardial infarction. Post-infarction angina was defined as typical chest pain occurring within 10 days following the infarction. Collateral flow to the infarct zone was determined to be present if any portion of the infarct-related epicardial artery or side branches was visualized. In cases of successful thrombolysis, the prevalence of post-infarction angina was not significantly influenced by pre-infarction angina and the extent of collateral circulation. However, in patients without recanalization, pre-infarction angina and collateral blood flow supply to the area at risk caused a high prevalence of angina after infarction. It is concluded that pre-infarction angina indicative of myocardial ischemia is associated with post-infarction angina especially in patients with conventional therapy, because the jeopardized myocardium is salvaged substantially by collateral circulation with a limited flow reserve.

Adult↗

[Usefulness of carotid artery compression test in the diagnosis of cerebral circulation disorders in patients with cerebral aneurysm. Evaluation by the rheoencephalographic method].

Rheoencephalographic investigations (REG) was carried out in patients with intracranial aneurysms and in healthy subjects. The purpose of the study was to obtain approximate data on the efficiency of collateral circulation of the brain before ligation of the internal carotid artery. For this purpose REG was associated with common artery compression test. It was found that this combined examination gives good prediction of the efficiency of collateral circulation after ligation of one carotid artery. This method is more sensitive than the Matas test combined with EEG used previously.

Adult↗

Coronary bypass revascularization with radial artery and internal mammary artery grafts.

OBJECTIVE: To evaluate radial artery (RA) and internal mammary artery (IMA) grafts in coronary artery bypass and the use of color Doppler ultrasound in the peri-operative evaluation of IMA and radial-ulnar collateral circulation. METHODS: From June 1998 to June 2000, sixty cases of coronary bypass revascularization with RA and IMA were performed. Preoperatively, the radial-ulnar collateral circulation was evaluated with the modified Allen's test, color Doppler ultrasound and noninvasive oxygen saturation measurement. The IMA lumen and blood flow were measured at the first intercostal space with color Doppler ultrasound preoperatively and postoperatively. RESULTS: One patient (1.7%) died of serious cardiac arrhythmia on the fourth postoperative day. There were no arterial graft harvest related complications. Before harvesting, the ulnar artery blood flow was 30.78 +/- 9.71 ml/min, and it increased to 43.36 +/- 13.98 ml/min (40.87% increase, P < 0.01) after the operation. Compared with the baseline, there was no obvious change of IMA blood flow postoperatively (P > 0.05), but the systolic/diastolic flow ratio markedly decreased from 8.57 +/- 3.98 ml/min to 3.41 +/- 4.87 ml/min (P < 0.01). CONCLUSIONS: Arterial grafts can be safely used for coronary bypass revascularization with good results. The ulnar artery blood flow can increase compensatively after RA harvesting. The diastolic blood flow of grafted IMA markedly increased postoperatively. Color Doppler ultrasound was very helpful both in evaluating the radial-ulnar collateral circulation before RA harvesting and in assessing the patency of the grafted IMA after coronary artery bypass grafting (CABG).

Adult↗

[Role of the collateral coronary circulation in the mechanism of action of verapamil and diltiazem on the ischemic myocardium].

In experiments on anesthetized cats and dogs it was shown that the anti-ischemic action of verapamil and diltiazem injected intravenously in acute permanent occlusion of the coronary artery is not related to their effect on the collateral blood supply to the myocardial ischemic focus. The protective effect of the drugs in this case is due to other mechanisms one of which is a decrease of oxygen consumption by the heart.

Animals↗

Effects of exercise on collateral development in myocardial ischemia in pigs.

To study the effects of exercise on collateral development in myocardial ischemia, we induced coronary arterial stenosis of the left circumflex coronary artery (LCCA) in 18 of 30 pigs. During that surgery, we identified the coronary bed at risk. Nine of these pigs were then subjected to 5 mo of exercise training on a treadmill. After exercise training, we determined regional collateral and myocardial blood flow using radiolabeled microspheres. At autopsy, all animals had complete occlusion of the LCCA. Infarct size in the exercise-trained pigs was significantly less than in the sedentary pigs (5.9 +/- 1.0 vs. 11.7 +/- 1.0% of the left ventricle). The exercise-trained animals had a greater increase in collateral flow, 35.1 +/- 3.0 vs. 28.7 +/- 4.1 ml X min-1 X 100 g-1, in the noninfarcted jeopardized zone of the LCCA bed. The major findings of the study were the following: 1) chronic coronary artery stenosis progressing to occlusion stimulated development of the collateral circulation and salvaged tissue in the jeopardized myocardium of an animal model with sparse collaterals; 2) development of the collateral circulation and tissue salvage is increased by exercise training; 3) collaterals develop primarily in or near the ischemic zone; and 4) all collateral beds develop a circumferential flow gradient following occlusion.

Animals↗

[Nontraumatic acute subdural hematoma caused by the rupture of transdural anastomotic vessels in moyamoya disease].

A case of nontraumatic acute subdural hematoma caused by the rupture of transdural anastomotic vessels in a patient with Moyamoya disease is reported. The patient was a 55-year-old woman who was admitted to our hospital in a comatose state. A diagnosis of acute subdural hematoma associated with Moyamoya disease was made on the basis of CT and angiographic findings. No lesions suggestive of trauma, such as cerebral contusion, could be detected during surgery. Although total evacuation of the hematoma was performed, she developed the apallic syndrome and did not recover consciousness. Judging from the angiographic and operative findings, it appears that subarachnoid hemorrhage occurred first and stretched the transdural anastomotic vessels which supplied the collateral circulation. This led to tearing of some of the vessels, and their proximal ends were consequently exposed in the subdural space. The surgical treatment of acute subdural hematoma associated with Moyamoya disease requires the closest attention to avoid damage to the collateral circulation. Although we carefully arrested the bleeding without using a coagulator in order to spare the collateral vessels, the transdural anastomosis was no longer visible on postoperative angiograms. Our experience suggests that hematoma irrigation with trephination therapy, which may minimize the damage to the collateral circulation, may be the most appropriate treatment for acute subdural hematoma associated with Moyamoya disease. Furthermore, cerebral revascularization should be performed for the treatment of the circulatory disturbance intercepted by the hematoma itself or by operative manipulation.

Acute Disease↗