Quantitative data on skin pigmentation in South African races.
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The wide angle fundus camera Clinitex CA-2 was tried out on patients and normal volunteers on evaluating the numerous photographs we found the three optic heads to deliver good results. The quality of the 60 degrees- and 100 degrees-pictures improved with the increasing dilatation of the pupil. Even retinal detachments and other changes with a different level were recoreded very well. In black-and-white- photography, uneven illumination of the fundus was successfully compensated by using a two-step developer with increased utilization of film speed. This procedure allowed good wide angle documentation of the fundus at comparatively low costs.
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The clinical features of Fuchs' heterochromic cyclitis (F.H.C.) were described thoroughly by him in 1906. Supplementary data was then supplied by Amsler and Verrey with respect to the vascular characteristics of this disease. Fuchs' disease is not a frequent affection and accounts for no more than 1-2% of the total cases of uveitis. The diagnosis is very difficult to establish at an early stage of the disease. Incomplete or atypical forms are frequent and differential diagnosis is difficult from other cases of cyclitis and/or intermediate uveitis. Furthermore, heterochromia is recognized with difficulty in brown-eyed people. The time of onset of the 3 main symptoms (cataract, heterochromia and cyclitis) varies considerably and the possibility that each of the symptoms follows an individual course at least for a certain period, cannot be excluded. Paraclinical and biological methods for investigating the disease are still limited. However immunological techniques have established the frequent incidence of immune complexes in the aqueous, while some anomalies in the vascular system have been detected on fluoroangiography of the iris. A congenital predisposition to this disease may explain the fact that F.H.C. is generally unilateral. Additionally it might explain Amsler's findings. The way to establish a link both in time and space between all these findings (so as to build up a unique theory which could explain different symptoms) is still unknown, but the so-called sympathetic theory and its theoretical consequences could be rejected permanently in the future.
Yellow intraocular filters are common among the teleosts, especially highly diurnal species. This yellow pigmentation may be uniform, more dense dorsally, or localized to a narrow dorsal ring near the limbus. Certain species possess occlusable yellow corneas and can vary the corneal colour in response to the level of illumination. Yellow lenses and corneas function as hi-pass filters, with the cutoff points varying depending on species. Thus, the amount of short-wavelength light reaching the retina can be regulated. Three distinct yellow pigments may be present in each of the lens, cornea and the retina of certain South American cichlids. The spectral absorbance of the yellow corneal pigment bears a close resemblance to that of beta-carotene. Possible functions of these yellow filters are: a reduction in chromatic aberration, the reduction of glare and dazzle, the improvement of detail by the absorption of "blue haze", the improvement of contrast vision, and the rendering of bioluminescence more conspicuous. Yellow intraocular filters may result in a loss of scotopic sensitivity due to absorption of short wavelengths. Various adaptations in diurnal teleosts to avoid the loss of sensitivity resulting from a yellow filter are presented. Normally, bottom-dwelling fishes lack yellow filters. These filters cause the effective absorbance maximum of scotopic visual pigments to be shifted to longer wavelengths. No correlation has been found between the presence of such filters and the water colour, diet or spectral absorbance of the visual pigment. A possible explanation for the lack of correlation with visual pigments is discussed. Investigation of cone spectral sensitivities may possibly reveal such a correlation.
A two-step technique for laser iridectomy in light blue irises is described, which simplifies penetration of these irises and allows success rates approaching 100%. Step one utilizes a high energy, long duration, predominantly thermal laser burn that destroys overlying iris stroma. In step two, the laser energy is reduced and exposure time is shortened to facilitate removal of remaining pigment epithelium.
4 cases of Waardenburg's syndrome in an Iranian family are presented and discussed. The patients, a 34-year-old father with his 6-month-old and 3-year-old sons and 2-year-old daughter, show symptoms of this syndrome in varying degrees of expression except for deafness.
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An allophenic mouse and three allophenic embryos were obtained by aggregating 8-cell-embryos of Miwh/Miwh and +/+ genotypes. The coat colour and pigment epithelium of the eyes indicated chimerism. Melanoblasts of genotype Miwh/Miwh were lost during the embryonic development. Variations of coat colour in a chimeric mouse were due to the interaction of normal melanocytes with the surrounding dermal cells which consisted of clones of Miwh/Miwh or +/+ genotypes and a mixture of both. Certain differences between the right (chimeric) and left (normal) eye development and a greater rate of normal clones growth were observed in the allophenic mouse. Pigmentation of the eyes of two allophenic embryos was less than normal. This indicated the autonomy of gene white action in mice.
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