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PubMedDate not supplied

p53 overexpression and K-ras codon 12 mutations in submucosal invasive depressed-type colorectal cancer.

We examined histological findings, p53 overexpressions and K-ras codon 12 mutations and the histology of submucosal invasive (sm) colorectal cancers. Sixty specimens of sporadic sm cancer were obtained by surgical resection or endoscopic polypectomy. p53 expression was examined by immunohistochemical staining using the streptavidin-biotin method. K-ras codon 12 mutations were detected by polymerase chain reaction (PCR) and dot blot hybridization. These tumors were classified as depressed-type or polypoid-type sm cancers. Among 60 sm cancer samples, depressed-type sm cancers were found in 9 (15%) and polypoid-type sm cancers were found in 51 (85%). The frequency of p53 expression was significantly higher in depressed-type [7/9 (78%)] as compared to polypoid-type [18/51 (35%)] sm cancers (p<0.05). The frequency of K-ras codon 12 point mutations was significantly lower in depressed-type [0/9 (0%)] as compared to polypoid-type [23/51 (45%)] sm cancers (p<0.05). We conclude that the development of depressed-type cancers may involve a distinct genetic pathway.

Adult↗
PubMed1999

Colorectal polyps.

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Adenomatous Polyposis Coli↗
PubMedDate not supplied

[The usefulness of endoscopic polypectomy of rectosigmoid and colon in childhood].

Rectal polyps are relatively frequent in infancy and constitute one of the main causes of hematoquezia during this time of life. They are usually treated with multiple drugs before the correct diagnosis is made. We report our experiences with the use of rectoscopy and colonoscopy for the diagnosis and treatment of 214 patients with rectosigmoid polyps, including other sites in the colon, studied between 1982-1988. The highest incidence was between 3 and 6 years of age (63.8%), and the most frequent location in 253 rectosigmoid polyps (91%) and histologically (99.7%) were juvenile polyps. Endoscopic polypectomy proved to be a valuable method, easy to perform and with few complications to treat colon polyps, thus eliminating the surgical interventions.

Child↗
PubMed1987

Genodermatoses with malignant potential.

Cowden's disease, which is characterized by multiple facial papules, gingival papillomas, acral papules, and other hamartomatous lesions, represents a genodermatosis with a high incidence of breast and thyroid carcinoma.

Adult↗