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Is laparoscopic radical nephrectomy with specimen morcellation acceptable cancer surgery?

Laparoscopic radical nephrectomy (LRN) for renal-cell carcinoma (RCF) with removal of the specimen by morcellation and suction remains controversial because precise pathologic tumor staging is lost, and there is a risk of tumor seeding. We assessed the theoretical impact of surrendering precise pathologic staging on the management of patients with low-stage RCC (T3a or less). In 22 patients who underwent open radical nephrectomy for RCC, the preoperative CT-based clinical stage was correlated with pathologic tumor staging. Possible clinical inclusion criteria for LRN were then correlated with pathologic tumor staging. When comparing clinical and pathologic staging, one patient was understaged and seven were overstaged by preoperative CT. However, if clinical stage T3a or lower was used as the inclusion criterion for LRN, 19 patients (86%) would have been so treated, none would have been underassigned, and future management would not have been compromised according to pathologic staging. Management of patients with low-stage RCC relying on clinical staging only is oncologically adequate. This would make LRN an acceptable option for this subset of patients.

Carcinoma, Renal Cell↗

Utility of the harmonic scalpel for laparoscopic partial nephrectomy.

Laparoscopic partial nephrectomy (LPN) remains a technically challenging procedure largely because of the lack of methods for obtaining consistent parenchymal hemostasis. The objective of this study was to determine if the extent of resection influences the ability of the harmonic scalpel to achieve hemostasis and to define the cases in which the harmonic scalpel is appropriate for LPN. Thirty LPNs were performed in a 25-kg domestic pig model. The blunt blade of the laparoscopic harmonic scalpel (LaparoSonic Coagulating Shears; Ethicon Endo-Surgery, Cincinnati, OH) at power level 5 was used to divide the parenchyma. Control of the renal hilar vessels was not obtained. Three standardized types of resections were performed: I = peripheral wedge biopsy; II = upper- or lower-pole nephrectomy; and III = heminephrectomy. Bleeding was graded on a scale from 0 to 4: 0 = no hemostasis; 1 = steady bleeding; 2 = moderate bleeding; 3 = parenchymal oozing; and 4 = dry. Hemostasis grades of 2 or less were clinically significant bleeding necessitating supplemental coagulation. The mean hemostasis scores showed a significant (P < 0.02) trend toward inadequate hemostasis with increasing extent of resection: 3.3 for Type I, 3.0 for Type II, and 2.4 for Type III. The percent of kidneys with grade 2 bleeding or worse was 9% for Type I surgery, 25% for Type II, and 57% for Type III. Successful hemostasis with the harmonic scalpel correlates with the extent of parenchymal resection in the porcine model. Most wedge excisions can be done with the harmonic scalpel alone, whereas larger resections necessitate supplemental coagulation. On the basis of this study, heminephrectomies with the harmonic scalpel are not recommended because of the high incidence of significant hemorrhage.

Animals↗

Simple nephrectomy: transperitoneal approach.

Transperitoneal laparoscopic nephrectomy is performed much as originally described by Clayman and associates, although preoperative embolization of the kidney is no longer routine. Some surgeons use a hand-assisted technique, especially in difficult cases or when the organ is being removed intact, as in live-donor nephrectomy.

Adult↗

Simultaneous bilateral simple nephrectomy.

Bilateral simultaneous nephrectomy is a rare procedure usually performed for end-stage renal disease, most often because of persistent hypertension after renal transplantation. Four trocars generally are inserted, with a lower abdominal and a subcostal port being used by the surgeon. An intra-abdominal pressure of 8 to 10 mm Hg is used during the procedure. The first kidney is left in situ while the other one is being dissected. Unless there is infection or malignancy, a retrieval sac is not used. In our series of 13 cases, the operating times ranged from 240 to 390 minutes (mean 320 minutes), and the mean 125 mL. Surgical discharges criteria usually were met on postoperative day 1 or 2. Laparoscopic bilateral nephrectomy in a single session is feasible in nearly all properly selected cases, even in patients with previous abdominal surgery or peritoneal dialysis. The operation takes longer than open surgery and may have a higher complication rate, but recovery is faster.

Adult↗

Hand-assisted laparoscopic nephrectomy: the transfer of experience to a new academic center.

BACKGROUND AND PURPOSE: Hand-assisted laparoscopic nephrectomy (HALN) has become widely used for the management of localized renal masses and for simple nephrectomy [corrected] Centers of excellence have slowly disseminated this surgical approach throughout academic institutions and private practices. The transfer of this technique to inexperienced surgeons and centers has not been well studied. We examined our outcomes for HALN with an experienced surgeon (DMA) [corrected] at a new academic center. We also examined the effectiveness of the transfer of these techniques as trainees go out into practice [corrected] PATIENTS AND METHODS: A total of 85 hand-assisted laparoscopy procedures were performed between September 2001 and August 2003 of which 61 were HALN. Four fellows and eight chief residents, under the guidance of one attending surgeon (DMA), performed all HALN procedures. Parameters measured included patient age, ASA score, body mass index, operative time, estimated blood loss, number of trocars used, time to oral intake, analgesics required, length of stay, complications, and tumor size. The average patient age was 57.4 years (range 26-87 years) and the mean ASA score 2.5 (1-4). The mean BMI was 28.3 (range 20-46) [corrected] There was a slight predominance of right-sided lesions. In addition to evaluating our early results with HALN, a questionnaire was sent to all graduates of our program starting 2 years prior to the arrival of DMA to assess the application of laparoscopy to their practices [corrected] RESULTS: All cases were completed without open conversion. The total operative time averaged 184 [corrected] minutes (range 67-257 [corrected] minutes), with 80% of patients requiring two trocars. The average blood loss was 136 [corrected] ml (range 25-700 mL), but only one patient required transfusion postoperatively [corrected] The mean time to oral intake was 17.1 hours (range 1.5-240 hours), the average length of stay was 4.3 days (range 1-28 days), and total narcotic requirements averaged 111 mg of morphine sulfate equivalents (range 6.7-519 mg). Sixty-six percent of the procedures were performed for malignancy. The average tumor size in these cases was 3.9 cm (range 1-12 cm). There was one death, in an 80-year-old patient who had a bowel injury necessitating re-exploration and bowel resection. This patient had a postoperative myocardial infarction and died. Two patients developed postoperative hernias at their hand-port site. Other significant [corrected] complications included diaphragmatic [corrected] injury (repaired laparoscopically), one [corrected] pulmonary embolus, two cases of pancreatitis, and one case of pneumonia. Three patients experienced postoperative ileus. Of the 20 graduates of this program since 2000, 4 were laparoscopic/endourology fellows, and 2 of the residents pursued fellowship training after graduating. Graduates of the year 2000 and 2001 represent surgeons who graduated prior to the arrival of DMA. Of those resident graduates who did not pursue fellowship, two of the seven surgeons who graduated prior to the arrival of DMA are performing laparoscopy. Both of these surgeons pursued formal postgraduate laparoscopic training. Six of the seven non-fellowship-trained residents who graduated since DMA's arrival are performing laparoscopy; the other is early in practice and intends to do so. None of these surgeons has pursued postgraduate training prior to performing laparoscopy in their practices [corrected] CONCLUSIONS: The HALN techniques can be transferred quickly and efficiently between [corrected]one center and [corrected] another under the guidance of an experienced surgeon. Operative times are acceptable, with complication rates comparable to [corrected] previously reported series. Our data show that exposure during residency markedly increases the likelihood that surgeons will carry the techniques into their practices [corrected]

Adult↗

Laparoscopic nephrectomy for renal-cell carcinoma during pregnancy.

Renal-cell carcinoma (RCC) during pregnancy is rare. Laparoscopic nephrectomy has been used effectively and safely in nonpregnant patients with RCC. We report a case of a 34-year-old pregnant woman with RCC, which we believe to be the first such case to be managed by laparoscopic nephrectomy.

Adult↗

Looped silk tie: surgical technique for management of the renal vein during laparoscopic live-donor nephrectomy.

Laparoscopic live-donor nephrectomy has revolutionized the field of kidney transplantation and has been adopted in many tertiary centers as the method of choice in procuring kidneys. While standard techniques for laparoscopic live-donor nephrectomy have been well described in the literature, there continues to be ample discussion about renal-vein ligation. Endo-GIA and other commonly used vascular stapling devices can be costly and prone to mechanical failures and may not be applicable in certain anatomic situations. Vascular clips, although simple to use for arteries, are difficult to apply to large renal veins. To address these issues, we describe a simple, cost-effective method of control that can be used for both right and left renal veins, using a loop constructed from a 0 silk tie.

Adult↗

Robot-assisted laparoscopic partial nephrectomy: the NYU technique.

The introduction of the daVinci surgical system has changed the way both surgeon and patient view radical prostatectomy. We hypothesized that the same theoretical and tangible benefits may be realized when employing the system for partial nephrectomy. This paper reviews our technique of robot-assisted laparoscopic partial nephrectomy (RALPN) utilizing the daVinci surgical system. Intraoperative hilar clamping is utilized in all cases. With the daVinci system, the tumor is excised with cold scissors, biopsies are taken from the base for frozen-section study, sutures are placed at the base, Gelfoam/fibrin glue is activated in the defect, a Surgicel bolster is laid in the defect, and mattress sutures are placed prior to releasing the clamp. After performing 12 RALPNs, it appears this technique is safe, feasible, and reproducible both for small exophytic masses and for deeper lesions involving the collecting system. A RALPN requires two surgeons, both well versed in laparoscopic and robotic techniques.

Biopsy↗

Comparison of hand-assisted laparoscopic and open donor nephrectomy: a single-center experience from South Korea.

PURPOSE: We report our experience with hand-assisted laparoscopic donor nephrectomy (HALDN) and compare to our results with conventional open donor nephrectomy (ODN). PATIENTS AND METHODS: From February 2000 to January 2003, 100 patients (M:F 54:46) underwent HALDN at the Kangnam St. Mary's hospital. These patients were divided into early (1st 50 cases) and late (2nd 50 cases) groups. These cohorts were compared with 40 patients (M:F 26:14) who underwent ODN via a flank incision from January 1999 to January 2003 at the same institution. Patient data were obtained from medical record review and personal and telephone interviews. RESULTS: The HALDN was completed successfully in 99 donors. The mean operative times (minutes) were 225 (140-425), 178 (135-250), and 188 (140-260) in the early HALDN, late HALDN, and ODN groups, respectively (P<0.05). The mean warm ischemia times (seconds) of the ODN (135+/-52.4) and late HALDN (150+/-76.7) groups were shorter than that of the early HALDN group (207+/-88.5) (P<0.05). On average, a regular diet was resumed after 2.1, 1.89, and 2.05 days, respectively. (P<0.05), and patients were discharged home 4.12, 4.04, and 6.8 days (P<0.05) after surgery in the early HALDN, late HALDN, and ODN groups. Analgesic use was significantly reduced in the HALDN group in comparison with ODN (P<0.05). Complications consisted of two cases of chyloperitoneum and one case each of open conversion, transfusion, prolonged ileus, liver enzyme elevation, and recipient ureteral necrosis in the early HALDN group; one case of subcutaneous emphysema in the late HALDN group; and one case each of transfusion and liver enzyme elevation in the ODN group. The mean donor (1 and 30 days) and recipient (6 months) serum creatinine concentrations did not differ among the groups (P>0.05). CONCLUSIONS: The HALDN appears to be a safe, technically feasible, and effective alternative to conventional ODN. The procedure may offer several advantages over conventional ODN in terms of less postoperative pain, shorter convalescence, and minimal cosmetic disfigurement. The recipient graft function is similar to that after ODN.

Adult↗

Case report: retroperitoneoscopic tumor nephrectomy during pregnancy.

When considering laparoscopic tumor nephrectomy during pregnancy, questions will arise about the consequences of the increased abdominal pressure (IAP) for uterine-placental perfusion and the impact of carbondioxide insufflation on the fetus. These considerations should be weighed against the advantages for the mother, in term of shorter convalescence and decreased wound problems. This situation presents the urologists with a dilemma. At 16 weeks of gestation, a 30-year-old woman underwent a retroperitoneoscopic tumor nephrectomy. This case report and the following discussion highlight the key issues involved in laparoscopic surgery during pregnancy. In theory, laparoscopy in pregnancy carries some specific hazards, which may influence fetal outcome. First, the elevation of IAP may lead to alterations in placental perfusion, and second, CO2 insufflation may disturb the acid-base balance. However, in a study covering more than 2 million pregnancies, no difference was found in fetal mortality or malformations after laparoscopic surgery for non-obstetric reasons compared with open surgery. Animal experiments have demonstrated an IAP of 15 mm Hg or less to cause almost no reduction in the uterine-placental blood flow. According to our limited experience and with the support of the literature, pneumo(retro)peritoneum during pregnancy seems to be safe.

Adult↗

Intraoperative conversion of laparoscopic partial nephrectomy.

PURPOSE: To assess the incidence of conversion from laparoscopic partial nephrectomy (LPN) to open surgery or laparoscopic radical nephrectomy (LRN) when liberal selection criteria are utilized. PATIENTS AND METHODS: A retrospective review of medical records was done for all patients scheduled for LPN at our institution from January 2000 through March 2004. The preoperative risk factors, intraoperative course, and pathologic outcomes of patients who were converted to LRN were compared with those of the cohort of patients who underwent LPN as originally scheduled. RESULTS: Among the 257 operations that started as LPN, 35 (13.6%) were converted to LRN and 4 (1.6%) to open surgery. Age, tumor size, operating time, and hypertension were significantly higher in patients requiring conversion in than those who underwent completed LPN. Patients over the age of 70 had a 3.8-fold higher risk of requiring conversion, and, independent of age, patients with tumor>4.0 cm had a 4-fold increase in the likelihood of conversion to LRN. CONCLUSION: Of the preoperatively determined factors compared across the cohort of patients who underwent LPN and the cohort of patients converted to LRN, only tumor size and patient age were predictive of an increased risk of conversion. Other variables, including sex, side of affected kidney, clinical stage, ASA score, comorbidity with hypertension or diabetes mellitus, and surgeon were not significant in predicting conversion.

Adult↗

Case report: laparoscopic partial nephrectomy for isolated renal hydatid disease.

A 73-year-old male patient with an isolated calcified hydatid cyst in the lower pole of the right kidney presented with a history of weight loss and cloudy, foul-smelling urine. Laparoscopic partial nephrectomy was performed, at which the cyst was removed en bloc. Six months postoperatively, a CT scan revealed no recurrence of hydatidosis. To our knowledge, this is the first report of laparoscopic partial nephrectomy for the treatment of isolated renal echinococcosis.

Aged↗

Delayed presentation of urinoma after radiofrequency ablation-assisted laparoscopic partial nephrectomy.

PURPOSE: To examine the outcomes and complications of thermal ablation-assisted laparoscopic partial nephrectomy (LPN). PATIENTS AND METHODS: Radiofrequency ablation (RFA)-assisted laparoscopic partial nephrectomy was employed in 16 consecutive renal masses with a mean size of 3.0 cm over 12 months. The indications were primarily adjacent bowel, hilar location, or both. After RFA, the renal mass was laparoscopically excised and examined pathologically. RESULTS: The mean operative treatment time was 99 minutes. The estimated blood loss was 121 mL, and no patient required a blood transfusion. Urinoma was diagnosed in three patients at an average of 13 days postoperatively and resolved with conservative management or ureteral stent placement. CONCLUSIONS: Radiofrequency ablation-assisted LPN provides effective hemostasis and, in the short term, cancer control. In this setting, urinoma presents as ipsilateral flank pain 1 to 2 weeks after surgery. The proposed mechanism for the delayed presentation is thermal injury to the collecting system, although an unrecognized direct collecting-system injury is possible. Conservative management, ureteral stent placement, or both led to resolution of all of the urinomas.

Adult↗

Case report: bilateral hand-assisted laparoscopic nephrectomy in a patient with polycystic horseshoe kidney.

PURPOSE: To report the use of the hand-assisted laparoscopic (HAL) technique for removal of a horseshoe kidney in a patient with autosomal dominant polycystic kidney disease (ADPKD). CASE REPORT: Hospital and outpatient records were reviewed for a 65-year-old man with end-stage renal disease secondary to ADPKD who underwent HAL bilateral nephrectomy of his horseshoe kidney in preparation for kidney transplantation. The surgical method is described. It was completed successfully with an operative time of 280 minutes and an estimated blood loss of 350 mL. CONCLUSION: Bilateral HAL nephrectomy can be considered as an option for surgical removal of very large polycystic horseshoe kidneys.

Aged↗

Conventional and hand-assisted laparoscopic radical nephrectomy: Comparative analysis of 271 cases.

PURPOSE: To compare the outcomes of patients undergoing conventional laparoscopic radical nephrectomy (CLRN) and hand-assisted laparoscopic radical nephrectomy (HALRN) at our institution. PATIENTS AND METHODS: We prospectively and retrospectively reviewed the files of consecutive patients who underwent HALRN (N = 158 patients) from April 2001 to May 2005 and CLRN (N = 113) from August 2002 to May 2005 for clinical stage T(1-3)N(0-1)M(0-1) renal-cell carcinoma. Clinical and perioperative variables of the two groups were compared. Patients were well matched with regard to baseline parameters except that patients undergoing CLRN were 8 years older (P < 0.001) and had higher American Society of Anesthesiologists scores (P = 0.001). RESULTS: Significantly different outcomes were faster operative time (P < 0.001), greater use of narcotic analgesia (P < 0.001), and longer hospitalization (P < 0.001) with HALRN. For the other variables analyzed, including blood loss, incision size, and complication rates, the two approaches were not significantly different. CONCLUSIONS: Within the limitations of a retrospective study, HALRN was a faster operation than CLRN but was associated with greater use of narcotic analgesia and longer hospitalization. Overall, the similarities between these two approaches outnumber the differences, some of which may be explained by surgeon-specific practices. Both modalities offer patients excellent immediate cancer control while minimizing perioperative morbidity.

Adult↗

Tubercular pyelonephritic nonfunctioning kidney--another relative contraindication for laparoscopic nephrectomy: a case report.

We present a case of tubercular pyelonephritic nonfunctioning kidney in which laparoscopic nephrectomy was attempted. The kidney was very difficult to mobilize due to dense perinephric adhesions and subsequently the procedure was converted to an open nephrectomy. Tubercular pyelonephritic kidney is a relative contraindication to laparoscopic approach as its dissection is difficult and fraught with potential complications such as leakage of caseous material into the peritoneal cavity and systemic dissemination of the disease.

Adult↗

Single-session laparoscopic radical and contralateral partial nephrectomy.

Renal tumor is likely to become one of the most important indications for laparoscopic surgery. We present an old woman, who underwent single-session laparoscopic nephrectomy and contralateral partial nephrectomy due to bilateral kidney tumor. The advantages of simultaneous bilateral intervention are reduced psychological stress, single anaesthesia, less medication, less blood loss, shorter hospital stay and convalescence, and considerable cost-effectiveness.

Aged↗