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[Ecology of indigenious arbovirus in Alsace. Tick Central European Encephalitis. I.--Complex Ixodes ricinus--bank voles. II.--Study of bank voles population immunity. III.--Virologic results in bank voles population (author's transl)].

I.--After showing that bank voles are parasited only by Ixodes ricinus larvae, the authors attempt to found different factors (demographic, biometric, and sexual) who favor individual parasitism. The authors conclude to absent of anti tick immunity for this rodent specie. II.--The search for anti-central european encephalitis antibodies (I.H.A.) are shown that 2 p. cent animals were immuns. Yearly and monthly chronologies of antibodies apparition are shown, factors favoring the growth of specific Central european encephalitis antibodies are discussed. III.--The Central european encephalitis tick viral infection of bank vole is studied according to the number of viral strains isolated from different viscera. The monthly chronology of this infection is shown.

Animals↗

The effect of steroids on the circulating lymphocyte population. I. Changes in the thoracic duct lymphocyte population of the rat after neonatal thymectomy and prednisolone treatment.

The influence of prednisolone on the thoracic duct cells of rats was measured by the cell count in lymph at different times after a single injection and correlated with lymphocytolysis in lymphoid tissues. In both control and neonatally thymectomized animals there was a marked fall in the cell count and flow at 3 hours and the percentage reduction was greater in thymectomized animals. Restitution was rapid in both groups and pretreatment levels were regained in 17 hours. The blood mononuclear cells followed the same pattern. In animals with an intact thymus adrenalectomy causes a significant increase in thoracic duct cell counts but in neonatally thymectomized animals thoracic duct lymph is unchanged after adrenalectomy. It can be concluded that in the rat lymphocyte level in the circulating pool is thymus dependent but restoration of the circulating cell count after steroid induced involution is independent of intact thymic function. Our data support the hypothesis of lymphocyte trapping and redistribution as a major mechanism after a single cortisone dose.

Adrenalectomy↗

The effect of steroids on the circulating lymphocyte population. II. Studies of the thoracic duct lymphocyte population of the guinea pig after neonatal thymectomy and prednisolone treatment.

The effect of corticosteroids on the lymphatic tissue and circulating lymphocyte pool in the guinea pig has been studied. No signs of increased lymphocytolysis was seen and only after 1--2 weeks treatment with a long acting corticosteroid was the thymic cortex reduced and thymic weight decreased. Three hours after injecting a short acting steroid a 30--40 per cent reduction in the thoracic duct cell count was seen in both control and thymectomized animals. Restitution to pretreatment cell level was completed in 17 hours. Mononuclear cells in the blood were markedly depressed up to 40 hours. The changes in the circulating lymphocyte pool in the resistant guinea pig seem to be in principle the same as in the sensitive rat but less pronounced. It can be concluded that the lymphocyte level in the circulating pool is thymus dependent but restoration of the cell count after steroid treatment is independent of intact thymic function. This data supports the hypothesis of lymphocyte trapping and redistribution after a single steroid treatment.

Animals↗