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Osteoarticular allografts for reconstruction after resection of a musculoskeletal tumor in the proximal end of the tibia.

An osteoarticular allograft was used to reconstruct a skeletal deficiency in sixteen patients after resection of a tumor in the proximal end of the tibia. The status of each allograft and the condition of each involved limb were evaluated an average of nine years (range, six to fourteen years) postoperatively. The status of the allograft was evaluated according to the survival of the allograft and the occurrence of complications. Of the original sixteen allografts, seven were removed: six, between two and five years after the reconstruction and one, seven years after the reconstruction. A second reconstruction with use of an allograft was performed in five of the seven patients. Fifteen complications occurred in association with eleven of the original sixteen allografts. These included fracture of the allograft (five patients), subchondral collapse (five patients), infection (two patients), non-union (two patients), and instability of the joint (one patient). At the latest follow-up examination, nine patients had retained the original allograft, five had had a second allograft procedure, and two had had an above-the-knee amputation. The most recent result was rated excellent or good in eleven patients and fair or a failure in five, with use of the system of Mankin et al. It was rated good or excellent in nine patients and fair, poor, or a failure in six, and it was not rated in one patient who had died, according to the system of the Musculoskeletal Tumor Society.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Localization of sudanophil material at the sites of calcification in dentine, and the compact bone and epiphyseal cartilage plate of tibia in the rat given beryllium carbonate.

The localization of sudanophil material at dentine, the compact bone and epiphyseal cartilage plate of tibia of rat given beryllium carbonate was examined. Sudanophil material was seen at the boundary parts between dentine and widened predentine, and between widened preosseous matrix and calcified bone, but it was not seen at the area corresponding to the zone of provisional calcification. These facts suggest that the localization of sudanophil material in hard tissue of rat with Be rickets was similar to that in vitamin D deficient-induced rickets. This sudanophil material was not disappeared by the enzymes such as papain, pepsin and hyaluronidase as described in vitamin D deficient-induced rickets (Irving, 1960, 1963). Accordingly, it was suggested that the substance was not proteins and mucopolysaccharide.

Animals↗

Congenital pseudarthrosis of the tibia in pediatric patients: MR imaging.

OBJECTIVE: The purpose of this study was to describe the characteristics of congenital pseudarthrosis of the tibia on MR images of infants and children and to assess the value of MR imaging in evaluating this disease. CONCLUSION: MR imaging of congenital pseudarthrosis allows assessment of the type and extension of the disease. It is especially recommended for the evaluation of periosteal and soft-tissue changes near the pseudarthrosis.

Child, Preschool↗

[Open wedge osteotomy and callus distraction by means of the external fixator in distal femur and proximal tibia in knee arthrosis with valgus and varus deformity].

Various methods can be applied for treatment of knee deformity. One of them is open wedge osteotomy and callus distraction by means of the external fixator. This paper presents the results of treatment of 16 patients with knee arthrosis associated with varus and valgus deformities (10 varus and 6 valgus deformities). Open wedge osteotomy of the varus deformity was performed in the proximal tibia, and in case of the valgus deformity in the distal part of the femur. The patients who were operated on had a knee varus larger than 10 degrees and a knee valgus larger than 12 degrees. Prior to open wedge osteotomy and application of the external fixator, knee arthroscopy was performed (meniscectomy, cartilage drilling and shaving, debridement, the extraction of loose bodies). After one-year follow-up, the final outcome of the treatment was positive in all patients. The treatment alleviated the pain in these patients. The method is minimally invasive and relatively easily applied. Mitkovic's external fixator type M20-CD-V allows for continuous callus distraction with simultaneous correction of the varus or valgus knee deformity.

Adult↗

Comparison of osseointegration between hydroxyapatite-coated and uncoated threaded titanium dental implants placed into surgically-created bone defect in rabbit tibia.

The purpose of this study was to compare the degree of osseointegration between hydroxyapatite (HA)-coated and uncoated threaded titanium dental implants placed into a surgically created bone defect with or without an expanded polytetrafluorethylene (ePTFE) membrane. A conventional implant site was prepared and either a HA-coated or an uncoated implant was placed in each tibia of 12 rabbits (conventional group). A bone defect approximately 3 mm in width was created on the distal end of the conventional site and either a HA-coated or an uncoated implant was placed there (bone defect group). For another group, the same procedure was performed as in the bone defect group, except the implant sites were covered with ePTFE membranes (ePTFE group). After 4 months, the rabbits were sacrificed. Specimens were prepared and examined histometrically. The results demonstrated that HA-coated threaded titanium dental implants consistently showed a greater amount of osseointegrated surface either in the conventional site or defect region with and without ePTFE membranes in this animal model. In conclusion, a HA-coated threaded titanium implant may be the choice of dental implants to establish greater osseointegration with the defect or conventional site.

Animals↗

Subchondral cystic lesions of the proximal extremity of the tibia in horses: 12 cases (1983-2000).

OBJECTIVE: To determine clinical and radiographic features of subchondral cystic lesions (SCL) of the proximal extremity of the tibia in horses that could be used to classify these lesions as being related to osteochondrosis or osteoarthritis and to evaluate results of surgical debridement. DESIGN: Retrospective study. ANIMALS: 12 horses with 14 SCL. PROCEDURE: Medical records and radiographs obtained before and after treatment were reviewed. RESULTS: In 6 young horses (8 lesions), SCL were considered to be related to osteochondrosis; all involved the lateral tibial condyle. The remaining 6 horses were mature and had radiographic evidence of osteoarthritis in addition to SCL. Arthroscopic debridement was performed in 4 horses in which lesions were considered to be a result of osteochondrosis and in 3 horses with osteoarthritis. Three horses in which SCL were considered to be a result of osteochondrosis performed athletically after debridement. Two horses with moderate osteoarthritis returned to work after arthroscopic debridement but at a lower level of athletic performance. One horse with SCL related to osteochondrosis responded to medical treatment and went on to race. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that arthroscopic debridement of SCL is feasible in horses in which lesions involve the cranial portion of the lateral or medial tibial condyle, and that treated horses may be able to perform athletically.

Animals↗

Sarcoma of the proximal portion of the tibia in a dog 5.5 years after tibial plateau leveling osteotomy.

Osseous neoplasia was identified in the proximal portion of the tibia and distal portion of the femur in an 11.75-year-old spayed female German Shepherd Dog. A tibial plateau leveling osteotomy, followed by application of a metal plate, had been performed on the affected limb 5.5 years earlier. Areas of osteolysis and periosteal proliferation were seen radiographically, with an intense area of osteolysis directly beneath the metal plate. Histologically, the tumor was identified as a poorly differentiated sarcoma. Extracellular and intracellular debris was seen histologically, and energy-dispersive x-ray analysis confirmed that this debris was metallic. On visual examination, areas of the underside of the metal plate that had been in contact with bone had a dull, roughened appearance, and scanning electron microscopy of these areas revealed multiple corrosion pits. The plate was strongly magnetic, suggesting that it contained ferrite, and metallographic examination of the plate revealed substantial differences in the chemical makeup of various parts of the plate. Microstructure analysis revealed that the plate consisted of an austenite matrix with a large fraction of ferrite. The plate was determined to be a cast 316L stainless steel implant, but it did not meet American Society for Testing Materials standards for implant-grade materials. The possibility that implant corrosion might have played a role in tumor development is of concern; however, a definitive association was not established.

Animals↗

Osteofibrous dysplasia of the tibia and fibula.

Osteofibrous dysplasia (ossifying fibroma of long bone) is an uncommon disorder of bone affecting the tibia and, rarely, the fibula of children and adolescents. It has been delineated from monostotic fibrous dysplasia, from which it can be distinguished by its radiological and histological characteristics and by its clinical course. We report 11 patients with osteofibrous dysplasia whose ages ranged from 10 months to 22 years. Four presented with a pathological fracture and in 2 a pseudarthrosis developed. A circumscribed area of intracortical lucency and expansion in the diaphysis is the characteristic radiological finding. Histologically there is a similarity to fibrous dysplasia but the trabeculae are lamellar or have a lamellar surface and most show osteoblastic rimming. Treatment may be difficult but more recent experience strongly favours a conservative approach wherever possible.

Adolescent↗

Weight-bearing porous fiber titanium implants in rat tibia: a restricted growth model for comparison of normal and pathological bone repair.

An experimental model in rats for comparison of bone repair under normal and pathological conditions is described. The low cost of rats and the simple surgical procedure used allow large-scale studies. Although clinical implications must be interpreted with care, our model may prove useful in the attempt to understand how various drugs and metabolic disorders may affect bone healing. We used porous fiber titanium implants to replace a segment of the right proximal tibia in rats. The void space to be filled with bone represented a known and constant volume allowing a direct comparison between differently treated groups. Selected parameters for bone ingrowth could be expressed in terms of growth curves as a function of time, using a mathematical equation for restricted growth. The following parameters for quantity and quality of the ingrown bone were monitored: micromoles calcium as parameter for amount; calcium/hydroxyproline molar ratio for extent of mineralization; calcium/phosphorus molar ratio for maturity of minerals; and ultimate bending stress for strength of the bone-implant interface. With this model we have studied the effect that cis-platinum, an anticancer drug that is used in the treatment of osteogenic sarcoma, has on bone repair.

Animals↗

Insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) immunoreactivity in normal and osteopetrotic (toothless, tl/tl) rat tibia.

Insulin-like growth factor-I (IGF-I) plays a major role in regulating cell growth. This study examined the immunohistochemical distribution of IGF-I and IGF-I receptor (IGF-IR) in tibias from normal and osteopetrotic (toothless, tl/tl) rats, following treatment with colony stimulating factor-1 (CSF-1). In normal rats, immunoreactivity for IGF-I and IGF-IR was detected in cells of the articular and epiphyseal cartilage, secondary ossification centres, zones of resting and proliferating chondrocytes and bone marrow. Bone marrow cells immunoreactive for IGF-I and IGF-IR were significantly reduced in the tl/tl rat (p < 0.001) compared with normal animals. Treatment of tl/tl rats with CSF-1 increased immunoreactivity for IGF-I and IGF-IR in bone marrow cells as well as the number of TRAP positive osteoclasts. This increase was the result of recruitment of a range of hematopoietic cell types, including eosinophils, polymorphs and a substantial number of monocyte-like cells demonstrating strong immunoreactivity to IGF-I/IGF-IR. The differences in relative immunoreactivity for IGF-I/IGF-IR by bone marrow cells in untreated and CSF-1-treated tl/tl rats indicate a CSF-1-dependent recruitment of cells bearing surface IGF-IRs which may be mediated by an increase in local or systemic IGF-I.

Acid Phosphatase↗

Congenital pseudarthrosis of the tibia and neurofibromatosis.

On the basis of 21 cases of congenital pseudarthrosis of the tibia, which were radiologically typed and later personally examined, it was found that all cases of the dysplastic type also showed evidence of neurofibromatosis. No evidence of neurofibromatosis was found among the cystic and the clubfoot type of pseudarthroses.

Humans↗

Adamantinoma tibiae.

A case with characteristic roentgenographic and microscopic findings of adamantinoma tibiae is reported. Knee disarticulation with early ambulation is the treatment of choice and was performed on this patient. Limb ablation followed by Unna Paste Bandage to prevent oedema and permit early prosthetic fitting facilitates rehabilitation. The 1 year follow-up showed excellent prosthetic function and no evidence of residual tumour.

Adult↗

Growth disturbance following fracture of the tibia in children.

Orthoradiographs were produced from 13 to 36 months after tibial fractures in 85 children. Fifty-nine were complete i.e. tranverse or longitudinal, and 28 fractures were incomplete i.e. infractions or fissures. The difference in the length of the tibia from growth disturbance caused by the fracture was found to be related to the age of the child at the time of fracture and the sex. An overgrowth was found to occur in the age group from 3 to 10 years in girls and from 3 to 12 years in boys, whereas in the older children a growth retardation was demonstrated. No correlation with the type of fracture, or with the residual angulation after reduction, could be established. The growth disturbance appeared to last for 1 to 2 years. We conclude that a more concerned attitude towards residual shortening at the time of reduction should be adopted in girls from the age of 10 and boys from the age of 12 years in order to compensate for the growth retardation induced by the fracture.

Adolescent↗

Effect of diaphyseal injury on the proximal growth zone of the tibia in rabbits.

In 130 growing chinchilla rabbits, the effect of various diaphyseal injuries--periosteal stripping, cortical drilling and fracture--on the growth plate and the metaphysis of the tibia was studied histologically and radiographically and with the aid of 51Cr labelled erythrocytes and the 85Sr isotope. It was found that the disturbed circulation and the venous stasis may have a marked effect on osteogenesis and bone growth but other factors are probably also involved. In the early stage after the injury an increase in the ground substance, widening of the zone of germinative and proliferative cells in the growth plate and a reticular arrangement of the bony trabeculae in the metaphysis were observed. In the late stage, along with a return to normal circulation, normalization of the osteogenesis and bone growth was also found.

Animals↗

Adamantinoma tibiae. A report of a new case.

This report describes a new case of adamantinoma of the tibia which is a rare primary malignant bone tumour. Just over 100 cases have been reported. The symptoms, treatment and problems of diagnosis are briefly discussed.

Aged↗

Reconstruction of the tibia by dual grafting. 3 cases of tumor resection.

Large defects of the tibia can be bridged with autologous cancellous grafts between the remaining fibula and a contralateral tibial cortical graft. The long-term results of this technique in 3 cases after resection of a malignant tumor were either excellent or fair. It is concluded that this technique is an effective limb-saving surgical procedure.

Adult↗

Vasoconstrictive action of neuropeptide Y in bone. The porcine tibia perfused in vivo.

The hemodynamic effects of neuropeptide Y (NPY) and norepinephrine (NE) in bone were studied by infusion into the nutrient artery of an in vivo and in situ perfused tibia in 19 pigs. NPY and NE caused elevation of the perfusion pressure and decline in intraosseous pressure, which was evidence of intraosseous vasoconstriction. The study suggests that NPY, along with NE, acts as a sympathetic neurotransmitter in the control of vascular tone in bone.

Animals↗