PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Particle Accelerators”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,477 records · Page 82Linked to original sources

A radiation accident at an industrial accelerator facility.

On 11 December 1991, a radiation overexposure occurred at an industrial radiation facility in Maryland. The radiation source was a 3-MV potential drop accelerator designed to produce high electron beam currents for materials-processing applications. This accelerator is capable of producing a 25 milliampere swept electron beam that is scanned over a width of 112.5 cm and which emerges from the accelerator vacuum system through a titanium double window assembly. During maintenance on the lower window pressure plate, an operator placed his hands, head, and feet in the beam. This was done with the filament voltage of the electron source turned "off," but with the full accelerating potential on the high voltage terminal. The operator's body, especially his extremities and head, were exposed to electron dark current. In an attempt to reconstruct the accident, radiochromic film and alanine measurements were made with the accelerator operated at two beam currents. Measured dose rates ranged from approximately 40 cGy s-1 inside the victim's shoe to 1,300 cGy s-1 at the hand position. Approximately 3 mo after the accident, it was necessary to amputate the four digits of the victim's right hand and most of the four digits of his left hand. Electron paramagnetic resonance spectrometry, which measures the concentration of radiation-induced paramagnetic centers in calcified tissues, was used to estimate the dose to the victim's extremities. A mean dose estimate of 55.0 +/- 3.5 Gy (95% confidence level) averaged over the mass of the bone was obtained for the victim's left middle finger (middle phalanx).

Accidents, Occupational↗

Microdosimetric single-event spectra for megavoltage electrons.

Experimental techniques have been developed for obtaining single-event microdosimetric spectra from hospital based linear accelerators. Therapeutic electrons of 12, 15, 18, and 20 MeV from Clinic 18 and 20 accelerators have been produced at ultralow dose rates. Details of the experimental methods have been described previously by the authors. Single-event lineal energy spectra for these beams, as measured by a Rossi chamber differ significantly from cobalt-60 both in shape and dose average lineal energy (yd) which, depending on electron energy, can be 20-40% lower. The spectral peaks for electrons are greatly enhanced compared to cobalt. The yd for electrons also differs from previously reported values for 10-15 MV photon beams. These differences are less pronounced than for differences with cobalt. Spectral peaks and shapes correlate well with the actual electron stopping powers in tissue. The theory of dual radiation action predicts changes in relative biological effectiveness at low doses for megavoltage photon and electrons. Although at clinical doses the predicted differences are not statistically significant.

Electrons↗

Technical innovation to calibrate the gantry angle indicators of linear accelerators.

Finding the actual zero degree of the gantry angle is important in order to perform the mechanical quality assurance (QA) of linear accelerators. To determine real zero, we must locate a "good surface" which could be defined as a plane on the surface of the gantry head that is perpendicular to the direction of radiation. The actual gantry angle could then be defined as the angle between vertical, as indicated by a plumb bob, and the direction of the beam axis that could be indicated by the position of a BB placed in the central axis and its shadow. From this we located the real zero degree and the good surface. The good surface can be applied to check the important mechanical readouts. The technique we introduce could solve the essential problems of a traditional QA technique, as well as taking up an important role in the quality assurance of a patient's treatment.

Calibration↗

Depth dose characteristics of 24-MV x-ray beams at extended SSD.

Depth dose characteristics of 24-MV beams from a medical linear accelerator at various SSDs have been measured. The dose buildup, percent depth dose (PDD), and output were measured using ionization chambers and a diode detector under full scatter. Surface dose ranged from 8% to 51% depending upon the collimator setting at 100-cm SSD. It decreased by 10%-15% as distance was increased to 200 cm, but remained unchanged beyond this distance. The dmax migrated rapidly toward the surface with increasing field size at 100-cm SSD. At extended SSD, the dmax occurred at greater depths and shifted a little toward the shallow depths with increasing field size. Large field PDDs measured at extended SSD agreed well with those predicted from 100-cm data. The output followed the 1/(distance)2 relationship quite well. The extended SSD beam data are clinically useful when treating hemibody or performing total body irradiation (TBI) procedures.

Humans↗

A first order approximation of field-size and depth dependence of wedge transmission.

The Radiological Physics Center, through its dosimetry review visits to participating institutions, is aware that many institutions ignore the field-size and depth dependence of wedge transmission values. Reference wedge transmission values are normally measured by the Radiological Physics Center for a 10 cm x 10 cm field at the calibration depth of 5 or 7 cm. Recently, additional measurements (1) for a 10 cm x 10 cm field at 20-cm depth and (2) for a 20 cm x 20 cm field at the calibration depth were included. The transmission under these two conditions was compared with that under reference conditions. The relative transmission values for 138 photon beams from 88 separate linear accelerators (4-25 MV) and 60Co units were measured. Our data suggest that the dependence of the wedge transmission on field-size and depth, in the first approximation, depends on the absolute value of the transmission under reference conditions. For wedges with a transmission value greater than 0.65%, field-size dependence and change in depth dose are typically less than 2%. However, for wedges with transmission values less than 0.65%, field-size dependence increases with decreasing reference wedge transmission. The change in wedge transmission with depth is significant (> 2%) only for photon energies less than or equal to 10 MV and can exceed 5% for thick wedges. Failure to include the depth and field-size dependencies of wedge transmission in patient dosimetry calculations can result in significant tumor-dose discrepancies.

Biophysical Phenomena↗

Linear accelerator as a neurosurgical tool for stereotactic radiosurgery.

A new system has been developed for stereotactically delivering prescribed high doses of radiation to precisely located volumes of approximately 0.6 to 10.0 ml within the brain. A Brown-Roberts-Wells stereotactic apparatus and a 6-MeV linear accelerator equipped with a special collimator (12.5 to 30 mm in diameter) have been adapted. The 20-mm collimator allows treatment of a nearly spherical volume of 2.1 ml. Outside the treatment field, the dosage declines to 80% of the dose prescribed for the periphery of the lesion over a distance of 1.8 mm and to 50% over the next 3.4 mm. Localization can be accomplished via computed tomography or cerebral angiography. Treatment is accomplished with an arcing beam of photon radiation with the turntable (couch) in each of four positions. The entire system has been extensively tested for accuracy in alignment and distribution of radiation. Errors have been measured for the alignment of the apparatus and for the process of localization. Safety of operation was emphasized throughout the design and testing phase.

Brain Diseases↗

[Leakage radiations in a medical electron accelerator facility--X-rays and capture gamma-rays].

Absorbed dose rates of photons are measured in the maze of a medical electron accelerator facility. Radiations in the maze include high energy recoiled electrons other than low energy reflected X-rays. An ionization chamber for low energy X-rays is used for measurement, and is put in a build-up cap thick enough to obstruct the recoiled electrons of which contribution to the chamber output comes sometimes equal to that of X-rays. Dose rates of capture gamma-rays in the maze are estimated applying the calculation of neutron dose equivalent rates reported in the preceding paper. It is proved that capture gamma-rays are dominant in the dose rates measured in the maze at 14 MV X-ray generation. The estimated absorbed dose rates of total photons including capture gamma-rays and reflected X-rays agree with the measured ones in the range from +10% to -27%.

Electrons↗

The irradiation of V79 mammalian cells by protons with energies below 2 MeV. Part I: Experimental arrangement and measurements of cell survival.

The relative biological effectiveness (RBE) has been determined for protons with mean energies of 1.9, 1.15 and 0.76 MeV, from measurements of the survival of V79 Chinese hamster cells. The cells are supported as a monolayer and are swept through a beam of scattered protons produced using a 4 MeV Van de Graaff accelerator. An estimation of the dose and unrestricted linear energy transfer (LET) variation within the sensitive volume of the cells is given for the three proton energies. The RBEs for cell survival (relative to 250 kVp X-rays) at the 10 per cent survival level are 1.6, 1.9 and 3.36 for protons with track-average LETs of 17, 24 and 32 keV microns-1 respectively, and the data suggest that protons are most effective at about 40-50 keV microns-1. It is shown that the proton RBEs can be reconciled with those of other light ions if plotted against z*2/beta 2 (where z* is the effective charge and beta is the relative velocity) rather than against LET.

Animals↗

The value of the PinPoint ion chamber for characterization of small field segments used in intensity-modulated radiotherapy.

Volume averaging and lack of electronic equilibrium complicate accurate dosimetry of small photon fields. In this paper the performance of the PinPoint ion chamber for characterizing small fields used in intensity-modulated radiotherapy (IMRT) was investigated and the results were compared with those obtained using the Markus ion chamber and a diamond detector. Sharp beam penumbras were measured for a 5 x 5 cm field defined using a cerrobend block mounted on the accelerator head. In addition, output factors were measured for a 6 MV photon beam and a variety of small rectangular fields collimated widthwise using the multileaf collimator (MLC) in combination with the back-up jaws. From this study, a reference field of 5 x 5 cm and a measuring depth of 5 cm are recommended. This is related to the over-response of the PinPoint chamber to low-energy Compton scattered photons, an effect that was investigated rigorously and turned out to limit the scope of this ionization chamber. However, taking into account some limitations, the PinPoint chamber is an excellent detector for output measurements in small fields down to 2 cm. In profile measurements the chamber causes a broadening of the measured penumbras but its spatial resolution is superior to that of the Markus chamber.

Calibration↗

Matching the 6-MV photon beam characteristics of two dissimilar linear accelerators.

A new prototype 6-MV flattening filter was designed by the manufacturer for use in a popular dual energy linear accelerator. To satisfy the contract demands, this filter was designed to produce a beam whose characteristics matched precisely with those of the 6-MV beam produced from a single photon peak energy unit from the same manufacturer and already in operation in the department. A single set of 6-MV dosimetric files for both units can now be maintained. The new filter has forced percent depth values over a wide clinical range of field sizes and depths to agree within 1.3%. Beam profiles now agree to within 1% over the useful area. For wedges with similar wedge angles, transmission factors now agree to within 1%. Standard acceptance testing performance specifications provided by the manufacturer were not adequate for clinical beam matching. The purchase contract for these units included our own specifications, which were more rigid and pertinent to our goal. Details of the effort are discussed.

Humans↗

The Clatterbridge high-energy neutron facility: dosimetry intercomparisons.

Dosimetry intercomparisons have been performed between the Clatterbridge high-energy neutron facility and the following institutions, all employing beams with similar neutron energies: Université Catholique de Louvain, Belgium; University of Washington, Seattle, USA; MD Anderson Hospital, Houston, USA; and Fermi National Accelerator Laboratory, Batavia, USA. The purpose of the intercomparison was to provide a basis for the exchange of dose-response data and to facilitate the involvement of Clatterbridge in collaborative clinical trials. Tissue-equivalent ionization chambers were used by the participants in each intercomparison to compare measurements of total (neutron plus gamma) absorbed dose in the host institution's neutron beam, following calibration of the chambers in a reference photon beam. The effects of differences in exposure standards, chamber responses in the neutron beams and protocol-dependent dosimetry factors were all investigated. It was concluded that the overall difference in the measurement of absorbed dose relative to that determined by the Clatterbridge group was less than 2%.

Calibration↗

[The radiotherapy satellite in Kristiansand--a model for Norwegian regional hospitals?].

BACKGROUND: During the first decade of 2000, significant increase of radiotherapy capacity in Norway will take place, as the number of linear accelerators will increase from 24 to 36. In Norway, radiotherapy departments are traditionally located only in university hospitals. However, six of the new accelerators will not be installed in existing radiotherapy centres, but in small, new radiotherapy units, set up in selected county hospitals and organized as satellites of the university hospitals, in order to secure the treatment quality. The university hospital is responsible for both medical and technical standards in the satellite, while the county hospitals have the financial responsibility. RESULTS: The satellite model combines two important aspects of hospital management; treatment is geographically decentralized, while treatment quality is centralized. The first radiotherapy satellite was established in the town of Kristiansand in January 2001. We report our experience with this new concept in radiotherapy. INTERPRETATION: The satellite model should be evaluated also for other medical specialties within the university hospitals.

Health Planning↗

[Comparison of dosimetric properties of 15-MV-photons and 14-MeV-neutrons in external stereotaxic convergence therapy].

Dosimetric properties for stereotaxic convergent beam therapy techniques with small field sizes have been investigated as well as for the linear accelerator Mevatron 77 as for the neutron generator KARIN. Additionally we also measured the dose distribution of single plane rotational therapy. As an indication of quality we calculated the V50 ratio as V50 = (F50-F90)/F90 and the corresponding V20 values. For the single plane irradiation there is a considerable difference in dose distribution in favour of photons. V50 (axial) amounts to 1.77 for photons and to 2.7 for neutrons. For the convergential non coplaner arc-therapy using nine plans there is nearly no difference in the high dose region including the 50%-isodose. V50 (axial): 1.16 and 1.6 respectively; (frontal) 1.36 and 1.35 respectively. Regarding to physical dose distributions our results indicate, that 14-MeV neutrons are suitable for high dosed stereotactic single irradiations.

Brain Neoplasms↗

[Study on the dose distribution of 8-MeV bremsstrahlung in mantle field techniques (author's transl)].

The dose distribution within the patient was studied with 8-MeV bremsstrahlung from a linear accelerator during mantle field irradiation using molded shielding blocks. Doses and dose distributions in the different layers of a modified Alderson phantom were measured by means of film dosimetry and related to the dose in the central ray beam at the middle of the body. Dose distribution within unshielded regions perpendicular to the central ray beam generally being relatively homogeneous, the highest relative doses, amounting to ca. 115%, are found in the region of the mandibular angle and in the supraclavicular region; the dose to superficial lymph nodes at the supraclavicular region reaches 100% of the dose in the central ray beam. As a cause for these important doses near the surface of the body are discussed the extension of mantle fields as well as the increased exit dose of the opposed field and the oblique incidence of radiation.

Humans↗

Experimental procedure for the manufacture and calibration of polyacrylamide gel (PAG) for magnetic resonance imaging (MRI) radiation dosimetry.

A simple methodology for the manufacture and calibration of polyacrylamide gel (PAG) for magnetic resonance imaging (MRI) radiation dosimetry is presented to enable individuals to undertake such work in a routine clinical environment. Samples of PAG were irradiated using a linear accelerator and imaged using a 0.5 T (22 MHz) Philips Gyroscan MRI scanner. The mean spin-lattice relaxation rate was measured using a 'turbo-mixed' sequence, consisting of a series of 90 degrees pulses, each followed by acquisition of a train of spin echoes. The mean sensitivity for five different batches of PAG in the range up to 10 Gy was calculated to be 0.0285 s-1 Gy-1 for the mean spin-lattice relaxation rate with a percentage standard deviation of 1.25%. The overall reproducibility between batches was calculated to be 2.69%. This methodology, which introduces the novel use of pre-filled nitrogen vials for calibration, has been used to develop techniques for filling anatomically shaped anthropomorphic phantoms.

Acrylic Resins↗

Linear accelerator calibration monitor with a memory.

A calibration monitor has been designed for measuring the constancy of linear accelerator or cobalt unit output between full calibrations. This monitor is battery operated, light-weight and slides into the shadow tray attachment on a linear accelerator or cobalt unit for easy setup. It provides a digital readout of the dose delivered, and a consistency check can be made in less than two minutes. The precision of the monitor, determined by cobalt-60 irradiations over a 2 1/2 period, is +/- 0.6% (standard deviation). The monitor also retains the dose reading in a CMOS digital counter indefinitely, hence it can be used in the same fashion as mailed thermoluminescent dosimeters (TLD) for calibration checks at remote facilities without the complicated readout procedures associated with TLD. The monitor can be mailed to a remote facility, positioned without ambiguity, and irradiated; and the reading can be verified on return to the originating center simply by pressing a switch. The monitor can easily be set up to carry out a "blind" check in which the reading obtained is not known to the remote facility.

Calibration↗

Stereotactic radiosurgery using a linear accelerator.

A basic and clinical study of radiosurgery using the linear accelerator (Linac) system for unremovable deep-seated brain tumors is reported. A Komai stereotactic ring was used to locate the target coordinates. The patient was laid on the Linac treatment table and held in the head fixation system. Irradiation was given in five positions. The dose profile by film dosimetry and Rando phantom was satisfactory. Seventeen tumors in 14 patients were treated. Clinical or histological diagnoses were nine metastases, one benign and two malignant gliomas, one meningioma, and one craniopharyngioma. Tumor sizes were between 8 and 30 mm. Doses were between 12 and 30 Gy. Computed tomographic evaluation after 3 months of 12 tumors in 11 survivors showed one complete remission, three partial remission, six no change, and two partial deterioration. For progressive tumors, Linac radiosurgery results are excellent.

Adult↗

Neutron dosimetry intercomparisons between National Accelerator Centre, Université Catholique de Louvain and Clatterbridge Hospital.

Neutron dosimetry intercomparison studies have been undertaken at three neutron therapy facilities which have similar beam characteristics; viz. National Accelerator Centre, South Africa [p(66 MeV)+Be], Université Catholique de Louvain, Belgium, [p(65 MeV)+Be] and MRC Cyclotron Unit, Clatterbridge Hospital, U. K. [p(62 MeV)+Be]. The procedures followed at all centres were the same: tissue equivalent (TE) ionization chambers were first calibrated in 60Co beams and then exposed under various conditions in the respective neutron therapy beams. Measurements were made with the chambers flushed with TE gas or filled with static air. The neutron beam measurements differed by a maximum of 2.4%, whereas if only one particular type of ionization chamber is considered the spread in values is reduced to +/- 0.5%. The TE gas/air response ratios are consistent with calculated values. The results obtained are highly satisfactory and confirm that the dosimetry procedures adopted by the participating institutes conform to international standards.

Belgium↗