[Mechanisms of biocidal action of neutrophils in patients with alcoholism and kidney damage of the chronic pyelonephritis type].
AIM: To study mechanisms of biocenosis action of neutrophils in alcoholics with chronic pyelonephritis (CP). MATERIAL AND METHODS: Functional potential of oxidase neutrophil system was studied in 37 males with chronic alcoholism stage II. 17 of them had CP. They were compared to 18 CP non-alcohol abusers (controls). RESULTS: CP alcoholics had lower potential of oxidase neutrophil system than controls and healthy subjects. CONCLUSION: Dysfunction of axygen-dependent mechanisms of biocidic action of neutrophils in chronic alcoholics weakens the ability of the organism to eliminate infection and can entail defects in immune response.