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At least 1,495 records · Page 83Linked to original sources

PubMed1999

Accuracy evaluation of fusion of CT, MR, and spect images using commercially available software packages (SRS PLATO and IFS).

PURPOSE: A problem for clinicians is to mentally integrate information from multiple diagnostic sources, such as computed tomography (CT), magnetic resonance (MR), and single photon emission computed tomography (SPECT), whose images give anatomic and metabolic information. METHODS AND MATERIALS: To combine this different imaging procedure information, and to overlay correspondent slices, we used commercially available software packages (SRS PLATO and IFS). The algorithms utilize a fiducial-based coordinate system (or frame) with 3 N-shaped markers, which allows coordinate transformation of a clinical examination data set (9 spots for each transaxial section) to a stereotactic coordinate system. The N-shaped markers were filled with fluids visible in each modality (gadolinium for MR, calcium chloride for CT, and 99mTc for SPECT). The frame is relocatable, in the different acquisition modalities, by means of a head holder to which a face mask is fixed so as to immobilize the patient. Position errors due to the algorithms were obtained by evaluating the stereotactic coordinates of five sources detectable in each modality. RESULTS: SPECT and MR position errors due to the algorithms were evaluated with respect to CT: deltax was < or = 0.9 mm for MR and < or = 1.4 mm for SPECT, deltay was < or = 1 mm and < or = 3 mm for MR and SPECT, respectively. Maximal differences in distance between estimated and actual fiducial centers (geometric mismatch) were in the order of the pixel size (0.8 mm for CT, 1.4 mm for MR, and 1.8 mm for SPECT). In an attempt to distinguish necrosis from residual disease, the image fusion protocol was studied in 35 primary or metastatic brain tumor patients. CONCLUSIONS: The image fusion technique has a good degree of accuracy as well as the potential to improve the specificity of tissue identification and the precision of the subsequent treatment planning.

Algorithms↗

PubMed2003

The Bayesian population approach to physiological toxicokinetic-toxicodynamic models--an example using the MCSim software.

The calibration of physiologically based toxicokinetic models against experimental data encompasses the merging of prior knowledge with information present in the data. This prior knowledge is manifested in the scientific literature and associated with various degrees of uncertainty. The most convenient way to combine these sources of information is via the use of Bayesian statistical methods. Furthermore, toxicokinetic models are subject to both inter- and intra-individual variability. This variability may be handled statistically by the use of a population model. The MCSim software, which is available for free download on the Internet, permits the use of a population model in combination with a Bayesian statistical approach. An example of the use of MCSim in a recent model-based risk assessment of dichloromethane (DCM) is given and discussed.

Animals↗

PubMed2003

Computerized forensic assistance software (FAS 1.0) for training and standardized investigation in distributed and disconnected services.

As part of a European union (EU) support program in forensic science for the Palestinian police, a forensic assistance software was designed to respect the quality management of the anti-terrorism laboratory of the Palestinian police by the different forensic teams in the disconnected Palestinian cities. This tool not only proposes up-to-date detection and identification protocols for traces, explosives, drugs, GSR, biological samples, but also appeared to be a convenient support for forensic practice teaching.

Databases, Factual↗

PubMed2003

A Windows-based software for common paternity and sibling analyses.

A new Windows-based freeware for kinship analysis from DNA data is presented. This software can be used to calculate likelihood ratios and probabilities of paternity in trio and motherless cases, as well as in cases when a parent is lacking but there are data from the grandparents. It can also be used to compute the probability of two subjects being full-brothers or half-brothers.

DNA Fingerprinting↗

PubMed2002

Clinical evaluation of the Vitek automated system with cards GNS 122 and 127 and VTK-R07.01 software for antimicrobial susceptibility testing of Pseudomonas aeruginosa.

The performance of the Vitek Automated Susceptibility Testing System software version VTKR07.01 (bioMerieux Vitek, Hazelwood, MO), for testing Pseudomonas aeruginosa was evaluated by comparing results for 200 clinical isolates with those of disk diffusion and manual broth microtiter dilution testing. For cefepime, the restricted major error rate was 0.53% and the minor error rate was 12.5%. For piperacillin, the restricted major error rate was 2.15%. For ticarcillin/clavulanic acid, restricted very major and major error rates of 6.5% and 3.2%, respectively, occurred. The results of our study indicate that the Vitek system performs within acceptable limits when testing piperacillin, but remains problematic for testing cefepime and ticarcillin-clavulanic acid.

Automation↗

PubMed1994

[Continuous administration of drugs by infusion pumps. Presentation of an infusion rate mathematical computing software].

Intensive therapy includes continuous delivery of drugs with infusion pump. This article describes an infusion rate computing programme using a Macintosh micro-computer and the HyperCard 2 software. The latter permits the classification of data onto cards collected in stacks. The card that is displayed when the programme is launched shows fifteen buttons assigned to various drugs. Click upon a button opens the corresponding card which displays the presentation of the drug and suggests a dilution. The next step associates input of patient's weight into the appropriate field and a click on the main button. A display then indicates for various standard dosages, the corresponding rate of infusion in mL.h-1 and the daily consumption of the drug. In order to avoid casual or voluntary changes of the setting, soft securities have been inserted in the programme.

Humans↗

PubMed1994

The validity of the prediction of Soft Tissue profile changes after LeFort I osteotomy using the dentofacial planner (computer software).

The purpose of this study was to examine the validity of the prediction of soft tissue changes after LeFort I osteotomy with the DentoFacial Planner (DFP) (computer software). The preoperative and postoperative lateral cephalograms of 21 white adult orthodontic patients (10 males and 11 females) who underwent only LeFort I osteotomy as part of their overall treatment were digitized. A coordinate system of X and Y axes were used to assess the amount and direction of movement of the maxilla. The SN + 7 degrees was the X axis, and a perpendicular to this plane from nasion was the Y axis. The sample was divided into two groups depending on the amount of forward movement of the maxilla. More than 2 mm of anterior placement of the maxilla comprised the advancement group (13 patients) and less than 2 mm comprised the impaction group (8 patients). The selection criteria for the sample were (1) before and after cephalograms taken with lips in repose and in centric occlusion; (2) all preoperative records taken almost immediately before surgery; (3) postoperative records taken at least 6 months after surgery and checked by regional superimposition of the preoperative and postoperative lateral cephalograms onto the maxilla and the mandible. No tooth movement occurred between the time the records were taken. The following soft tissue landmarks were examined: pronasale, subnasale, stomion superior, middle upper lip, stomion inferior, middle lower lip, labrale inferior, labiomental fold, and pogonion. The results indicate that for some of these landmarks the amount and direction of soft tissue changes differed between the DFP prediction and the actual surgical changes by LeFort I osteotomy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1998

A hardware-software system for analysis of video images.

The purpose of this paper is to describe a software/hardware system for the analysis of digitized video images and a number of applications for which it may be used. The system described includes a Macintosh computer, a frame-grabber board, and Image, a public domain software program available at no cost from the U.S. National Institutes of Health. In our clinic and laboratory, this system is routinely used to make quantitative measurements from videofluoroscopic x-ray images of dynamic swallow studies and studies performed to assess velopharyngeal dysfunction in speech. It can also be used to examine various laryngeal parameters obtained from videotaped endoscopic and stroboscopic examinations. With a videocamera attached to a microscope, the system permits quantitative analysis of tissue characteristics, e.g., thickness of epithelial or connective tissue layers of the vocal folds. The relatively low cost and ease of use of the image analysis system make it a particularly attractive option when quantitative assessment of clinical or research materials in video format is desirable.

Computers↗

PubMedDate not supplied

VoxeLine: a software program for 3D real-time visualization of biomedical images.

The architecture and implementation of VoxeLine, a new interactive environment for display and analysis of 2D and 3D images in real-time, is discussed. This modular software project comprises two main parts: a user part (without programming expertise) and a programming part which permits its adaptation to specific problems. VoxeLine has the ability to deal with almost all sorts of data types encountered in the biomedical field (e.g. images, vectors). Another important feature is its ability to show datasets in all directions without duplicating data into the main memory. This feature allows VoxeLine to be used on machines with limited memory capacities and power. Real-time 3D manipulations (10 Hz for a 256 x 256 x 124 MRI dataset) are possible on a classic monoprocessor architecture such as a personal computer.

Color↗

PubMed2000

Identifying the proteome: software tools.

The interest in proteomics has recently increased dramatically and proteomic methods are now applied to many problems in cell biology. The method of choice in proteomics for identifying and characterizing proteins is mass spectrometry combined with database searching. Software tools have been improved to increase the sensitivity of protein identification and methods for evaluating the search results have been incorporated

Databases, Factual↗

PubMed2000

BIOPLAN: software for the biological evaluation of. Radiotherapy treatment plans.

Distributions of absorbed dose do not provide information on the biological response of tissues (either tumor or organs at risk [OAR]) to irradiation. BIOPLAN (BiOlogical evaluation of PLANs) has been conceived and developed as a PC-based user-friendly software that allows the user to evaluate a treatment plan from the (more objective) point of view of the biological response of the irradiated tissues, and at the same time, provides flexibility in the use of models and parameters. It requires information on dose-volume histograms (DVHs) and can accept a number of different formats (including DVH files from commercial treatment planning systems). BIOPLAN provides a variety of tools, such as tumor control probability (TCP) calculations (using the Poisson model), normal tissue complication probability (NTCP) calculations (using either the Lyman-Kutcher-Burman or the relative seriality models), the ATCP method, DVH subtraction, plots of NTCP/TCP as a function of prescription dose, tumor and OAR dose statistics, equivalent uniform dose (EUD), individualized dose prescription, and parametric sensitivity analysis of the TCP/NTCP models employed.

Humans↗

PubMed2001

TRITON: graphic software for rational engineering of enzymes.

Engineering of the catalytic properties of enzymes requires knowledge about amino acid residues interacting with the transition state of the substrate. TRITON is a graphic software package for modelling enzymatic reactions for the analysis of essential interactions between the enzyme and its substrate and for in silico construction of protein mutants. The reactions are modelled using semi-empirical quantum-mechanic methods and the protein mutants are constructed by homology modelling. The users are guided through the calculation and data analysis by wizards.

Enzymes↗

PubMed2001

GPMAW--a software tool for analyzing proteins and peptides.

General Protein/Mass Analysis for Windows (GPMAW) is a valuable piece of software for any molecular biologist, biochemist or mass spectrometrist wishing to analyze protein or peptide sequences. All steps from the acquisition of protein sequence from a built-in web interface, to proteolytic digests, theoretical peptide fragmentation, detailed annotation of sequences and secondary structure prediction, can be performed rapidly and intuitively without first having to spend days reading manuals.

Amino Acid Sequence↗

PubMed2004

Pandemic influenza planning: using the U.S. Centers for Disease Control FluAid Software for small area estimation in the Canadian context.

PURPOSE: The U.S. Centers for Disease Control and Prevention (CDC) developed software (FluAid 2.0) to provide estimates of pandemic impact (deaths, hospitalizations, and outpatient visits). We wished to develop inputs for Alberta, Canada to use in place of program default values. We also wished to examine how FluAid output could be better contextualized for local users. METHODS: We developed distributions for age and age-sex specific proportions of population in groups at high risk of influenza complications for Alberta, Canada. In addition, we developed interpandemic influenza rates for Alberta, Canada. We used FluAid with this local data to obtain estimations of both pandemic and interpandemic impacts of influenza. The ratio of these impacts presents a context for understanding the FluAid outputs. RESULTS: There were differences in both the pattern and the magnitude of the Alberta rates from the FluAid defaults. For a pandemic estimate at a 25% attack rate (most likely) compared to an interpandemic year, the pandemic would result in 3.7 times as many outpatient visits, 3.9 times as many hospitalizations and 8.2 times as many deaths. CONCLUSIONS: We recommend that health service planners who use FluAid develop estimates for interpandemic influenza to provide crucial contextual information for pandemic planning.

Adolescent↗

PubMed2004

A software application for multiattribute utility models.

RATIONALE AND OBJECTIVES: A software application for the building of preference-weighted quality of life instruments was constructed. The purpose of this application is to make the process of building such instruments with multiattribute utility (MAU) methods more accessible to physician investigators. Our application, "multiattribute outcomes evaluator" or "MOE," could facilitate the use of such methods for constructing disease-specific instruments for assessing the cost-effectiveness of new treatments. MOE could also be useful for building outcomes measures that are intended to aid individual decision making, assessment of patient satisfaction with care, or measuring of multiattribute outcomes that do not need to be scaled for cost-effectiveness analysis. MATERIALS AND METHODS: MOE was programmed in Visual Basic and runs atop a Microsoft Access data base. Data from groups or individuals can be stored, and valuations of health states can be performed using standard gambles and rating scale methods. Solutions to MAU models with multiplicative or additive utility independence are possible with this application. RESULTS: Initial tests of the program algorithms have been successful. CONCLUSION: We anticipate The MOE approach to MAU modeling will be a useful tool for health services researchers.

Humans↗

PubMed2003

COMPARE radiology: creating an interactive Web-based training program for radiology with multimedia authoring software.

RATIONALE AND OBJECTIVES: Computer-based training has two primary benefits: Content can be presented interactively, and students can choose the time, place, and pace of learning. As a subject of medical education, radiology lends itself particularly well to computer-based training because of its highly visual content. To improve the efficiency of radiology training at their institution, the authors decided to create an interactive Web-based training site. MATERIALS AND METHODS: Working with a group of medical students knowledgeable in multimedia authoring, the authors used authoring software to create "COMPARE Radiology," an interactive training program that follows the modality-based structure of the undergraduate curriculum for radiology at the University of Erlangen-Nuremberg, Erlangen, Germany, and at medical schools worldwide. RESULTS: The Web-based program offers cases and exercises in radiographic anatomy at different selectable levels of difficulty, allowing users to test and build their knowledge of radiology. Pathologic images are initially presented without any further information. Additional information (patient history, laboratory results, reports from other imaging studies, and normal images for comparison) can be retrieved selectively and successively. Further information regarding the diagnosis and pathologic findings can be found by following links to external Web sites. The COMPARE Radiology program content is extended and updated regularly. The program is subject to internal peer review and can be evaluated by the user online. CONCLUSION: The authors' experience shows that a highly interactive Web-based training program for radiology, tailored to the requirements of the target group, can be developed economically by a team of medical students using an advanced storing system, with the guidance of a radiologist and without the help of professionally trained computer experts.

Computer-Assisted Instruction↗

PubMed2002

Development of perfusion CT software for personal computers.

RATIONALE AND OBJECTIVES: The authors developed software for creating quantitative maps of arterial and portal perfusion in the upper abdominal organs on personal computers. The image quality of these perfusion computed tomographic (CT) images was visually evaluated. MATERIALS AND METHODS: In 58 patients (38 men, 20 women; mean age, 63.9 years +/- 11.9; range, 22-85 years) with various diseases of the upper abdomen, 91 single-section dynamic CT studies were obtained. The data were transferred on-line to a personal computer, and quantitative maps of arterial and portal perfusion were created by means of the maximum-slope method. Perfusion CT images were reviewed by a radiologist and a radiation technologist, and image quality was rated according to a four-category scoring system (1 = good quality, 2 = moderate, 3 = poor, 4 = images could not be created). RESULTS: Arterial perfusion CT images could be created in 81 (89%) of 91 examinations, and 74 images (81%) were scored as 1 or 2. Portal perfusion CT images could be created in 60 (68%) of 88 examinations, in which a portal trunk was included in the section, and 33 of them (38%) were scored as 1 or 2. Patient motion during dynamic CT sequences resulted in poor image quality in seven arterial and 27 portal perfusion images. CONCLUSION: Perfusion CT can combine quantitative perfusion maps with good anatomic detail in one image, although patient movement frequently degrades image quality in portal perfusion CT.

Abdomen↗

PubMed2003

CT-based surgical planning software improves the accuracy of total hip replacement preoperative planning.

The present study is aimed to compare accuracy and the repeatability in planning total hip replacements with the conventional templates on radiographs to that attainable on the same clinical cases when using CT-based planning software. The sizes of the cementless components planned with new computer aided preoperative planning system called Hip-Op and with standard templates were compared to those effectively implanted. The study group intentionally included only difficult clinical cases. The most common aetiology was congenital dysplasia of hip (65.6%). The Hip-Op planning system allowed the surgeons to obtain a preoperative planning more accurate than with templates, especially for the socket. Assuming correct a size planned one calliper above or below that implanted the accuracy increased from 83% for the stem and 69% for the socket when using templates to 86% for the stem and 93% for the socket when using the Hip-Op system. The repeatability of the Hip-Op system was found comparable to that of the template procedure, which is much more familiar to the surgeons. Furthermore, the repeatability of the preoperative planning with the Hip-Op system was consistent between surgeons, independently from their major or minor experience. The study clearly shows the advantages of a three-dimensional computer-based preoperative planning over the traditional template planning, especially when deformed anatomies are involved. The surgical planning performed with the Hip-Op system is accurate and repeatable, especially for the socket and for less experienced surgeons.

Arthroplasty, Replacement, Hip↗