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[Clinical evaluation of the amalagam restorations for cavities Class I and Class II. 3: Comparison between dental school and dental institutions in the community].

Comparison of conventional amalgam restorations produced either in dental college by students or in out-patient department showed that the portion of clinical acceptable restorations was higher at the college. The frequency of secondary caries was distinctively higher in the out-patient department (28.2%) than in the college (16.4%). Secondary caries mainly caused unacceptable quality of fillings of both the institutions. Causes brought about by material defect prevailed at the dental school. In the community errors of preparation mainly led to secondary caries.

Dental Amalgam↗

[Clinical evaluation of amalgam restorations for Class I cavities and Class II. Part II: Cause analysis of unacceptable restorations].

627 not acceptable amalgam restorations using conventional alloy were investigated. Main failure was the secondary caries (60%) which was caused more by failures of preparations than by failures of material. New caries led to replacement of fillings in 16%. Fractures of restorations (13%) and unacceptable forms of fillings (9%) had a relative important position. The clinicians can influence 75 percent of the causes. With regard to material improvement, the results are discussed to avoid failures in therapy.

Dental Amalgam↗

Regulation of antibody response in different immunoglobulin classes. V. Establishment of T hybrid cell line secreting IgE class-specific suppressor factor.

Establishment of a mouse T hybrid cell line secreting suppressor factor(s) specific for the IgE antibody response is described. Fusion was made with polyethyleneglycol between AKR-derived T lymphoma cells (BW5147) and T cells from mice sensitized with DNP-Mycobacterium. Treatment of spleen cells with nondialyzable factor(s) in the culture supernatants of the T cell hybrid clone, 26-M10, showed a suppressive effect on IgE formation but not on IgG formation in adoptive transfer experiments. The suppressive effect was exerted through inactivation of normal or antigen-primed B cells responsible for IgE formation. It was also shown by direct cytotoxic test that the hybrid cells expressed H-2 and Thy-1 antigens derived from both parental cells on their surface. Karyotype analysis of the hybrid cells revealed that the number of chromosomes was less than the sum of the two parental cells' and the average was 50 (45 to 55). Although the 26-M10 hybrid cells lost the ability to secrete active suppressive factor(s) into culture medium 21 weeks after hybridization when the number of chromosomes in most of the cells was less than 41, recloning of the 26-M10 cells successfully recovered active suppressive clones.

Animals↗

Role of class I and class II HLA antigens in cadaveric renal transplantation.

HLA matching at MT and DQ appears to be an important predictor of allograft survival. Allografts with no MM at MT and DQ have a good outcome while a known MM at MT and DQ appears to be associated with poor allograft outcome. Thus, our priority should be to avoid an MM for these broad-reacting specificities and then to minimize incompatibilities at DR and HLA-B. Furthermore, our data indicate that allografts with MM at DQ and two MMs at HLA-B appear to be at a higher risk. Perhaps these latter transplants should not be performed with conventional immunosuppressive therapy.

Cadaver↗