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PubMedDate not supplied

Interictal aggression in epilepsy: the Buss-Durkee Hostility Inventory.

Adult patients with left, right, or bilateral temporal lobe epilepsy or absence epilepsy, and normal controls completed the Buss-Durkee Hostility Inventory (BDHI), a standardized questionnaire of aggressive tendencies. Patients with left temporal lobe seizure foci scores higher on the Suspicion scale than did other patients or controls (p < 0.05). Factor analysis scale scores identified three factors: hostile feelings, covert aggression, and overt aggression. The groups differed on their pattern of factor scores (p < 0.01): patients with left temporal lobe epilepsy scored higher than other groups on hostile feelings, normal controls scored higher on Covert aggression, and bitemporal patients scores higher on Overt aggression. Patients with absence seizures did not differ from controls. Lateralization of the seizure focus in patients with temporal lobe epilepsy may alter expression of aggressive behavior.

Adult↗

PubMed1991

Aggressive and nonaggressive behavior as a function of alcohol intoxication and frustration in women.

An experiment tested whether alcohol increases aggression in women in a situation in which both an aggressive and a nonaggressive response alternative of equal instrumentality and of equal variability are available. Subjects were assigned to one of three groups, namely, an alcohol, a placebo, or a control group. The alcohol dose was 1.0 ml of pure alcohol/kg body weight. After drinking their respective drink, subjects were instructed to supervise a bogus partner on a visual scan test over a series of trials. Each time this partner made a mistake, subjects could either give an uncomfortable electric shock (scale 1 to 10) or a comfortable vibration (scale 1 to 10) to the partner. Aggressive and nonaggressive behavior was measured as numbers, intensities, and durations of shocks or vibrations, respectively. Neither alcohol nor frustration differentiated the groups on aggressive or nonaggressive behavior. All groups were significantly more inclined to use the nonaggressive alternative irrespective of alcohol dose and level of frustration. In conclusion it was stated that women do not increase their aggression as a function of alcohol in a situation with more than one response alternative available. The need to incorporate gender differences as to aggressive effects of alcohol was stressed.

Adult↗

PubMed2006

Sleep apnea as a possible factor contributing to aggression in sex offenders.

Sleep disorders, such as obstructive sleep apnea (OSA), are often unrecognized and undertreated. A disruption in normal sleep may be associated with increased irritability and aggression. To elucidate further the impact of OSA on hostility of forensic patients, we performed a retrospective chart review of 10 consecutive outpatient sex offenders who were diagnosed with OSA and treated with continuous positive airway pressure (CPAP). The Buss-Perry Aggression Questionnaire was compared pre- and posttreatment. Following treatment, the total Buss-Perry score was significantly lower, with lower scores on the anger, physical aggression, hostility, and verbal aggression subscales. These results suggest that in sex offenders suffering from OSA, aggression and hostility may be significantly reduced through CPAP treatment. Further investigation is required to investigate if reducing aggression and hostility in this manner impacts recidivism and overall functioning.

Adult↗

PubMed1987

Staff observation aggression scale, SOAS: presentation and evaluation.

A new psychiatric report and rating scale assessing severity and frequency of aggressive behaviour is presented and evaluated. It is based on the staff's standardized reports of aggressive incidents. By using a special aggression report form, comprehensive and standardized information is obtained, thereby permitting scoring and further analysis of different aspects of aggressive incidents. The reliability of scoring is tested and found to be good as is the scale's capacity to discriminate between different patterns of aggressive behaviour in different groups of patients. As a result of this and because of the simplicity of the scale, it is thought to be a potentially useful tool in scientific research on aggressive behaviour from psychiatric inpatients.

Adult↗

PubMed1988

Influence of child-rearing on aggressive behavior in a transcultural perspective.

The aim of this paper is to summarize the literature and exemplify the author's research findings concerning the influence of different systems of child-rearing across cultures on aggressive behavior by using an individual-environment interaction approach. The question is whether a restrictive environment (e.g., China), foster children with lower levels of and less variation in aggression than children in a more permissive environment (e.g., Sweden). The main results involve 290 primary school children, mean age 10.3, their mothers and teachers in Beijing. The children showed distinct individual differences in aggression, though at a lower level and with less variation than Scandinavian children. Aggression was meaningfully related to other selfreport dimensions, such as positive attitude to school and negative relations with parents, findings similar to those in the Western literature. In line with the literature, sex differences in terms of aggression was also found among the Chinese children, namely, that girls seem better able to control aggression than boys. Chinese mothers in comparison to Swedish mothers, seemed to be more in control of their children. Children preferred their mothers, shame was the most frequent disciplinary method used, followed by reasoning. Both parents made decisions concerning the child. Finally, theoretical and practical implications are concluded in the paper.

Aggression↗

PubMed1995

Citalopram, a selective serotonin reuptake inhibitor, in the treatment of aggression in schizophrenia.

The aim of this double-blind cross-over study was to investigate whether treatment with the selective serotonin reuptake inhibitor, citalopram reduces aggressiveness in chronically violent schizophrenic inpatients. Initially 19 patients were enrolled into this double-blind cross-over study in which the patients were treated for 24 weeks with placebo and 24 weeks with citalopram (20-60 mg/day) as a supplement to their previous neuroleptic medication. Fourteen patients completed the entire study, but sufficient data on 15 patients could be used in the end-point analysis of efficacy. Psychiatric assessments (Brief Psychiatric Rating Scale, Clinical Global Impression Scale for Severity of Illness, Social Dysfunction and Aggression Scale and the Global Aggression Scale) and side effects (UKU Side Effect Scale) were recorded at baseline and 4 times during both periods. Aggressive incidents (Staff Observation Aggression Scale) were recorded throughout the study. During citalopram treatment, the frequency of aggressive incidents was significantly lower and the mental state did not deteriorate. Patients either experienced no side effects or else side effects were equally mild during both periods.

Adolescent↗

PubMed1998

Anxiety and increased aggression as pacemakers of depression.

The concept of a serotonin (5-HT)-related, anxiety and/or aggression-driven, stressor-precipitated depression is formulated and discussed. The serotonergic disturbances found in some depressed individuals, particularly those with lowered CSF 5-HIAA, are linked to the anxiety and aggression components of the depressive syndrome. In this type of depression, called 5-HT-related depression, dysregulation of anxiety and/or aggression is hypothesized to be primordial and mood-lowering is a derivative phenomenon. In other words, this is a group of anxiety/aggression-driven depressions. The author submits that the serotonergic impairment in certain types of depression is a trait phenomenon, i.e. it persists during remission. This disturbance makes the individual susceptible to perturbation of anxiety and aggression regulation. Anxiety and (overt or suppressed) anger are core constituents of the stress syndrome. Thus the serotonergic disturbance will induce a heightend sensitivity to stressful events, i.e. the latter will induce stress phenomena, including anxiety and anger, more readily than normal. The latter psychological features induce lowering of mood, and thus 'drive' the patient into a full-blown depression. Furthermore, it is predicted that anxiolytics and serenics (i.e. anti-aggressive drugs) that act via normalization of serotonergic circuits will exert an antidepressant effect in 5-HT related depression, in addition to their therapeutic actions in anxiety disorders and states of increased aggressiveness, respectively. The exact nature of the serotonergic impairment in 5-HT-related depression has yet to be elucidated.

Affect↗

PubMed2004

Aggression and arginine vasopressin immunoreactivity regulation by androgen receptor and estrogen receptor alpha.

In the following study, we asked which steroid receptors regulate aggression and arginine vasopressin (AVP) immunoreactivity (-ir) in several limbic regions. Using spontaneous mutant and knockout mice, we generated a novel cross of mice whose offspring lacked estrogen receptor alpha (ER alpha), androgen receptor (AR) or both ER alpha and AR. The wild-type (WT) males and females were compared with ER alpha knockout (ER alphaKO) male, mutated AR (Tfm) male and ER alphaKO/Tfm (double knockout; DKO) male littermates. Animals were gonadectomized and treated with 17beta-estradiol (E2) prior to resident-intruder aggression tests. WT and Tfm males showed aggression whereas WT females, ER alphaKO and DKO males did not. In the lateral septum, WT and Tfm male brains had significantly denser AVP-ir as compared with WT females and DKO males. ER alphaKO male brains were intermediate in the amount of AVP-ir present. In the medial amygdala, brains from all genotypes had equivalent AVP-ir, except DKO males, which had significantly less AVP-ir. Overall, the expression of aggressive behavior coincided with AVP-ir in WT, Tfm and DKO males. However, in ER alphaKO males and WT females, the amount of AVP-ir was not associated with resident-intruder aggression. In sum we have shown that E2 acts via ER alpha to regulate aggression in male mice. In contrast both ER alpha and AR contribute to AVP-ir in limbic brain regions.

Aggression↗

PubMed1998

Pupil-class determinants of aggressive and victim behaviour in pupils.

BACKGROUND: Aggressive behaviour in pupils is expressed in, e.g., bullying, sexual harassment, and violence. Different kinds of variables could be relevant in explaining a pupil's aggressive or victim behaviour. AIMS: To develop a multilevel theoretical and empirical explanation for different kinds of aggressive and victim behaviour displayed by pupils in a classroom and school environment. SAMPLES: A national survey was carried out to identify different kinds of aggressive and victim behaviour displayed by pupils and to assess other variables related to pupils, classes, and schools. A total of 1998 pupils from 100 third and fourth year classes attending 71 different secondary schools took part in the research. METHODS: Data were analysed by a series of secondary multilevel analyses using the MLA-program. RESULTS: Being a boy, being more extravert, being more disagreeable, coming across fewer teachers with positive teaching behaviour, and attending a lower type of secondary school, help explain why someone is a perpetrator as such. Being a boy, being more disagreeable, being more emotionally unstable, being open to new ideas, and seeing more teachers as being strict, function as explanatory pupil variables for victim behaviour. Other pupil level variables determine more specific aggressive and victim behaviour aspects. Various other class level and school level variables are relevant, too. CONCLUSIONS: Personal and environmental pupil variables are more important than class variables but class variables are in turn more important than school variables in explaining a pupil's aggressive and victim behaviour.

Aggression↗

PubMed1991

The influence of testosterone on human aggression.

Animal studies show clear evidence for a causal link between testosterone and aggression. This review assesses studies involving androgens, principally testosterone, and human aggression. Evidence for a possible effect of prenatal androgens is inconclusive. In adults, higher testosterone levels are found in groups selected for high levels of aggressiveness. Correlations between testosterone and aggression were low when hostility inventories were used, but higher (r = .38) when aggressiveness was rated by others. Regression analysis data and studies of boys at puberty were inconclusive. Other studies show that the outcome of aggressive and competitive encounters can alter testosterone levels, thus confounding interpretation of the correlational evidence. The design of future studies to reveal evidence of a causal link is considered. Suggestions concerning two important methodological problems, the experimental manipulation of hormone levels and the nature of the dependent variable, are made.

Aggression↗

PubMed1981

Sex differences in the aggressive behaviour of schoolchildren.

An observational study was carried out to investigate whether sex differences in aggression, found in pre-school children in free-play situations, would also be found at older ages in the classroom. Equal numbers of boys and girls, aged 6 and 11 years, were observed individually in their school classrooms for eight 5 min periods, carried out over several weeks. At 11 years of age, boys showed more physical aggression than girls, a finding which resulted from a few boys showing higher scores than the remaining boys and the girls; girls showed more verbal aggression. These sex differences were not found at 6 years of age. At both ages, there was a higher proportion of same-sex than opposite-sex encounters. These results are discussed in terms of the generality of sex differences in aggression, the possibility of a sex difference in the form of aggressive acts, and the sex of the recipient of aggression.

Age Factors↗

PubMed1992

Psychoanalytic views of aggression: some theoretical problems.

Various problems in relation to psychoanalytic theories of aggression are considered in a review which is by no means exhaustive but includes areas which have puzzled and interested the author. First to be considered is why the concept of aggression as a major drive was a relative late-comer in psychoanalysis; next the contentious concept of a 'death instinct' and some of the factors in Freud's lifetime which may have contributed to both. Then it is suggested that we seem to have theories of aggression which might be called primary or secondary in two different senses. First is the question whether aggression is innate or secondary to frustration. In another sense, primary and secondary theories of aggression seem to survive paralleling Freud's original primary and secondary theories of anxiety. In this sense the primary theory survives as an explanation of psychosomatic disorder. Lastly, the link between suicide and murder is considered and the turning of aggression against the self in depression and self-destructive attacks.

Aggression↗

PubMed2004

Novel insect picorna-like virus identified in the brains of aggressive worker honeybees.

To identify candidate genes involved in the aggressive behavior of worker honeybees, we used the differential display method to search for RNAs exclusively detected in the brains of aggressive workers that had attacked a hornet. We identified a novel, 10,152-nucleotide RNA, termed Kakugo RNA. Kakugo RNA encodes a protein of 2,893 amino acid residues that shares structural features and sequence similarities with various picorna-like virus polyproteins, especially those from sacbrood virus, which infects honeybees. The Kakugo protein contains several domains that correspond to the virion protein, helicase, protease, and RNA-dependent RNA polymerase domains of various picorna-like virus polyproteins. When the worker bee tissue lysate was subjected to sucrose density gradient centrifugation, Kakugo RNA, except for the material at the bottom, was separated into two major peaks. One of the peaks corresponded to the position of Kakugo mRNA, and the other corresponded to the position of the poliovirus virion. These results suggest that the Kakugo RNA exists as an mRNA-like free RNA and virion RNA in the honeybee. Furthermore, injection of the lysate supernatant from the attacker heads into the heads of noninfected bees resulted in a marked increase in Kakugo RNA. These results demonstrate that Kakugo RNA is a plus-strand RNA of a novel picorna-like virus and that the brains of aggressive workers are infected by this novel virus. Kakugo RNA was detected in aggressive workers but not in nurse bees or foragers. In aggressive workers, Kakugo RNA was detected in the brain but not in the thorax or abdomen, indicating a close relation between viral infection in the brain and aggressive worker behaviors.

Aggression↗

PubMed1998

Hemispheric control of territorial aggression in Anolis carolinensis: effects of mild stress.

Previous work has demonstrated that the brain of Anolis carolinensis is functionally split, in that the left and right eyes project predominantly to the contralateral hemisphere, and as there are minimal connections between the left and right hemispheres. Using this model, the current experiment examined the effect of mild acute stress on hemispheric regulation of territorial aggression. Thirteen adult male Anolis were paired with an antagonistic males, and eye use and behavioral responses were repeatedly measured during 3 minute behavioral trials. Trials were conducted either after exposure to mild stress, produced by handling the subject, or without stress, and they were run either in the subject's home cage or in a cage foreign to the subject. Left eye preference for aggressive movements was found during the trials run in the non-stressed conditions (p < 0.05). Conversely, stressed subjects showed a reduction in left eye/right hemisphere mediated aggressive movements relative to the non-stressed subjects but no changes in right eye/left hemisphere aggression. This effect was independent of whether or not the subject was in its home or a foreign cage. No laterality in aggressive responding was found when the subjects were placed in separate cages with visual contact. These findings suggest that territorial aggression in Anolis is preferentially initiated and processed by the left eye/right hemisphere but is subject to right-hemispheric inhibition following exposure to acute mild stress.

Aggression↗

PubMed2006

Cerebral lateralization and its relationship to phylogeny and aggression in anabantoid fishes.

We examined the relationship between aggression and cerebral lateralization, as expressed by eye-use preference in a mirror-response paradigm, in six species of anabantoid fishes in the teleost family Belontiidae. Our objective was to test the hypothesis that frequency-dependent selection should decrease lateralization at the population level in more aggressive species. The mean laterality index did not differ significantly among the six species, nor did any of the species differ from zero, which suggests that populations of these fishes are neither left- nor right-eye biased. In spite of species differences in aggressive behavior, there was no relationship between population-level laterality and aggression as we had originally predicted. The degree of individual lateralization did differ significantly among some species. A phylogenetic generalized least squares (PGLS) analysis showed that these species differences were not due to phylogenetic distance. Individual laterality was also unrelated to aggression. Fishes in the genus Betta were the most individually lateralized, but varied in the intensity of aggressive behavior they displayed toward the mirrors. Taxa such as paradise fish (Macropodus opercularis and Pseudosphromenus dayi) were intermediate in eye-use preferences and gourami (Trichogaster trichopterus) displayed little cerebral lateralization. We also used the PGLS method to reconstruct ancestral values for individual lateralization in this group of fishes, from which we conclude that the ancestral condition was one of low variance in eye-use preference.

Aggression↗

PubMed1981

Psychopharmacology of aggression: an overview.

Aggression is not a single unitary behavioral entity, then it is impossible to find a single drug showing "specific' and "universal' antiaggressive efficacy and potency. Furthermore, spontaneous aggression is essential to the self-and species preservation, and plays an important role in the process of evolution. In contrast, aggressiveness induced by prolonged socioenvironmental deprivation or isolation, raises the feature of anomalous behavior. The effect of drugs on aggressive behavior must therefore be considered in the light of this distinction, that accounts for discrepancies between the results of literature on "antiaggressive' properties and potency of psychoactive drugs. In addition, and impaired inhibitory control of the brain may be responsible for violent aggression and drugs capable of restoring such control may prove useful in managing the pathology of aggressiveness.

Aggression↗

PubMed1995

Cerebral glucose metabolism, CSF 5-HIAA levels, and aggressive behavior in rhesus monkeys.

OBJECTIVE: Considerable evidence suggests that low concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in CSF are associated with a history of aggressive behavior in both human and nonhuman primates. The purpose of this investigation was to examine the relationships among CSF 5-HIAA concentration, history of aggressive behavior, and cerebral glucose metabolism in a group of nonhuman primates whose CSF 5-HIAA had been sampled several times over the preceding 2 years and whose social behavior had been observed since birth. METHOD: The subjects were nine adult male rhesus monkeys studied under isoflurane anesthesia. Cerebral glucose utilization was measured by [18F]fluorodeoxyglucose positron emission tomography. Aggressiveness ratings were made by a primatologist who had had frequent contact with the animals over several years. RESULTS: There was a significant negative correlation between ratings of aggressive behavior and CSF 5-HIAA concentrations. There was also a negative correlation between the dose of pentobarbital required to induce anesthesia and level of CSF 5-HIAA. Moreover, there were significant negative correlations between CSF 5-HIAA levels and both whole brain glucose utilization and regional glucose utilization in the orbital-frontal cortex. CONCLUSIONS: These results suggest that both increased aggressiveness and low concentrations of CSF 5-HIAA are associated with higher brain glucose metabolism in rhesus monkeys under standardized anesthesia. Aggressive nonhuman primates with low CSF 5-HIAA concentrations may have "innate" tolerance toward functional gamma-aminobutyric acid A receptor agonists such as pentobarbital, isoflurane, and possibly alcohol.

Aggression↗

PubMed1999

Intramuscular flunitrazepam versus intramuscular haloperidol in the emergency treatment of aggressive psychotic behavior.

OBJECTIVE: The authors examined the efficacy of intramuscular flunitrazepam compared with intramuscular haloperidol for the immediate control of agitated or aggressive behavior in acutely psychotic patients. METHOD: Twenty-eight actively psychotic inpatients, aged 20-60 years, who were under treatment with neuroleptic agents were selected for the study. Each was randomly assigned on a double-blind basis to receive either 5 mg i.m. of haloperidol (N=13) or 1 mg i.m. of flunitrazepam (N=15) during an aggressive event. Verbal and physical aggression was measured over time with the Overt Aggression Scale. Patients were also rated with the Brief Psychiatric Rating Scale and the Clinical Global Impression scale. RESULTS: Both flunitrazepam and haloperidol exhibited acute antiaggressive activity. This beneficial effect, as assessed by the Overt Aggression Scale, was obtained within 30 minutes. CONCLUSIONS: Intramuscular flunitrazepam may serve as a convenient, rapid, safe, and effective adjunct to neuroleptics in reducing aggressive behavior in emergency psychiatric settings.

Acute Disease↗