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At least 1,531 records · Page 85Linked to original sources
PubMed2006

The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats.

NPY is one of the most abundantly expressed peptides within the CNS, and has been previously demonstrated to be altered in several animal models of depression, as well as to be differentially regulated by acute and repeated stress. The effect of social deprivation, through isolation housing, on brain NPY concentrations in adult rats has not been previously investigated. The effects of 12 weeks of social isolation, in adult rats, on anxiety-related behaviors and central concentrations of NPY in: hypothalamus, amygdala, caudate-putamen, hippocampus, and frontal cortex were evaluated. Single housed animals spent significantly more time on the open arms of the elevated plus maze and in the central area of the open field as compared to pair housed controls. These data are most likely indicative of enhanced exploration and novelty seeking. Concentrations of neuropeptide Y were increased in the caudate-putamen of the single housed subjects. NPY levels in caudate/putamen and hypothalamus were also significantly correlated with time spent in the open arms of the elevated plus maze. These data suggest that chronic social isolation, in these adult Wistar rats, did not increase anxiety but produced enhanced exploration in tests of anxiety, an effect that was associated with NPY concentrations in the striatum and hypothalamus.

Animals↗
PubMed1992

Age and sex as factors influencing spontaneous exploration and object investigation by preadult rats (Rattus norvegicus).

This study examined developmental and sex differences in the exploratory and investigatory behaviors of Long-Evans rats (Rattus norvegicus). Littermate sextuplets were divided into sex-matched groups (at 30, 60, and 90 days of age) and were individually videotaped on 2 consecutive nights in an arena that contained stimulus objects. Multiple measures of locomotor exploration and object investigation increased significantly with age but were not influenced by sex. Older rats entered more quickly, were more active, spent more time in the arena, and spent more time investigating inanimate stimulus objects than did younger rats. Sex did not significantly affect most measures of open-field behavior; however, the data suggest that the sexes may begin to diverge by 90 days. These results suggest that preadult rats of both sexes are equipped early in development with similar strategies and repertoires for exploration and investigation.

Age Factors↗
PubMedDate not supplied

[Interhemispheric asymmetry of the exploratory and emotional characteristics of rat behavior in the open field].

Interhemispheric asymmetry of motor activity as well as of emotional and investigating behaviour of male and female rats was studied in the open field. With this purpose during 1 hour the number of square intersections, raising to hinds and peeping into the holes as well as the number of defecations and urination was recorded in intact rats and rats with unilateral decortication. Inactivation of the hemispheres was carried out by means of potassium spreading depression. In male rats, in the first minutes of the exposition and in the second part of the session the left hemisphere dominated during motor and investigating activities. In female rats in the second part of the experiments the right hemisphere dominated. For emotional reactivity the left hemisphere dominated in male rats.

Animals↗
PubMed1984

Congressional voting behavior on hospital legislation: an exploratory study.

This paper analyzes Congressional voting behavior on the Gephardt Amendment to President Carter's hospital cost containment legislation. The impact of opposing interest groups is examined: on one side were hospital and medical interest groups; on the other was the Carter Administration and its political party, as well as states with large Medicaid expenditures. The effect of political contributions from MEDPACs is evaluated, and the relative importance of various factors affecting the vote's outcome is analyzed.

Cost Control↗
PubMedDate not supplied

Nursing behaviors in bereavement: an exploratory study.

Twenty-five pairs of terminally ill patients and their loved ones were studied to determine nursing behaviors which offer greatest support, comfort, and ease of suffering to the loved ones. The Q-sort methodology, consisting of 88 cards, each with one behavior, was used. A three-tier classification of behaviors was derived: those that promote the dying patient's comfort and hygiene; those that indicate understanding of the emotional needs of the dying patient; and those that indicate understanding of the impact on the bereaved of grief, grieving, and loss. The most-desired behaviors pertained to the patient, and the most-desired behavior of the total group was to "keep the patient well groomed." The least-desired behavior (ranked 88th) was to "encourage me to cry."

Adult↗
PubMed1990

Exploratory cluster analysis of behavioral risks for chronic disease and injury: implications for tailoring health promotion services.

Identifying population subgroups with similar behavioral risks could assist in the social marketing of health promotion programs by providing target segments to whom services and outreach could be specifically matched. In this paper we describe an exploratory application of cluster analysis to health behavior data from a representative telephone sample of Michigan adults (n = 2,285). In addition to replication of the cluster solution through cross validation, we found significant between cluster demographic differences further confirming cluster validity. Demographic and risk profiles of four clusters are presented, and key health promotion services appropriate to each cluster are discussed. Although further research on the construct validity of the clusters is critical, we conclude that this approach can be useful in tailoring health promotion messages, materials, and services.

Adolescent↗
PubMed2003

Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior.

The serotonin transporter (5-HTT) regulates serotonergic neurotransmission via clearance of extracellular serotonin. Abnormalities in 5-HTT expression or function are found in mood and anxiety disorders, and the 5-HTT is a major target for antidepressants and anxiolytics. The 5-HTT is further implicated in the pathophysiology of these disorders by evidence that genetic variation in the promoter region of the HTT (SLC6A4) is associated with individual differences in anxiety and neural responses to fear. To further evaluate the role of the 5-HTT in anxiety, we employed a mouse model in which the 5-HTT gene (htt) was constitutively inactivated. 5-HTT -/- mice were characterized for anxiety-related behaviors using a battery of tests (elevated plus maze, light<-->dark exploration test, emergence test, and open field test). Male and female 5-HTT -/- mice showed robust phenotypic abnormalities as compared to +/+ littermates, suggestive of increased anxiety-like behavior and inhibited exploratory locomotion. The selective 5-HT(1A) receptor antagonist, WAY 100635 (0.05-0.3 mg/kg), produced a significant anxiolytic-like effect in the elevated plus maze in 5-HTT -/- mice, but not +/+ controls. The present findings demonstrate abnormal behavioral phenotypes in 5-HTT null mutant mice in tests for anxiety-like and exploratory behavior, and suggest a role for the 5-HT(1A) receptor in mediating these abnormalities. 5-HTT null mutant mice provide a model to investigate the role of the 5-HTT in mood and anxiety disorders.

Animals↗
PubMed2006

Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice.

Adolescence is characterized by behavioral traits such as emotional lability and impulsivity that are associated with increased vulnerability to affective illness and addictions. Research in rodents has found that adolescent rats and mice differ from adults on measures of anxiety-like behavior, novelty seeking and stress-responsivity. The present study sought to extend these data by evaluating fear-, anxiety- and depression-related behaviors in male C57BL/6J mice aged four (early adolescent), six (peri-adolescent) or eight (early adult) weeks of age. Age groups were compared on: Pavlovian fear conditioning and extinction, anxiety-like behavior and exploratory locomotion (using elevated plus-maze and novel open field), and depression-related behavior (via forced swim test). Results showed that early adolescent mice exhibited enhanced fear conditioning, but extinguished at a similar rate as adults. There were no major differences in anxiety-like behavior across age groups, although early adolescent and peri-adolescent mice exhibited less exploratory locomotion than adults. Depression-related immobility behavior in the forced swim test was lower in early adolescents than adult mice across three test exposures. Present findings in the C57BL/6J inbred strain add to growing evidence of changes in rodent fear- and stress-related behaviors across the developmental transition from juvenility through adulthood. Understanding the neural basis of these ontogenic changes could provide insight into the pathogenesis and treatment of affective disorders that have their origins in adolescence.

Age Factors↗
PubMed2003

An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross.

To explore the genetic dimensions of the stress response in rodents, we tested 12 inbred strains of mice and an F2 intercross (n=745) on the Tail Suspension Test (TST) and the Tail Suspension-Induced Hyperthermia (TSIH) paradigm. These selected 12 strains provide a representative sampling of the genetic heterogeneity of mousedom. An F2 intercross was derived from NMRI and 129S6 strains, which differ in their responses on the TST. Both inbred strains and F2 mice underwent a standardized protocol of automated TST with two sessions: (1) baseline and (2) imipramine TST. The duration of immobility and the body temperature after TST were recorded. The inbred strains were also tested in the Light-Dark Transition (LDT) test and in the Open Field Test (OFT), measuring the distance traveled, vertical movements, and center time as independent variables. The F2 mice were measured for core temperature after TST (TSIH). High intercorrelations among strain means were found for the LDT and OFT measures. Principal components analysis extracted four factors: "exploratory fear," body weight, imipramine response on immobility, and "stress reactivity." These dimensions were largely confirmed in the F2 population with one additional factor: imipramine response on TSIH. The results support a distinction between "stress reactivity" as measured by the TST and "exploratory fear" behavior as measured by the LDT and OFT.

Adrenergic Uptake Inhibitors↗