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PubMed1995

The effect of non-absorbable fat on energy and fat intake.

One of the main issues with respect to the usefulness of fat-replacers is their effectiveness. The question is whether or not people compensate for the "missing" energy due the replacement of fat by the fat-substitute. The present paper is concerned with the results of a number of studies carried out on the effects of the fat-replacer sucrose-polyester on food intake. Sucrose-polyester (SPE) is a substance with similar sensory and physical-chemical properties as fat, but it contains no metabolizable energy, because it is not digested in the human gastrointestinal tract. In the first two short-term studies, we replaced the fat by SPE in croissants. Thirty-three subjects in the first study and 34 subjects in the second study consumed 2 1/2 croissants, either with fat or SPE. After ingestion they rated subjective feeling of hunger, and recorded their ad libitum food intake. The results of both studies showed that the croissants with SPE had a similar satiating effect as the croissants with fat. In two subsequent short-term studies, we added either fat, SPE or water to warm meals served as lunch. The high water and high SPE lunches contained about 450 kcal, whereas the high fat lunches contained about 900 kcal. After ingestion of the lunches, subjects (39 in study 3; 35 in study 4) recorded their feelings of hunger. Two hours after the lunches, subjects were presented with an attractive buffet from which they could eat ad libitum. The results showed that hunger and food intake were similar after the water, SPE and fat lunches. The subjects did not detect the 450 kcal energy difference in the lunches. The last two studies with SPE lasted for 12 days. The results of these two longer-term studies were similar to the results of the short-term studies. There was little energy compensation and no fat compensation. It is concluded that fat replacers can be helpful in reducing fat and energy intake.

Adult↗

PubMed1996

Surface hardness of light-cured composite resin cured directly or through a transparent matrix using three different light guides.

The purpose of this study was to compare the Vickers Hardness (HV) of composite resin which was light-cured by 3 different light guides, either through or without a transparent polyester matrix band. The 3 light guides, standard Demetron (SG), Turbo Tip (TT) and a standard Demetron, with obvious accidental damage (DL) were tested with both Model 100 and Cure Rite radiometers. HV tests were done on all samples both immediately and one hour after light-curing. Results were analysed using the Anova and Student t-test. The light intensity readings in mW/cm2 were SG 600 and TT 850 with both radiometers and DL tested 350 and 380. Composite resin surfaces undergo significant surface hardening in the first hour after light-curing. A 350-380 mW/cm2 intensity gives significantly lower HV than 600 + mW/cm2 but 800 mW/cm2 does not produce significantly greater HV than 600 mW/cm2. Curing through a transparent polyester matrix gives marginally greater HV than curing directly. The output of light guides is a significant factor in the surface hardness of cured composite resin.

Analysis of Variance↗

PubMed1997

[Possibility of using saliva for therapeutic monitoring of digoxin].

Digoxin in salvia and blood serum of 24 patients obtained Bemecor was determined by the method of FPIA (IMx-ABBOT). Mixed saliva was collected by three different types of Salivette (Sarstedt) given in order: normal Salivette with cotton wool swab, Slivette with polyester wool and Salivette with citric acid as a stimulator. It was found, that the correletio between the digoxin concentrations in saliva and serum and saliva/serum rations depended on the type of Salivette. The highest correlation was obtained with the Salivette with polyester wool (r = 0.892), but low concentrations of this drug in serum were good reflected in all samples of saliva, independent on kind of Salivette.

Digoxin↗

PubMed2001

Comparison of materials used in frontalis suspension.

OBJECTIVE: To compare various materials used in frontalis suspension surgery for incidence of infection and/or granuloma formation and incidence of recurrent ptosis. DESIGN AND METHODS: A retrospective medical record analysis was performed for 102 frontalis suspension operations performed on 43 patients between January 1, 1991, and December 31, 1996, at Indiana University Medical Center, Indianapolis. Materials used for surgery were compared for incidence of infection and/or granuloma formation and incidence of recurrent ptosis. Materials included autogenous fascia lata, banked fascia lata, monofilament nylon, braided polyester, expanded polytetrafluoroethylene, and polypropylene. RESULTS: Infection and/or granuloma formation occurred in 10.8% of all frontalis suspensions and in less than 10.0% for each material used except expanded polytetrafluoroethylene. Five (45.5%) of the 11 frontalis suspensions using expanded polytetrafluoroethylene required removal of the material because of suspected infection. Ptosis recurred in 32 cases (31.4%). Low incidence of recurrence was found with autogenous fascia lata and expanded polytetrafluoroethylene. CONCLUSIONS: Of the materials compared in this study, autogenous fascia lata may be the material of choice for frontalis suspension surgery in congenital ptosis. Other materials are useful for temporary eyelid elevation. All materials carry the risk of potential infection and/or granuloma formation.

Adolescent↗

PubMed1989

Hemodynamic effects on endothelial cell monolayer detachment from vascular prostheses.

The establishment of an early blood-contacting endothelialized surface may improve the graft-host relationship. This study evaluated the adherence of indium 111-radiolabeled endothelial cells that were cultured to confluence on fibronectin-treated polyester elastomer (Hytrel) grafts that were perfused for two hours on a pulse duplicator apparatus under high- and low-shear conditions. Perfusate samples were serially assayed for radioactivity. After perfusion, grafts were sectioned into four segments and assayed for retained radioactivity. All graft segments were hematoxylin stained and examined under light microscopy for evaluation of cell density. Excellent endothelial cell adherence (90%) was observed under both hemodynamic conditions at 120 minutes, with most losses occurring within the first 15 minutes. No differences were seen between high- and low-shear conditions or proximal vs distal graft segments.

Animals↗

PubMed1996

Hydrolytic degradation of films prepared from blends of high and low molecular weight poly(DL-lactic acid)s.

Biodegradable films were prepared by casting acetone solutions of mixtures of a high molecular weight poly(DL-lactic acid) (HMW-PLA50) with 0, 10, and 30% w/w poly(DL-lactic acid) oligomers (LMW-PLA50), before drying. From size exclusion chromatography (SEC) it was shown that degradation occurred during film processing, in agreement with the acid-catalyzed degradation of polyesters. The higher the content of LMW-PLA50, the larger the decrease of the molar masses. The three selected film formulations were then allowed to age in isoosmolar 0.13M, pH 7.4 sodium phosphate buffer at 37 degrees C. The hydrolytic degradation was monitored by using various techniques, namely weighing to quantify water absorption and weight loss, SEC to evaluate molar mass changes, head space gas chromatography to assess the desorption of residual acetone, and enzymatic assay of the L-lactic acid released in the aging media. The presence of LMW-PLA50 clearly accelerated film degradation. Moreover, it was shown that the mechanism of degradation greatly depended on the content in the oligomers.

Absorption↗

PubMed1996

Neomembranes: a concept review with special reference to self-reinforced polyglycolide membranes.

Absorbable implants are being increasingly used in various fields of medicine. Important materials for these applications include the polyesters polylactide and polyglycolide. Following implantation of any absorbable device there occurs a proliferation of fibrous tissue, which along with material from the degrading implant forms a composite membranous structure-a neomembrane. Neomembranes can be exploited in guiding tissue regeneration. Success in this respect has been achieved in treatment of bone defects, nerve defects, and periodontal ligaments. Future research may ultimately permit taking advantage of neomembranes in the reconstruction of more complex organs such as the liver. Gaining an understanding of implant characteristics and implant-tissue interaction is essential for further progress in this area.

Animals↗

PubMed1997

Development of degradable polyesterurethanes for medical applications: in vitro and in vivo evaluations.

To evaluate the biocompatibility of a newly developed degradable class of polyesterurethanes and their possible use as biomaterials, we investigated the cell and tissue interactions with these polymers using a small number of chemical base entities. The polymers were prepared by chain extension with diisocyanates of PHB/HV-diol and either PCL-diol or Diorez, another aliphatic polyester-diol. Regardless of the chemical composition of the four tested polyesterurethanes used as substrates, no morphological difference was observed either in the macrophages (macrophage cell line J774) or in the fibroblasts (fibroblast cell line 3T3) cultured on the polymers. In contrast, however, cell adhesion and growth of macrophages and fibroblasts were affected by the polymer properties. Compared to macrophages cultured on tissue culture polystyrene (TCPS), cells cultured on the test polymers exhibited levels of cell adhesion that varied from 65-100% of TCPS, and the doubling time was 25-43% higher on the polymers than on TCPS. Likewise, fibroblasts adhered to the polymers at lower rates (50-85% of TCPS) and grew at higher doubling times (125-140% of TCPS). Furthermore, cells cultured on the test polymers preserved their phenotypes: fibroblasts produced high amounts (up to 280% of control cells) of collagens Type I and Type IV and fibronectin; and macrophages produced nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) in the same concentrations as control cells and responded to lipopolysaccharide treatment by the elevation of the production of NO and TNF-alpha, indicating that the cell-to-polymer interactions allow fibroblasts and macrophages to maintain their phenotypes. In vivo investigations showed that all four test polymers exhibit favorable tissue compatibility. The formed capsule was 60-250 microns thick. In addition, the polymers are degradable. After one year's subcutaneous implantation in rats, the molecular weight of the test polymers were reduced to about 50%, depending on the composition. Taken collectively, the present data demonstrate that the newly developed polyesterurethanes are cell and tissue compatible and biodegradable.

3T3 Cells↗

PubMed1999

Enhancing knot security by heat treatment of knot ears.

Heat treatment of the ears of knotted sutures markedly enhances knot security. Using coated polyester sutures commonly used in arthroscopic surgery, heat treatment of the knot ears allows secure knot construction to be achieved with a two throw granny (1 x 1) or square (1 = 1) knot. A heat source is being designed for secure knot construction in arthroscopic surgery.

Arthroscopy↗

PubMed1999

Synthetic nano-scale fibrous extracellular matrix.

Biodegradable polymers have been widely used as scaffolding materials to regenerate new tissues. To mimic natural extracellular matrix architecture, a novel highly porous structure, which is a three-dimensional interconnected fibrous network with a fiber diameter ranging from 50 to 500 nm, has been created from biodegradable aliphatic polyesters in this work. A porosity as high as 98.5% has been achieved. These nano-fibrous matrices were prepared from the polymer solutions by a procedure involving thermally induced gelation, solvent exchange, and freeze-drying. The effects of polymer concentration, thermal annealing, solvent exchange, and freezing temperature before freeze-drying on the nano-scale structures were studied. In general, at a high gelation temperature, a platelet-like structure was formed. At a low gelation temperature, the nano-fibrous structure was formed. Under the conditions for nano-fibrous matrix formation, the average fiber diameter (160-170 nm) did not change statistically with polymer concentration or gelation temperature. The porosity decreased with polymer concentration. The mechanical properties (Young's modulus and tensile strength) increased with polymer concentration. A surface-to-volume ratio of the nano-fibrous matrices was two to three orders of magnitude higher than those of fibrous nonwoven fabrics fabricated with the textile technology or foams fabricated with a particulate-leaching technique. This synthetic analogue of natural extracellular matrix combined the advantages of synthetic biodegradable polymers and the nano-scale architecture of extracellular matrix, and may provide a better environment for cell attachment and function.

Algorithms↗

PubMed2000

Effect of porosity and surface hydrophilicity on migration of epithelial tissue over synthetic polymer.

The relative effects of porosity and surface chemistry on the migration of epithelial tissue over the surface of a polymer were determined in vitro. These studies compared nonporous polymers with those having 0.1-microm diameter track-etched pores and were conducted on polycarbonate and polyester. Epithelial tissue migration over the polymer surface was stimulated by the presence of these pores. The surface chemistries of the polymers were modified by deposition of various polymer films using radio frequency gas deposition, giving a range of surfaces that varied in air:water sessile contact angle (SCA) of between 26 and 100 degrees. Tissue migration on the nonporous surfaces was affected by the surface chemistry, being generally linear as a function of the SCA and higher on hydrophilic than on hydrophobic surfaces but reduced if the hydrophilic surface had a mobile chemistry. The effects of the 0.1-microm diameter pores and the surface hydrophilicity were additive with the maximal level of epithelial tissue migration occurring on a porous, hydrophilic polymer surface.

Animals↗

PubMed2001

Reinforcement of acrylic denture base resin by incorporation of various fibers.

This study was designed to evaluate improvements in the mechanical properties of acrylic resin following reinforcement with three types of fiber. Polyester fiber (PE), Kevlar fiber (KF), and glass fiber (GF) were cut into 2, 4, and 6 mm lengths and incorporated at concentrations of 1, 2, and 3% (w/w). The mixtures of resin and fiber were cured at 70 degrees C in a water bath for 13 h, then at 90 degrees C for 1 h, in 70 x 25 x 15 mm stone molds, which were enclosed by dental flasks. The cured resin blocks were cut to an appropriate size and tested for impact strength and bending strength following the methods of ASTM Specification No. 256 and ISO Specification No. 1567, respectively. Specimens used in the impact strength test were reused for the Knoop hardness test. The results showed that the impact strength tended to be enhanced with fiber length and concentration, particularly PE at 3% and 6 mm length, which was significantly stronger than other formulations. Bending strength did not change significantly with the various formulations when compared to a control without fiber. The assessment of Knoop hardness revealed a complex pattern for the various formulations. The Knoop hardness of 3%, 6 mm PE-reinforced resin was comparable to that of the other formulations except for the control without fiber, but for clinical usage this did not adversely affect the merit of acrylic denture base resin. It is concluded that, for improved strength the optimum formulation to reinforce acrylic resin is by incorporation of 3%, 6 mm length PE fibers.

Acrylic Resins↗

PubMed2001

Polylactide implants and bacterial contamination: an animal study.

Although bioresorbable aliphatic polyesters derived from lactic acid are now used clinically as sutures, bone-fracture fixation devices and sustained-release drug-delivery systems, very little is known about their behavior in the infected environment. The aim of the present study was to compare the resistance to infection of two polylactide implants with different degradation characteristics, and to evaluate the influence of a bacterial challenge on their mechanical and physicochemical properties. Various quantities of a beta-haemolyzing strain of Staphylococus aureus (V 8189-94) were inoculated into the medullary cavity of rabbit tibiae, and an extruded polylactide rod composed of either P(L)LA (Poly(L-Lactide)) or P(L/DL)LA (Poly(L/DL-Lactide)) was then inserted. Animals were sacrificed four weeks after surgery. The tibiae and implants were removed under sterile conditions and evaluated microbiologically by culturing. The severity of infection was graded according to positive colony-forming units in the bone. The mechanical properties of the retrieved implants were assessed by 4-point bending and shear tests, performed in compliance with the ASTM D790 standard and their physicochemical characteristics also were characterized. P(L)LA and P(L/DL)LA implants were equally resistant to local infection, their mechanical and physicochemical properties being unaffected by bacterial challenge. Hence, once an infection has become established, the release of bactericidal/bacteriostatic by-products during implant degradation does not appear to affect its natural course. The release of bactericidal/bacteriostatic degradation products at the implantation site is unlikely to affect the natural course of an established infection.

Animals↗

PubMed2007

Large scale dielectrophoretic construction of biofilms using textile technology.

Arrays of microelectrodes for AC electrokinetic experiments were fabricated by weaving together stainless steel wires (weft) and flexible polyester yarn (warp) in a plain weave pattern. The cloth produced can be used to collect cells in low conductivity media by dielectrophoresis (DEP). The construction of model biofilms consisting of a yeast layer on top of a layer of M. luteus is demonstrated, using polyethylenimine (PEI) as the flocculating agent. This technique offers an alternative to the formation of biofilms at microelectrodes made by photolithography, and would allow the construction of biofilms with defined internal architectures by DEP at much larger scales than was possible previously. Furthermore, the flexibility of the cloth would also allow it to be distorted or folded into various shapes.

Biocompatible Materials↗

PubMed1988

Improved transfer of high molecular weight proteins using fabric-reinforced soft polyacrylamide gels.

Rapid transfer of electrophoretically separated, high molecular weight proteins from fabric-reinforced, soft, low-concentration polyacrylamide gels (3.5%T, 2.6%C) is described. Polyester fabrics proved useful for gel reinforcement during vertical slab gel electrophoresis. The fabric-reinforced gel retains its dimension during transfer, equilibration and drying, facilitating comparison of protein bands in the separation gel and transfer matrix.

Collodion↗

PubMed1978

Biocompatibility tests of components of an implantable cardiac assist device.

A permanently implantable in-series left ventricular assist device, the dynamic aortic patch (DAP), has been tested in chronic animal experiments. The DAP replaces a section of the intrathoracic aortic wall. Hemothorax and hematocele at the implantation site have been complications in recent experiments. Primary postoperative hemorrhage was ruled out, and the biocompatibility of all components was therefore examined. Dacron velour, Teflon felt, conductive polyurethane, segmented polyether polyurethane, and Teflon-coated polyester fiber sutures were implanted in the pleural cavities of dogs and tested in vitro by culturing canine saphenous vein explants on them. In vivo experiments demonstrated that all components elicited mild to moderate inflammatory reactions, but hematocele occurred only when the components were implanted in the aorta with direct blood contact and exposed to arterial blood pressures. In vitro, cells were cultured on all components with no signs of toxic reactions. These results indicated that the host tolerated all implant components without major inflammatory responses. However, histological data indicated that chronic slow bleeding into or through the Dacron velour in contact with the arterial blood serum could account for hemothorax or hematocele formation. Therefore, a configuration of the assist device using materials impermeable to blood may obviate these difficulties.

Animals↗

PubMed1980

Thrombogenicity of different suture materials as revealed by scanning electron microscopy.

The thrombogenicity of five suture materials--polypropylene (Prolene), polyester (Mersilene), polyglactin 910 (Vicryl), nylon (Tthilon), and silk--was examined in vivo by scanning electron microscopy. The most blood-compatible material appeared to be Prolene. A rather satisfactory antithrombogenciity was shown by Mersilene, in comparison with which Ethilon and Vicryl provided less thromboresistance. The possible connection between the chemical changes which occur during the hydrolysis of Vicryl and its blood compatibility is discussed. Of the tested materials, silk proved to be the most thrombogenic. This study shows that the thrombogenicity of a suture material could be easily and conveniently tested in an experimental model by scanning electron microscopy, thus enabling the first choice of a suitable suture for the cardiovascular surgery, before one continues with other more sophisticated methods for the evaluation of thromboresistance.

Animals↗

PubMed1985

The intracellular degradation of poly(epsilon-caprolactone).

Poly(epsilon-caprolactone) [PEC], a biodegradable aliphatic polyester, undergoes a two-stage degradation process: The first lengthy phase involves nonenzymatic hydrolytic cleavage of ester groups, the second phase beginning when the polymer is more highly crystalline, and of low molecular weight. The cellular events of the second phase were examined by implanting gelatin capsules containing 25 mg of low molecular weight (Mn 3000) PEC powders, 106 to 500 micron, in rats. PEC fragments ultimately were degraded in phagosomes of macrophages and giant cells, the process requiring less than 13 days for completion at some sites. PEC was also identified within fibroblasts. These studies support the intracellular degradation of PEC as the principal pathway of degradation once the molecular weight of the aged polymer is reduced to 3000 or less.

Animals↗