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PubMed2001

Changing views of brain evolution.

Although brain studies began in ancient Egypt, speculations on vertebrate brain evolution occurred only much later, after the publication of Darwin's Origin of Species in 1859. Subsequently, views of brain evolution have been shaped by a complex interplay of theory and technique. Darwin's theory allowed the variation in brain size and complexity to be re-interpreted within an evolutionary context, albeit an erroneous pre-Darwinian context based on scala naturae. With the development of histological techniques, research shifted to descriptions of cellular structure, cellular aggregates and their putative interconnections. In spite of these technical advances, brain evolution continued to be viewed within the context of scala naturae. Following the publication of The Comparative Anatomy of the Nervous System of Vertebrates by Ariëns Kappers, Huber, and Crosby in 1936, there followed a period of stasis, after which biological views of evolution were radically altered by the confluence of genetics, paleontology, and systematics, termed the Evolutionary Synthesis. Against this background, the development of new experimental techniques for establishing neural connections resulted in a new flowering of comparative neuroanatomy. While comparative descriptive and experimental studies of brain organization continue, the rapprochement of embryology and genetics is fueling a new renaissance that promises to increase our understanding of brain evolution and its genetic basis.

Animals↗

PubMed2001

The kidney and hypertension in pregnancy: twenty exciting years.

Before 1980 research on the kidney and hypertension during pregnancy was neglected, although these diseases, especially hypertension, are major causes of morbidity to mother and child. The past 20 years, however, has witnessed a striking reversal of this neglect. This review focuses on recent progress in renal physiology, kidney disease, and hypertension as relates to pregnancy. Why do renal hemodynamics increase markedly in pregnancy? Studies have suggested roles for nitric oxide synthase, prostaglandins, endothelin and relaxin. This area of research is exciting, as unraveling why glomerular filtration rate and renal plasma flow increase in pregnancy may eventually help all patients with acute and chronic renal function loss. Concerning other advances: Micropuncture studies in rats, and the interpretation of fractional dextran clearances in humans show that the hyperfiltration that occurs during normal gestation is not associated with increased glomerular capillary pressure. Finally, description of changes in osmoregulation and in the metabolic disposal of arginine vasopressin in human pregnancy led to identification and appropriate treatment of a new group of disorders termed "transient diabetes insipidus of pregnancy." Chronic renal disease of any severity once led to proscription or interrupting of pregnancy. Clinical-pathological correlation studies and long-term follow-up of the mothers have revealed that most of these gestations succeed with little risk of worsening the natural history of the kidney disorder. This is also true in allograft recipients, and we now have guidelines to counsel both groups of patients. Progress relating to hypertension in pregnancy has been in 2 broad areas; systematic attempts to accurately define and differentiate the various disorders and population studies to predict, prevent, and improve the management of preeclampsia. There has also been considerable progress in unraveling the pathophysiology and identifying the cause of preeclampsia.

Animals↗

PubMed1987

[Electroencephalographic foci without structural diagnostic correlates].

On account of the increasing availability of various new, computer-aided and non-invasive imaging techniques it seems advisable to reconsider the structural-diagnostic use of the EEG which is a functional-diagnostic instrument by its nature. On the level of visuo-morphologic description local and locally accentuated patterns can only be conceived as deformations of the temporo-spatial gestalt of the EEG. On the level of interpretation, i.e. in answering the question whether such patterns are indicative of a circumscribed structural lesion or not, further information is required. In addition to clinical data such information is provided by the electroencephalographic context. Typical arrangements of the EEG-context which make improbable an assumption of a structural lesion can be demonstrated for certain anterior-left as well as posterior-right localized patterns. From such regular co-incidencies, which are illustrated by paper chart examples, we conclude that these "foci" represent local manifestations of a global functional impairment. Whereas the intermittently occurring anterior-left accentuated slow wave patterns refer to an incipient global functional disintegration, the posterior-right accentuated slow wave patterns can be regarded as a reflection of a global functional deficit of maturation. A third phenomenal domain which persistently confronts us with the structural-diagnostic limitations of the EEG consists of the focal patterns in patients with epilepsy. It may be assumed that the pronounced lateral inconsistency of these focal patterns, occurring within the recording period and even more when comparing serial recordings, is dependent both on the actual (vigilance) and the relatively outlasting level of central nervous organization (maturation).

Brain Damage, Chronic↗

PubMed1993

[The supplemental motor area].

Following an introduction dealing with the developments which led to the discovery of the supplementary motor area (SMA), its anatomy and neuronal connections are described. Subsequently, a report concerning the pathology of the SMA (epilepsy, tumours, ablations, defects and possible neuroleptic effects) and related experimental findings is presented. This is followed by a description of the motor function, and especially the speech motor function of the SMA. The article concludes with an exposition of Sir John C. Eccles' interpretation of the SMA as providing the basis for a naive solution of the mind-body dualism.

Animals↗

PubMed1989

The burden of responsibility: duty, depression, and nervios in Andean Ecuador.

Saraguro Indian women possess relatively high status in their community. Nevertheless, they experience high rates of the culturally interpreted illness nervios. This syndrome produces symptoms characteristic of stress-induced depression and is identified by Saraguros as the product of suffering and misfortune. Descriptive and quantitative interview data indicate that episodes of nervios correlate with experiences of gender role failure, and the condition is identified as a coping mechanism for excessive responsibility and unrealistic social expectation. This syndrome also appears to serve as an effective strategy for enhancing power and social status.

Cultural Characteristics↗

PubMed2001

Organic pollutants in surface waters from Portugal using chemometric interpretation.

Surface water samples from 45 sampling points across Portugal have been analyzed monthly by automated Solid Phase Extraction (SPE) and Gas Chromatography-Mass Spectrometry (GC/MS) in SIM and SCAN modes. Sampling was carried out during a period of six months (April-September, 1999), in order to determine the levels of contamination of 72 organic compounds mainly selected from the EC Council Directive list (CEC 76/464/EEC). Atrazine, simazine, deethylatrazine, alachlor, metolachlor, Irgarol, terbuthylazine, tributhylphosphate, 2,4,6-trichlorophenol, 2-chlorophenol, 3-chlorophenol, pentachlorophenol, dimethoate, lindane, linuron, propanil, o,p'-DDD, o,p'-DDT, o,p'-DDE and malathion were the main detected compounds. Although Irgarol, terbuthylazine, deethylatrazine and deisopropylatrazine are not listed in the EC Directive, these herbicides and transformation products are currently in use and they were also included in the monitoring program and detected at some sites. Fifty-nine percent of the samples were below 0.1 microg l(-1), the detection limit required the EEC Drinking Water Directive (DWD). Some compounds were detected at values higher than the DWD, e.g. atrazine (2.7 microg l(-1)) and alachlor (5.43 microg l(-1)) in April. Simazine was also present with a high value (2.3 microg l(-1)) in September. Tributhylphosphate (5.40 microg l(-1)) and 2,4,6-trichlorophenol (2.31 microg l(-1)) were also found at high concentrations near industrial sites. Chemometric interpretation of the more representative contaminants was performed by means of Principal Component Analysis, allowing the resolution of the more relevant contamination sources and the description of their temporal and spatial (geographical) distributions.

Environmental Monitoring↗

PubMedDate not supplied

Early development and segment formation in the centipede, Strigamia maritima (Geophilomorpha).

Geophilomorph centipedes exhibit a number of unique characteristics that make them of particular developmental and evolutionary interest. Segment numbers in geophilomorphs are higher than in any other centipedes, ranging from 27 to 191. They may be constant within a species, presenting in extreme form the "counting" problem in development, or they may vary--a situation that provides us with the opportunity to study naturally occurring variation in segment numbers. All their segments are generated during embryogenesis, a situation unlike that in the more basal centipede orders, which generate only a fraction of their 15 trunk segments in the embryo and develop the rest postembryonically. Here we provide a foundation for further developmental studies of the Geophilomorpha, building on the one study that has been conducted to date, on the coastal species Strigamia maritima. Development begins with the migration of nuclei to the surface of the egg, which then condense to form an embryonic rudiment of more than 20,000 cells, covering an entire hemisphere. During early development, the embryo can be divided into two distinct areas: a large terminal disc of apparently undifferentiated tissue and the germ-band, which has a clear anteroposterior axis and differentiated segments. The germ-band forms from the anterior of the terminal disc and extends anteriorly as the disc contracts. New segments are formed at the posterior margin of the germ-band. Once the process of segmentation ends, the germ-band folds and sinks into the yolk. We note that the classic description of centipede development, by Heymons more than a century ago, contains a fundamental error in the identification of the axes and hence in the interpretation of early segmentation.

Animals↗

PubMed1999

Religious faith in Mexican-American families dealing with chronic childhood illness.

PURPOSE: To explore Mexican-American family experiences with chronic childhood illness, from the perspective of parents, and report findings about the influence of religious faith on families' spiritual and secular responses to illness. Mexican-Americans are often characterized as religious, fatalistic, and passive, but families' perceptions of the consequences of their daily faith and its meaning in the face of chronic childhood illness is not well understood. DESIGN: Descriptive. The sample included 25 parents from 19 families living with children with a variety of chronic conditions. Data were collected in 1995-1996. METHODS: Interpretive, using symbolic interaction as the framework, and in-depth interviewing for data collection. FINDINGS: Parents professed a variety of beliefs and devotional practices. Six unifying dimensions of religious faith were related to parental caretaking and decision making for the family: (a) God determined the outcome of the child's illness, (b) God and health care for the child were closely linked, (c) parents took an active role in facilitating God's will, (d) families had obligations to God, (e) intercession with God by others was often sought by or offered to the family, and (f) faith encouraged optimism. CONCLUSIONS: Families were not fatalistic in the sense of feeling outcomes were predetermined and unalterable. Family members took spiritual and secular actions to assure the best possible familial and professional care for their child and sought to influence God's good will on behalf of the child and family.

Adult↗

PubMed2004

Cytologic diagnosis: expression of probability by clinical pathologists.

BACKGROUND: Clinical pathologists use descriptive terms or modifiers to express the probability or likelihood of a cytologic diagnosis. Words are imprecise in meaning, however, and may be used and interpreted differently by pathologists and clinicians. OBJECTIVES: The goals of this study were to 1) assess the frequency of use of 18 modifiers, 2) determine the probability of a positive diagnosis implied by the modifiers, 3) identify preferred modifiers for different levels of probability, 4) ascertain the importance of factors that affect expression of diagnostic certainty, and 5) evaluate differences based on gender, employment, and experience. METHODS: We surveyed 202 clinical pathologists who were board-certified by the American College of Veterinary Pathologists (Clinical Pathology). Surveys were distributed in October 2001 and returned by e-mail, fax, or surface mail over a 2-month period. Results were analyzed by parametric and nonparametric tests. RESULTS: Survey response rate was 47.5% (n = 96) and primarily included clinical pathologists at veterinary schools (n = 58) and diagnostic laboratories (n = 31). Eleven of 18 terms were used "often" or "sometimes" by >/= 50% of respondents. Broad variability was found in the probability assigned to each term, especially those with median values of 75 to 90%. Preferred modifiers for 7 numerical probabilities ranging from 0 to 100% included 68 unique terms; however, a set of 10 terms was used by >/= 50% of respondents. Cellularity and quality of the sample, experience of the pathologist, and implications of the diagnosis were the most important factors affecting the expression of probability. CONCLUSION: Because of wide discrepancy in the implied likelihood of a diagnosis using words, defined terminology and controlled vocabulary may be useful in improving communication and the quality of data in cytology reporting.

Adult↗

PubMed1980

Congruence of personality assessments within families with a schizophrenic son.

Following the phenomenological approach to interaction in psychiatrically disturbed families a personality questionnaire ('Giessen Test') was used to assess the views three family members (father, mother, son) had of themselves and of each other. These views may be regarded as quite stable results of interaction processes, so that conclusions about family interaction patterns may be drawn from the level of concordance of any two of them. Comparisons were made between families in which a son had been hospitalized for the first time with a diagnosis of schizophrenia and those in which a son had been hospitalized for surgical treatment, n = 30 in each category. The psychiatric patients did not on the whole give distorted personality descriptions. But in the index families the relationship between father and son was found characteristically different from that in the control families. This fact is interpreted as a reaction of the father to the deviant behaviour of the son, who did not conform with the male sex-role expectations of the father. The father as it is could not then identify with his son as a father usually does and perhaps necessarily should. The answers of the mothers partly confirm this conclusion. With regard to the parental dyad, the findings suggest that the fathers' needs for reciprocal consideration are not met by their wives.

Adolescent↗

PubMed1990

Determination of cellular mechanical properties by cell poking, with an application to leukocytes.

In this paper we review the cell-poking technique as an approach for investigating the mechanical properties of living cells. We first summarize the rationale for the technique and the mainly qualitative results obtained so far. Then we provide a technical description of the instrument as it is configured at present. This is followed by a discussion of the current status of analytical results available for interpreting cell-poking measurements. In the final section we apply these results to an analysis of unmodulated and modulated lymphocytes and neutrophils, and conclude that the mechanical response of these leukocytes to indentation is not consistent with simple models developed by previous investigators on the basis of micropipette-aspiration experiments.

Animals↗

PubMed1979

Doerr's theory of morphogenesis of arterial transposition in light of recent research.

Doerr's theory of the morphogenesis of transposition is discussed with special reference to recent studies by Goor and co-workers and Anderson and associates. The views advanced by all these authors coincide in three points: (a) the description of the reorganisation process occurring at the arterial end of the embryonic heart (a process called by Doerr vectorial bulbus rotation); (b) the pathogenetic interpretation of transposition as the result of an arrest of vectorial bulbus rotation; (c) the recognition of a teratological series or spectrum of anomalies pathogenetically related to transposition. Vectorial bulbus rotation is explained mainly as the result of three largely simultaneous events; bulbar shift, bulbus torsion, and truncus torsion. The spectrum of anomalies related to transposition appears as a close-knit series. Bulbar retraction does not seem to be a necessary condition for the connection of the aorta to the left ventricle.

Heart↗

PubMed1989

Postsecondary transition needs and employment patterns of individuals with mild disabilities.

Descriptive data on the initial employment patterns of mildly disabled individuals who participated in a postsecondary, time-limited transition program are presented. Results were interpreted to indicate that the participants (a) obtained entry-level positions with varying employee benefits; (b) benefited from periodic yet ongoing support to maintain employment; and (c) requested continued but minimal support to negotiate job changes in the work world. Further research is indicated concerning longitudinal employment needs of individuals with disabilities.

Adult↗

PubMedDate not supplied

The effects of direct feedback and practice on metaphor performance in children with learning disabilities.

Children with learning disabilities may have a problem in interpreting metaphor and need specific guidance and practice. This study found that direct feedback and practice could significantly increase metaphor performance of these children. Further descriptive analyses indicated that grade and reading levels of the subjects correlated with their metaphor performance.

Adolescent↗

PubMed2003

The reporting of methods for reducing and detecting bias: an example from the WHO Misoprostol Third Stage of Labour equivalence randomised controlled trial.

BACKGROUND: The aim of this article is to explore ways in which selection bias and ascertainment bias can be reduced and investigated in trials, by using the example of a drug trial carried out in both developed and developing countries in hospital delivery wards. METHODS: We describe an innovative and practical design for the boxes for packing the drugs as a way of increasing the security of allocation concealment and blinding. We also assess ascertainment bias using sensitivity analyses, as some unblinding could have occurred due to a potential side effect of one of the drugs. RESULTS: The sensitivity analyses indicated that the conclusions about the relative effects of the treatments could be maintained even in the unlikely worst-case scenarios. CONCLUSIONS: Detailed description of the procedures protecting against common biases and of the assessment of ascertainment bias in this trial should allow readers to confidently appraise and interpret the results obtained. In addition, our experiences will assist others in planning trials in the future.

Developed Countries↗

PubMed2007

Rituximab for the treatment of acquired antibodies to factor VIII.

BACKGROUND AND OBJECTIVES: Rituximab, a monoclonal chimeric antibody to the CD20 antigen, is an effective therapy for the treatment of non-Hodgkin's lymphomas. Moreover, rituximab has also shown to be effective in various autoimmune diseases including spontaneous antibodies to factor VIII. The aim of this study was to assess the efficacy of rituximab treatment of spontaneous inhibitors to factor VIII. DESIGN AND METHODS: We studied the efficacy of rituximab by analyzing the data of 42 previously published cases as well as one so far unpublished case. For comparison, we also analyzed 44 patients treated with cyclophosphamide/prednisone reported in the literature. RESULTS: Treatment with rituximab resulted in an overall rate of complete remission (CR) of 78.6%. Similar results were found when analyzing patients who had (75%) or had not (77%) received previous treatment with other immunosuppressive drugs. The median time to CR was 8.3 weeks. In follow-up 66% of the patients were still in CR after 2 years and the plateau in the Kaplan-Meier analysis suggests that a substantial number of patients had been cured. Among the 44 patients treated with cyclophosphamide/prednisone reported in the literature, the CR-rate was 84.1%, which was slightly higher than that for rituximab. The median time to CR with cyclophosphamide/prednisone treatment was 6.3 weeks, which was similar to that in the rituximab-treated patients; the probability of continuous CR at 2 years was 94%. INTERPRETATION AND CONCLUSIONS: All in all, both treatment schemes are effective therapies in patients with spontaneous antibodies to factor VIII. Our data analysis is only descriptive and no conclusions can be drawn as to the relative efficacy of the two regimens. However, these data may serve as a useful basis for planning randomized studies to definitively resolve these issues.

Adolescent↗

PubMedDate not supplied

[Distribution of D1S80 alleles in a random sample of the population of the Russian Federation].

The distribution of alleles of chromosomal locus D1S80 was studied within a random selection of population of the Russian Federation. Typing was made for 255 persons who were not blood relatives and who lived in 56 Russia's regions. A correlation was found between the observed frequencies of genotypes and those theoretically expected and estimated on the basis of the hypothesis of Hardy-Weinberg equilibrium. The main population characteristics of locus D1S80, i.e. probability of an incidental coincidence of a genotype, discriminating potential, polymorphism factor, potential excluding cases of incorrectly named parents and mean value of paternity index, were estimated to evaluate the efficiency of the locus as a molecular-genetic marker in solving the identification tasks applicable to Russia's population. The obtained descriptive data on the distribution of alleles of the studied locus in Russia's population can be used to determine the needed estimated parameters in interpreting the results of forensic molecular-genetic identification examinations.

Alleles↗

PubMedDate not supplied

[Obtaining informed consent and resorting to ethical committee in clinical and epidemiological research in Italy. A survey].

OBJECTIVES: To describe how informed consent (CIn) and ethical review (CEt) are obtained in the Italian clinical and health research. DESIGN: survey SETTING: 6 Italian and 7 foreigner journals in the years 2001 and 2002. SAMPLE: 157 original or short articles, letters and case reports for which a member of an Italian institution was the corresponding author. MAIN OUTCOME: Mention in the text of CIn and CEt procedures. RESULTS: In 42% of such studies (95% CI: 35-50%), informed consent was obtained; in 30% (95% CI: 23-37%), ethical committee approval was obtained, in 27% (95% CI: 21-35%) both had been obtained. The probability of informed consent and ethical review varied with type of data used (primary or secondary source). No significant differences, however, were noted based on the type of study population (vulnerable or non-vulnerable), the year, or the country in which the article was published (Italy or elsewhere). Keywords search in the articles text showed that ethical aspects of the study were not debated. Ethical procedures were synthetically reported as a rule, yet there were differences in their formulation. CONCLUSIONS: The limited resorting to CIn and CEt procedures and the concision and variability of their description might depend on the plethora of the ethical, legal, editorial guidelines available for Italian researchers that partially overlap and partially present specific aspects whose interpretation is not free of niceties.

Epidemiology↗