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PubMedDate not supplied

On the requirement of calcium, phosphorus and vitamin D by premature and low birthweight infants.

During recent years the increased survival rate of very low birthweight infants has lead to an increased incidence of rickets and/or osteopenia in these infants. The pathogenesis is multifactorial. From several studies performed under different conditions it can be concluded that the vitamin D requirement of these infants is about 3 times higher than the normal prophylactic dose. Breastfed infants should be supplemented with extra phosphorus and possibly also extra calcium. Infant formulas designed for low birthweight infants should have a calcium content compensating for the initially poor calcium absorption of these infants.

Calcium↗

PubMed2000

[Extremely low birth weight (less than 1000 gram) and early postnatal weight gain in preterm infants].

Improving survival of extremely low birthweight (< 1000 g) preterm infants opens the practical issues of their postnatal nutrition and growth. The authors studied nutrition and weight gain in 16 extremely low birthweight preterm infants (birthweight: 890 +/- 22 g, gestational age: 28.0 +/- 0.2 week, mean +/- SEM) during the first 12 weeks of life. Milk of the mother, or fortified pooled human milk or preterm infant formula was fed. The preterm infants approximated their birthweight by the end of the 3rd week of life (21st day: 866 +/- 29 g). Body weight expressed as per cent of birthweight was 109 +/- 2% at the end of the 4th, 176 +/- 7% at the end of the 8th and 275 +/- 6% at the end of the 12th week of life. Weight gain during the 1st to 8th postnatal weeks was compared to the mean in utero weight gain of foetuses with identical gestational age, gender and weight percentile position. Cumulative weight gain of preterm infants during the first 8 weeks of life was significantly lower than that of the theoretical controls (76 +/- 7% versus 136 +/- 2%, per cent of the initial value, preterm versus control, p < 0.0001). Additional weight gain of preterm infants was lower than that of the controls on the 1st to 5th weeks of life (g/kg/day, 1st week: -14.4 +/- 1.6 versus 16.7 +/- 0.5, p < 0.0001; 5th week: 13.3 +/- 1.2 versus 16.4 +/- 0.3, p < 0.05), there were no differences between the two groups on the 6th and 7th weeks, whereas preterm infants gained significantly more weight on the 8th week of life than the theoretical control value (18.2 +/- 0.9 versus 14.0 +/- 0.2, p < 0.001). These data indicate that the first weeks of life represent an especially important period for the improvement of the nutrition of extremely low birthweight preterm infants.

Gestational Age↗

PubMedDate not supplied

Diet counseling during the infant oral health visit.

Diet counseling is an integral part of anticipatory guidance during the infant oral health visit. Similar to dietary instructions for children of all ages, the primary emphasis is on sugar intake frequency. There are, however, other infant-specific dietary issues that must also be addressed during the infant oral health visit. Breast-feeding should be promoted during the first year of life, although ad libitum nocturnal breast-feeding should be discouraged after the first primary tooth erupts. Bottle-fed infants should not be put to sleep with the bottle. Weaning from the breast or the bottle should be encouraged by 12 to 14 months of age. Infants older than 6 months and with exposure to less than 0.3 ppm fluoride in their drinking water need dietary fluoride supplements of 0.25 mg fluoride per day. Only 4 to 6 oz of fruit juice should be consumed by infants per day. Infants should not be given powdered beverages or soda pop, as these drinks pose increased risk for dental caries. Iron-fortified infant cereals, along with breast milk or infant formula, should be consumed by infants who are at least 6 months of age. Cow's milk should be completely avoided in the first year of life and restricted to less than 24 oz per day in the second year of life. Parents should be cautioned regarding the potential of various foods to constitute a choking hazard for infants.

Bottle Feeding↗

PubMedDate not supplied

[Methods of feeding and illness in infants in the first six months of life].

UNLABELLED: There is now a general agreement, that breast feeding prevents infantile gastrointestinal infections and non-gastrointestinal infections in all settings. In this study, we tried to pay attention to Kovar et al. who suggested that studies to detect the effects of breast feeding on health should be undertaken for other reasons and should include the collection of related information as part of the study. METHODS: Data collection. The population consisted of all infants born in the community of Krushevac in 1994. After at least 36 weeks of pregnancy their weight was 2500 g or more. The babies were selected by a modified cluster sampling. Data were collected by access to health cards where data of systematic medical examination of infants after the first, third and sixth month of life were recorded. Feeding method. Breast feeding was defined as the period of breast feeding from birth until the infant was totally weaned, even if other food was offered. The term bottle feeding referred to no breast feeding but to an infant formula or cow milk. Each infant was classified every month into either a breast feeding group or a bottle feeding group. Infectious diseases. We studied gastrointestinal and respiratory diseases, and all other illnesses except trauma were included in the third category. Statistical analysis. Every infant was classified each month as breast or bottle fed and thus was included in a 6-month observation. An episode of illness was associated either with breast feeding or bottle feeding according to the method of feeding in the month during which the episode occurred. The incidence density of diseases in breast fed infants was computed as follows: The rate numerator corresponded to the total number of episodes of diseases reported while infants were breast fed. The denominator was the number of month of breast feeding of all infants. The rate of diseases in bottle fed infants was obtained in the similar way. To compare the rates of illnesses in breast fed and bottle fed infants, we computed the incidence density ratio (IDR). So, when less than one, the IDR indicated a protective effect of breast feeding. RESULTS: Figure 1 illustrates the distribution of infants by the method of feeding at each age in months. Sixty four percent of babies were breast fed at the end of the first month, 43 percent at the end of the third month and 37.8 percent at the end of the sixth month. A total of 305 episodes of diseases were observed in 448 infants. An approximate incidence density analysis revealed the significant protective effect of breast feeding in relation to the total number of illnesses during the first sixth months of life (Table 1). The incidence density for gastrointestinal diseases was 49 percent lower in breast fed infants than in bottle fed infants (IDR = 0.51). The protective effect of breast feeding on gastrointestinal diseases persisted after individual adjustment according to the infant's age (Table 2). The rough incidence density for respiratory diseases was 38 percent lower in breast fed infants than in bottle fed infants (IDR = 0.62)(Table 1). The protective effect of breast feeding on respiratory diseases persisted after individual adjustment according to the infant's age (Table 3). DISCUSSION: The results of this retrospective cohort study revealed protective effects of breast feeding in relation to respiratory illnesses as well as gastrointestinal diseases during the first six months of life. The statistical analysis based on Person-time methods best emphasizes the common problems that arise in such studies, because it takes in account the fact that (1) the outcome may be recurrent in one individual; (2) the duration of breast feeding is associated with the infant's age, and (3) the incidence is also age related. We conclude that breast feeding was protective against respiratory illnesses including ear infection and against gastrointestinal diseases. The study thus reinforces the benefits of breast feeding for

Bottle Feeding↗

PubMed1994

Dietary nucleotides: cellular immune, intestinal and hepatic system effects.

Investigations with animals demonstrate that dietary nucleotides influence immune function. Restriction of dietary nucleotides in mice decreases several indices of cell-mediated immunity as well as resistance to challenge with Staphylococcus aureus or Candida albicans. Spleen cells of mice maintained on nucleotide-free diet produce less interleukin-2 and have lower natural killer cell cytotoxicity and macrophage activation than those of animals fed nucleotide-supplemented diets. In vivo lymphoproliferative response, macrophage phagocytic activity and expression of interleukin-2 receptor and lyt1 surface marker are also lower in animals fed nucleotide-free diets. At 2 mo of age, infants fed breast milk or nucleotide-supplemented infant formula exhibit increased natural killer cell activity compared with infants fed unsupplemented formula. Dietary nucleotide restriction in animals may also result in hepatic lipid accumulation and decreased mucosal height and gut wall thickness. Adenosine monophosphate, a mediator of hepatic and small bowel blood flow, may play a unique role among the nucleotides studied. In conclusion, de novo synthesis and salvage of nucleotides is a metabolically costly process. An exogenous source of nucleotides from the diet may optimize the function of rapidly dividing tissues, particularly when growth is rapid and the diet is low in nucleotides.

Animals↗

PubMed1998

Effect of increasing dietary threonine intakes on amino acid metabolism of the central nervous system and peripheral tissues in growing rats.

The threonine content of most of the infant formulas currently on the market is approximately 20% higher than the threonine concentration in human milk. Due to this high threonine content the plasma threonine concentrations are up to twice as high in premature infants fed these formulas than in infants fed human milk. To study the effect of different threonine intakes on plasma and tissue amino acid concentrations, 24 young male Wistar rats were fed three experimental diets based on a mixture of bovine proteins with a whey protein/casein ratio of 60/40 with different threonine contents [group A, 0.86 g of threonine/100 g (n = 8); group B, 1.03 g of threonine/100 g (n = 8); group C, 2.21 g of threonine/100 g (n = 8)]. Eight animals were fed a typical rat diet based on bovine casein as controls. After a feeding period of 15 d, amino acids were measured in plasma and in homogenates of the cerebral cortex, brain stem, liver, and muscle. There was a significant correlation between threonine intake and plasma threonine levels (r = 0.687, p < 0.001). The plasma threonine concentration correlated significantly with the threonine concentration in the cortex (r = 0.821, p < 0.01) and the brain stem (r = 0.882, p < 0.01). There was a positive significant correlation between threonine and glycine concentrations in the cortex (r = 0.673, p < 0.01), and the brain stem (r = 0.575, p < 0.01), whereas the glycine concentration decreased with increasing threonine intakes in the liver and muscle. The presented data indicate that increasing the threonine in plasma leads to increasing brain glycine and thereby affects the neurotransmitter balance in the brain. This may have consequences for brain development during early postnatal life. Therefore, excessive threonine intake during infant feeding should be avoided.

Amino Acids↗

PubMed1976

Questions to the supply of young infants with fat and fatty acids. II. Fat content and fatty acid pattern in milk formulae for healthy infants in the first 6 months of life.

The fat content and the fatty acid pattern were analyzed in 30 commercially prepared milk formulae for healthy infants in the fisrt 6 months of life. We found an average fat content of 3.4 g or 3.6 g/100 ml in "partly adapted" and "adapted" milk formulae, between 1.4 g and 3.3 g/100 ml in "not defined" milk formulae. We regard a fat content lower than 3.0 g/100 ml and more than 4.0 g/100 ml as not advisable. In most milk formulae the ratio of saturated: unsaturated fatty acids is similar to the ratio in human milk fat. This ratio is obtained from a mixture of cow's milk fat with vegetable oils or by a mixture of various vegetable fats. The difference in the fatty acid pattern between the milk formulae and the fatty acid pattern in mature human milk are demonstrated and discussed. The tolerance of milk formulae for young infants is not influenced in an unfavorable manner by butyic acid. A high portion of lauric acid in mild formulae seems undesirable. The importance of the position of palmitic acid in the triglycerides of milk formulae for infants is discussed, and it is referred to the advantage of a mixture of cow's milk fat with vegetable fats. A linoleic acid content of 3 kcal% in the minimum and 7 kcal% in the maximum in milk formulae for infants is regarded as advisable.

Animals↗

PubMed2006

Has the WIC incentive to formula-feed led to an increase in overweight children?

We explored the relationship between the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and overweight status in children, with a focus on WIC's provision of infant formula, through secondary analyses and review of existing literature. Because of the complexity involved and the lack of previous research on the combined link between WIC, breast-feeding, and overweight status, we considered evidence for each of these relations separately. Using food-cost data from the WIC's 1996 Participant and Program Characteristics Survey, we found that the state-level average for 1 y of program benefits for women who formula-fed was over twice the value of program benefits for those who breast-fed (BF). This difference in benefit levels, or formula incentive, was negatively associated with both the in-hospital and 6-mo BF rates in state-level multiple regression models. Despite WIC's efforts to promote BF, other large-scale studies have found a negative association of program participation with BF rates. An inverse association of BF on subsequent overweight in children also has been shown in a number of studies. Despite this accumulating evidence for the protective effect of BF, it has not been seen in African American or Latino populations. In sum, there is reason to be concerned that WIC's incentive to formula-feed may have led to an increase in overweight children; yet there is too much uncertainty about the issue to conclude that this is so. Further research is needed to understand this relationship, as is the development of applied interventions to increase BF rates.

Black or African American↗

PubMed1994

Effects of diet on the lipid and fatty acid status of full-term infants at 4 months.

OBJECTIVE: To compare the effects of the exogenous supply of long-chain polyunsaturated fatty acids (LCP) and cholesterol on the lipid and fatty acid status in full-term, 4-month old infants. METHODS: Twenty-three infants received a standard infant formula while twenty-one were given a formula enriched with LCP and cholesterol in a prospective, randomized study. The composition of the two formulas differed only in fat quality. A group of fifteen breastfed infants fed was used as reference. No one was complemented with solid foods before blood sampling at 4 months of life. RESULTS: Differences in total-cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels between feeding groups were mainly gender-related. Dietary cholesterol tended to increase LDL-C plasma levels. The breastfed and the enriched formula-fed groups had higher levels of circulating LCP than the group that received the standard formula. In the erythrocytes of infants fed the standard formula, C22:6 n-3 levels were less than 50% those of the breastfed and the enriched formula-fed ones. Higher C20:4 n-6 levels were found in the erythrocytes of the enriched formula-fed group. CONCLUSIONS: Formula-fed, full-term infants maintain a lipid and fatty acid status close to that of breastfed infants when supplied with dietary LCP and cholesterol.

Cholesterol↗

PubMed1975

Nutrition for the low birth weight infant.

Satisfactory nutrition of the low birth weight infant concerns the nurse, obstetrician, pediatrician, and nutritionist. It may be that at present the most satisfactory feeding for the low birth weight infants is human milk. Such factors as protein quantity and quality, fat quantity and quality, immune factors, and osmolar factors may be uniquely suitable for the human infant regardless of his weight. Because of present limitations in the availability of fresh human milk, infant formulas have been adopted with reasonable success in the nutriture of the low birth weight infant. Those formulas which most nearly simulate human milk are most widely used. Broad outlines for the composition of these formulas have been given. Regardless of the availability and ease of administration of either human milk or formula, it is unlikely that any form of external nutriture can equal the advantages provided by intrauterine growth. Until better methods are devised for prolonging intrauterine growth, presently available feeding regimens should be considered experimental and in a state of flux.

Dietary Carbohydrates↗

PubMed2002

Free formula milk for infants of HIV-infected women: blessing or curse?

There is vigorous controversy around whether HIV-infected women in developing countries should choose formula or breastfeeding for their infants. Formula eliminates HIV transmission but incurs risk of increased mortality, whereas breastfeeding has multiple benefits but entails risk of HIV transmission. International guidelines are available but need to be strengthened. This commentary summarizes data on the scale and rate of mother-to-child transmission (MTCT) of HIV through breastfeeding, and the hazards and benefits of breast- and formula-feeding. The case against providing free or subsidized formula to HIV-infected mothers is based on the following: it exacerbates disadvantages of formula feeding; compromises free choice; targets beneficiaries erroneously; creates a false perception of endorsement by health workers; compromises breastfeeding; results in disclosure of HIV status; ignores hidden costs of preparation of formula; increases mixed breastfeeding, which is an unsatisfactory method for all women; requires organization and management of programmes that are complicated and costly; and finally increases the 'spill-over' effect into the normal breastfeeding population. Recommendations to minimize these drawbacks include use of affordable antiretrovirals to reduce MTCT; investments in high-quality, widely available HIV counselling; support for choice of feeding; and exclusive breastfeeding for those who choose to breastfeed.

Acquired Immunodeficiency Syndrome↗

PubMed2004

Nutrition influences bone development from infancy through toddler years.

During the last decade a greater appreciation has developed for determining factors that influence bone accretion in healthy children. Nutritional factors that may contribute to bone accretion in infants and toddlers include maternal nutritional status during pregnancy, type of infant feeding, calcium and phosphorus content of infant formula, introduction of weaning foods, and diet during the toddler and preschool years. Maternal vitamin D deficiency during pregnancy is associated with disturbances in neonatal calcium homeostasis, and maternal calcium deficiency leads to reduced neonatal bone mineral content (BMC). Preterm infants are at increased risk of osteopenia, and, although the use of high mineral formula has reduced the risk of osteopenia in these infants, it has not eliminated it. The reason for the long-term bone deficiency among preterm infants is not clear, although lower physical activity levels have been suggested as a potential cause. Studies find that human milk-fed infants have lower bone accretion than do formula-fed infants; that the greater the mineral content of formula, the greater the bone accretion; and that the inclusion of palm olein oil in infant formula may reduce bone mineral accretion. Bone accretion is not influenced by the timing of the introduction of weaning foods, despite higher serum parathyroid hormone (PTH) concentrations among infants who receive solids earlier. There is evidence of calcium intake-by-gene and calcium intake-by-physical activity interactions among toddlers and young children. The long-term effects of these early nutritional influences on later bone health are unknown.

Bone Development↗

PubMed1993

Decreased glucose oxidation in preterm infants fed a formula containing medium-chain triglycerides.

Several formulas for preterm infants contain medium-chain triglycerides (MCT) to enhance fat absorption. Although fat absorption with MCT was slightly higher in several studies in preterm infants, a beneficial effect on growth has only been reported in one publication. We hypothesized that when part of the fat blend of preterm formula is substituted by MCT oil, this might lead to a different metabolic pattern in which, due to the preferential oxidation of MCT, an increase in lipogenesis from glucose could lead to an increase in metabolic rate. To study the impact of MCT on glucose metabolism, 18 preterm infants were randomized to receive either an MCT or an LCT formula containing 38- and 6%-by-weight medium-chain fatty acids, respectively, in their fat blend. At 4 wk of age, the metabolic rate, substrate utilization, glucose kinetics, and oxidation were measured by indirect respiratory calorimetry in combination with a constant-rate oral infusion of [U-13C]glucose. The "true" rate of appearance of glucose (Ra "true") was measured from the dilution of the uniformly labeled (m + 6) species of infused tracer, whereas "apparent" rate of appearance of glucose (Ra "apparent") was measured from the dilution of infused tracer C (carbon). The latter was measured by an on-line combustion method using a gas chromatograph-isotope ratio mass spectrometer. At a carbohydrate intake of 8.4 mg.kg-1.min-1, total utilization of carbohydrate was equal in both groups at 7.6 mg.kg-1.min-1.(ABSTRACT TRUNCATED AT 250 WORDS)

Dietary Carbohydrates↗

PubMed1985

Diarrhoea: after rehydration, what next?

Successful management of diarrhoea depends firstly on restoring fluid and electrolyte balance. Following this, the child needs to be fed, to prevent malnutrition and morbidity. Conventionally, this is achieved by regrading onto the previous feed. In our series of 42 infants with mild gastroenteritis, six out of 12 infants had persistent diarrhoea after one week on normal infant formula. Twenty-five out of 27 infants who were given a low-lactose formula (HN25) had normal stools within 4 days. (chi2 = 18.487; P less than 0.001). Only two out of 27 infants had a recurrence of loose stools at 1 week and these became normal after regrading back on to HN25. Recovery time was shortened, while nutritional status was maintained. Short-term substitution of a low-lactose formula after rehydration speeds recovery from gastroenteritis.

Combined Modality Therapy↗

PubMedDate not supplied

Lead and cadmium levels in commercial infant foods and dietary intake by infants 0-1 year old.

Lead and cadmium levels were determined in 131 infant foods. Mean lead and cadmium levels were 19.3 and 3.3 ng/g for meats, 8.4 and 4.1 ng/g for vegetables, 14.9 and 0.58 ng/g for fruits and desserts, 9.6 and 0.53 ng/g for juices and drinks, and 32.8 and 33.6 ng/g for dry infant cereals. These data, combined with those from other recent surveys, yielded average dietary (food and water) intakes of lead and cadmium by infants 0-1 year old of 2.4 and 0.37 microgram/kg/day, respectively. Lead intakes were most strongly influenced by storage of infant formulas in lead-soldered cans. For infants 0-1 month old, they ranged from 0.5 microgram/kg/day when human or cow milk was fed to infants to 5.3 micrograms/kg/day (exceeding the FAO/WHO provisional tolerable daily intake, PTWI, of lead by children of 3.5 micrograms/kg) when ready-to-use formula stored in lead-soldered cans was fed. Cadmium intakes were most strongly affected by soya based formulas, and ranged, for 0-1 months olds, from 0.16 microgram/kg/day for infants fed human or cow milk to 0.50 microgram/kg/day for infants fed soya-based concentrated liquid formula. Cadmium intakes were all below the FAO/WHO PTDI of cadmium by adults of 0.96-1.2 micrograms/kg.

Animals↗

PubMed2006

Dioxin and dioxin-like PCB exposure of non-breastfed Dutch infants.

The exposure of humans to PCDD/Fs (polychlorinated dibenzo-p-dioxins and dibenzofurans) and dioxin-like PCBs (dl-PCBs, i.e. polychlorinated non-ortho and mono-ortho biphenyls) occurs predominantly via the intake of food. Young children have a relatively high intake of these substances, due to their high food consumption per kilogram body weight. As the exposure of non-breastfed infants to these compounds has not been assessed before in The Netherlands, we studied the dietary intake of 17 PCDD/Fs and 11 dioxin-like PCBs in 188 Dutch non-breastfed infants between 4 and 13 months. The food intake of the infants was assessed by a 2-d food record. From these data PCDD/F and dioxin-like PCB intake was calculated using PCDD/F and dioxin-like PCB concentrations of food products sampled in 1998/1999 in The Netherlands. The long-term PCDD/F and dioxin-like PCB exposure of the infants was calculated using the statistical exposure model (STEM). For infants of 5 months the chronic exposure to PCDD/F and dioxin-like PCB was 1.1pg WHO-TEQ (toxic equivalents) per kilogram body weight (bw) per day (95th percentile: 1.7pg WHO-TEQ/kg bwxd), which mainly originated from infant formula and vegetables and increased to 2.3pg WHO-TEQ/kg bwxd (95th percentile 3.7pg WHO-TEQ/kg bwxd) for infants just over 1 year old eating the same food as their parents. The percentage of formula-fed infants with an exposure exceeding the TDI of 2pg WHO-TEQ/kg bwxd was 5% at 5 months, 49% at 9 months and 64% at 12 months.

Dioxins↗

PubMed2005

The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system.

BACKGROUND: Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are major components of the cerebral cortex and visual system, where they play a critical role in neural development. We quantitatively mapped fatty acids in 26 regions of the four-week-old breastfed baboon CNS, and studied the influence of dietary DHA and ARA supplementation and prematurity on CNS DHA and ARA concentrations. METHODS: Baboons were randomized into a breastfed (B) and four formula-fed groups: term, no DHA/ARA (T-); term, DHA/ARA supplemented (T+); preterm, no DHA/ARA (P-); preterm and DHA/ARA supplemented (P+). At four weeks adjusted age, brains were dissected and total fatty acids analyzed by gas chromatography and mass spectrometry. RESULTS: DHA and ARA are rich in many more structures than previously reported. They are most concentrated in structures local to the brain stem and diencephalon, particularly the basal ganglia, limbic regions, thalamus and midbrain, and comparatively lower in white matter. Dietary supplementation increased DHA in all structures but had little influence on ARA concentrations. Supplementation restored DHA concentrations to levels of breastfed neonates in all regions except the cerebral cortex and cerebellum. Prematurity per se did not exert a strong influence on DHA or ARA concentrations. CONCLUSION: 1) DHA and ARA are found in high concentration throughout the primate CNS, particularly in gray matter such as basal ganglia; 2) DHA concentrations drop across most CNS structures in neonates consuming formulas with no DHA, but ARA levels are relatively immune to ARA in the diet; 3) supplementation of infant formula is effective at restoring DHA concentration in structures other than the cerebral cortex. These results will be useful as a guide to future investigations of CNS function in the absence of dietary DHA and ARA.

Animal Feed↗

PubMed1995

Selenate fortification improves selenium status of term infants fed soy formula.

Thirty-three healthy term infants were fed either soy formula (SF, 0.028 mumol Se/L; n = 17) or soy formula with added selenate (SF+Se, 0.17 mumol Se/L; n = 16) from birth (+4 d) to 16 wk. Selenium intakes of infants fed SF+Se were similar to the recommended dietary allowance and significantly greater than those of SF-fed infants. The SF group had significantly lower plasma, erythrocyte, and urine selenium, and lower plasma and erythrocyte glutathione peroxidase (GPx) activities at 16 wk compared to those of infants fed SF+Se. A decrease in plasma selenium was observed in SF-fed infants, whereas no differences in plasma selenium were found in infants fed SF+Se. These results indicate that selenate added to soy formula is highly available and effective at maintaining infant plasma and erythrocyte selenium concentrations and GPx activities that are greater than those of infants fed soy formula not fortified with selenium.

Double-Blind Method↗