Haptoglobin types in the population of the Gran Canaria.
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The investigation of serum samples of 200 unrelated adult Turks revealed the following gene frequencies: Hp-1 = 0.265; Hp-2 = 0.735. The frequencies are in the range of most of the Asiatic population.
THE Hl1f, Hp1s and Hp2 gene frequencies were studied in two French population samples: one from the Toulouse area and one from a Basque district. The hp alpha1F and alpha1S polypeptide chains were determined by a simple technique. The observations were in accordance with previous findings in Caucasoid populations. The frequency of the Hp1S gene was slightly higher in the Basque sample than in the group from Toulouse.
The occurrence of the rare Hp 2-Jo type in a Danish family is reported. By subtyping procedure the 2alphaJ polypeptide chain was demonstrated for the first time in an HP 2-Jo sample. Apparently independent of the transmission of the HpJo gene hypohaptoglobinaemia was found in a rather high proportion of the members of the kindred.
Results on 605 patients and 597 controls carefully matched in relation to sex, age, marital status and profession are reported. A higher frequency of nonsecretors, as well as an excess of B and lack of A2 were observed among the filarial patients. Since these differences do not occur in other series, however, their significance is doubtful.
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Five tribal populations, Koya Dora, Raj Gond, Naikpod, Pardhan, and Lambadi from Andhra Pradesh were examined for Tf, Hp, Gc, ceruloplasmin and albumin types. Koya Doras were sampled at five localities to study intra-tribal variation. Tf DChi, a mongoloid genetic marker, was found in high frequencies among Koya Doras (0.029) and Naikpods (0.033) whereas if was absent among Pardhans and showed a very low frequency in Lambadis. A new slow transferrin allele, Tf DGond, is reported from Raj Gonds and is found in polymorphic frequency (0.01). The Hp1 gene frequency ranged from 0.056 to 0.159, and Gc2 ranged from 0.165 to 0.397. No variation was observed with respect to ceruloplasmin. One new albumin variant was found in a single individual of the Koya Dora tribe. The intra-tribal variation in gene frequencies among Koya Doras equalled that found between different tribal populations.