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[Survival time of patients with cardiac pacemakers (author's transl)].

A comparison between the life expectancy of patients with pacemakers and that of a control population of similar structure shows a parallel course, although originally, after a postoperative phase of 2 months, the mortality rate of the patients with pacemakers was higher. Today the results are considerably better. Implantation of pacemakers is one of the greatest cardiological advances in the last 10 years for the effective treatment and prevention of cardiac arrest in atrioventricular block. The significance of this type of therapy becomes understandable if the fact that the mortality of Adams-Stokes attacks used to be about 50% is taken into consideration. In France, about 5000 persons each year have Adams-Stokes attacks.

Adams-Stokes Syndrome↗

[Pacemaker treatment in myocarditis (author's transl)].

The occurrence of bradycardial arrhythmias in the course of myocarditides of different etiologies is reported. The many different variations in the course of the disease are presented with reference to seven typical examples, and also the indications and risks for pacemaker therapy and its predominantly successful but sometimes, in the last analysis, unsatisfactory use.

Adams-Stokes Syndrome↗

Life-threatening "vagal reaction" to emotional stimuli.

"Vagal reactions" may follow sudden emotional or physical strain in "vagotonic individuals" and are usually benign. In the case described, emotional stimuli caused life-threatening vagal reactions in a "healthy individual." Implantation of an artifical pacemaker was necessary to control the attacks.

Adams-Stokes Syndrome↗

[Isoproterenol in the emergency treatment of cardiac stimulus conduction].

Continuous infusion with isoproterenol (mean dose 2 mug/min) was carried out for periods of a few hours to a few days in 22 patients recurrent Adams-Stokes syncope. In all cases, an improvement leading to or in the direction of physiological cardio-circulatory conditions was noted. Undesired side-effects foreseeable as the result of beta-adrenergic stimulation were not observed. Isoproterenol is more active than metaproterenol and is to be preferred on this account. It is indicated in Adams-Stokes crises due to conduction disturbances when pacemakers cannot or should not be fitted, or as a prelude to their application.

Adams-Stokes Syndrome↗

Recurrent electromechanical dissociation due to severe underlying coronary heart disease.

Recurrent electromechanical dissociation, eventually fatal, presented as Stokes-Adams-like syncope in a patient with severe underlying coronary heart disease. Mechanical function was probably suppressed because of myocardial ischemia due to recent occlusion of the proximal right main coronary artery; the left main coronary artery had been occluded previously. Spasm of the proximal right coronary artery may have accounted for his recurrent attacks of pain and syncope. It is suggested that this clinical picture has a grave prognosis, demanding urgent therapeutic measures. While these measures are likely to be more hazardous than usual, the grave prognosis and potential for therapeutic success make them well worth the risk.

Adams-Stokes Syndrome↗

[Pregnancy in women with atrioventricular block. 13 cases].

Thirteen women aged between 18 and 37 years and suffering from atrio-ventricular block had 36 pregnancies. Foetal prognosis was excellent and the pregnancy quite unaffected by the block in 9 cases. In 4 women, Stokes-Adams attacks occurred. In one case from some time ago therapeutic abortion was necessary. Temporary pacing at the time of delivery was used in one case and a permanent pacemaker in one patient. The problems posed by the insertion of a pacemaker in a woman of childbearing age are discussed.

Abortion, Therapeutic↗

Long-term follow-up after cardiac pacing in bradyarrhythmias.

Fifty-nine patients aged 39-80 years underwent implantation of a cardiac pacemaker and were followed for up to 9 years (average duration of pacing 39 months). Atrioventricular conduction disturbances (complete atrioventricular block, 2 : 1 atrioventricular block, bifascicular block, and atrial fibrillation with slow ventricular rate) were present in 49 patients and sick sinus syndrome (sinus arrest or sino-atrial block, and bradycardia-tachycardia syndrome) in 10. Pacing was required because of Adams-Stokes attacks in 41 patients, 2 of whom also had congestive heart failure. It was required in 6 because of frequent dizziness, in 10 because of congestive heart failure, and in 2 because of low cardiac output. The symptomatic improvement after cardiac pacing was well recognized in most of our patients, and 32 (54 percent) of the 59 patients pursued normal physical and daily activity. Although the efficacy of pacemaker therapy was of limited value in some patients with congestive heart failure or underlying or coexisting diseases, the beneficial effects following pacemaker implantation were: (1) abolishment of transient neurologic symptoms such as Adams-Stokes attack, (2) relief from a constant fear of a recurrence of an Adams-Stokes attack or sudden cardiac death, and (3) improvement in restricted physical activity due to low cardiac output. Thus, we conclude that pacemaker implantation in most patients with bradyarrhythmias is beneficial not only for the treatment of the acute problem but also because it prolongs life and greatly enhances its quality. However, in spite of the beneficial effects after pacemaker implantation, we still observe a number of complications connected with the use of a permanent pacemaker. Therefore, our policy is to implant a permanent pacemaker following the execution of sufficient studies of the bradyarrhythmia and the etiology of symptoms, and then under taking long-term follow-up of the patients.

Adult↗

Overdrive suppression in diagnosis of sick sinus syndrome.

A criterion to determine the indication for pacemaker implantation in the sick sinus syndrome by overdrive suppression is proposed. Overdrive suppression was performed in 10 patients with the sick sinus syndrome (SSS) and another 10 patients with normal sinus rhythm (NSR) who served as controls. In the SSS group, 9 patients had complained of such severe symptoms as Adams-Stokes attack and/or congestive failure and were referred to our laboratory for pacemaker implantation. One other patient, an apparently robust young man (20 years old) referred for detailed cardiac examination, had no remarkable symptoms except for arrhythmias, but was found dead two months later. Atrial pacing for overdrive suppression was carried out at first at various rates ranging from 60 to 180 beats/min for 15 sec, and then at a rate of 100 beats/min for various durations ranging from 5 to 180 sec. After cessation of the atrial pacing, asystolic pauses were measured and the maximum (maximum pause) among the pauses obtained was used as a parameter indicating depression of cardiac automaticity. The maximum pause in the SSS group ranged from 5.6 to 9.0 sec (mean +/- SD = 7.0 +/- 1.2), WHILE THOSE IN THE NSR group ranged from 0.7 to 1.5 sec (mean +/- SD = 1.2 +/- 0.14). Therefore, the maximum pause was considered not only to reflect the severity of the symptoms necessitating pacemaker implantation in the 9 patients of the SSS group but to have warned us of sudder death in another patient. We concluded that overdrive suppression is useful as a supplementary challenge to determine indications for pacemaker implantation for the sick sinus syndrome, and that prolongation of the maximum pause beyond 5.0 sec is the critical level for pacemaker implantation.

Adult↗

[A case of subarachnoid hemorrhage with sick sinus and advanced AV block].

A 35-year-old man was hospitalized after a sudden onset of transient syncopal attack without accompanying complaints of headache or nausea. He was slightly disorientated but neurologically normal. He had a blood pressure of 150/90mmHg and a pulse rate of 40/min. An ECG showed marked sinus brady-cardia with ventricular escaped rhythm followed by advanced atrioventricular (AV) block. Some components of conducted ventricular beats showed aberration. There was no significant ST or T wave abnormality in normally captured QRS components except for prominent T in leads II, III and aVF. At first, we thought that he might require temporary pacing because of Adams-Stokes attack. However, after administration of atropine sulfate, the ECG returned to normal sinus rhythm with heart rate of 88/min. Then he began to complain of headache followed by a convulsive seizure. A CT scan and angiogram revealed a ruptured aneurysm at the top of the basilar artery, which was successfully clipped. A wide spectrum of ECG changes can be demonstrated in practically all patients with subarachnoid hemorrhage (SAH). Prolonged QT interval, ST-T changes, U wave, sinus tachycardia, or ventricular premature complex are the common abnormalities probably caused by increased circulating catecholamine. As bradyarrhythmia in patients with SAH is an uncommon finding, its mechanism has not yet been defined. Transient sinus bradycardia with advanced AV block in this patient might have been caused not by elevated intracranial pressure (Cushing phenomenon) but by drastic discharge of the parasympathetic nerve. This case serves to illustrate the vigilance required in determining whether abnormalities of cardiac rhythm are instrumental in causing neurological symptoms and signs or a disorder of cerebral function.

Adult↗

[Anti-bradycardia pacemaker therapy: rational choice of system in relation to hemodynamic and prognostic aspects].

UNLABELLED: Currently, the most important indications for pacemaker treatment include high-grade AV-block, the sinus node syndrome, atrial fibrillation with slow ventricular rate as well as the hypersensitive carotid sinus. In the Federal Republic of Germany, 88.5% of the units employed were fixed-rate ventricular single-chamber systems (VVI), in less than 10% dual-chamber systems (DDD) and in 2.4% fixed-rate atrial single-chamber systems (AAI) as well as rate-adaptive systems (VVIR, AAIR). In 1986, a total of 32,000 pacemakers were implanted in the Federal Republic and about 105,000 in the USA. State-of-the-art: Miniaturization of single-chamber systems to less than 20 grams and dual-chamber systems to less than 30 grams has been associated with markedly improved lead technology which has lowered energy requirements. The development of atrial-independent, variable rate systems has enabled rate adaptation in patients who are not candidates for DDD-stimulation or in whom the atrial rate is inadequate. With Holter functions various physiological parameters can be continuously monitored and their response as well as biorhythmicity are analyzed. INDICATIONS: The following guidelines are those of the working group "Cardiac Pacing" of the German Society for Heart and Circulatory Research for the choice of pacemaker systems which are considered to provide the best respective physiologic form of stimulation with the goal of rendering optimal hemodynamics. For characterization of the pacemaker modes, the five-letter NASPE/BPEG code is used. The possibility for single modes, AV-synchrony and rate adaptation as central factors for physiologic stimulation forms is shown in Table 2. Those systems are designated as "physiologic" which reestablish AV-synchrony, that is, pacing modes in which the atria are incorporated With the VAT-, VDD- and DDD-modes there is an additional atrial-triggered rate modulation. In AAI- order DDD/I-modes rate adaptation is independent of the atria (AAIR, DDD/IR) via physiologic parameters while rate-adaptive VVI stimulation does not enable AV-synchrony. Atrioventricular conduction disturbances: Pacemaker treatment is carried out for prevention of Adams-Stokes symptoms and for improvement of the hemodynamic situation. Prognostic implications of pacemaker treatment: With pacemaker treatment the one-year mortality of patients with Adams-Stokes symptoms and/or complete AV-block can be lowered to 5 to 19% from 50 to 70%.(ABSTRACT TRUNCATED AT 400 WORDS)

Bradycardia↗