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PubMedDate not supplied

[Cognitive evoked potentials in the hyperactivity attention deficit disorder].

INTRODUCTION: The Attention Deficit Hyperactivity Disorder, ADHD, is characterized by deficient attention, impulsiveness and excessive motor activity. The incidence is estimated between 5 and 9% of children of school age. The P300 wave is one of the cognitive components of the event related potential ( ERP) that is more used to investigate the attention and the cognitive processes. OBJECTIVE: The aim of this study was to investigate the information processing in children with ADHD predominantly inattentive type by means of the visual and auditory P300 component. PATIENTS AND METHODS: P300 wave using an auditory and visual oddball paradigm were recorded in 18 children with ADHD and in 18 normal children ( control group ). RESULTS: We found differences in reaction time and in the percentage of errors between children with ADHD and between controls. In the ADHD the latency of the auditory and visual P300 were significantly longer than in the control group, and the amplitude of both components were significantly smaller in the ADHD group than in controls. We didn t found differences in the cortical distribution of the P300 between the two groups. CONCLUSIONS: These data suggests that there is an abnormal processing of cognitive information in children with ADHD predominantly inattentives and a dysfunction in attentional mechanisms.

Attention Deficit Disorder with Hyperactivity↗
PubMed2006

Therapeutic challenges of attention-deficit hyperactivity disorder with substance use disorders.

Attention-deficit hyperactivity disorder (ADHD), a common neuropsychiatric disorder of childhood, adolescence and adulthood, is frequently comorbid with substance use disorders (SUDs) in both adolescents and adults. This paper will provide an overview of the relationship between ADHD and SUDs and discuss the primary areas of therapeutic challenge in the treatment of individuals with comorbid ADHD and SUDs, including the diagnosis of ADHD in populations with SUDs, selecting appropriate agents for use and prevention of abuse and/or diversion of the therapeutic pharmacological agents used in ADHD treatment. The authors will also provide a discussion on the future of research and treatment in this area and key issues for clinicians.

Attention Deficit Disorder with Hyperactivity↗
PubMed2004

Reduced electrodermal response to errors predicts poor sustained attention performance in attention deficit hyperactivity disorder.

Research into attention deficit hyperactivity disorder (ADHD) has indicated abnormalities in electrodermal system activity (EDA) and separately, deficits in sustained attention. Here we asked whether reduced EDA in ADHD was consequential for the attention problems associated with this disorder. On a sustained attention task ADHD participants had higher overall error rates and exhibited a marked decrease in skin conductance responses (SCRs) to errors, relative to control children. Further, sustained attention errors were predicted by SCR amplitudes. Evidence of post-error slowing in both groups suggested comparable error awareness. It is proposed that attenuation of the normal autonomic response to errors reflects impairment in ADHD participants' psychological response to error significance and results in decreased behavioural correction and hence poorer sustained attention.

Analysis of Variance↗
PubMed2001

Attention deficit hyperactivity disorder. Epidemiologic, pathophysiologic, diagnostic and treatment perspectives.

Although attention deficit hyperactivity disorder is a common child psychiatric disorder, the epidemiology and pathophysiology of attention deficit hyperactivity disorder is variable in different studies. Attention deficit hyperactivity disorder and comorbid disorders in children aided both by attention deficit hyperactivity disorder diagnostic criteria and assessment scales entails a comprehensive neuropsychiatric interview plus collection of information from different sources. Although psychosocial and behavioral therapies are of great therapeutic values, the psychopharmacological drugs are often used in the treatment of patients with attention deficit hyperactivity disorder. With a combined approach, a substantial proportion of patients with attention deficit hyperactivity disorder (90%) show good recovery. The patients with attention deficit hyperactivity disorder need careful evaluation and appropriate long-term treatment in order to prevent subsequent negative consequences. In rapidly developing countries, the researchers should carry out studies, which explore different aspects of attention deficit hyperactivity disorder in children, adolescents and adults.

Adolescent↗
PubMed2004

[Experimental bases for evaluating attention in attention deficit hyperactivity disorder].

INTRODUCTION: The experimental evaluation of the time variable in attention enables us to distinguish between what can be considered as its normal and its pathological behaviour. It has proved to be useful in evaluating the population suffering from attention disorders (attention deficit hyperactivity disorder, frontal lesions, etc.) as a means of defining the extent to which the patient is affected by the disorder and also in designing a training programme for later use. DEVELOPMENT: The most notable attentional paradigms are attentional blink (AB), repetition blindness, change detection, psychological refractory period, task switching, and negative and positive priming. Patients with ADHD showed a poor capacity for identification of target stimuli (T1) in attentional blink tests; they also displayed a significantly higher attentional blink than that observed in the control group, especially for time intervals between 300 and 600 ms after the first target letter (T1). CONCLUSIONS: Attention is a complex, dynamic concept derived from the interaction of different neuroanatomical systems. There are several different theories to explain disorders affecting the attentional skills. One of the explanations comes into being as a result of linking sustained attentional disorder with impulsiveness and hyperactive behaviour. Another is related to selective attention disorders. This distinction allows us to discern the involvement of two systems that will give rise to different clinical symptoms and hence the presence of attentional subtypes. Thus, for example, it is possible to find a first group with disorders affecting attention, impulsiveness and disinhibition, and a second group with slow reactions and in a state of confusion and/or inattention as regards the events taking place around them (but they do not have impulsiveness or disinhibition).

Attention↗
PubMed2001

On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder.

1. The objective of the present study was to compare the phenomenology and pathophysiology of obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder/deficits in attention, motor control and perception (ADHD/DAMP). 2. Through detailed studies of the literature on OCD and ADHD/DAMP, the phenomenology of these two conditions is compared, and possible underlying pathophysiological mechanisms involving interactions between glutamate, dopamine, serotonin and acetylcholine are discussed, with emphasis on OCD. The present paper also discusses possible mechanisms of action for current pharmacological treatments of OCD and ADHD, as well as possible future treatment strategies for these disorders. 3. OCD and ADHD/DAMP are common neuropsychiatric conditions which in many regards appear to be each other's antipodes with respect to clinical manifestations, associated personality traits and brain biochemistry, notably prefrontal cortical glutamate activity. Future pharmacological treatments of these disorders may involve manipulations with glutamate, dopamine D , serotonin 2A and nicotine receptors. 4. It appears that OCD is a hyperglutamatergic and ADHD a hypoglutamatergic condition, with prefrontal brain regions being especially affected.

Acetylcholine↗
PubMed1998

The dominance of behavioural activation over behavioural inhibition in conduct disordered boys with or without attention deficit hyperactivity disorder.

On the basis of Gray's theory, Quay suggested that conduct disorder (CD) is associated with a Behavioural Activation System (BAS) that dominates over the Behavioural Inhibition System (BIS), whereas attention deficit hyperactivity disorder (ADHD) is characterised by an underactive BIS. Two studies were conducted to test the hypothesis that the dominance of the BAS over the BIS is more pronounced in CD comorbid with ADHD (CD/ADHD) than in CD alone. First of all, a response perseveration task was used, i.e. the door-opening task (Daugherty & Quay, 1991). In this game, the subject chooses either to open the next door or to stop playing; there is a steadily increasing ratio of punished responses to rewarded responses and a large number of doors opened is indicative of response perseveration. As expected, a steady increase in the number of doors opened was found across normal control (NC) boys, CD boys, and CD/ADHD boys (NC < CD < CD/ADHD). Second, the dominance of the BAS over the BIS was examined by observing the social behaviour of the child in interaction with a research assistant who alternately activated the BAS and the BIS while a game was played. The behaviour of the children was analysed according to ethological methods. Group differences in the frequencies of three out of five behavioural categories were in line with the results of the door-opening task (NC < CD < CD/ADHD).

Antisocial Personality Disorder↗
PubMedDate not supplied

Comorbidity of central auditory processing disorder and attention-deficit hyperactivity disorder.

UNLABELLED: Research has indicated that children with attention-deficit hyperactivity disorder (ADHD) demonstrate significant difficulty on tasks used to assess central auditory processing skills. These findings have raised the question of whether ADHD and central auditory processing disorder (CAPD) represent a singular disorder. OBJECTIVE: The current study explored the incidence of ADHD in a group of 30 children who met diagnostic criteria for CAPD. METHOD: Consecutive referrals specifically for this project were assessed on a variety of measures. In addition, rating scales were completed by teachers and structured interviews were completed with parents. RESULTS: Results indicate that although the incidence rate of ADHD (50%) in this sample significantly exceeds that found in the normative population (p < .001), not all children with CAPD demonstrated behaviors consistent with diagnostic criteria for ADHD. Furthermore, there was a low incidence of any other behavioral disorder in this sample. In contrast, it was found that the sample as a whole demonstrated impaired language abilities. No significant differences emerged across cognitive, auditory, or language measures. CONCLUSION: This study further supports the need for increased collaboration of those professionals who work with these children given the extent of overlap of language and behavioral difficulties in this sample.

Adolescent↗
PubMed2002

Behavioral characteristics of auditory processing disorder and attention-deficit hyperactivity disorder: predominantly inattentive type.

Auditory processing disorder (APD) and attention-deficit hyperactivity disorder (ADHD) present overlapping symptomatology. Previous research has demonstrated that professionals use different behavioral descriptors to characterize APD and ADHD combined and predominantly hyperactive-impulsive subtypes, which present with hyperactivity, impulsivity, and inattention. The present study extends this research by comparing audiologists' and pediatricians' rankings of 58 behavioral symptoms associated with APD and ADHD predominantly inattentive (PI) subtype, the ADHD subtype that presents without hyperactivity and impulsivity. Audiologists ranked the degree to which each symptom pertained to individuals with APD, and pediatricians ranked the same symptom as it relates to ADHD-PI. Item analysis revealed that respondents identified a reasonably exclusive set of behaviors characterizing APD and ADHD-PI. None of the four behaviors ranked 2 SD above the grand means (i.e., inattention, academic difficulties, asking for things to be repeated, and poor listening skills) was ranked in common.

Attention Deficit Disorder with Hyperactivity↗
PubMed2001

Attention Deficit Hyperactivity Disorder.

Management of attention deficit hyperactivity disorder (ADHD) encompasses two general domains: pharmacologic therapies and nonpharmacologic therapies, including educational, cognitive-behavioral, and other psychological and psychiatric approaches. Within the past year there have been two seminal developments in treatment. The first is that the Evidence-based Practice Center at McMaster University, under contract with the Agency for Health Care Policy and Research, produced an evidence based report on the treatment of ADHD. The topic was proposed to the AHCPR by the American Academy of Pediatrics and American Psychiatric Association, who served as partners to the center. The second is the completion of the Multisite Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (MTA) study by the National Institutes of Mental Health, a 14-month double-blind placebo trial of medication and behavioral therapy in ADHD. In general, the result of the evidence-based review and the MTA study is that stimulants are the most effective agents for the treatment of ADHD. Results from the MTA study indicate that methylphenidate (MPH) and MPH combined with behavioral therapy are superior to behavioral therapy alone and that all three are superior to community therapy. The evidence-based review indicates that each of the stimulants is superior to placebo and the stimulants (regular and sustained-release MPH as well as d and l isomers of the stimulants) are comparable. As for other agents, tricyclic antidepressants, specifically desipramine, are superior to placebo. Only a few studies compared stimulants directly with tricyclic antidepressants, and these were technically inadequate, leading to the conclusion that more rigorous studies are required. Only five studies were found that examined nonpharmacologic treatment, and all contained major limitations in methodology. Despite the limitations, all showed that stimulants were more effective than the nonpharmacologic therapies, consonant with the results of the MTA study. There was lack of evidence to support the superiority of combination multimodal treatment over stimulant therapy alone, again consonant with the MTA study. Both the evidence-based review and the MTA study examined ADHD in middle childhood. Finally, most studies are relatively short-term, including the MTA study (at 14 months). Some evidence suggests that MPH reduces behavioral disturbance as long as it is taken.

Journal Article↗
PubMed2003

Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial.

OBJECTIVE: Recent reports raise concern that children with attention deficit hyperactivity disorder (ADHD) and some manic symptoms may worsen with stimulant treatment. This study examines the response to methylphenidate in such children. METHODS: Data from children participating in the 1-month methylphenidate titration trial of the Multimodal Treatment Study of Children with ADHD were reanalyzed by dividing the sample into children with and without some manic symptoms. Two "mania proxies" were constructed using items from the Diagnostic Interview Schedule for Children (DISC) or the Child Behavior Checklist (CBCL). Treatment response and side effects are compared between participants with and without proxies. RESULTS: Thirty-two (11%) and 29 (10%) participants fulfilled criteria for the CBCL mania proxy and DISC mania proxy, respectively. Presence or absence of either proxy did not predict a greater or lesser response or side effects. CONCLUSION: Findings suggest that children with ADHD and manic symptoms respond robustly to methylphenidate during the first month of treatment and that these children are not more likely to have an adverse response to methylphenidate. Further research is needed to explore how such children will respond during long-term treatment. Clinicians should not a priori avoid stimulants in children with ADHD and some manic symptoms.

Attention Deficit Disorder with Hyperactivity↗
PubMed2000

Assessment of attention deficit hyperactivity disorder: a review of recent literature.

Attention deficit hyperactivity disorder is one of the most common behavioral disorders of childhood and is frequently assessed and treated by pediatricians and other primary care physicians. The diagnosis of attention deficit hyperactivity disorder is based on the careful synthesis of clinical data derived from multiple sources, notably, the patient, parents, and teachers. Standard behavioral rating scales simplify and standardize collection of clinical data but by themselves are not sufficient for a diagnosis. Recognition and treatment of disorders comorbid with attention deficit hyperactivity disorder are necessary for optimal outcomes. Psychoeducational testing is useful in the assessment of suspected associated learning disabilities, but there is no evidence at present to support use of psychologic testing, laboratory measures of attention, electroencephalography, or neuroimaging studies in the clinical assessment of attention deficit hyperactivity disorder.

Adolescent↗
PubMed2004

Knowledge of social anxiety disorder relative to attention deficit hyperactivity disorder among educational professionals.

Social anxiety disorder (SAD), the 3rd most common psychiatric disorder in the United States, follows a chronic and unremitting course, often resulting in severe impairments in multiple areas of functioning. Despite a typical age of onset in early adolescence, the disorder is rarely recognized and treated in adolescent populations. Given its early age of onset, school professionals are arguably in the best position to detect symptoms of SAD and to provide appropriate referrals for assessment and intervention. This study examined the knowledge that teachers, school counselors, and school psychologists have of SAD in relation to their knowledge of a prototypical externalizing disorder, attention deficit hyperactivity disorder (ADHD). The results suggest that all 3 groups of educational professionals are surprisingly unfamiliar with adolescent SAD.

Adult↗
PubMed1998

Effect of reinforcement on facial responsivity and persistence in children with attention-deficit hyperactivity disorder.

Children with Attention Deficit-Hyperactivity Disorder (ADHD) may learn poorly under conditions of inconsistent (partial) reinforcement because they are easily frustrated and fail to develop persistence. To test this hypothesis, a nonsense word spelling task was used with 22 ADHD and 20 control children to investigate the effects of partial and continuous reinforcement on facial responsivity (frustration measure), words spelled correctly (learning performance measure), and persistence ratings. Partially reinforced ADHD children manifested higher levels of frustration in both acquisition and extinction than any other group and gave significantly lower persistence ratings across acquisition than partially reinforced control children. ADHD children spelled fewer words correctly than controls, regardless of reinforcement schedule. These findings suggest that partial reinforcement training develops persistence in normal but not ADHD children. The findings have theoretical implications for the etiology of ADHD as well as practical implications for designing behavior modification programs to treat ADHD.

Attention↗
PubMedDate not supplied

[Attention deficit hyperactivity disorder and epilepsy].

INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is currently one of the morbid clinical pictures in childhood and adolescence that is most frequently diagnosed in the Neuropaediatric clinic. DEVELOPMENT: ADHD is sometimes associated to other important neurological problems, such as behavioural disorders, tics or headaches, and may occasionally be related to epilepsy, although in this particular case the epileptic syndromes often involve disorders affecting behaviour and attention. Due to the frequent association of these disorders (epilepsy and ADHD) it is wise to perform an electroencephalographic study in patients who visit because of symptoms of disattention. Likewise, the neuropsychological assessment of epileptic children must not be neglected. We analyse the therapeutic options regarding the use of stimulants when both disorders coexist and we endorse the association of antiepileptic and psychostimulant drugs when necessary.

Adolescent↗
PubMed2003

[Attention deficit hyperactivity disorder in adults].

The attention deficit hyperactivity disorder (ADHD) is the most common diagnosis in child psychiatry, and persists very often in adulthood. These patients have poor lifestyles, especially in affective, work and social areas. Although patients with ADHD have a high rate of comorbidity (e.g. drug and alcohol abuse, depressive and anxiety disorders), this diagnosis is missed by the general physician, deferring its identification and opportune treatment. This article is a review about this disorder and gives tools for its recognition and derivation.

Adult↗