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At least 163 records · Page 9Linked to original sources
PubMed1993

Platelet GPIIb/IIIa receptor inhibition by SC-49992 prevents thrombosis and rethrombosis in the canine carotid artery.

OBJECTIVE: Platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptors represent the final common pathway for aggregation. GPIIb/IIIa inhibition with antibodies or RGD peptides prevents arterial thrombosis. The present study examined the ability of SC-49992 (SC), a GPIIb/IIIa receptor antagonist, to prevent thrombosis in a canine model of carotid artery thrombosis. METHODS: Both carotid arteries of anaesthetised dogs were instrumented with Doppler probes. A 300 microA current was applied to the intimal surface of the right carotid artery via an intraluminal electrode; time to occlusive thrombus formation was noted. SC (30 and 60 micrograms/.kg-1 x min-1, intravenously) or saline was infused for 240 min. The procedure for thrombus formation was repeated after 60 min of drug infusion for the left carotid artery. RESULTS: SC did not alter heart rate or blood pressure. Frequency of occlusive thrombus formation was reduced or prevented in a dose dependent manner (control = 100%, n = 12; SC 30 micrograms = 50%, n = 6; SC 60 micrograms = 0%, n = 6; p < 0.05). SC resulted in a reduction in thrombus weight (p < 0.05) v control. Ex vivo platelet aggregation to ADP and arachidonic acid was inhibited. Platelet reactivity remained inhibited 60 min after cessation of SC infusion. In a second group of animals, a carotid artery thrombus was formed and lysed with administration of anisoylated plasminogen streptokinase activator complex (0.05 U.kg-1). SC (60 micrograms.kg-1 x min-1, intravenously, n = 6) or saline (n = 6) was infused for 240 min. In dogs receiving saline there was an 83% rate of rethrombosis; none of the SC treated animals had reocclusion after recanalisation (p < 0.05). CONCLUSIONS: SC-49992 inhibits ex vivo platelet aggregation, prevents occlusive thrombus formation in a canine model of arterial thrombosis, and prevents rethrombosis after thrombolysis. The data are consistent with results obtained with murine monoclonal antibodies directed against the platelet GPIIb/IIIa receptor.

Animals↗
PubMed1990

Salvage after postoperative thrombosis of the carotid artery.

When dense hemiparesis has developed appropriate to the operated vessel after carotid surgery, the patient has been immediately returned to the operating room for reexploration of the vessel and thrombectomy. Over a 5-year period, we identified four patients who developed dense hemiparesis in the recovery room postoperatively. A fifth patient with a similar problem after carotid subclavian bypass was included for analysis. All patients were found to have thrombosis of the operated vessel. Direct closure had been used after endarterectomy. All vessels were thrombectomized and patched with autogenous vein. Interposition graft was used in the patient who underwent carotid subclavian bypass. There were no deaths, and only one patient did not improve. Our experience encourages us to continue this practice but also suggests that the frequency of this problem may be reduced further by patch angioplasty.

Adult↗
PubMed1978

Comparison of antithrombotic activity of heparin, ASA, sulfinpyrazone and VK 744 in a rat model of arterial thrombosis.

Rat carotid arteries were injured electrically (350 V, 2 mA DC for 5 min) before and after the intravenous administration of heparin (1,000 U/kg), VK 744 (25, 50, 100 mg/kg) ASA (100, 200 mg/kg) and sulfinpyrazone (50, 100, 150, 200 mg/kg). Thrombus growth was quantified by recording arterial temperature change distal to the injury. Heparin completely blocked thrombus formation in most experiments. All other agents exhibited antithrombotic activity with sulfinpyrazone being most potent. None was as effective as heparin. This model may be a useful tool for screening antithrombotic drugs.

Animals↗
PubMedDate not supplied

[Monolateral thrombosis of the carotid artery. Contribution of cases].

The clinical problems posed by a series of partial or total monolateral carotid occlusions complicated by cerebral infarction are discussed. Emphasis is laid on the frequent aspecificity of the symptomatology, the inconsistency of palpatory and auscultatory findings in the cervical region, and the value of certain medical techniques that may precede angiographic diagnosis. Considering the lack of reports in the literature, a case in which carotid stenosis was considered to be of luetic nature is noteworthy. Prophylactic treatment designed to prevent another cerebral attack hinges essentially on the correction of arterial hypertension and on the use of antiaggregating drugs. Endarterectomy is contraindicated by the presence of limiting factors.

Aged↗
PubMed2000

Thrombosis of the internal carotid artery secondary to soft palate injury in children and childhood. Report of two cases.

Trauma to the soft palate is a uncommon event during childhood. Stroke following intraoral trauma is also rare, but has been well documented by the current literature as a potentially serious complication. In this article, we report 2 cases of posttraumatic internal carotid artery thrombosis depicted by imaging studies. We discuss pathogenesis, and the literature is reviewed.

Adolescent↗
PubMedDate not supplied

Partial acute thrombosis of internal carotid artery: a case report.

OBJECTIVE: The effectiveness of the urgent carotid TEA in patients with not stabilizes serious neurological symptoms, remains controversial. MATERIAL: The authors report on a case of a partial acute carotid thrombosis. The patient had outcomes of pulmonary tumor dealt with surgical removal of the medium right lobe. At admission, the neurological examination evidenced non specific neurological deficits to both the advanced limbs above all. The blood test evidenced 628000 platelets. The color-doppler showed in the internal carotid artery of right the presence of floating thrombus, during very small fibro-calcified plate, likely ulcerated. RESULTS: The patient was submitted to surgical urgent procedure without ulterior diagnostic deepening. Such attitude was justified from the total regression of the symptomatology and from the absence of alterations of the BEE. DISCUSSION: The urgent surgical treatment has had good outcome. In literature there are similar cases but not place upon ones because of "aetiology" to the inner presence of floating thrombus in carotid not completely occluding in all and the three cases, causes do not correspond from alters platelet parameters, but thrombus was of cardiogenic origin in one case, it was caused by hormonal therapy for sterility in the second, there was thrombosis of carotid aneurysm in third. CONCLUSION: We remark the importance of eco-color Doppler for urgent diagnosis of acute thrombosis, and timeliness of surgical treatment in the "acute" patient with attenuation or regression of the debut symptomatology.

Carotid Artery Thrombosis↗
PubMed1997

Inhibition of arterial thrombosis by recombinant annexin V in a rabbit carotid artery injury model.

BACKGROUND: The procoagulant effect of anionic phospholipid may play a major role in the development of arterial thrombosis. METHODS AND RESULTS: Annexin V, a calcium-dependent anionic-phospholipid-binding protein, was expressed and isolated from Escherichia coli and its antithrombotic effect examined in a rabbit carotid artery thrombosis model. A partially occlusive thrombus was formed in the left carotid artery by application of electric current to produce an approximately 50% occlusion of the lumen. After the current was discontinued, flow ceased completely within 42+/-12 minutes (n=6) because of continuing platelet/fibrin thrombus formation. When annexin V was given at doses of 2.8 to 16.6 microg x kg(-1) x min(-1) for a period of 180 minutes, starting at the time the current was stopped, there was a dose-dependent inhibition of thrombus formation. At a dose of 5.6 microg x kg(-1) x min(-1), blood flow remained patent throughout the infusion and for an additional 60 minutes after the infusion was stopped. In addition, there was a decrease in thrombus weight (16+/-7.4 versus 2.0+/-1.0 g), (125)I-fibrin deposition (approximately 45% reduction, P<.001), and (111)In-labeled platelet accumulation (approximately 43% reduction, P<.001). Prior mixing of annexin V with phosphatidylserine micelles abolished the antithrombotic effect of annexin V, whereas mixing with phosphatidylcholine micelles had no effect. The antithrombotic effect of annexin V was not associated with bleeding tendency, as judged by the amount of blood absorbed in a gauze pad placed in a surgical incision extending to the muscle tissue and by the standard template bleeding time. CONCLUSIONS: These observations support a potentially important role for anionic phospholipid exposure in platelets in arterial thrombosis, and inhibition of this activity could be a novel target for therapy in coronary thrombosis and stroke and after angioplasty.

Animals↗