PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “COARCTATION OF AORTA”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

[Role of stationary activation of glycolysis in the heart during compensatory hyperfunction and aging].

Stationary stimulation of glycolysis was observed in rat heart muscle which produced the compensatory hyperfunction after aorta coarctation. The general character of alterations in energy balance of the hypertrophic heart muscle corresponded to the rearrangements, which occurred during ageing; therefore the coarctation of aorta caused more distinct stimulation of glycolysis in old animals than in young ones. Stimulation of glycolysis in ;the hypertrophic heart muscle was carried out via phosphofructokinase activation as G-PPK was increased by 87% during the heart compensatory hyperfunction. Stimulation of glycolysis, which developed at the beginning of the heart compensatory hyperfunction and continued up to its final steps, was apparently the adaptational mechanism providing the additional intake of ATP into the contractile apparatus, and so this stimulation prevented the decrease of oxygen consumption, produced in the hypertrophic heart muscle.

Adenosine Diphosphate↗
PubMed2006

[Clinical features of coarctation of aorta: analysis of 96 cases].

OBJECTIVE: To investigate the clinical features of coarctation of aorta (CoA). METHODS: The clinical data of 96 pediatric patients with CoA, 60 male and 36 female, aged 3.7 months (7 - 12 years), were analyzed. RESULTS: The male to female ratio was 1.7:1. Infants aged less than 6 months accounted for 60% (57/96). The proportion of CoA in all hospitalized patients with congenital heart diseases admitted in this hospital was 0.5% (5/924) in 1996, increased every year, and reached 4.3% (15/330) in 2005. The coarctation was situated at the distal end of the left subclavian artery opposite to or near the ductus arteriosus in 93 cases, between the left common carotid artery and left subclavian artery in 2 cases, and at the opening of the left subclavian artery in 1 case. Thirteen patients (4%) suffered only from CoA, 47 patients were complicated with patent ductus arteriosus (PDA, 47/96, 49%) and/or ventricular septum defect (VSD, 47/96, 49%), 22 of the 96 patients (23%) complicated with both PDA and VSD. Eighty-nine cases were diagnosed by echocardiography, however, echocardiography failed to diagnose CoA in 7 cases (7.3%). Fifty-five patients underwent surgical repair and 2 of them died with a mortality of 3.8%. Seven patients with large VSD and severe pulmonary hypertension underwent two-stage repair. Immediate post-operative echocardiography showed satisfactory outcome. CONCLUSION: The morbidity of CoA among Chinese is similar to that among the Western population. Most of the coarctation is situated at the distal end of the left subclavian artery opposite to or near the ductus arteriosus, and most of the cases are complicated by PDA and/or VSD. Echocardiography is the first choice in the diagnosis of CoA; however, angiography is still necessary in some cases. Primary radical operation is indicated for infants with CoA, but older patients, especially those complicated with VSD and severe pulmonary hypertension, should undergo two-stage procedure.

Aortic Coarctation↗
PubMed1999

Immediate and follow-up findings after stent treatment for severe coarctation of aorta.

Experimental studies have shown that stents implanted at the aorta become incorporated within the aortic wall and can be further expanded in growing animals. Few clinical studies have shown that the stent repair of severe coarctation of aorta provides excellent initial results, and little is known on the follow-up of these patients. We assessed the immediate and follow-up results obtained in a series of 48 patients (mean age 14+/-12 years) with severe coarctation of the aorta who were treated by Palmaz stent implantation; 30 of them (63%) underwent angiographic follow-up studies at a mean of 25+/-11 months after treatment. Quantitative serial analysis of the aortogram (baseline, after treatment, and at follow-up) was performed. Significant relief (mean residual gradient 3+/-4 mm Hg) was always obtained after stent implantation. The isthmus, when hypoplastic (60%), was always expanded with the stent. One associated aneurysm became occluded after the implant. Complications included aortic disruption, stent migration, and decreased or absent femoral pulses. At angiographic follow-up, the stent remained always in place, without recoil. In 22 patients (73%), there were no detectable neointimal proliferation at late angiogram; however, 8 patients (27%) had some degree of intimal thickening (1 to 5 mm), causing mild restenosis in 3 patients treated at early age, and nonsignificant lumen reduction in 5. The serial aortogram analysis revealed a minor but significant increase in nonstented aortic diameters that seemed related to the normal growth of children. No need for stent reexpansion was observed at 2-year follow-up (mean). Two patients (7%) developed late small aneurysm formation at the stented wall; both were occluded by the insertion of coils through the stent orifices. We conclude that stent treatment for severe coarctation of aorta provides excellent immediate and long-term results in young adults and children. However, at early age, restenosis by intimal growth may develop.

Adolescent↗
PubMed1992

Increased stiffness and persistent narrowing of the aorta after successful repair of coarctation of the aorta: relationship to left ventricular mass and blood pressure at rest and with exercise.

Fifteen children and adolescents who had repair of coarctation of the aorta before age 15, who were not hypertensive at rest, and who had resting arm-leg blood pressure gradients of less than 20 mm Hg underwent noninvasive evaluation of left ventricular structure and function, aortic stiffness, and residual coarctation as well as bicycle exercise testing. These results were compared with those in 15 age- and sex-matched control subjects. The mean resting age-related systolic blood pressure percentiles (63% versus 46%), transverse aortic stiffness measured by the elastic modulus (Ep) (42.1 versus 23.2 kPa), stiffness index beta (beta) (3.66 versus 2.17), echocardiographic left ventricular fractional shortening (0.42 versus 0.36), left ventricular mass index (99.3 versus 81.0 gm/m2), maximum exercise right arm systolic blood pressure (173 versus 156 mm Hg), and exercise arm-leg blood pressure gradient (35 versus 6 mm Hg) were significantly increased in the coarctectomy patients compared with controls. Univariate correlations in the coarctectomy group showed significant relationships of residual aortic narrowing with left ventricular mass index (r = 0.68, p less than 0.01) and resting systolic blood pressure percentile for age (r = 0.55, p less than 0.05). Residual aortic narrowing did not significantly correlate with aortic stiffness, resting blood pressure gradient, or exercise blood pressure gradient. Neither left ventricular mass index nor resting systolic blood pressure percentile significantly correlated with age of repair or years after repair. These results demonstrate persistent abnormalities in aortic stiffness and left ventricular mass and function after successful repair of coarctation of the aorta in childhood and adolescence.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1979

Evaluation of persistent coarctation of aorta after surgery with blood pressure measurement and exercise testing.

In 16 patients with coarctation of the aorta blood pressure in the arms and legs was measured before and after exercise using a treadmill and the Bruce protocol to achieve a standardized level of exercise. Three patients had had no previous operation; 13 had had a previous surgical repair of the coarctation. Three patients were studied both before and after operation. Two of the 13 patients studied postoperatively were found to have significant residual coarctation on the basis of a postexercise arm to leg pressure gradient that had not been appreciated on routine postoperative examination, and one of these patients was found to have residual coarctation after his second operation. One patient not operated on was believed to have mild coarctation of no clinical significance. Eleven of the 13 patients previously operated on (85%) were found to have had a satisfactory repair. A postexercise arm to leg systolic blood pressure gradient of more than 35 mm Hg after repair of coarctation of the aorta is suggested as an indication for recatheterization.

Adolescent↗
PubMed1990

Coarctation as a deformation.

Several aspects of coarctation of the aorta conform with the concept of a deformation, a disorder of morphogenesis resulting from altered fetal hemodynamics. Based on its location at the junction of the aortic isthmus and the ductus arteriosus, the continuity of the ductal wall with the fibromuscular curtain, and the association with cardiovascular malformations causing decreased blood flow through the ascending aorta, coarctation of the aorta is interpreted as the result of diminished blood flow through the fetal aorta, which leads to persistence and aggravation of the normally narrow isthmus and subsequent development of the curtain.

Animals↗
PubMedDate not supplied

Single therapeutic catheterization for treatment of native coarctation of aorta and large patent ductus arteriosus using a covered stent.

A 20-year-old girl was diagnosed to have severe coarctation of the aorta, large patent ductus arteriosus and severe pulmonary artery hypertension. She underwent single therapeutic catheterization for the treatment of native coarctation of aorta and closure of ductus arteriosus using 39 mm long Cheatham-Platinum covered stent. The procedure was done successfully under local anesthesia without any complication. This appears to be a safe strategy while dealing with an adolescent or an adult with this combination of lesions.

Abnormalities, Multiple↗
PubMed1997

[Late postoperative complications of coarctation of aorta].

Main complications of the remote 2-35 years period after coarctation of the aorta repair are studied up. Of 2746 patients 2464 (89.7%) were operated upon at the age of 2-25 years old. In 841 (30.61%) of patients were determined coexistent heart diseases, more often aortic valve lesion. End-to-end anastomosis was fulfilled in 44.6% of operations and patch repair was done in 43.6%. The most frequent complication of the remote period was the aortic aneurysm-in 61 (2.2%) of cases. It occurred seven times more frequently after the patch repair (4.1%) then after anastomosis end-to-end conduction (0.6%). Late postoperative mortality equaled 1.5%. The main reasons of it were aneurysms at the site of repair--in 12 patients, aneurysms of the ascending aorta--in 4 and progressing of the coexisting heart diseases--in 10.

Adolescent↗
PubMed1996

[A case of extra anatomical bypass grafting for coarctation of aorta associated with Turner's syndrome].

A 24-year-old woman with manifestations of Turner's syndrome was referred for detail examinations and treatment of right subclavian tumor on chest X-ray. She was short and obese (147 cm tall and weigh 65 kg). And she had hypertension at upper extremities (160/100 mmHg). Chest enhanced CT revealed right subclavian arterial aneurysm and coarctation of aorta. Aortography showed interrupted descending thoracic aorta with short atretic segment followed by distal descending aorta, aneurysmal collateral artery from right subclavian artery to abdominal aorta and other small collateral arteries. Left lateral thoracotomy was thought to have a high risk for bleeding in the short and obese patient with ample collateral arteries. Therefore, extra anatomical bypass grafting from ascending aorta to abdominal aorta was performed through median sternotomy and laparotomy. After operation recovery was uneventful without residual hypertension. In this report, we discuss about the operation of adult coarctation of aorta and usefulness of extraanatomical bypass grafting.

Adult↗
PubMed1988

Coarctation of aorta: late aneurysm formation with Dacron onlay patch grafting.

Repair of coarctation of the aorta using Dacron onlay patch grafting performed in a 2 1/2-year-old child, with subsequent late formation of a true aneurysm on the side of the graft, is reported. Review of the literature did not reveal other cases of late formation of true aneurysm on the side of the Dacron onlay patch graft.

Aortic Aneurysm↗