PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “CYTOPATHOGENIC EFFECT, VIRAL”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

[Immunofluorescent study of the reproduction of human rotavirus in cell culture].

The mechanism of rotavirus antigen amplification in cell culture was studied by immunofluorescence. Reproduction of human rotavirus in cell culture was shown to begin 6 h after inoculation and to be accompanied by a regular increase in the number of antigen-containing cells. A good correlation with the results of electron microscopic studies was demonstrated. The possibility of reliable detection of rotavirus antigen in cell culture by the fluorescent antibody technique at relatively early intervals after infection has been established.

Animals↗
PubMed1980

Peculiarities of the virus-host cell relationship in a calf kidney cell line persistently infected with measles virus.

Persistent infection with measles virus established in a calf kidney cell line differed in some features from other measles virus carrier systems. After a variable life span, ranging from 50 to 1100 days, six of the chronically infected cell lines showed an evolution towards lytic infection. Only one of these lines, the K-2 cell line, exhibited marked morphological, growth and chromosomal alterations suggesting in vitro cellular transformation. The transformed K-2 cells released infectious measles virus with several modified biological parameters. Persistent infection was not due to the accumulation of thermosensitive mutants or defective particles. The role of the host-cell factor and of the selection of the virus population during its passage in RV cells are discussed.

Animals↗
PubMed1983

Properties of the retrovirus RPMI8226V.

The retrovirus designated RPMI8226V (isolated from human myeloma cells RPMI8226) has been characterized with respect to its morphological, biochemical and immunological properties as well as to find the most permissive cells for its propagation. The RPMI8226V with its morphological, biochemical and immunological characteristics was not found to be related to any known avian and mammalian oncoviruses. The most permissive cells for its propagation were bat (CCL88) and mink (CCL64).

Animals↗
PubMedDate not supplied

[Associated action of the measles and mumps viruses on the lymphatic apparatus of guinea pigs].

The immunomorphological and cytopathological properties of vaccine strains of measles and epidemic mumps viruses inoculated individually and together were studied in experiments in guinea pigs. The optimal doses of measles and mumps monovaccines were found to produce morphological changes of similar intensity in the lymphatic apparatus of guinea pigs. Measles virus stimulated increased alterative changes in lymphoid elements with increased inoculations; mumps virus produced maximum degeneration of the cells immediately after the first inoculation. The combined injection of both viruses enhanced proliferation of lymphoid cells, the extent of their alteration and the frequency of pathological mitoses more than each monovaccine individually. The increased frequency of pathological mitoses occurred mainly due to moderate non-lethal changes in mitosis in which there was a likelihood of the appearance of viable cells with an altered karyotype.

Animals↗
PubMed1978

[Cell transformation by viruses and the development of tumours (author's transl)].

The history of tumour virology and some main points of recent experimentation are described. First, a definition of the term virus is presented. Subsequently, four main topics are discussed: The tumour virus and the integration of its nucleic acid; The mechanism of transformation; The genes of the tumour virus and their products; The importance of the genetic background of animals and cells for transformation and tumour development. The mutual influence of cell and virus genomes is in the focus of consideration. The particulare tumour virus, at least for limited periods of time, comes under the influence of the cell genome. The theories about tumour development by viruses and the possibility of prophylactic measures are described.

Animals↗
PubMed1993

[Milestones in virology].

The "milestones" of virology try to depict the development from variolation to construction of hybrid viruses. Not only single observations or detections are listed, in contrast, this is an attempt to delineate from single events conclusions for the more general development of virology. Because of the increase of specialization in experimental sciences, it is often difficult for researchers to realize the roots of their present problems. Often, earlier conclusions are being overlooked, from which recent experimentations have been delineated.

Animals↗