Colour vision defects in alcoholism.
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Extensive copper infiltration of Descemet membrane of the central cornea and of the anterior and posterior surfaces of the lens is associated with marked hypercupremia related to an abnormal immunoglobulin. Observation of this spectrum of ophthalmic changes in an apparently well middle-aged woman heralded the diagnosis of a unique variety of multiple myeloma.
This paper compares the performance of color defective patients on the Farnsworth Lantern test in both unlit and lit room conditions. We examined 18 dichromats and 33 anomalous trichromats, as diagnosed by the Mark I Nagel Anomaloscope. No statistically significant differences were found between their performance in the two conditions.
The Davidson and Hemmendinger (DH) color rule was evaluated for color vision screening of normal and congenital color-defective subjects. Ninety-eight normal and 14 color-defective subjects were tested on the color rule under Macbeth illumination of 5,400 K. The color-defective subjects were also tested on the Nagel anomaloscope, the Farnsworth D-15, and the H-R-R pseudoisochromatic plates. The DH color rule performed as accurately as the anomaloscope and was superior to the other two tests in detecting anomalous trichromats and in discriminating protanomalous subjects. The color rule also discriminated dichromats from anomalous trichromats. For severe color-defective subjects (dichromats, achromats), the color rule was more time-consuming than the other tests and discrimination was less certain. Response patterns on the DH color rule and response variability of the different classifications are reported.
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A red contact lens (X-Chrom lens) worn on the nondominant eye by 12 color-defective subjects caused significant improvements on the Dvorine, Ishihara, and Hardy-Rand-Rittler pseudo-isochromatic color plate tests. Color vision scores on the Farnsworth Lantern, Color Threshold Tester, and Aviation Signal Light Gun were not improved. Minimal changes were found on the Farnsworth D-15 test, aeronautical chart color identification task, visual acuity, phoria, and stereoscopic depth perception. Control and color-defective subjects perceived a change in the path of a pendulum (Pulfrich test) when viewing through the X-Chrom lens or a monocular red filter. The X-Chrom lens may require extended wearing before its optimum effect becomes apparent.
Two cases, those of a man and a woman, developed retinal periphlebitis after hormonal treatment for infertility and contraceptives, respectively. Both had a unilateral severe decrease in visual acuity, and a central scotoma and defect in color vision were also present. The fundus had retinal edema, especially of the macula, a hyperemic disc with blurred margins, normal arteries, congested veins, and marked sheathing along the main veins, with retinal hemorrhages in the inferior half of the retina. Fluorescein angiography showed a delayed filling of the veins in the affected retina and late staining of these veins. Since there was severe visual impairment in each case, systemic adrenocorticosteroids were administered, and a rapid improvement in visual acuity occurred. In one patient, a trace Marcus-Gunn sign, a few small paracentral scotomas, and a defect in color vision were permanent sequelae.
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