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At least 163 records · Page 9Linked to original sources

Fibrin sealant in experimental tubal microsurgery.

This study compares the results of microsurgical tubal anastomosis performed using a fibrin sealant, 9-0 monofilament polyglycolic acid (PGA) suture, or fibrin sealant in combination with 9-0 PGA suture. Sixty rabbits were divided into three groups of 20 rabbits each. The pregnancy rate of the rabbits was 95%, 95%, and 85%, respectively; without any intervention, the fertility rate was 95% in 20 nonexperimental rabbits (control group). We conclude that fibrin adhesive employed for reanastomosing of the fallopian tube in rabbits, compared with synthetic microsutures, results in identical pregnancy rate and identical conditions of passage through the tubes. Fibrin sealant is absorbed more rapidly than absorbable microsutures, results in fewer adhesions, and shorter operating time. Thus, fibrin adhesive possibly provides an alternative to the traditional employment of sutures in gynecological microsurgery.

Animals↗

Nd:YAG laser therapy for infertility with a contact-type probe.

Laparoscopic Nd:YAG laser surgery for tubal adhesiolysis, hydrosalpinx and other disorders is an effective treatment for female infertility that causes relatively little tissue damage. In initial studies using contact-type probes, the 0.4-mm-diameter probe and 10 mm/sec incision speed were found to cause less tissue degeneration than did other combinations (P less than .05). Fifteen infertile women were treated at laparoscopy with a Nd:YAG laser; one of six with hydrosalpinx achieved pregnancy after salpingostomy using a contact-type probe, two of three with tubal adhesions achieved pregnancy after adhesiolysis with the Nd:YAG laser, and three of six with polycystic ovaries achieved pregnancy after wedge resection using a contact-type probe. Five of fifteen infertile women conceived after Nd:YAG laser surgery with a contact-type probe under laparoscopy. We confirmed that contact irradiation with a ceramic incising probe is capable of creating an adequate incision at low power levels and that laparoscopic Nd:YAG laser surgery for infertile women is an effective treatment.

Adult↗

[Laparoscopic picture in patients with oligomenorrhea treated for chronic salpingo-oophoritis].

Sixty patients with oligomenorrhea and the painful syndrome were examined to study the course of a chronic inflammatory process of the genitals. Laparoscopy has confirmed the initial diagnosis of salpingo-oophoritis in 24 of the 60 examinees. The authors call for a more thorough examination of this patient population, for an erroneous diagnosis of a chronic inflammation leads to erroneous therapeutic strategy, consisting in irrational administration of antibacterial, balneo- and physiotherapy.

Adult↗

[Evaluation of the radionuclide hysterosalpingography].

In 22 patient in control for sterility and in 6 healthy women the Radionuclide Hysterosalpingography was used and its results were compared to classic Hysterosalpingography and laparoscopy. This new method allows the diagnosis of functional obstructions, reanastomosis and evaluation of the tubal sterilization.

Adult↗

[Significance of prognostic factors in the treatment of tuboperitoneal infertility].

The results of microsurgical treatment for tubo-peritoneal infertility are reported in 78 patients. Neosalpingostomy, combined with salpingo-ovariolysis, was performed in 51 patients, fimbriolysis and fimbrioplasty, in 8, tubal anastomosis in 7, and combined operations, in 12. Anatomical and functional assessment of the postoperative tubes was made using roentgeno-television hysterosalpingography, tubal insufflation and dynamic scintigraphy. Postoperative rehabilitation was supplemented by physical factors affecting tubal motility (supratonic frequency currents, tubal electrostimulation) with regard to the type of functional tubal disorder. Tubal patency was regained in 74.4%, and reproductive capacity, in 20.5% of the patients.

Adult↗

Microsurgical reversal of female sterilization. Long-term follow-up of 117 cases.

A prospective study of 117 consecutive microsurgical reversals of female sterilization from April 1981 to December 1984 was carried out to determine which factors affected the pregnancy outcome. Nylon sutures, 8-0, were placed through the muscularis and mucosal layers. A short abdominal incision was made. The patients were followed for 3.5 to 7.0 years. The term delivery, intra-uterine pregnancy, spontaneous abortion and ectopic pregnancy rates were 81.2%, 83.8%, 1.7% and 1.7%, respectively; two ectopic pregnancies occurred 14 and 24 months after the reversal procedures. We found that the time interval between sterilization and reversal and the methods of sterilization affected the pregnancy outcome. The success rate with intervals of less than five years was much higher than with intervals of more than five years; Pomeroy cases were more reversible than Uchida cases. We did not observe any influence of the anastomosis site on the pregnancy results. The term delivery rates for isthmus-isthmus, isthmus-ampulla and ampulla-ampulla anastomoses were 78.8%, 80.0% and 84.6%, respectively. Patients should be followed for two years at least to determine the pregnancy outcome as well as the occurrence of ectopic pregnancy.

Anastomosis, Surgical↗

Fertility after salpingostomy following mechanically produced hydrosalpinx in rabbits.

Microsurgical salpingostomy results in 90% of tubes remaining patent following surgery. Although pregnancy rates have improved to a slight extent, the percentage of patients having live babies after salpingostomy is still disappointing. The discrepancy between patency rates and pregnancy rates seems to be due mainly to long standing tubal damage after the original infection. Possibly, raised intraluminal pressure from accumulated fluid may be a factor. Mechanically produced hydrosalpinges in rabbits show similar morphological characteristics to human hydrosalpinges (Vasquez et al., 1981, Otubu et al., 1984). This rabbit model was used in this study to examine the relationship between the severity of these changes and fertility after salpingostomy. Mechanical hydrosalpinges were produced in thirty mature New Zealand white rabbits by double clip application. After a period varying from 8 to 52 weeks of clip application, cuff salpingostomy and ampullary-isthmic anastomosis was done. One week after surgery, the animals were mated with bucks of proven fertility. There were pregnancies in all the uterine horns on the unoperated side (control) in all animals. There were pregnancies on the operated side in only two animals giving a pregnancy rate of 6.7%. A total of sixteen tubes were patent out of thirty operated, giving a patency rate of 53.3%. Adhesion was a major problem. We conclude that fertility is reduced after salpingostomy in mechanically produced hydrosalpinges in rabbits. The significance of this finding is discussed.

Animals↗

Hysterosalpingoscintigraphy: a simple and accurate method of evaluating fallopian tube patency.

A prospective study was designed to evaluate the efficacy of radionuclide hysterosalpingoscintigraphy using 99mTc-labelled human serum albumin macroaggregates in 17 patients (34 tubes). In normal females the macroaggregates migrate spontaneously through the female reproductive tract following application into the posterior vaginal fornix. They can be seen in the uterine fornix 20 min p.i. (range: 5-90 min) and as free pelvic activity 120 min p.i. (range 40-180 min). Free pelvic activity could also be demonstrated by culdocentesis. In infertile patients with failure of tubal patency images after 180 min offered no additional information. For the routine diagnosis camera images 5, 60 and 180 min p.i. are recommended. Using 5-10 MBq 99mTc the radiation exposure to the ovaries is about 1/9th of the exposure from a normal radiologic hysterosalpingogram. The reported data show results comparable with those of hysterosalpingography (HSG) in females with patent or with nonpermeable tubes, but in cases of high-pressure by patency by HSG the results of scintigraphy are superior to those of HSG. Moreover, this method provides new insights into sperm motility under various physiological and pathological conditions.

Adult↗

A preliminary study on rabbit tubal anastomosis with the Nd-YAG laser.

This is the first report on the use of the Nd-YAG laser in performing tubal end to end anastomosis in rabbit. At first, the optimal intensity of laser exposure was evaluated using histological preparations of tubal ampullary tissues which were exposed in various conditions. It was determined that the most suitable condition was 12 watts/cm2 of energy density of 0.2 second duration and a 0.6mm focal spot. Subsequently, these treatment conditions were applied practically to end end anastomosis of severed tubal ampulla of three rabbits. Four weeks later, the second laparotomy was done to confirm the restoration of tubal patency by chromopertubation in vivo, and to excise the restored tube to study the reconstruction of luminal epithelium histologically by scanning electron microscope. Proven by chromopertubation in vivo, tubal patency was restored in 4 out of 6 tubal samples, but in two, tubes were dehisced at the anastomosed line. By scanning electron microscopic observation of tubal samples in which patency was restored some injury to mucosal epithelial cells was seen at the anastomosed site. It is concluded that the Nd-YAG laser technique is useful in tubal end to end anastomosis of rabbit and accurate placement of tubal stumps is essential to the proper restoration of tubal patency.

Animals↗

Radionuclide hysterosalpingography for evaluation of fallopian tube patency.

A prospective study was undertaken to evaluate the efficacy of radionuclide hysterosalpingography (RNHSG) using a technique with some modifications, that was described by Iturralde and Ventner (1). As these investigators demonstrated, technetium-labeled human albumin microspheres (HAM) will normally migrate spontaneously from the vagina to the ovaries. This study confirms that in the presence of fallopian tube obstruction, fibrosis and/or lack of motility, this migration does not take place, and that the presence or absence of migration of HAM can be imaged with a gamma camera. In the evaluation of 52 tubes we found that the efficiency of RNHSG for evaluation of fallopian tube patency when compared with contrast hysterosalpingography and/or direct observation of surgical pathology was over 94%. RNHSG is an essentially innocuous technique for assessing functional and mechanical fallopian tube obstruction that can be performed with conventional nuclear imaging equipment.

Evaluation Studies as Topic↗