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PubMed1986

Ventral tegmental area infusion of substance P, neurotensin and enkephalin: differential effects on feeding behavior.

The neuropeptides substance P, neurotensin and [Met]enkephalin are found in the ventral tegmental area, site of the A10 dopamine cell bodies. Evidence suggests a functional interaction between these peptides and the dopaminergic neurons. All three peptides have been shown to exert an activating effect on these neurons. The present study analyzed the effects of ventral tegmental area infusion of neurotensin, substance P and D-ala-[Met]enkephalin on feeding behavior. These effects were studied in both food-deprived and satiated rats. During a 30 min test, the following parameters were registered: latency to eat, total food intake, food spillage, number of eating bouts and duration of eating. Similar measures were taken for drinking. In deprived rats substance P (0.5, 3.0 micrograms) increased latency to eat but did not affect other parameters, and substance P did not affect eating in satiated rats. Neurotensin (0.5, 2.5 micrograms) increased latency to eat and markedly reduced food consumption in deprived rats and had no effect in satiated rats. D-Ala-[Met]enkephalin (0.1, 1.0 micrograms) stimulated feeding behavior in both deprived and satiated rats. These results show that although the different peptides are presumed to activate the dopaminergic A10 neurons, their effects on feeding behavior can be differentiated. The findings are discussed in terms of motor and motivational mechanisms, and the relative contributions of specific and non-specific influences on feeding are considered.

Animals↗

PubMed2005

Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves).

We investigated the role of 5-HT2C receptors and serotonergic transmission in the feeding behavior control of quails. Administration of serotonin releaser, fenfluramine (FEN) and 5-HT2C agonists, mCPP and MK212, 1.0 and 3.3 mg/Kg induced significant inhibition of food intake in previously fasted fowls (0.71 +/- 0.18 g and 0.47 +/- 0.2 g; 0.49 +/- 0.22 g and 0.48 +/- 0.29 g; 0.82 +/- 0.13 g and 0.71 +/- 0.16 g, respectively). Control groups ranged from 2.89 +/- 0.21 g to 2.97 +/- 0.22 g, 60 min after reintroduction of food, P < 0.0001). Similar results were obtained with normally fed quails. Both serotonin releaser and 5-HT2C agonists, in a 3.3 mg/Kg dose, induced hypophagy (FEN, 0.78 +/- 0.08 g; mCPP, 0.89 +/- 0.07 g; MK212, 1.25 +/- 0.17 g vs. controls, 2.05 +/- 0.12 g, 120 min after food was presented, P < 0.0001 to P < 0.01). Previous administration of 5-HT2C antagonist, LY53857 (5.0 mg/Kg) blocked the hypophagic response induced by 5-HT2C agonists 60 min after food was reintroduced. Current data show a modulatory role of serotonin release and postsynaptic 5-HT2C receptors in the feeding behavior of quails.

Animals↗

PubMed1986

Neuronal responses in monkey lateral hypothalamus during operant feeding behavior.

Single neuron activity was recorded from monkey lateral hypothalamus to investigate neuronal events correlated with operant bar press feeding behavior. The behavioral paradigm was divided into three phase: visual (discrimination), bar press (procurement), and ingestion (consummatory). Of 669 neurons tested, 158 (24%) responded in one or more phases. During the visual phase, 106 neurons (16%) responded. Of 80 neurons that responded in the visual phase and were tested systematically, 33 (41%, 33/80) responded selectively to the sight of food or nonfood objects associated with a juice reward, but not to the sight of nonfood or objects associated with aversive saline. Neuronal activity related to discrimination was modulated by satiation and learning (i.e., acquisition and extinction). During the bar press phase, 51 neurons (7.6%) responded. These responded tonically during the early or late stage of the bar press period, but did not depend on individual bar pressing motions. During ingestion, 90 neurons (13%) responded. The ingestion response was modulated by palatability of food and satiation. Data suggest that the LHA is deeply involved in operant feeding behavior; discrimination of food, drive to get food, and perception of reward, all of which are affected by learning and internal states such as hunger and satiety.

Animals↗

PubMed1995

Inhibitory effects of anti-prolactin receptor antibodies on prolactin binding in brain and prolactin-induced feeding behavior in ring doves.

Although binding sites for prolactin (PRL) have been mapped and partially characterized in the brains of several species, there is as yet no direct evidence that the effects of intracranial PRL on brain function are receptor-mediated events. We addressed this question by testing whether antibodies generated against rat liver PRL receptors can effectively antagonize the ability of PRL to enhance feeding behavior in male ring doves (Streptopelia risoria). Both agents were administered directly to the ventromedial hypothalamic nucleus (VMN), which is an effective site of PRL action in promoting hyperphagia in this species. In the initial study, affinity-purified gamma-globulin (IgG) from the receptor antiserum preparation was tested for its ability to compete with 125I-ovine PRL for binding to receptors in rat liver, dove choroid plexus, and 6 PRL-sensitive dove brain regions using in vitro quantitative film autoradiography. Although the binding affinity of the anti-PRL receptor antibodies was at least 50 times lower in dove brain than in rat liver, a 40-50% inhibition of specifically bound 125I-ovine PRL was observed in choroid plexus and in 5 of 6 brain regions with anti-receptor IgG concentrations of 5.8 x 10(-7) M and 1.2 x 10(-6) M, using sections incubated with normal rabbit serum (NRS) IgG as a control. In a second study, anti-PRL receptor IgG or NRS IgG (2.4 micrograms) was injected unilaterally into the VMN at 45-60 min prior to VMN injection of ovine PRL (50 ng) or saline vehicle. This procedure was repeated at twice-daily intervals for 5 days. When compared to the feeding behavior of PRL-injected birds given NRS IgG, antireceptor antibody-treated animals showed a marked reduction in PRL-induced hyperphagia. The magnitude of this reduction was calculated to be approximately 50% after corrections were made for a mild hypophagia induced by the anti-receptor IgG treatment alone, as reflected in the feeding behavior of the anti-PRL receptor IgG + vehicle-treated group. These results suggest that PRL receptors in dove brain and rat liver exhibit structural similarities as well as differences and that the hyperphagia induced by intracranial injections of PRL is mediated, at least in part, by interactions with PRL receptors in the brain.

Animals↗

PubMed1983

Cholinergic role in monkey dorsolateral prefrontal cortex during bar-press feeding behavior.

Cholinergic involvement in the neuronal activity of the dorsolateral (DL) prefrontal cortex in the monkey was investigated during bar-press feeding behavior. Iontophoretic application of ACh increased the firing rate of more than half of the cells through muscarinic receptors. Activity of ACh-sensitive cells did not correlate with any particular event during the feeding task. Continuous application of ACh markedly enhanced increases in response to events during the feeding task, and application of an ACh antagonist diminished response levels. This indicates that ACh release may occur during the feeding task and affect cortical cells to improve the signal-to-noise ratio of the excitatory input. Decreased responses to events during the feeding task diminished during ACh application. Driven discharges in the cells were evoked by stimulation of the basal nucleus of Meynert (BNM) where ACh containing cells are localized. This response was specifically blocked by iontophoretic application of atropine. In conclusion, cholinergic inputs arising from the BNM are distributed profusely among the cortical cells and modulate their excitability during bar-press feeding behavior.

Acetylcholine↗

PubMed2003

Personal breast-feeding behaviors of female physicians in Mississippi.

BACKGROUND: In this study, we examined the personal breast-feeding behaviors of female physicians in Mississippi. METHOD: Two hundred fifteen of 350 female physicians responded to a survey inquiring of their personal breast-feeding behaviors. RESULTS: One hundred fifty-five mothers (74%) reported having biologic children, and 146 (94.2%) breast-fed at least 1 child. Approximately 21% of the responding mothers breast-fed their first-born children for at least 6 months. There was a positive relationship between the duration of breast-feeding of older children and the breast-feeding duration for younger children. The major reasons for weaning were return to work, diminishing milk supply, and lack of time to pump breast milk. CONCLUSION: The breast-feeding initiation rates among female physicians surpassed those of women in the general population, yet duration rates were comparable. Their own breast-feeding success might enhance the potential of female physicians as advocates and sources of credible information regarding breast-feeding; however, physicians need to be better educated regarding the management of breast-feeding.

Adult↗

PubMed2000

Chronic cocaine treatment induces dysregulation in the circadian pattern of rats' feeding behavior.

The effects of protracted cocaine administration (15 mg/kg i.p., twice a day for 9 days) on the circadian pattern of feeding behavior was studied in individually housed male Sprague-Dawley rats, maintained under a 12:12 light:dark cycle. Water and food were available ad libitum and food intake was measured twice a day before, during and after withdrawal of cocaine (or saline) treatment. Neither total 24-h food intake, nor body mass at the end of the experiment, was significantly different between cocaine-treated and control animals. However, cocaine administration affected the temporal distribution of food consumption. During the dark (activity) phase, rats receiving cocaine injections consumed significantly less food than control animals, and this effect persisted for up to 3 days of cocaine withdrawal. During the light (rest) phase, cocaine administration promoted food consumption and a significantly higher food intake was also observed during the first five cocaine withdrawal days. Continuous monitoring of locomotor activity did not reveal significant changes in the circadian pattern of activity between the two experimental groups during different treatment periods, except for an acute increase in locomotion within an hour after daytime cocaine injection. The results of this study demonstrate that sub-chronic cocaine administration alters the circadian pattern of rats' feeding behavior.

Animals↗

PubMed1991

Common regulation of feeding and mating in Aplysia fasciata: pheromones released by mating and by egg cordons increase feeding behavior.

We examined whether pheromones released by reproductive behaviors (mating and egg-laying) affect feeding behavior. A preliminary experiment demonstrated that the quantity of food eaten can be used to measure the effects of pheromones on feeding. Using this measure, we then showed that Aplysia that were prevented from mating, but that were in the same aquarium as mating conspecifics, eat more food than do Aplysia in a medium lacking mating animals. Mating and feeding were not temporally correlated, indicating that pheromones released by mating probably do not initiate feeding, but rather modulate feeding after it has begun. Aplysia that were in the same aquarium as freshly deposited egg cordons also ate more than did animals in a medium lacking eggs.

Animals↗

PubMed1999

Effects of delta 9-tetrahydrocannabinol and diazepam on feeding behavior in mice.

The present study examined effects of diazepam (DZP) alone or in combination with delta 9-tetrahydrocannabinol (THC) on feeding behavior as well as body weight in male ddY strain mice at 5 weeks of age. Because we saw no hyperphagic effect of DZP with or without THC in mice, we explored the hyperphagia elicitable by DZP. THC [2 (THC2) or 4 (THC4) mg/kg/day s.c.] was given daily for 7 days. For the last day the mice were starved and injected i.p. with DZP (2 mg/kg) 10 min prior to a food or maze test. Controls received vehicle injections. Feeding behavior was measured after giving food for 2 hr. THC4 significantly reduced body weight gain. DZP, with or without THC, induced hyperphagia. THC4 alone also induced hyperphagia that was not significantly affected by DZP. Time taken to find food was extended by DZP and further with THC. Both DZP and THC can therefore interact on food ingestion but synergize on food seeking in mice through different mechanisms.

Animals↗

PubMed2001

Effects of abomasal infusion of long-chain fatty acids on intake, feeding behavior and milk production in dairy cows.

Fat is often fed to dairy cows to increase the energy concentration of their diet; however, feeding fat often reduces dry matter intake (DMI), which limits its impact on metabolizable energy (ME) intake. To investigate the effects of postruminal fat infusion on intake, feeding behavior, and milk production of dairy cows at two stages of lactation (55 and 111 d postpartum), six Holstein x British Friesian cows were infused into the abomasum, with a mixture of rapeseed and sunflower oils supplying predominantly unsaturated long-chain fatty acids (LCFA). Dry matter intake was significantly depressed by oil infusion, but estimated ME intake was unchanged, and thus there was no effect of oil infusion on milk yield. There was no effect of stage of lactation on the DM or ME intake response to oil infusion. Milk fat concentration was increased by oil infusion in mid-lactation but not in early lactation, suggesting that the infused LCFA were utilized differently in early compared with midlactation. Cows spent an average of 654 min idling, 462 min ruminating, and 248 min eating during the last 22.8 h of each infusion. There were no significant effects of oil infusion or stage of lactation on the total time spent engaged in these activities. An assessment of the circadian pattern of feeding behavior suggested that the depression in DMI in response to oil infusion occurred after the 1630 and 2230 h feeding times. This may reflect differences in mechanisms regulating feed intake behavior and appetite during the day. Comparison of the results of the present study with the results of other trials involving postruminal fat infusion suggests that polyunsaturated nonesterified fatty acids have the most potent effect on DMI intake.

Abomasum↗

PubMed1989

Chronic intracerebral cannula can affect feeding behavior in the rat.

Intracerebral cannulae were placed in the lateral ventricle of rats. It was shown that the cannulae per se can affect feeding behavior. After recovery from surgery, rats displayed an unusual eating rate which consisted of very long, slow and large meals. This slow eating rate led to a modification of the circadian pattern; it induced a decrease in night-time and increase in day-time cumulative intakes. This phenomenon appeared when cannulae crossed the cortical motor area concerned with forelimb movements. Different stereotaxic coordinates had to be used in order to place cannulae in the lateral ventricle without disturbing the feeding pattern. This observation underlines the importance of recording feeding pattern before any surgery in any study of feeding behavior.

Animals↗

PubMed1997

Effect of restraint stress on feeding behavior of rats.

The expression of appetite reflects the complex functioning of a psychobiological system organized in different levels closely related to each other, in which emotional changes can influence feeding behavior. Benzodiazepines are widely used as anxiolytics and can change behaviors caused by stress. The aim of the present study was to verify the feeding behavior of rats, submitted or not to fasting, after acute and chronic restraint stress. We also evaluated the response to the ingestion of sweet food of chronically restrained animals after the administration of diazepam. Male adult Wistar rats were exposed to restraint 1 h/day for 50 days in the chronic model. In the acute model, there was a single exposure. Four hours after the stress, the animals were placed in a lightened area in the presence of 10 pellets of sweet food (Froot Loops). The number of ingested Froot Loops was measured during a period of 3 min in the presence or absence of fasting. The groups acutely stressed showed ingestion similar to that of the control group, whether they had been fasted or not. The chronically stressed animals showed increased ingestion of sweet food. Diazepam given 60 min before the test session of the stressed rats reduced the ingestion of these animals to control levels. Thus, the chronic stress increases appetite for sweet food, independently of hunger, and diazepam is able to reverse this behavior.

Animals↗

PubMed1998

Central opioid control of feeding behavior in the white-crowned sparrow, Zonotrichia leucophrys gambelii.

Many behavioral responses to stress do not appear to be mediated by glucocorticoids, suggesting another mechanism. We tested the effects of intracerebroventricular administration of beta-endorphin, a neuropeptide implicated in the stress response, on feeding behavior in captive, wild-caught white-crowned sparrows (Zonotrichia leucophrys gambelii). The amount of time spent feeding and the number of feeding bouts were higher after infusion with beta-endorphin than after saline infusion. Beta-endorphin decreased the latency to feed compared with saline. Naloxone, an opioid antagonist, suppressed feeding behavior and increased latency to feed. These results support our hypothesis that neuropeptides associated with stress may initiate adaptive responses to natural stressors in wild species.

Adaptation, Physiological↗

PubMed2003

Feeding behavior problems in children with cystic fibrosis in the UK: prevalence and comparison with healthy controls.

BACKGROUND: Feeding behavior problems contribute to inadequate dietary intake for many patients with cystic fibrosis (CF). However, to establish effective intervention programs, more needs to be known about the occurrence and distribution of these difficulties. The aims of this study were to establish the prevalence and range of disruptive child behaviors (DCB) in patients with CF and the inappropriate parental responses (IPR) during mealtimes and to compare the results with those of healthy children. METHODS: In study A, parents of 108 patients (aged 1-7 years) completed a Behavioural Paediatric Feeding Assessment Scale comprising two domains: DCBs and IPRs during mealtimes. Parents rated the frequency of the behaviors and responses and identified those they considered problematic. In study B, data from the CF group (n = 69, aged 1-12 years) were compared with 69 age- and sex-matched control subjects. RESULTS: Parents of children with CF aged 5 to 8 years recorded significantly more DCBs than those in all other age ranges. These parents also reported significantly more IPRs than did parents of children aged 9 to 12 years and 13 to 17 years. Parents of children with CF reported significantly more DCBs and IPRs than did those of the control subjects. There were significantly more problematic DCBs and IPRs in the CF group than in the control group for children aged 5 to 8 years and 9 to 12 years but not for those aged 1 to 4 years. CONCLUSIONS: Parents of children with CF report more feeding behavior problems than do those of healthy control subjects. The high prevalence of feeding behavior problems in older children suggests that preventative and reactive interventions must continue throughout childhood and vary according to the child's developmental abilities.

Adolescent↗

PubMed2006

How does maternal and child feeding behavior relate to weight gain and failure to thrive? Data from a prospective birth cohort.

OBJECTIVES: The aim of this study was to study the influences of child and maternal feeding behavior on weight gain and failure to thrive in the first year of life. METHODS: The Millennium Infant Study recruited a population birth cohort in Northeast England shortly after birth and studied them prospectively to the age of 13 months. Parents completed questionnaires at 6 weeks and 4, 8, and 12 months. Appetite was rated on a 5-point scale at each age, and a core group of questions was used to generate scores of oromotor dysfunction, avoidant eating behavior, maternal feeding anxiety, and response to food refusal. Routinely collected weights were used to assess weight gain using the thrive index (TI); weight faltering was defined as TI below the 5th percentile from birth to age 6 weeks or 4, 8, or 12 months. RESULTS: Of 923 eligible infants, 75% of the mothers returned at least 1 questionnaire and > or =2 weights. Weight gain to 6 weeks was independently related to appetite and oromotor dysfunction rated at 6 weeks. Appetite rated at 6 weeks and 12 months both independently predicted weight gain to 12 months. Some avoidant eating behavior was seen in most children by 12 months old, but there was no relationship with weight gain or faltering after adjustment for appetite. However, the extent to which caregivers responded to food refusal was a significant inverse predictor of weight gain, even after adjustment for appetite. CONCLUSIONS: Inherent child appetite characteristics seem to be an important risk factor for weight faltering and failure to thrive, but high maternal promotion of feeding may also have an adverse influence.

Anxiety↗

PubMed2005

Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks.

Neuropeptides containing a C-terminal Arg-Phe-NH2 motif (RFamide peptides) are suggested to be involved in the control of feeding behavior in both invertebrates and vertebrates. Gonadotropin-inhibitory hormone (GnIH) is the first identified avian RFamide peptide that inhibits gonadotropin release from the pituitary. The GnIH precursor encodes one GnIH and its related peptides (GnIH-RP-1 and -RP-2) that shared the same C-terminal motif, Leu-Pro-Xaa-Arg-Phe-NH2 (Xaa = Leu or Gln) (LPXRFamide). GnIH neurons are localized in the paraventricular nucleus, with their fibers visible in multiple brain locations including the median eminence and brainstem. In this study, we therefore investigated the action of GnIH and its related peptides on feeding behavior. Intracerebroventricular (ICV) injection of GnIH, GnIH-RP-1 and GnIH-RP-2 significantly stimulated food intake in chicks. The chicken pentapeptide LPLRFamide, a degraded C-terminus of GnIH and GnIH-RP-1, did not stimulate feeding thereby demonstrating the importance of the N-terminus of GnIH and its related peptides for the orexigenic effect. Anti-GnIH antiserum suppressed appetite induced by fasting, but did not modify feeding under ad libitum conditions. The present study suggests that GnIH and its related peptides act as endogenous orexigenic factors in the brain of chicks.

Amino Acid Sequence↗

PubMed1988

Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior.

Recent studies show that bilateral neural transections (NT) at the level of dorsal tegmentum in the mesencephalon significantly increase food intake and decrease latency to onset of feeding behavior in response to neuropeptide Y (NPY). The increased responsiveness to NPY may be due to denervation-induced hypersensitivity to NPY in hypothalamic sites that mediate feeding behavior in rats. To test this hypothesis we have studied the effect of NT on NPY concentrations in 7 neural sites of male rats. Two weeks after NT, NPY levels in 3 hypothalamic nuclei--suprachiasmatic nucleus, arcuate nucleus and ventromedial hypothalamus--were not altered by NT thereby suggesting that NPY innervations in these nuclei may be derived mainly from NPY perikarya in the ARC and elsewhere in the diencephalon. On the other hand, NPY concentrations were markedly decreased (50-60%) in the medial preoptic area, paraventricular nucleus, median eminence and dorsomedial nucleus indicating that a substantial number of neurons in the brainstem, which show coexistence of NPY and adrenergic transmitters, project into these 4 diencephalic nuclei. These findings indicate that NPY-containing neurons in the brainstem may project into selected hypothalamic sites and the reduction in the NT rats of NPY levels, especially in the paraventricular nucleus, may be responsible for the reported increase in sensitivity of the NPY-induced feeding response.

Animals↗

PubMedDate not supplied

The influence of bufotenin on the feeding behavior and cerebral serotonin content in rats.

By researches carried out in male adult rats (Wistar), the influence of the intraperitoneally injected bufotenin (5 mg/kg b.w. active substance in saline solution) was followed on: I--feeding behavior; II--the serotonin concentration in hypothalamus, rhinencephalon, mesencephalon and sensorimotor cerebral cortex. The obtained results show that bufotenin influences the feeding behavior by reducing the motor functions. Its action depends on the physiological state of the animal: by increasing the alimentary motivation the rats can escape the bufotenin influence, showing a normal behavior; bufotenin does not influence the sensorials, the natural dispositions and the excitability level of the feeding and satiety hypothalamic centers. Bufotenin increases serotonin concentration only in the mesencephalic region, but not in the other studied regions. The results are interpreted as a primary bufotenin action on the serotoninic vasoconstrictive receptors at the mesencephalic level, thus disturbing the serotonin-releasing processes and possibly other chemical neurotransmitters.

Animals↗