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Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

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At least 163 records · Page 9Linked to original sources
PubMed1998

Therapeutic dilemmas in prostate cancer: justification for watchful waiting.

Despite the large numbers of elderly men known to harbour pathological evidence of prostate cancer and evidence from observational studies suggesting the prolonged time course of such disease, conservative management of such patients has not enjoyed the widespread support of urologists, particularly in the USA, where monitoring of patients is often dismissed as 'intentional neglect' rather than 'watchful waiting'. This paper outlines the rationale and principles underlying expectant treatment of patients with prostate cancer.

Aged↗
PubMed2006

Writing good abstracts.

INTRODUCTION: Writing an abstract means to extract and summarize (AB - absolutely, STR - straightforward, ACT - actual data presentation and interpretation). Thousands of abstracts are submitted to stroke conferences each year. The following suggestions may improve the chances of your work being selected for presentation, and to communicate results in the most efficient and unambiguous way. TITLE AND STRUCTURE: Make the title dynamic and informative, rather than descriptive. Structure the abstract following the IMRaD (Introduction, Methods, Results and Discussion) principle for your future original paper where background would become Introduction and conclusions would enter Discussion. Select the appropriate category for submission carefully. This determines which experts grade the abstract and the session where your competitors represent their work. If selected appropriately, your abstract is more likely to be graded by peers with similar interests and familiarity with your work or field. Methods should describe the study design and tools of data acquisition shortly, not data. RESULTS: Provide data that answer the research question. Describe most important data with numbers and statistics. Make your point with data, not speculations and opinions. Abbreviations should be avoided and only be used after they have been spelled out or defined. Common mistakes include failure to state the hypothesis, rationale for the study, sample size and conclusions. Highlight the novelty of your work by carefully chosen straightforward wording. CONCLUSIONS: Conclusions have to be based on the present study findings. Make sure your abstract is clear, concise and follows all rules. Show your draft to colleagues for critique, and if you are not a native English speaker show it to a person who can improve/correct your text. Remember that accepted abstracts of completed original research should be followed by published original papers - if this is not intended or fails, it may indicate an impaired ability to succeed in scientific writing and an academic career.

Abbreviations as Topic↗
PubMed1997

Application of clinical trials to the care of patients with bladder cancer.

Patients with bladder cancer are fortunate because much of the treatment they receive is based on the findings of randomized clinical trials that ensure a sound, scientific basis for the treatment decisions they will agree with their urologist. Patients with Ta or T1 transitional cell carcinoma will be distressed to learn their diagnosis but will be comforted to know that they are most unlikely to die of the disease. They will be well advised to have at least one instillation of intravesical chemotherapy and if they are confirmed to have a good-prognosis tumour, they will probably need only annual follow-up cystoscopies. Other patients will have to accept the inconvenience of more frequent cystoscopies. Should they develop multiple superficial recurrences, more intensive intravesical chemotherapy or BCG is effective. This should probably be repeated at 6-monthly intervals for up to 3 years, although the optimum duration of treatment and the best treatment regimens require further clarification. Patients with muscle invasive bladder cancer do not have a good prognosis and, unfortunately, the addition of systemic chemotherapy does not offer any clear survival advantage at the present time. New, more effective forms of treatment are awaited. The confidence with which bladder cancer patients can be treated is based on the results of collaborative, multicentre trials that have been conducted over the past two decades. The important lesson to be learned, by physician and patient alike, is that randomized clinical trials are worthwhile because the results influence clinical practice and assure best possible care.

Carcinoma in Situ↗
PubMed2004

Medical waste management in Trachea region of Turkey: suggested remedial action.

The main objective of this paper was to analyse the present status of medical waste management in the Trachea region of Turkey and subsequently to draw up a policy regarded with generation, collection, on-site handling, storage, processing, recycling, transportation and safe disposal of medical wastes. This paper also presents the results of study about awareness on how to handle expired drugs. Initially all health-care establishments in Tekirdağ, Edirne and Kýrklareli provinces in Trachea region were identified and the amounts of hospital wastes generated by each of them were determined. Current medical waste-management practices, including storage, collection, transportation and disposal, in surveyed establishments were identified. Finally, according to results, remedial measurements for medical waste management in these establishments were suggested. Unfortunately, medical wastes are not given proper attention and these wastes are disposed of together with municipal and industrial solid wastes. The current disposal method is both a public health and environmental hazard. When landfill sites are visited, many scavengers can be seen sorting for recyclable materials, a practice which is dangerous for the scavengers. In addition, it was found that some staff in health-care establishments are unaware of the hazard of medical wastes. It is concluded that a new management system, which consists of segregation, material substitution, minimization, sanitary landfilling and alternative medical waste treatment methods should be carried out. For the best appropriate medical waste management system, health-care establishment employers, managers and especially the members of house- keeping divisions should be involved in medical waste management practice.

Evaluation Studies as Topic↗
PubMed1995

The effectiveness of Medicare Part B medical review: issues and alternatives.

The part B medical review methods currently used by Medicare carriers to control resource use suffer from a series of problems including failure to reward deterrence of unnecessary claims, failure to detect substitution of nonreviewed claims, reliance on average rather than marginal measures of performance, excessive focusing of reviews, and the inability to measure effectiveness separately from the intervention. This article describes these problems and proposes a series of alternative strategies for review that may improve these problems.

Cost-Benefit Analysis↗
PubMedDate not supplied

Establishing electronic patient record standards using paper-based record functions and standards.

The South Australian Health Commission has embarked on a long term project to establish an Electronic Patient Record (EPR) for South Australia. The process requires extensive evaluation at the conclusion of each phase of development using a range of existing and purpose-developed evaluation tools. This paper describes a purpose-developed evaluation tool that uses the functional aspects of, and existing standards for, paper-based medical records in hospitals as its basis. The resulting EPR Standards are a tool which can be used to establish a benchmark against which to evaluate the efficiency and effectiveness of an electronic patient record.

Benchmarking↗
PubMed2003

Animal ethical evaluation: an observational study of Canadian IACUCs.

Three Canadian institutional animal care and use committees were observed over a 1-year period to investigate animal ethical evaluation. While each protocol was evaluated, the observer collected information about the final decision, the type of protocol (research vs. teaching), and the category of invasiveness. The observer also wrote down verbatim all verbal interventions, which were coded according to the following categories: scientific, technical, politics, human analog, reduction, refinement, and replacement. The data revealed that only 16% of the comments were devoted to the 3 explicit ethical categories (i.e., reduction, refinement, and replacement) and that most of the comments were technical. However, the analysis revealed that ethical concerns were implicit in both scientific and technical language, or some of the scientific and technical comments had an impact on the ethical treatment of animals. The results are discussed in relation to previous nonobservational research that identified potential pitfalls and bias in animal ethical evaluation.

Animal Care Committees↗
PubMed1996

Questionnaire development.

The mail questionnaire is one of the most common forms of research conducted in applied health. It is used primarily for assessing community health needs, exploring opinions on health issues, determining self-reports of health behavior, and aiding program evaluations (Torabi, 1991). The accuracy of conclusions based on questionnaire responses depends upon many factors, including the wording of questions, the physical appearance of the questionnaire (Berdie, Anderson & Niebuhr, 1986; Sudman & Bradburn, 1982), and the response rate (Jones, 1993). Therefore, careful planning must precede the development and administration of any questionnaire. This article, providing a summary of some of the issues and techniques to consider when developing and administering a questionnaire, is organized into two main topics: Writing the questions and increasing response rate. Several subtopics are discussed within each of these two main topics, and suggestions for improving questionnaires are made throughout.

Attitude to Health↗
PubMed2001

Writing manuscripts describing clinical trials: a guide for pharmacotherapeutic researchers.

Once researchers have completed a clinical trial and analyzed the data, they have a duty to make the results known to their peers by writing a manuscript suitable for publication in a biomedical journal. Before beginning any writing, those involved in the clinical drug trial first need to decide among themselves who is to be the first author and secondary authors, the readership they want to influence, and the most appropriate target journal to reach this readership. For content and formatting of the manuscript, writers need to carefully follow the instructions for authors as stipulated by the target journal. In general, a manuscript based on a clinical trial is presented sequentially in four sections: Introduction, Methods, Results, and Discussion (IMRAD). The introduction concisely presents background information about the topic that was researched in the clinical trial, provides the study hypothesis, and describes the study rationale, purpose, and objectives. The Methods section delineates the study design, subject/patient selection process, procedures, end points, and types of analysis conducted in the clinical trial to investigate the study hypothesis. The Results section presents the findings of the clinical trial, and the Discussion section interprets the meaning of these findings, assesses how the findings answer the study hypothesis, and compares the study data with findings reported in earlier studies. Writers should select a title for the clinical trial manuscript that is fewer than 10 words and which embodies the essence of the study findings clearly and specifically without being sensationalistic. Writers should create the abstract last; the abstract should provide an overview of the manuscript and stimulate readers' interest. Overall, following the above principles in writing a manuscript based on a clinical drug trial will make the actual writing easier and more enjoyable, as well as increase the possibility of the manuscript being accepted for publication.

Clinical Trials as Topic↗
PubMed2005

The U.S. Environmental Protection Agency's examination of its risk assessment principles and practices: a brief perspective from the regulated community.

In March 2004, the U.S. Environmental Protection Agency (U.S. EPA) published a review of its risk assessment principles and practices. In examining this review, we find a broad, but not particularly deep, review by the authors and areas where the U.S. EPA should strive to further improve the risk assessment process. Recommended areas of improvement include the use of less conservative default assumptions, calculating risk based on populations instead of individuals, and fostering research on multiple stressors and their impacts on estimating risks to ecological receptors.

Animals↗
PubMed2005

Ecological risk assessment issues identified during the U.S. Environmental Protection Agency's examination of risk assessment practices.

Recently, the U.S. Environmental Protection Agency examined its current risk-assessment principles and practices. As part of the examination, aspects of ecological risk-assessment practices were reviewed. Several issues related to ecological risk assessment were identified, including the use of organism-level versus population-level attributes to characterize risk, the possible opportunities associated with the increased use of probabilistic approaches for ecological risk assessment, and the notion of conservatism in estimating risks. The agency examination provides an understanding of current practices and is intended to begin a dialogue in which the risk assessment community can engage in addressing the identified issues to improve and enhance ecological risk assessment.

Animals↗
PubMed2005

The future direction of ecological risk assessment in the United States: reflecting on the U.S. Environmental Protection Agency's "Examination of risk assessment practices and principles".

As part of an agency evaluation of the development of risk assessment tools, the U.S. Environmental Protection Agency (U.S. EPA) issued a staff paper in March 2004 describing the current state of practices and policies regarding risk assessment from the agency's perspective. The staff paper provided a rationale for the agency's positions regarding technical topics frequently the subject of comments or complaints. Considerations relevant to ecological risk assessment were included, primarily in a single chapter focused on this topic. This commentary highlights four technical issues important to the advancement of ecological risk assessment practice and discusses how some of the points raised by the U.S. EPA in the staff paper have significance to ecological risk assessors. Discussion regarding incorporating population- and community-level analysis into risk assessments and the apparent reluctance of the U.S. EPA to adopt advances in this area is provided. Also, continuing inconsistencies in the body weight scaling of toxicity values between human health and ecological risk assessment practices are discussed. Ideas for refining the calculation of exposure point concentrations for ecological receptors and the progression between screening steps and comprehensive risk assessment are also discussed.

Animals↗