PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “MENIERE'S DISEASE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9Linked to original sources
PubMed2003

Herpes simplex virus and Meniere's disease.

OBJECTIVE/HYPOTHESIS: This study was designed to investigate the hypothesis that Meniere's disease is associated with herpes simplex virus (HSV) reactivation in the vestibular ganglion. STUDY DESIGN: Case control study. METHODS: Vestibular ganglia were obtained from archival surgical pathology specimens from patients undergoing vestibular neurectomy for vertigo caused by Meniere's disease. All patients met criteria for classification as definite Meniere's disease according to American Academy of Otolaryngology/Head and Neck Surgery (AAO-HNS) criteria. Control specimens were obtained from willed body donors. Sections from each ganglion were studied for prevalence of viral DNA using a nested polymerase chain reaction designed to amplify the HSV DNA polymerase gene. Quantitative analysis determined the number of viral copies per standard unit of ganglionic DNA. RESULTS: HSV DNA was more prevalent in paraffin embedded ganglia from patients with Meniere's disease (100%) than in fresh-frozen control ganglia (81%) (P =.02). Fixation and paraffin embedding substantially reduced recovery of HSV virus in selected control specimens. Quantitative analysis found no correlation between viral copy number in control ganglia processed frozen versus formalin fixed and paraffin embedded. CONCLUSIONS: HSV is more commonly isolated from vestibular ganglia of patients with Meniere's disease than the general population. The routine histologic preparation of formalin fixation and paraffin embedding significantly altered the quantity of virus detected though not in a predictable manner. The study provides supportive evidence for a viral etiology in Meniere's disease.

Adult↗
PubMed1979

Low plasma renin concentration in patients with Meniere's disease (preliminary report).

Endolymphatic hydrops is the histopathologic hallmark of Meniere's disease. The cause of excess inner ear fluid is unknown, but the possibility of a systemic abnormality of fluid-solute regulation has been considered. One indicator of systemic fluid and electrolyte balance is the enzyme renin. Plasma renin levels were measured in patients with a clinical diagnosis of Meniere's disease and compared to a group of patients who did not have Meniere's disease. The mean plasma renin concentration of patients with Meniere's disease was statistically lower than that of the other subjects. The study's results are consistent with a systemic abnormality in fluid and solute regulation in some patients with M eniere's disease, leading to abnormal expansion of the extracellular fluid volume, and possibly contributing to endolympathic hydrops.

Ear Diseases↗
PubMedDate not supplied

Electrocochleography in patients with Meniere's disease.

OBJECTIVE: The objective of this study was to evaluate the role of electrocochleography (ECoG) in the diagnosis of Meniere's disease. STUDY DESIGN: This study is a retrospective case review. METHODS: Patients undergoing ECoG for Meniere's disease between 1995 and 2003 were identified and segregated as having definite , probable , or possible Meniere's disease according to the 1995 American Academy of Otolaryngology-Head and Neck Surgery guidelines for Meniere's disease classification. Those determined to have probable and possible Meniere's disease were then combined to form a less-than-definite group for statistical analysis. Electrocochleography summating potential (SP)/action potential (AP) ratios were determined, and ratios greater than 0.4 were considered abnormal. The 2 groups were then compared to assess for any correlation between ECoG with the 1995 American Academy of Otolaryngology-Head and Neck Surgery Meniere's disease classification. RESULTS: Sixty patients with definite Meniere's disease and 37 with less-than-definite Meniere's disease were identified. Overall, 59.8% had abnormally elevated SP/AP ratios. Of those with definite Meniere's disease, 66.7% had abnormally elevated SP/AP ratios, whereas of those with less-than-definite Meniere's disease, 52.7% had abnormal ECoGs ( P = .069). CONCLUSIONS: A significant difference in ECoG results was not seen between the definite and less-than-definite Meniere's disease groups. Furthermore, approximately 30% of those with definite Meniere's disease would not be classified as having Meniere's disease based on ECoG results. Because of its lack of sensitivity, ECoG should not play a decisive role in determining the presence or absence of Meniere's disease.

Electrooculography↗
PubMed2005

The association of antidiuretic hormone levels with an attack of Meniere's disease.

OBJECTIVES: An elevation of the plasma antidiuretic hormone (ADH) levels has frequently been observed in Meniere's disease patients. However, little is known regarding the mechanism behind such an elevation of ADH level in Meniere's disease patients. Therefore, we measured the plasma ADH in Meniere's disease patients and other vertigo patients to elucidate the association between the ADH levels, stress levels and the development of Meniere's symptom. DESIGN AND SETTING: The plasma ADH levels and plasma osmotic pressure were determined in 23 definite Meniere's disease patients and 160 patients with other types of vertigo/dizziness. All participants were administered questionnaire regarding their psychological status including their stress levels. RESULTS: The ADH levels of Meniere's disease patients in the acute phase (5.80 +/- 1.37 pg/mL) were significantly higher in comparison with that of Meniere's disease patients in the remission phase (2.26 +/- 0.41 pg/mL) (P < 0.05). In other peripheral vertigo patients, the ADH level in the acute phase (1.71 +/- 0.23 pg/mL) was not significantly different from that in the remission phase (1.45 +/- 0.15 pg/mL). Meniere's disease patients in the acute phase had a significantly higher stress score (114 +/- 23) than Meniere's disease patients in the remission phase (56 +/- 13) (P < 0.05). However, there was no significant correlation between their stress score and the ADH levels. CONCLUSIONS: These results suggest that the elevation of the plasma ADH levels in Meniere's disease patients in the acute phase is, therefore, associated with the pathogenesis of Meniere's disease attacks rather than with stress.

Acute Disease↗
PubMed1986

Predictive tests for Meniere's disease.

The prognostic value of electrocochleography and of the glycerol dehydration test in Meniere's disease is well recognized. Abnormal electrocochleographic waveforms carry a poorer prognosis. After adequate dehydration, significant threshold changes for better or worse predict the likely course of events following endolymphatic sac surgery. Meniere's disease frequently becomes bilateral. Vestibular aqueduct tomography in patients with Meniere's disease gives very different results, in both ears, compared with those in control patients. The acetazolamide cochlear hydration test can help detect latent hydrops. Plasma osmolality studies are an essential part of all these tests. Otoadmittance investigations show significantly higher baseline values in fluctuant endolymphatic hydrops compared with nonfluctuant Meniere's disease or control subjects. When the hearing improves after dehydration there is a paradoxical increased resistance to the flow of sound energy through the inner ear. Reduced hearing after glycerol is associated with an increase in maximum conductance or a decreased cochlear resistance. Otoadmittance studies on the "normal" ear of patients with "unilateral" Meniere's disease show similar abnormalities and changes. A study of serum levels of immune complexes and complement in patients with Meniere's disease shows elevated levels compared with controls. As yet the significance of this finding is unclear, though it may be related to disease activity.

Acetazolamide↗
PubMed2004

[The saccular function in Meniere's disease].

OBJECTIVE: To record and analyze the vestibular evoked myogenic potentials (VEMP) in Meniere's disease. METHOD: VEMP in 15 patients diagnosed as Meniere's disease were investigated and made out different kinds of manifestation of VEMP. The results of VEMP were compared with these caloric test. RESULT: The wave of p13 and n23 appeared 100% in normal subjects, but only appeared 30% in Meniere's disease. There were 3 kinds of manifestation of VEMP-normal response, bilateral no response and lower amplitude in hydrops side. CONCLUSION: Membranous hydrops in Meniere's disease may damage the saccular function and VEMP test may be helpful for diagnosis of Meniere's disease.

Adolescent↗
PubMed2000

Clinical indicators useful in predicting response to the medical management of Meniere's disease.

OBJECTIVES: To identify factors that may correlate with responsiveness to medical management of Meniere's disease. STUDY DESIGN: Retrospective chart review. METHODS: The 1995 guidelines of the American Academy of Otolaryngology-Head and Neck Surgery (AAOHNS) Committee on Hearing and Equilibrium were used for data acquisition and measuring clinical response. New patients with 2 years' follow-up were evaluated and grouped as either medically or surgically treated. Patients were excluded for inadequate follow-up or prior otological surgery. Dietary sodium restriction (<1,500 mg/d) and a diuretic were employed initially. A compliance rating system was devised to evaluate diet adherence. Patients whose medical management failed were offered surgery. RESULTS: Of 65 patients reviewed, 29 patients qualified for analysis. Seventeen patients were treated medically (patients had either definite or possible Meniere's disease), and 12 patients required surgery. Patients with definite Meniere's disease were at a higher stage (based on audiogram) than patients with possible Meniere's disease (P = .002). Patients who required surgery for Meniere's disease were at a higher stage than patients with either definite or possible disease (P < .001). Patients with definite disease had lower compliance than patients with possible disease (P = .004), but both groups showed symptom improvement. Patients with possible disease had better control than patients with definite disease (P < .001). Hearing was stabilized in patients with possible disease and improved at 500 Hz in patients with definite disease (P = .04). CONCLUSIONS: Sodium restriction and diuretic treatment response are correlated to clinical measures of Meniere's disease. Patients with possible Meniere's disease should be treated with aggressive medical therapy to prevent disease progression.

Adult↗
PubMed2000

Anti-heat shock protein 70 antibodies in Meniere's disease.

OBJECTIVES: To determine the prevalence of anti-heat shock protein 70 (anti-HSP70) antibodies in patients with Meniere's disease and healthy subjects and to probe the relationship between antibody status and clinical features of Meniere's disease. STUDY DESIGN: Prospective cohort study of consecutive consenting patients with Meniere's disease. METHODS: Serum samples were obtained prospectively from 134 patients with Meniere's disease and 124 blood donors. Serial samples were taken at 3-month intervals in 38 of 134 patients with Meniere's disease. Demographic data and clinical characterization of vestibular and auditory status were acquired with each sample. Serum was assayed for anti-HSP70 antibodies by Western blot using bovine renal extract, recombinant bovine HSP70, and recombinant human HSP70 antigens. RESULTS: Immunoreactivity against bovine renal extract HSP70 was found in 38% of patients with Meniere's disease, compared with 25% of blood donors (P < .04). Reactivity with recombinant antigens was not significantly different between patients with Meniere's disease and healthy control subjects. Patients with Meniere's disease who reacted with all three antigens were more likely to have simultaneously active hearing and balance symptoms (P = .03). Neither univariate nor multivariate statistical analysis established any other association between serological findings and clinical features of Meniere's disease. Tests performed on serial samples of patients with Meniere's disease also showed no association of positive or negative test results with changes in clinical course. CONCLUSIONS: Because of the high prevalence of antiHSP70 antibodies in healthy subjects and the very limited association of anti-HSP70 antibody status with clinical features or course of Meniere's disease, we conclude that, at present, the detection of anti-HSP70 antibodies by Western blotting offers little clinically useful information in Meniere's disease.

Adult↗
PubMedDate not supplied

Immediate relief of symptoms during acute attacks of Meniere's disease, using a pressure chamber.

Five patients with Meniere's disease were exposed to underpressure in a pressure chamber while suffering from acute attacks with vertigo, nausea, tinnitus and fullness of the ear. Spontaneous nystagmus was the objective criterion for the selection of suitable cases. Subjective as well as objective symptoms subsided much faster than they do with other kinds of treatment. Four patients were free from symptoms within 40 minutes, while the fifth case still complained of vertigo, tinnitus and fullness of the ear after the treatment. However, the symptoms were less severe. A mechanism is discussed by means of which an ambient pressure decrease might cause a reduction of the endolymphatic volume, thus relieving acute symptoms of Meniere's disease.

Acute Disease↗
PubMed1999

[Diagnostic significance of transiently evoked otoacoustic emissions in meniere's disease].

OBJECTIVE: To judge the diagnostic significance of TEOAE by glycerol test in Meniere's disease. METHOD: TEOAE were recorded from all testing ears with or without Meniere's disease. RESULT: The wave reproducibility, amplitude of response, band reproducibility, band SNR in ears of affected ears with meniere's disease after administration of glycerol were increased, about which the parameters of affected ears in positive glycerol test were obviously higher than that in negative glycerol test. All parameters in normal ears with Meniere's disease increased too, and there have the changes of main frequency. CONCLUSION: TEOAE records of glycol test may be more sensitive and more simple than pure tone audiometry in diagnosing meniere's disease, and should be used more extensively.

Audiometry, Pure-Tone↗
PubMed1982

Overpressure in treatment of Meniere's disease.

Influence of ambient pressure changes on the hearing levels in Meniere's disease was previously demonstrated, using a pressure chamber. The present report concerns a new method for management of Meniere's disease by local application of overpressure. The experimental background and methodologic considerations in therapy are summarized. Five illustrative cases of verified Meniere's disease are presented. The patients had advanced, nonfluctuating hearing loss and incapacitating vestibular symptoms. Long periods of remission were obtained in all cases. Improvement of hearing was a major clinical consideration in the treatment. Use of local overpressure seems to offer possibilities of improving hearing even in advanced stages of Meniere's disease. Despite the disabling pretreatment hearing loss, hearing in these 5 patients was restored to normal or serviceable levels. The follow-up period was about 2 years from start of treatment.

Adult↗
PubMed1999

Innovar treatment for Meniere's disease.

Patients with intractable vertigo due to clinical Meniere's disease were offered treatment with Innovar, a neurolept analgesic. The patients were from a single clinical practice, had failed conventional dietary and medical treatment and were eligible on clinical grounds for endolymphatic sac surgery. After a follow-up of 2-8 years, 58% of patients had long-lasting relief of vertigo. Hearing was not affected. Risk factors for a favorable response were male gender, fluctuating hearing, and early stage of the disorder. Innovar is a safe, cost-effective second-line therapy for patients with Meniere's disease who have failed conventional first-line medical therapy.

Adolescent↗
PubMedDate not supplied

Streptomycin treatment for Meniere's disease.

This paper describes the author's 10-year experience using streptomycin sulfate in the treatment of Meniere's disease in the following: the classical Schuknecht ablation of the vestibular system in bilateral Meniere's disease (eight patients); the classical Schuknecht ablation of the vestibular system in unilateral Meniere's disease in the only hearing ear (five patients); the intratympanic treatment of unilateral Meniere's disease (four patients); and low dose intramuscular outpatient treatment in unilateral Meniere's disease (five patients). The results of bilateral vestibular ablation were similar to those obtained previously by Schuknecht and others: patients developed profound ataxia with a wide-based gait and oscillopsia, which improved rapidly over a period of months; approximately 30% of patients experienced significant improvement in hearing, which usually deteriorated again after several months; and all patients were relieved of vertigo. Patients with unilateral Meniere's disease in the only hearing ear responded similarly, and hearing was preserved in all cases. Intramuscular streptomycin ablation of the vestibular system is strongly recommended in place of surgery in the only hearing ear in Meniere's disease. Controlled intratympanic injection of streptomycin is not successful as yet because of difficulty in controlling the dose. Low dose subototoxic streptomycin treatment on an outpatient basis offers promise for relief of Meniere's attacks, and may improve hearing in some cases without producing the temporary disabling effects of ataxia and oscillopsia. Streptomycin and similar drugs which may reduce endolymph production may eventually be the treatment of choice for Meniere's disease.

Cochlea↗