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At least 163 records · Page 9Linked to original sources
PubMed2000

Redesigned proficiency testing materials improve survey outcomes for prostate-specific antigen. A College of American Pathologists Ligand Assay Survey tool.

CONTEXT: Large disparities in prostate-specific antigen (PSA) results from different assays have been observed in the College of American Pathologists (CAP) Ligand Assay Survey, with interassay results varying severalfold. Survey specimens are predominately composed of free PSA and do not reflect the composition of typical patient specimens. OBJECTIVES: To characterize a pilot material developed for CAP in which pooled sera samples were spiked with purified PSA and alpha(1)-antichymotrypsin-bound PSA at targeted concentrations and to compare it to CAP survey and reference materials. DESIGN: CAP survey, reference, and pilot materials were analyzed using 10 total PSA and 7 free PSA assays. These assays included Food and Drug Administration-approved assays and assays for research use only. RESULTS: Variability among the 10 total PSA methods was greatest for the 1997 ligand survey material (CV range, 56%-65%) followed by the pilot material (CV range, 10%-29%) and the reference material (CV range, 6%-13%). In contrast, interassay variability for the 7 free PSA methods was similar for the 3 preparations, with the exception of one specimen close to the limit of detection of the assays. As determined with the Hybritech Tandem-R method, the ligand survey specimens were essentially composed of all free PSA, whereas the reference and pilot materials were composed of approximately 10% and 35% free PSA, respectively. CONCLUSIONS: The newly formulated pilot material prepared using a human base that contained defined concentrations of free PSA and alpha(1)-antichymotrypsin-bound PSA more closely resembled patient specimens and minimized differences among methods compared with the semen-supplemented original survey material.

Humans↗
PubMed1999

By the way, doctor. At my annual physical, I received cards to return to my doctor after collecting small samples of stool to test for fecal occult blood. I'm having trouble getting around to collecting these samples, because it is hard to get along without the motrin I take for back pain. The test materials instruct me to discontinue aspirin or NSAIDs and some foods for at least a week before collecting the samples. What should I do?

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Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1976

[Materials-testing research on hard and high strength dental plasters].

Types of III and IV dental plasters (ADA specifications No. 25) are used for making working models for clinical and laboratory purposes. 14 plaster products of these two types were examined for their physical properties and compared to the specifications, namely of setting time, volume changes, resistance to pressure and accuracy of detail. Additionally the values of surface hardness, bending strength and resistance to scraping were examined. Accordingly, three products were attributed to special stone (specification No IV): Duricap red (predosed capsule), Glastone, and Vel Mix Stone.

Calcium Sulfate↗