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At least 163 records · Page 9Linked to original sources

PubMed2002

Rasch analysis of the Rivermead Mobility Index: a study using mobility measures of first-stroke inpatients.

OBJECTIVE: To evaluate the validity and item unidimensionality of the Rivermead Mobility Index (RMI) by using Rasch analysis. DESIGN: Application of Rasch analysis on the RMI partial data set. SETTING: A stroke program at a rehabilitation hospital in Italy. PARTICIPANTS: A total of 308 consecutive patients (155 women, 153 men; avg age, 62.79+/-11.94 y) hospitalized between 1990 and 1996. Average interval between stroke onset and admission was 52.48+/-36.22 days. INTERVENTION: Medical inpatient rehabilitation. MAIN OUTCOME MEASURES: Patients' mobility status was assessed using the RMI administered at admission and discharge. Ratings were assigned by 4 staff members working as a team. We performed separate Rasch analyses on the RMI data, gathered from different groups of first stroke inpatients examined before and after rehabilitation treatment. RESULTS: asch analysis showed the overall good validity of the RMI, except for item 15, which did not fit the unidimensional continuum estimated through the Rasch rating model. CONCLUSION: The RMI is a unidimensional scale with a hierarchy of easy-to-hard test questions. Item difficulty level was stable when processed on different groups of patients assessed on different occasions.

Adolescent↗

PubMed2004

1800 MHz radiofrequency (mobile phones, different Global System for Mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors.

PURPOSE: To study if prolonged in vitro exposure to 1800MHz radiofrequency (RF) could exert an effect on human peripheral blood mononuclear cells (PBMC) from young and elderly donors by affecting apoptosis, mitochondrial membrane potential and heat shock protein (HSP) 70 levels. MATERIALS AND METHODS: Endpoints were analysed in the presence or absence of the apoptosis-inducing agent 2-deoxy-D-ribose. Three different signal modulations typical of the Global System for Mobile communication (GSM) system were applied. The modulations are widely used in mobile telephony (GSM Basic, discontinuous transmission [DTX] and Talk) at specific absorption rates of 1.4 and 2.0 W kg(-1). RESULTS: In all conditions and for all endpoints tested, there was no significant difference between RF- and sham-exposed cells. CONCLUSION: 1800MHz RF could not induce apoptosis by itself or affect the apoptotic phenomenon when induced by an apoptotic agent. Moreover, RF did not modify the mitochondrial functionality and the expression of HSP 70.

Adult↗

PubMed1994

Use of granulocyte colony-stimulating factor (G-CSF) for mobilizing peripheral blood stem cells: risk of mobilizing clonal myeloma cells in patients with bone marrow infiltration.

Peripheral blood stem cells have been used for autologous reconstitution of haemopoiesis after high dose cytotoxic therapy and produce similar disease response rates as autologous bone marrow transplants. Peripheral blood stem cell transplants are an especially attractive option for patients in whom marrow harvest is not feasible due to bone marrow damage or infiltration. Recombinant growth factors mobilize adequate numbers of stem cells from the marrow but their effect on tumour cell circulation kinetics is not known. We report a patient with multiple myeloma and bone marrow infiltration in whom the use of G-CSF for stem cell mobilization led to release of plasma cells into the peripheral circulation and contamination of the stem cell harvest.

Adult↗

PubMed2006

Determination of the non-constant component of the ion mobility using the spectrometer of ion mobility increment.

A new method for determination of the non-constant component, alpha(E), of an ion mobility, k(E), is suggested. The method uses the relationship U(C) (US) that can be experimentally obtained with a spectrometer of ion mobility increment with planar drift chamber. (UC is a compensating voltage, U(S) is separating voltage amplitude.) A general equation for alpha(E) has been derived. We have explored the possibility of determination of alpha(E) from the experimental data for different types of US(t). In two specific cases, analytical solutions have been obtained.

Journal Article↗

PubMed1988

Correlations of hip mobility with degree of back pain and lumbar spinal mobility in chronic low-back pain patients.

Mobility of hips and lumbar spine were measured in 301 men and 175 women who were in employment but suffered from chronic or recurrent low-back pain. The degree of low-back pain (LBP) was assessed with a questionnaire. Hip flexion, extension, internal rotation, and hamstring flexibility in the men, and hip flexion and extension in the women had statistically significant negative correlations with LBP. Among the correlations between hip and lumbar spinal mobility, hip flexion and extension with lumbar rotation were strongest.

Adult↗

PubMed1996

Practical community screening for diabetic retinopathy using the mobile retinal camera: report of a 12 centre study. British Diabetic Association Mobile Retinal Screening Group.

OBJECTIVE: To document the performance of 12 diabetes eye screening units in different health districts which were financed by a single charitable donation. DESIGN: Each location was equipped with a retinal camera and screening vehicle, and the lead clinician developed the screening service configuration to suit local conditions. SETTINGS: Districts were chosen on the basis of interest in developing effective diabetes eye screening services. Characteristics of districts varied from largely rural to exclusively urban. SUBJECTS: People with diabetes who attended either general practice or hospital diabetes services were screened. MAIN OUTCOME MEASURES: Referral for ophthalmological opinion and use of laser therapy for new vessel formation or exudative maculopathy. RESULTS: A total of 64,905 screening episodes were recorded. Full data were available on 42,803 episodes which led to 2400 referrals (5.6%) and 516 of which resulted in laser therapy (1.2% of those screened or 21.5% of those referred). Where sequential data were available a year by year fall in sight threatening retinopathy incidence was demonstrated as the screening programmes detected incipient problems in the initial cycles of screening. The average cost of screening was Pounds13.11 per patient and the average cost of identifying a person requiring laser therapy was Pounds1110. Financial responsibility for running the service has been taken on by 10 of the 12 health districts. CONCLUSIONS: Diabetes eye screening using a mobile retinal camera is effective, efficient and robust. It is important that the service specification is designed to suit the geography and existing diabetes services in each district.

Costs and Cost Analysis↗

PubMed2003

Second mobilization of peripheral blood progenitor cells in patients with poor first mobilization.

The aim of this study was to analyse the efficacy of 2 second mobilization (MB) protocols in 2 groups of patients who failed to obtain enough peripheral blood progenitor cells (PBPC) in the first MB. In 1 group (8 patients), 10 microg/kg of G-CSF was administered, and in the other group (8 patients), a double dosage (10 microg/kg twice a day) was administered. Both groups of patients received Cyclophosphamide (1.5 g/kg) 10 days before the apheresis. No difference was found among both groups of patients in diagnosis, previous chemotherapy, and time elapsed after the first MB. Administration of higher doses of G-CSF decreased the number of apheresis needed in the second MB to complete 2 x 10(6)/kg of CD34+ cells. It also increased the number of patients who achieved sufficient CD34+, namely, 75% versus 50%.

Blood Cells↗

PubMed1991

Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein.

The class I of the high mobility group (HMG) proteins is formed by phosphoproteins which are associated with AT-rich DNA sequences in the nucleus. Three HMGI proteins have previously been described in proliferating rodent cells (HMG Y, HMG I and HMGI-C). All three proteins exhibit microheterogeneity. The microheterogeneity of mouse HMG Y has been investigated in detail and shown to be due to phosphorylation of the protein which is sensitive to alkaline-phosphatase treatment. HMG I is similarly modified. Human cells have up to now only been found to contain HMG Y and HMG I. A search for the third protein, HMGI-C, in human cells was carried out and the protein was found in a hepatoma cell line, but not in normal or transformed T-cells. This HMGI-C protein was found to be modified by phosphorylation, part of which was found to be phosphatase insensitive. An unexpected additional finding in this study was that human cells contain two HMG17 proteins which differ in their N-terminal primary sequences.

Alkaline Phosphatase↗

PubMed1992

Screening for diabetic retinopathy in a widely spaced population using non-mydriatic fundus photography in a mobile unit. Tayside Mobile Eye Screening Unit.

A screening project was established to assess the prevalence and severity of retinopathy in diabetic patients in Tayside (area: 3000 square miles, population: 390,000). A questionnaire was used to examine patient acceptability. Of 2112 patients photographed during the first year, 32% had abnormal photographs; 20.2% had diabetic retinopathy; 7.4% cataracts; 4.6% non-diabetic eye disease. Among this patient population, 73% were registered at a hospital diabetic clinic. The overall prevalence of diabetic retinopathy was similar between the two groups (hospital 23% vs non-hospital 20%). The prevalence of severe diabetic retinopathy was also similar (hospital 8.5% vs non-hospital 10%). This had been previously unrecognized or incorrectly defined in 6.5% of those not attending a hospital diabetic clinic, compared to 3.7% attending the hospital clinic (p less than 0.01). A favourable response to the service was indicated by 40% of patients with 7% unfavourable and 41% uncommitted. Non-mydriatic fundal photography housed in a mobile unit is a practical and effective method of assessing diabetic retinopathy. It is particularly suitable for screening in a widely spread population.

Diabetic Retinopathy↗

PubMed2006

[Cross-cultural adaptation and reliability analyses of the Southampton Assessment of Mobility to assess mobility of Brazilian elderly with dementia].

The objective was to perform a cross-cultural adaptation of the Southampton Assessment of Mobility and test its intra- and inter-examiner reliability for Brazilian elderly living in the community and diagnosed with dementia, with severity classified according to the Clinical Dementia Rating. The instrument was applied to 107 elderly (76.26 years +/- 7.59; 27.1% males, 72.9% females) diagnosed with dementia by the geriatric clinic at the university hospital of the Federal University in Minas Gerais. From the initial group, a randomized sample of 39 elderly (76.85 years +/- 7.75; 23.1% males, 76.9% females) was selected for the reliability tests. The statistical tool was the kappa test. The respective reliability indices were: mild dementia - 0.89-0.86; moderate - 0.79-0.85; and severe - 0.53-0.49. After cross-cultural adaptation and reliability tests, the instrument proved adequate for the target population, with "near-perfect" reliability for mild and moderate dementia. For severe dementia, the reliability was moderate.

Aged↗

PubMed2003

[Mobile hospital -real time mobile telehealthcare system with ultrasound and CT van using high-speed satellite communication-].

A real-time telescreening system is developed to detect early diseases for rural area residents using two types of mobile vans with a portable satellite station. The system consists of a satellite communication system with 1.5Mbps of the JCSAT-1B satellite, a spiral CT van, an ultrasound imaging van with two video conference system, a DICOM server and a multicast communication unit. The video image and examination image data are transmitted from the van to hospitals and the university simultaneously. Physician in the hospital observes and interprets exam images from the van and watches the video images of the position of ultrasound transducer on screenee in the van. After the observation images, physician explains a results of the examination by the video conference system. Seventy lung CT screening and 203 ultrasound screening were done from March to June 2002. The trial of this real time screening suggested that rural residents are given better healthcare without visit to the hospital. And it will open the gateway to reduce the medical cost and medical divide between city area and rural area.

Computer Communication Networks↗

PubMed1971

Effect of free fatty acid mobilization on the electrophoretic mobility of alpha-lipoproteins in the dog.

Dogs were given infusions of norepinephrine and subsequent additional infusions of propranolol and nicotinic acid over a 4-hr period. Under different physiological conditions, alpha-lipoproteins of three different electrophoretic mobilities were identified by means of paper electrophoresis; they were designated alpha-lipoproteins X, Y, and Z. During norepinephrine infusion, alpha-lipoprotein Y fell from 45% (of all lipoproteins) to 14%. There was a reciprocal rise in alpha-lipoprotein Z. On the other hand, alpha-lipoprotein X was not significantly changed. There was evidence that alpha-lipoprotein Y was progressively transformed into alpha-lipoprotein Z by increasing plasma FFA concentrations. The percentages of both alpha-lipoproteins Y and Z returned to original values after the dogs were given either nicotinic acid or propranolol. The alterations in the alpha-lipoprotein peaks Y and Z were rapid, being noted within 5 min of change in plasma FFA concentration. However, there appeared to be a threshold of plasma FFA concentration of 1200 micro Eq/liter, below which no changes in alpha-lipoproteins were noted. It was concluded that alpha-lipoprotein Y is rapidly, progressively, but reversibly transformed into alpha-lipoprotein Z by binding to plasma FFA above a threshold level of 1200 micro Eq/liter. However, alpha-lipoprotein X does not appear to be involved in the binding of plasma FFA.

Animals↗

PubMed1981

Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in high mobility group proteins 14 and 17.

Duck erythrocytes were incubated with [3H]acetate both in the presence and absence of sodium butyrate. Subsequent perchloric acid extraction of the nuclei, followed by selective acetone precipitation, CM-Sephadex ion exchange chromatography, and gel filtration yielded radioactively labeled high mobility group (HMG) proteins HMG-14 and HMG-17 in pure form. Extensive enzymatic degradation of the proteins followed by amino acid analysis of the digests yielded a significant amount of material eluting in the position of epsilon-N-acetyllysine. Furthermore, automated Edman degradation of intact 3H-labeled HMG-14 and HMG-17 identified the specific sites of acetylation of these proteins. In both erythrocyte HMGs isolated from cells not exposed to butyrate, the lysine residue at position 2 was the only one found to be labeled. However, one additional site in HMG-14 and two additional sites in HMG-17 were found in the proteins from cells incubated in butyrate. Finally, studies of the enzymatic deacetylation of HMG-14 and HMG-17 confirmed that both nuclear proteins serve as deacetylase substrates and that butyrate inhibits their deacetylation, just as in the case of other HMG proteins and nucleosomal core histones.

Acetates↗

PubMed1998

Chain Mobility in Polymer Systems: On the Borderline between Solid and Melt. 2. Crystal Size Influence in Phase Transition and Sintering of Ultrahigh Molecular Weight Polyethylene via the Mobile Hexagonal Phase.

Polymorphism is a well-established phenomenon in crystalline materials and is important for pharmaceutical and polymeric materials. In our study concerning the processability of polymers, we came across an unusual observation related to polymorphism induced by pressure. The experimental observation is that polyethylene crystals transform from the stable orthorhombic crystal into a transient hexagonal phase. The occurrence of a transient hexagonal phase is shown to be dependent on the polymer crystal size; smaller crystals transform into the transient hexagonal phase at temperatures and pressures much below the thermodynamic critical point Qo, which is located at P = 3.6 kbar and T = 230 degreesC. The crystal size dependence in the phase transition was investigated by in situ X-ray studies in the unirradiated and irradiated solution-crystallized films. Since the chain mobility is rather high in the hexagonal phase, sintering has been attempted via this transient phase using ultrahigh molecular weight polyethylene (UHMW-PE) as a model system. UHMW-PE is an intractable polymer due to its high molar mass but possesses excellent abrasion resistance properties. For this reason it is used as an inlay in demanding applications such as artificial hip and knee joints. The service life of UHMW-PE in these artificial joints, however, is limited due to the poor processing characteristics notably during sintering, and often a second operation is needed to replace the UHMW-PE interface. Sintering via the transient hexagonal phase could provide a solution for this important problem which concerns an increasing number of people.

Journal Article↗

PubMed1979

The isolation and partial sequence of peptides produced by cyanogen bromide cleavage of calf thymus non-histone chromosomal high-mobility-group protein 2. Sequence homology with non-histone chromosomal high-mobility-group protein 1.

Peptides produced by CNBr cleavage of non-histone chromosomal protein HMG 2 (CNBr peptides) were isolated and characterized, and their partial sequences were determined. The present sequence data account for over half of the sequence of the protein HMG (high-mobility-group) 2 molecule, and, together with previously published results, provide interesting information on the charge distribution within the molecule. Comparison of the CNBr-peptide-sequence data for protein HMG 2 with the previously published data on the CNBr peptides from protein HMG 1 reveals extensive sequence homology between the two proteins. Detailed evidence for the amino acid-sequence data has been deposited as Supplementary Publication SUP 50095 (6 pages) at the British Library Lending Division, Boston Spa, Wetherby, West Yorkshire LS23 7BQ, U.K., from whom copies may be obtained on the terms given in Biochem. J. (1978) 169, 5.

Amino Acid Sequence↗

PubMed2001

Mobile phone use and subjective symptoms. Comparison of symptoms experienced by users of analogue and digital mobile phones.

In 1995 many people reported symptoms such as headaches, feelings of discomfort, warmth behind/around or on the ear and difficulties concentrating while using mobile phones. The number of complaints was higher for people using the digital (GSM) system, i.e. with pulse modulated fields, than for those using the analogue (NMT) system. Our main hypothesis was that GSM users experience more symptoms than NMT users. An epidemiological investigation was initiated including 6379 GSM users and 5613 NMT 900 users in Sweden, and 2500 from each category in Norway. The adjusted odds ratio did not indicate any increased risk for symptoms for GSM users compared with NMT 900 users. Our hypothesis was therefore disproved. However, we observed a statistically significant lower risk for sensations of warmth on the ear for GSM users compared with NMT 900 users. The same trend was seen in Norway for sensations of warmth behind/around the ear and in Sweden for headaches and fatigue. Factors distinguishing the two systems (radio frequency emission, phone temperatures and various ergonomic factors) may be responsible for these results, as well as for a secondary finding: a statistically significant association between calling time/number of calls per day and the prevalence of warmth behind/around or on the ear, headaches and fatigue.

Adult↗

PubMed1994

Rapid mobilization of intracellular Mg2+ by bombesin in Swiss 3T3 cells: mobilization through external Ca(2+)- and tyrosine kinase-dependent mechanisms.

We examined the effects of growth factors on intracellular free Mg2+ concentrations ([Mg2+]i) in single Swiss 3T3 fibroblasts, using microfluorometry of a Mg(2+)-sensitive dye mag-fura-2. We had already noted an increase in [Mg2+]i after exposure to bombesin for 30-60 min [Ishijima, S., Sonoda, T., & Tatibana, M. (1991) Am. J. Physiol. 261 (Cell Physiol. 30), C1074-C1080]. In the present work, we found that bombesin also induced early changes in [Mg2+]i. The [Mg2+]i reached peak values within 15 s in most cells, and the significant rise lasted only for 1-2 min. The extent of the increase varied from cell to cell (0-600 microM above basal). On the average, the [Mg2+]i was increased from basal 0.33 to 0.54 mM. Since the time course was similar to that of [Ca2+]i changes, and the dye mag-fura-2 also binds Ca2+, we evaluated Ca2+ interference with measurement of [Mg2+]i. The contribution of Ca2+ binding would be below 20% of the mag-fura-2 signal. The bombesin-induced [Mg2+]i increase was not dependent on external Mg2+, but the omission of external Ca2+ decreased by 60% the [Mg2+]i increase, and the Ca2+ channel blocker, nicardipine inhibited by 90% the [Mg2+]i response. This inhibition was partially reversed by raising the concentration of external Ca2+. Two structurally distinct tyrosine kinase inhibitors, genistein and lavendustin A, almost completely inhibited the [Mg2+]i response. These results suggest that bombesin rapidly induces Mg2+ mobilization from the intracellular pool, through external Ca(2+)- and tyrosine kinase-dependent mechanisms.

3T3 Cells↗

PubMed1977

Treatment of ankle sprains with joint aspiration, xylocaine infiltration, and early mobilization. Ankle sprains treated with xylocaine infiltration and early mobilization.

Ninety-nine ankle sprains were arbitrarily divided into a control (54 patients) and a study (45 patients) group. Both groups were treated with elevation, ice compression wraps crutches, and early mobilization. In addition, the study group underwent ankle joint aspiration and local injection of the involved ligaments with 4-10 cc of 1% xylocaine. The difference between recovery times in the control group (mean, 10.7 days) and in the study group (mean, 4.4 days) reached statistical significance at p less than 0.001 by Wilcoxon two-sample test. Because there are inherent risks in this treatment, it is not recommended for all patients. However, for those requiring early remission of symptoms to allow early return to pre-injury activities, this treatment is suggested by the author.

Adult↗