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Results for “Muscle Strength”

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PubMed1989

Is the measurement of muscle strength appropriate in patients with brain lesions? A special communication.

Controversy exists as to whether muscle strength is a variable that should be measured in patients with brain lesions. The purpose of this special communication is to provide evidence for the inclusion of muscle strength testing in the assessment of these patients. This evidence consists of information that 1) is relevant to weakness following brain lesions and concerns about its measurement, 2) provides a precedent and support for muscle strength testing, and 3) relates muscle strength to patient capacity and outcome. I believe that this information justifies the inclusion of muscle strength in the assessment of patients with brain lesions, but not to the exclusion of other behavioral functional variables.

Brain Damage, Chronic↗

PubMed2002

Peripheral muscle strength in young males with cystic fibrosis.

BACKGROUND: In children with cystic fibrosis there is a decrease in peak work capacity and oxygen consumption on maximal exercise testing when compared to controls. Previous studies have shown that peripheral muscle force is decreased in children with cystic fibrosis even in those with minimal changes in lung function. However, no studies have examined peripheral muscle strength using isokinetic dynamometry which permits measurement of muscle strength throughout range and is considered the gold standard in orthopaedics and sports medicine. METHODS: Isokinetic muscle strength was measured in the knee flexors and extensors and shoulder flexors and extensors at two speeds of movement in children with cystic fibrosis and matched controls. Activity levels in both groups were calculated. RESULTS: Thirteen subjects and 13 age and height matched controls were assessed. Average peak torque was calculated and expressed in terms of body weight. There was a significant difference in peak torque/body weight in children with cystic fibrosis when compared to controls. FEV1 was significantly correlated with knee muscle strength and shoulder flexion at 90 degrees /s in subjects with CF. CONCLUSION: Children with CF had lower muscle strength than control subjects. Airflow limitation was associated with decreased muscle strength. The relationship between muscle strength and exercise tolerance requires investigation.

Adolescent↗

PubMed2005

Bone properties and muscle strength of young haemophilia patients.

PURPOSE: To evaluate bone properties, muscle strength and the relationship between the two, in young (7.0-17.7 years) haemophilia patients (h) and healthy boys (c). SUBJECTS: Twenty-seven boys with severe haemophilia and 33 healthy boys, of similar age, body mass, height, (mean +/- sd for h and c, respectively: 11.2 +/- 3.2 vs. 11.4 +/- 2.9 years, 42.6 +/- 16.6 vs. 41.6 +/- 17.3 kg, 145 +/- 18 vs. 146 +/- 17 cm) and pubertal stage according to secondary sex characteristics, volunteered for the study. all subjects were physically inactive (as determined by questionnaire). METHODS: Subjects performed isokinetic elbow and knee extension and flexion tests at two angular velocities (biodex system ii dynamometer). Bone properties were evaluated by qualitative ultrasound (sunlight omnisense), at the distal radius and tibial mid-shaft. H subjects received prophylactic factor viii treatment within the 24 h preceding testing. No test was performed in the presence of haemorrhage. RESULTS: Muscle strength was consistently higher in c compared with h, especially in the lower limbs (e.g. knee extension: 1.80 +/- 0.44 vs 1.48 +/- 0.53 N x m x kg(-1) body mass, respectively, p = 0.01). No differences were observed in tibial or radial speed of sound between groups. Correlations between muscle strength and bone properties were observed only in the lower limbs and only in c (r = 0.37-0.48). CONCLUSION: Muscle strength, especially lower limbs' strength, was lower in haemophilia patients compared with a matched, similarly inactive population of healthy boys. Nevertheless, at this age range, this relative weakness is not associated with inferior bone properties.

Adolescent↗

PubMed2004

Interrelationships among thigh muscle co-contraction, quadriceps muscle strength and the aerobic demand of walking in children with cerebral palsy.

The purpose of this study was to quantify interrelationships among thigh muscle co-contraction, quadriceps muscle strength, and the aerobic demand of walking in 13 children with spastic hemiplegic cerebral palsy (CP). During Session 1, subjects were familiarized with testing procedures, given five minutes of treadmill walking practice, and completed quadriceps muscle strength testing. In Session 2, subjects performed three 5-min walking bouts on the treadmill at 0.67 m x s(-1) to further accommodate to treadmill ambulation. During Session 3, resting VO2 was measured and subjects walked at 0.67, 0.89, and 1.12 m x s(-1) for five minutes while oxygen uptake (VO2) and thigh muscle co-contraction data were collected. Results demonstrated that no significant relationship existed between net VO2 and measures of thigh muscle co-contraction or quadriceps muscle strength. In addition, thigh muscle co-contraction was not shown to be associated with quadriceps muscle strength. Collectively, thigh muscle co-contraction and quadriceps muscle strength explained 13. 5%, 6.2%, and 2.2% of the variance in VO2 at 0.67, 0.89, and 1.12 m x s(-1), respectively. Viewed in concert, these results suggest that the walking energy expenditure of children with spastic hemiplegic CP is not influenced by the level of thigh muscle co-contraction or quadriceps muscle strength.

Cerebral Palsy↗

PubMed2005

Pain, lower-extremity muscle strength, and physical function among older Mexican Americans.

OBJECTIVE: To examine the relation between pain on weight bearing, lower-extremity muscle strength, and physical function among older Mexican Americans. DESIGN: Cross-sectional study. SETTING: Five Southwestern states: Texas, New Mexico, Colorado, Arizona, and California. PARTICIPANTS: A population-based sample of 544 noninstitutionalized Mexican-American men and women age 71 years and older. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Pain on weight bearing, lower-extremity muscle strength, and physical function. RESULTS: Of the 544 subjects, 244 (44.9%) reported pain on weight bearing. Mean muscle strength in men ranged from 9.3 kg for knee extension, 12.8 kg for hip flexion, to 13.0 kg for hip abduction. In women, mean strength ranged from 6.6 kg for knee extension, 9.5 kg for hip flexion, to 8.6 kg for hip abduction. Mean of physical function score was 70.7 for men and 60.6 for women. Pain on weight bearing was negatively associated with summary lower-extremity muscle strength only in women (-.05, P < .001) after controlling for all covariates. Pain on weight bearing was negatively associated with physical function in both men (-15.33, P < .001) and women (-11.03, P < .001), and lower-extremity muscle strength was positively associated with physical function in both men (37.77, P < .001) and women (73.50, P < .001), after controlling for all covariates. CONCLUSIONS: Among older Mexican Americans, the presence of pain was associated with decreased muscle strength in women and decreased physical function in both men and women. High muscle strength was associated with high physical function in both men and women.

Activities of Daily Living↗

PubMed2000

A comparison of lower extremity muscle strength, obesity, and depression scores in elderly subjects with knee pain with and without radiographic evidence of knee osteoarthritis.

OBJECTIVE: To determine, in subjects with knee pain but no radiographic changes of tibiofemoral or patellofemoral compartment osteoarthritis (OA), whether mean body weight, quadriceps and hamstring strength, lower extremity muscle mass, depression scores, and perceptions of their general health status differed from those of subjects with symptomatic knee OA. METHODS: Subjects were 25 women and 10 men with knee pain and radiographic evidence of OA at the baseline examination, and 21 women and 16 men who had knee pain at the baseline examination but no radiographic evidence of knee OA at either baseline examination or followup evaluation performed, on average, 31 months later. These individuals were a subset of a cohort of 462 independently living elderly individuals recruited by telephone interview after random selection through random digit dialing of households in central Indiana. Data from an additional 134 subjects who had neither knee pain nor radiographic changes of OA at either the baseline or followup examination were analyzed for comparison. Lower extremity muscle strength was measured by isokinetic dynamometry, lean tissue (i.e., muscle) mass in the lower extremities by dual x-ray absorptiometry, depression by Center for Epidemiology Depression (CES-D) scale. knee pain by Western Ontario McMaster University OA instrument, and perceived general health status by the Medical Outcome Survey Short Form-36. RESULTS: In contrast to those with symptomatic knee OA, those who had knee pain but no radiographic evidence of OA were less obese, had hamstring as well as quadriceps weakness, and had CES-D scores high enough to qualify for a diagnosis of clinical depression. CONCLUSION: Among subjects with knee pain but no OA--and among women in this subset, in particular--knee pain may be a manifestation of depression. rather than of joint disease.

Aged↗

PubMed2003

Pain, trunk muscle strength, spine mobility and disability following lumbar disc surgery.

OBJECTIVE: To study associations between pain, trunk muscle strength, flexibility and disability in patients with lumbar disc herniation 2 months after surgery. DESIGN: Clinical cross-sectional survey. PARTICIPANTS: 172 operated lumbar disc herniation patients. METHODS: Back and leg pain on Visual Analogue Scale, Oswestry Disability Index and Brief Depression Scale were applied to assess the subjectively perceived outcome. Isometric and dynamic strength of trunk muscles and mobility of the lumbar spine were measured to mirror physical impairment. RESULTS: Two months after the operation median leg pain had decreased by 87% and back pain by 81%, respectively. However, moderate or severe leg pain was still reported by 25% and back pain by 20% of the patients. Approximately 30% of the patients perceived moderate or severe disability measured by the Oswestry index. Decreased muscle strength and spine mobility caused functional disability, especially in older patients and patients with postoperative pain. Furthermore, the ratio of trunk extension/flexion strength had changed in favour of the flexion muscles, being 0.98. Greater age and depression were associated with poorer postoperative recovery. CONCLUSION: Pain, decreased trunk muscle strength and decreased mobility still remained in a considerable proportion of patients with lumbar disc herniation 2 months after surgery. Early identification of those patients with restrictions is essential in order to commence rehabilitation.

Adolescent↗

PubMed1995

Dynamic muscle strength as a predictor of bone mineral density in elderly women.

Although muscle strength has been shown to predict bone mineral density (BMD) in older adults, the variance explained by isometric and isokinetic testing has been generally low (< 20%) and limited to only a few exercises and muscle groups. To elucidate the relationship of muscle strength to BMD at multiple sites, and to ascertain the most robust predictor of BMD using isotonic strength testing apparatus, we examined dynamic muscle strength and BMD in 40 healthy elderly women aged 65-82 years. BMD of the spine (L2-4), proximal femur (neck, trochanter, Ward's triangle), forearm (midradius), and whole body were measured by dual-energy X-ray absorptiometry. Dynamic strength (1-RM), utilizing isotonic weight-lifting equipment, was assessed for 10 standard upper and lower body exercises. In stepwise multiple regressions, leg press was the only independent predictor of spine (R2 = 0.11), neck and trochanter (R2 = 0.21 and 0.18), forearm (R2 = 0.21), and whole body BMD (R2 = 0.19), while bench press was an independent predictor of Ward's BMD (R2 = 0.12). The most robust predictor of regional and whole body BMD using isotonic equipment was the leg press, which may reflect overall skeletal health in this population. The portion of variance explained by dynamic muscle strength (11-21%) is similar to that reported when strength is assessed by isometric and isokinetic testing. The relationship of dynamic strength to BMD was not generally site-specific.

Absorptiometry, Photon↗

PubMed1999

Unilateral lower limb injury: its long-term effects on quadriceps, hamstring, and plantarflexor muscle strength.

OBJECTIVE: To ascertain if long-term deficits in quadriceps, hamstring, and plantarflexor muscle strength remain after unilateral lower-limb musculoskeletal injury and to quantify whether improvements in performance continue once a subject concludes rehabilitation and returns to everyday activities. The relation between the size of decrement and limb dominance, type of injury, and time since injury was also considered. DESIGN: Isometric and/or dynamic muscle strength of both legs was measured (using the KinCom 500H isokinetic dynamometer) in 48 subjects. SETTING: A physiological laboratory at Brunel University. PATIENTS: Patients were recruited locally via a district general hospital, sports injury clinic, and university. MAIN OUTCOME MEASURES: Muscle strength in the injured limb, reported as a percentage of muscle strength in the uninjured limb. It was assumed that the preinjury state of the injured limb was similar to that of the uninjured limb. RESULTS: Decrements were seen in mean isometric and peak isometric, concentric, and eccentric quadriceps activity (p < .0001) and isometric plantarflexor activity (p < .05) in the injured limb, with the type of injury influencing the size of the decrement. Minimal difference was found in the hamstring muscles. CONCLUSIONS: The decrements in performance in the quadriceps muscle imply that full recovery (as defined by the preinjury state) is frequently not achieved and stress the need for accurate, objective assessment of muscle strength and further investigation into the nature and duration of rehabilitation after musculoskeletal injury.

Adult↗

PubMed1998

Muscle strength and hormonal levels in adolescents: gender related differences.

The purpose of the present investigation was to study muscle strength in adolescents and its relationship to serum levels of testosterone and growth hormone in both genders. Thirty active adolescents (15 boys; age range 11 -12 y/o) participated in the first study. Isokinetic muscle strength of the dominant knee extensors (KE) was determined at 0, 12, 20, 30, 120, 180 and 240 deg/sec using a Cybex 340 dynamometer. The assessment of pubertal status was accomplished using the criteria of Tanner. Serum levels of total testosterone (T) and growth hormone (GH) were determined using radioimmunoassay techniques. Boys had higher (p< 0.001) T levels but no differences in muscle strength were detected between genders. Fifty-seven additional subjects representing three age groups (11-12 y/o, n=18; 13-14, n=21; 17-18, n=18) participated in the second study. A significant increase in peak torque (absolute and corrected for body weight) with age was observed in both genders. There were no significant gender differences in strength for the two youngest age groups, but boys were stronger than girls in the oldest age group (group 3). Testosterone and GH levels increased with age in boys but not in girls. Gender related differences in T were found in groups 2 and 3. A positive correlation (r=0,64 boys; r=0.46 girls) between testosterone levels and absolute muscle strength was seen in both genders. Our results suggest that increases in anabolic hormones precede muscle strength gains in adolescent males. In addition, gender related differences in muscle strength during adolescents cannot be explained solely on the basis of difference in body size or T levels.

Adolescent↗

PubMed1991

Muscle strength as an indicator of the habitual level of physical activity.

This study focused on age and physical activity as determinants of muscle strength. The study involved 620 women 25-73 yr of age. The five muscle groups assessed were: grip, plantarflexors, hip abductors, trunk flexors, and trunk extensors. Pearson correlations yielded significant negative correlations of muscle strength with age and positive correlations with height as well as physical activity. The greatest decremental differences in muscle strength were registered in the perimenopausal years between the age decades of 45-54 yr and 55-64 yr. In stepwise regression analyses age was the strongest predictor of the strength of all muscle groups, with smaller contributions to the variance by physical activity and anthropometric variables. When the sample population, divided by decades of age, was further subdivided by tertiles of physical activity, the results of factorial analysis indicated that the main effects due to age and physical activity were significant. It was concluded that 1) moderate levels of physical activity tend to improve muscle strength even in older women, and 2) normative values of muscle strength could serve as an indicator of the adequacy of the habitual levels of physical activity.

Adult↗

PubMed2001

Muscle strength and motor function in children and adolescents with spinal muscular atrophy II and III.

The aim of this study was to quantify isometric muscle strength and motor function in children and adolescents with spinal muscular atrophy (SMA) and to analyse the impact of reduced muscle strength on motor function. Six children and adolescents with SMA II and eight with SMA IlI were assessed regarding isometric muscle strength and motor function. Isometric muscle strength was tested with a myometer and the values obtained were compared with normative data. Motor function was videotaped and 20 movements were scored according to a three-point scale. All of the assessed children and adolescents with SMA II and SMA III showed reduced muscle strength, but there were great differences within the group. The typical pattern of muscle weakness in SMA, with proximal weakness greater than distal and the lower limbs more affected than the upper, was also seen in these children. The muscle weakness affected motor function in all assessed children. Walking, transfer from lying or sitting to the standing position and stair-climbing were possible in some of the children, despite marked reduction of muscle strength. The study increases our knowledge concerning the degree of muscle weakness in children with SMA and the impact of muscle weakness on motor function. The results increase our possibilities of understanding the prerequisites for everyday life in these children and planning therapeutic interventions. Repeated assessments with the methods used in this study may be used to monitor the course of the disease and to evaluate the efficacy of treatment.

Activities of Daily Living↗

PubMed1992

Bone mineral density, muscle strength, and recreational exercise in men.

Muscle strength has been shown to predict bone mineral density (BMD) in women. We examined this relationship in 50 healthy men who ranged in age from 28 to 51 years (average 38.3 years). BMD of the lumbar spine, proximal femur, whole body, and tibia were measured by dual-energy x-ray absorptiometry (Hologic QDR 1000W). Dynamic strength using one repetition maximum was assessed for the biceps, quadriceps, and back extensors and for the hip abductors, adductors, and flexors. Isometric grip strength was measured by dynamometry. Daily walking mileage was assessed by 9 week stepmeter records and kinematic analysis of video filming. Subjects were designated as exercisers and nonexercisers. Exercisers participated in recreational exercise at least two times each week. The results demonstrated that BMD at all sites correlated with back and biceps strength (p < 0.01 to p = 0.0001). Body weight correlated with tibia and whole-body BMD (p < 0.001); age negatively correlated with Ward's triangle BMD (p < 0.01). In stepwise multiple regressions, back strength was the only independent predictor of spine and femoral neck density (R2 = 0.27). Further, back strength was the most robust predictor of BMD at the trochanter, Ward's triangle, whole body, and tibia, although biceps strength, age, body weight, and leg strength contributed significantly to BMD at these skeletal sites, accounting for 35-52% of the variance in BMD. Exercisers and nonexercisers were similar for walking (3.97 versus 3.94 miles/day), age (37.8 versus 38.5) years, and weight (80.0 versus 77.7 kg). However, BMD and muscle strength were significantly greater in exercises than in nonexercisers.(ABSTRACT TRUNCATED AT 250 WORDS)

Absorptiometry, Photon↗

PubMed1998

Bone mass and muscle strength in female college athletes (runners and swimmers).

OBJECTIVE: To determine whether female college athletes had increased muscle strength and bone mass in comparison with age-matched nonathletic female subjects and, if so, whether participation in weight-bearing versus non-weight-bearing exercise made a difference. MATERIAL AND METHODS: We performed a comparative statistical analysis of the bone mineral density (BMD) of the total body, lumbar spine, and femoral neck, maximal oxygen uptake (VO2max), muscle strength, and level of physical activity in 21 runners, 22 swimmers, and 20 control subjects. The study participants were female college students, 18 to 24 years old, who had had more than 8 normal menstrual cycles during the past year. RESULTS: Statistical analyses showed significantly higher VO2max in the two athletic study groups than in the control subjects (P < 0.0001). No significant difference in BMD was noted among the three groups. Total body BMD (r = 0.30; P = 0.02) and femoral neck BMD (r = 0.39; P = 0.002) were positively correlated with weight-bearing activity but not with non-weight-bearing activity. VO2Max (an index of physical fitness) was positively correlated with femoral neck BMD (r = 0.33; P = 0.009) and trochanteric BMD (r = 0.29; P = 0.021). Shoulder muscle strength (determined by isokinetic dynamometry) was positively correlated with total body BMD (r = 0.34; P = 0.007) and lumbar spine BMD (r = 0.28; P = 0.028). Swimmers had higher muscle strength in the back and upper extremities than did runners and control subjects. Hip girdle muscle strength was not significantly different among the three groups. Total body BMD had a positive correlation with percentage of body fat and height. Lumbar spine BMD was higher in subjects who had previously used oral contraceptives. The athletes had a lower percentage of body fat, were less likely to have used oral contraceptives, and had fewer years of normal menses than did the control subjects. CONCLUSION: Our study shows that (1) total body BMD and femoral neck BMD were significantly higher in the study group that performed weight-bearing exercises than in control subjects, (2) swimming exercise had no effect on BMD, and (3) although swimming is not a bone-building exercise, it can significantly improve shoulder, back, and grip muscle strength.

Adult↗

PubMed2005

Cognitive status, muscle strength, and subsequent disability in older Mexican Americans.

OBJECTIVES: To examine the association between Mini-Mental State Examination (MMSE) score and subsequent muscle strength (measured using handgrip strength) and to test the hypothesis that muscle strength will mediate any association between impaired cognition and incident activity of daily living (ADL) disability over a 7-year period in elderly Mexican Americans who were initially not disabled. DESIGN: A 7-year prospective cohort study (1993-2001). SETTING: Five southwestern states (Texas, New Mexico, Colorado, Arizona, and California). PARTICIPANTS: Two thousand three hundred eighty-one noninstitutionalized Mexican-American men and women aged 65 and older with no ADL disability at baseline. MEASUREMENTS: In-home interviews in 1993/1994, 1995/1996, 1998/1999, and 2000/2001 assessed social and demographic factors, medical conditions (diabetes mellitus, stroke, heart attack, and arthritis), body mass index (BMI), depressive symptomatology, handgrip muscle strength, and ADLs. MMSE score was dichotomized as less than 21 for poor cognition and 21 or greater for good cognition. Main outcomes measures were mean and slope of handgrip muscle strength over the 7-year period and incident disability, defined as new onset of any ADL limitation at the 2-, 5-, or 7-year follow-up interview periods. RESULTS: In mixed model analyses, there was a significant cross-sectional association between having poor cognition (MMSE<21) and lower handgrip strength, independent of age, sex, and time of interview (estimate=-1.41, standard error (SE)=0.18; P<.001). With the introduction of a cognition-by-time interaction term into the model, there was also a longitudinal association between poor cognition and change in handgrip strength over time (estimate=-0.25, SE=0.06; P<.001), indicating that subjects with poor cognition had a significantly greater decline in handgrip strength over 7 years than those with good cognition, independent of age, sex, and time. This longitudinal association between poor cognition and greater muscle decline remained significant (P<.001) after controlling for age, sex, education, and time-dependent variables of depression, BMI, and medical conditions. In general estimation equation models, having poor cognition was associated with greater risk of 7-year incident ADL disability (odds ratio=2.01, 95% confidence interval (CI)=1.60-2.52); the magnitude of the association decreased to 1.66 (95% CI=1.31-2.10) when adjustment was made for handgrip strength. CONCLUSION: Older Mexican Americans with poor cognition had steeper decline in handgrip muscle strength over 7 years than those with good cognition, independent of other demographic and health factors. A possible mediating effect of muscle strength on the association between poor cognition and subsequent ADL disability was also indicated.

Activities of Daily Living↗

PubMed1995

Measurement, nature, and implications of skeletal muscle strength in patients with neurological disorders.

Muscle strength is frequently impaired in patients with neurological disorders. Numerous instrumented and non-instrumented options exist for measuring the strength of such patients. Such measurements are useful for clarifying patient status and documenting changes over time. Moreover the measurements are often informative of present or future function among a variety of diagnostic groups. Measurements of muscle strength are an essential component of the neurological evaluation and provide information of substantial importance to clinical care.

Journal Article↗

PubMed1995

Cross-sectional study of muscle strength and bone mineral density in a population of 106 women between the ages of 44 and 87 years: relationship with age and menopause.

This study examined the correlations between isokinetic muscle strength of knee and elbow flexors and extensors with vertebral and femoral bone mineral density in a population of 106 women between the ages of 44 and 87 years. The absolute value of muscle strength correlated significantly with bone mineral density; muscle strength of the upper limb appeared to be more closely correlated with bone mass, while muscle strength in the lower limb was more specific for femoral mineral bone density. The most important finding that these results demonstrated was a concomitant decline in muscle strength of the upper limb and bone mineral density between the 5th and 6th decades. In contrast, they also showed a decline in muscle strength of the lower limbs after the 6th decade, occurring before the decline in bone mineral density observed between the 7th and 8th decades. From these results it would appear that other studies are required to examine the relationship between the essentially hormonal role in postmenopausal decline in muscle strength and the decline in physical activity during the senile period. These elements are important because they must be taken into account in physical exercise programmes designed to prevent osteoporosis.

Adult↗

PubMed1995

Maximal muscle strength of elderly women is not influenced by oestrogen status.

It has recently been reported that oestrogen replacement may preserve the ratio of muscle strength to cross-sectional area in the hand in addition to its beneficial effect on bone mass in postmenopausal women. Since muscle strength is associated with falls and fractures in elderly people, this additional effect of oestrogen replacement could be of considerable benefit to postmenopausal women. We therefore wished to determine whether this effect was also evident in larger muscle groups that are involved in ambulation, balance, and activities of daily living. We examined the relationship of oestrogen replacement therapy (ORT) to maximal dynamic muscle strength in 85 healthy women aged 65-82 years. Thirty-seven women were currently taking ORT and had been on stable doses for 2 to 43 years [17.8 (1.8); mean (SEM)], while 48 women had no previous exposure to postmenopausal oestrogen therapy. Dynamic muscle strength was determined for five standard lower-body exercises using isotonic equipment by the 1-RM method. Bone mineral density (BMD, g/cm2) of the axial and appendicular skeleton as well as body composition was assessed by dual-energy X-ray absorptiometry. There was no difference between subjects according to ORT status for age, height, weight, lean body mass (LBM), fat mass, or percentage body fat. BMD of the spine (L2-4), mid-radius, and whole body was greater (p < 0.001) in individuals receiving ORT, with no significant difference at the femoral neck. No differences existed between groups for lower-body muscle strength. Normalizing muscle strength to body mass and LBM did not alter the result.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗